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Fusion gene ID: 2656 |
FusionGeneSummary for ARID3A_TEX38 |
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Fusion gene information | Fusion gene name: ARID3A_TEX38 | Fusion gene ID: 2656 | Hgene | Tgene | Gene symbol | ARID3A | TEX38 | Gene ID | 1820 | 374973 |
Gene name | AT-rich interaction domain 3A | testis expressed 38 | |
Synonyms | BRIGHT|DRIL1|DRIL3|E2FBP1 | ATPAF1-AS1|C1orf223|THEG4 | |
Cytomap | 19p13.3 | 1p33 | |
Type of gene | protein-coding | protein-coding | |
Description | AT-rich interactive domain-containing protein 3AARID domain-containing 3AARID domain-containing protein 3AAT rich interactive domain 3A (BRIGHT- like) proteinAT rich interactive domain 3A (BRIGHT-like)B-cell regulator of IgH transcriptionE2F-binding | testis-expressed protein 38ATPAF1 antisense RNA 1ATPAF1 antisense gene protein 1testis highly expressed protein 4testis-expressed sequence 38 protein | |
Modification date | 20180523 | 20180329 | |
UniProtAcc | Q99856 | Q6PEX7 | |
Ensembl transtripts involved in fusion gene | ENST00000263620, ENST00000592216, | ENST00000569393, ENST00000334122, ENST00000415500, ENST00000564373, | |
Fusion gene scores | * DoF score | 5 X 5 X 5=125 | 1 X 1 X 1=1 |
# samples | 5 | 1 | |
** MAII score | log2(5/125*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: ARID3A [Title/Abstract] AND TEX38 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | STAD | TCGA-BR-8677-01A | ARID3A | chr19 | 960164 | + | TEX38 | chr1 | 47138696 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000263620 | ENST00000569393 | ARID3A | chr19 | 960164 | + | TEX38 | chr1 | 47138696 | + |
Frame-shift | ENST00000263620 | ENST00000334122 | ARID3A | chr19 | 960164 | + | TEX38 | chr1 | 47138696 | + |
5CDS-5UTR | ENST00000263620 | ENST00000415500 | ARID3A | chr19 | 960164 | + | TEX38 | chr1 | 47138696 | + |
5CDS-5UTR | ENST00000263620 | ENST00000564373 | ARID3A | chr19 | 960164 | + | TEX38 | chr1 | 47138696 | + |
intron-3CDS | ENST00000592216 | ENST00000569393 | ARID3A | chr19 | 960164 | + | TEX38 | chr1 | 47138696 | + |
intron-3CDS | ENST00000592216 | ENST00000334122 | ARID3A | chr19 | 960164 | + | TEX38 | chr1 | 47138696 | + |
intron-5UTR | ENST00000592216 | ENST00000415500 | ARID3A | chr19 | 960164 | + | TEX38 | chr1 | 47138696 | + |
intron-5UTR | ENST00000592216 | ENST00000564373 | ARID3A | chr19 | 960164 | + | TEX38 | chr1 | 47138696 | + |
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FusionProtFeatures for ARID3A_TEX38 |
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Hgene | Tgene |
ARID3A | TEX38 |
Transcription factor which may be involved in thecontrol of cell cycle progression by the RB1/E2F1 pathway and inB-cell differentiation. {ECO:0000269|PubMed:11812999,ECO:0000269|PubMed:12692263}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ARID3A_TEX38 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ARID3A_TEX38 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ARID3A | BTK, E2F1, ELAVL1, UBC, SP100, UBE2E3, PML, TP53, E2F2, E2F4, APP, TP53BP1, SOX2, TTC32, NOTCH2NL, FOXB1, FOXH1, FOXL1, NANOG, ARID3C, ARID3B, ZBED8, HERC2, LCN15, KIAA0430, HELZ, SOWAHA, EIF4ENIF1, PAN2, PCGF3, NISCH | TEX38 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ARID3A_TEX38 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ARID3A_TEX38 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |