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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26559

FusionGeneSummary for PDS5A_PDS5A

check button Fusion gene summary
Fusion gene informationFusion gene name: PDS5A_PDS5A
Fusion gene ID: 26559
HgeneTgene
Gene symbol

PDS5A

PDS5A

Gene ID

23244

23244

Gene namePDS5 cohesin associated factor APDS5 cohesin associated factor A
SynonymsPIG54|SCC-112|SCC112PIG54|SCC-112|SCC112
Cytomap

4p14

4p14

Type of geneprotein-codingprotein-coding
Descriptionsister chromatid cohesion protein PDS5 homolog APDS5, regulator of cohesion maintenance, homolog Acell proliferation-inducing gene 54 proteinsister chromatid cohesion protein 112sister chromatid cohesion protein PDS5 homolog APDS5, regulator of cohesion maintenance, homolog Acell proliferation-inducing gene 54 proteinsister chromatid cohesion protein 112
Modification date2018052320180523
UniProtAcc

Q29RF7

Q29RF7

Ensembl transtripts involved in fusion geneENST00000303538, ENST00000503396, 
ENST00000303538, ENST00000503396, 
Fusion gene scores* DoF score3 X 4 X 2=246 X 7 X 4=168
# samples 47
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDS5A [Title/Abstract] AND PDS5A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM449661PDS5Achr4

39826436

+PDS5Achr4

39826374

-
ChiTaRS3.1CK822313PDS5Achr4

39867233

+PDS5Achr4

39865708

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000303538ENST00000303538PDS5Achr4

39826436

+PDS5Achr4

39826374

-
intron-intronENST00000303538ENST00000503396PDS5Achr4

39826436

+PDS5Achr4

39826374

-
intron-3UTRENST00000503396ENST00000303538PDS5Achr4

39826436

+PDS5Achr4

39826374

-
intron-intronENST00000503396ENST00000503396PDS5Achr4

39826436

+PDS5Achr4

39826374

-
intron-intronENST00000303538ENST00000303538PDS5Achr4

39867233

+PDS5Achr4

39865708

+
intron-intronENST00000303538ENST00000503396PDS5Achr4

39867233

+PDS5Achr4

39865708

+
intron-intronENST00000503396ENST00000303538PDS5Achr4

39867233

+PDS5Achr4

39865708

+
intron-intronENST00000503396ENST00000503396PDS5Achr4

39867233

+PDS5Achr4

39865708

+

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FusionProtFeatures for PDS5A_PDS5A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PDS5A

Q29RF7

PDS5A

Q29RF7

Probable regulator of sister chromatid cohesion inmitosis which may stabilize cohesin complex association withchromatin. May couple sister chromatid cohesion during mitosis toDNA replication. Cohesion ensures that chromosome partitioning isaccurate in both meiotic and mitotic cells and plays an importantrole in DNA repair. {ECO:0000269|PubMed:15855230,ECO:0000269|PubMed:19907496}. Probable regulator of sister chromatid cohesion inmitosis which may stabilize cohesin complex association withchromatin. May couple sister chromatid cohesion during mitosis toDNA replication. Cohesion ensures that chromosome partitioning isaccurate in both meiotic and mitotic cells and plays an importantrole in DNA repair. {ECO:0000269|PubMed:15855230,ECO:0000269|PubMed:19907496}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PDS5A_PDS5A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PDS5A_PDS5A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PDS5A_PDS5A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PDS5A_PDS5A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource