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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26544

FusionGeneSummary for PDLIM7_PDLIM7

check button Fusion gene summary
Fusion gene informationFusion gene name: PDLIM7_PDLIM7
Fusion gene ID: 26544
HgeneTgene
Gene symbol

PDLIM7

PDLIM7

Gene ID

9260

9260

Gene namePDZ and LIM domain 7PDZ and LIM domain 7
SynonymsLMP1|LMP3LMP1|LMP3
Cytomap

5q35.3

5q35.3

Type of geneprotein-codingprotein-coding
DescriptionPDZ and LIM domain protein 71110003B01RikLIM domain proteinLMPLim mineralization protein 3PDZ and LIM domain 7 (enigma)protein enigmaPDZ and LIM domain protein 71110003B01RikLIM domain proteinLMPLim mineralization protein 3PDZ and LIM domain 7 (enigma)protein enigma
Modification date2018051920180519
UniProtAcc

Q9NR12

Q9NR12

Ensembl transtripts involved in fusion geneENST00000359895, ENST00000356618, 
ENST00000355841, ENST00000505746, 
ENST00000393551, ENST00000355572, 
ENST00000359895, ENST00000356618, 
ENST00000355841, ENST00000505746, 
ENST00000393551, ENST00000355572, 
Fusion gene scores* DoF score4 X 5 X 2=405 X 6 X 2=60
# samples 56
** MAII scorelog2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/60*10)=0
Context

PubMed: PDLIM7 [Title/Abstract] AND PDLIM7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW028807PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
ChiTaRS3.1Z28913PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000359895ENST00000359895PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-3CDSENST00000359895ENST00000356618PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-3CDSENST00000359895ENST00000355841PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-intronENST00000359895ENST00000505746PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-intronENST00000359895ENST00000393551PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-intronENST00000359895ENST00000355572PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-3CDSENST00000356618ENST00000359895PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-3CDSENST00000356618ENST00000356618PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-3CDSENST00000356618ENST00000355841PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-intronENST00000356618ENST00000505746PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-intronENST00000356618ENST00000393551PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-intronENST00000356618ENST00000355572PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-3CDSENST00000355841ENST00000359895PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-3CDSENST00000355841ENST00000356618PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-3CDSENST00000355841ENST00000355841PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-intronENST00000355841ENST00000505746PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-intronENST00000355841ENST00000393551PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-intronENST00000355841ENST00000355572PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-3CDSENST00000505746ENST00000359895PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-3CDSENST00000505746ENST00000356618PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-3CDSENST00000505746ENST00000355841PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-intronENST00000505746ENST00000505746PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-intronENST00000505746ENST00000393551PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-intronENST00000505746ENST00000355572PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-3CDSENST00000393551ENST00000359895PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-3CDSENST00000393551ENST00000356618PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-3CDSENST00000393551ENST00000355841PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-intronENST00000393551ENST00000505746PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-intronENST00000393551ENST00000393551PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-intronENST00000393551ENST00000355572PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-3CDSENST00000355572ENST00000359895PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-3CDSENST00000355572ENST00000356618PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-3CDSENST00000355572ENST00000355841PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-intronENST00000355572ENST00000505746PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-intronENST00000355572ENST00000393551PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-intronENST00000355572ENST00000355572PDLIM7chr5

176918963

+PDLIM7chr5

176916447

-
intron-intronENST00000359895ENST00000359895PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000359895ENST00000356618PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000359895ENST00000355841PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000359895ENST00000505746PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000359895ENST00000393551PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000359895ENST00000355572PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000356618ENST00000359895PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000356618ENST00000356618PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000356618ENST00000355841PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000356618ENST00000505746PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000356618ENST00000393551PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000356618ENST00000355572PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000355841ENST00000359895PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000355841ENST00000356618PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000355841ENST00000355841PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000355841ENST00000505746PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000355841ENST00000393551PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000355841ENST00000355572PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000505746ENST00000359895PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000505746ENST00000356618PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000505746ENST00000355841PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000505746ENST00000505746PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000505746ENST00000393551PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000505746ENST00000355572PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000393551ENST00000359895PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000393551ENST00000356618PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000393551ENST00000355841PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000393551ENST00000505746PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000393551ENST00000393551PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000393551ENST00000355572PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000355572ENST00000359895PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000355572ENST00000356618PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000355572ENST00000355841PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000355572ENST00000505746PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000355572ENST00000393551PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-
intron-intronENST00000355572ENST00000355572PDLIM7chr5

176917322

+PDLIM7chr5

176924602

-

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FusionProtFeatures for PDLIM7_PDLIM7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PDLIM7

Q9NR12

PDLIM7

Q9NR12

May function as a scaffold on which the coordinatedassembly of proteins can occur. May play a role as an adapterthat, via its PDZ domain, localizes LIM-binding proteins to actinfilaments of both skeletal muscle and nonmuscle tissues. Involvedin both of the two fundamental mechanisms of bone formation,direct bone formation (e.g. embryonic flat bones mandible andcranium), and endochondral bone formation (e.g. embryonic longbone development). Plays a role during fracture repair. Involvedin BMP6 signaling pathway (By similarity). {ECO:0000250,ECO:0000269|PubMed:11874232, ECO:0000269|PubMed:7929196}. May function as a scaffold on which the coordinatedassembly of proteins can occur. May play a role as an adapterthat, via its PDZ domain, localizes LIM-binding proteins to actinfilaments of both skeletal muscle and nonmuscle tissues. Involvedin both of the two fundamental mechanisms of bone formation,direct bone formation (e.g. embryonic flat bones mandible andcranium), and endochondral bone formation (e.g. embryonic longbone development). Plays a role during fracture repair. Involvedin BMP6 signaling pathway (By similarity). {ECO:0000250,ECO:0000269|PubMed:11874232, ECO:0000269|PubMed:7929196}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PDLIM7_PDLIM7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PDLIM7_PDLIM7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PDLIM7PSMF1, PAK7, GFAP, SPP1, UBE2I, ENKD1, WWP2, AP5B1, CCDC185, BSG, GEM, ZNF165, C20orf195, TPM2, RET, ZMYND11, SMURF1, MDM2, TP53, NR2C2, TAB2, TRAF6, TRAF2, TRAF3, UBQLN4, PCBP1, NDUFA7, MYC, PRKD2, TRADD, BAG3, SH3BP2, HNRNPD, YAP1, COPS5, PARP1, CBLC, DGCR6, PHF1, TSG101, IQGAP1, SHMT2, NXF1, OBSL1, LUZP4, FHL5, HBB, ZCCHC7, SYT11, ETV7, TRIP6, CEP128, NINL, XPO1, ACTG1, ACTN4, ACTN1, AP2A1, ATP6V1A, CALM1, CALML3, CAPZA2, CAPZB, AP2M1, CLTA, CLTB, CLTC, CPM, EPS15, FLNA, GNAI2, GNB1, ABLIM1, MYO1B, MYH9, MYL6, MYO1E, MYO5A, PLEC, SOAT1, SORD, SPTAN1, SPTBN1, SVIL, TCEB2, TMOD1, TPM1, TPM3, TPM4, VARS, YES1, LUZP1, MYO1C, ARPC4, ARPC3, ACTR3, ARPC2, MYL12A, AKAP2, SYNPO, CEP162, PALLD, MPRIP, COBL, SPECC1L, RAI14, REPIN1, BMP2K, MYO5C, QSER1, ARPC5L, MISP, ACTRT1, MYL6B, TPRN, NEDD4, SNW1, CDC5L, RNF31, RBCK1, SHARPIN, CDH1, PTPN14, PDLIM5, ZBTB10, LPXN, SLFN12, LPP, PRICKLE3, ZNF576, NFATC2IP, RGS3, LIMD1, THRB, IKZF5, RPGR, RAB3IP, TRAPPC9, TRAPPC10, TRAPPC3, TRAPPC4, TRAPPC1, TRAPPC2L, TMEM102, RAB3IL1, MB21D2, TESPDLIM7PSMF1, PAK7, GFAP, SPP1, UBE2I, ENKD1, WWP2, AP5B1, CCDC185, BSG, GEM, ZNF165, C20orf195, TPM2, RET, ZMYND11, SMURF1, MDM2, TP53, NR2C2, TAB2, TRAF6, TRAF2, TRAF3, UBQLN4, PCBP1, NDUFA7, MYC, PRKD2, TRADD, BAG3, SH3BP2, HNRNPD, YAP1, COPS5, PARP1, CBLC, DGCR6, PHF1, TSG101, IQGAP1, SHMT2, NXF1, OBSL1, LUZP4, FHL5, HBB, ZCCHC7, SYT11, ETV7, TRIP6, CEP128, NINL, XPO1, ACTG1, ACTN4, ACTN1, AP2A1, ATP6V1A, CALM1, CALML3, CAPZA2, CAPZB, AP2M1, CLTA, CLTB, CLTC, CPM, EPS15, FLNA, GNAI2, GNB1, ABLIM1, MYO1B, MYH9, MYL6, MYO1E, MYO5A, PLEC, SOAT1, SORD, SPTAN1, SPTBN1, SVIL, TCEB2, TMOD1, TPM1, TPM3, TPM4, VARS, YES1, LUZP1, MYO1C, ARPC4, ARPC3, ACTR3, ARPC2, MYL12A, AKAP2, SYNPO, CEP162, PALLD, MPRIP, COBL, SPECC1L, RAI14, REPIN1, BMP2K, MYO5C, QSER1, ARPC5L, MISP, ACTRT1, MYL6B, TPRN, NEDD4, SNW1, CDC5L, RNF31, RBCK1, SHARPIN, CDH1, PTPN14, PDLIM5, ZBTB10, LPXN, SLFN12, LPP, PRICKLE3, ZNF576, NFATC2IP, RGS3, LIMD1, THRB, IKZF5, RPGR, RAB3IP, TRAPPC9, TRAPPC10, TRAPPC3, TRAPPC4, TRAPPC1, TRAPPC2L, TMEM102, RAB3IL1, MB21D2, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PDLIM7_PDLIM7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PDLIM7_PDLIM7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource