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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26542

FusionGeneSummary for PDLIM5_ZRANB1

check button Fusion gene summary
Fusion gene informationFusion gene name: PDLIM5_ZRANB1
Fusion gene ID: 26542
HgeneTgene
Gene symbol

PDLIM5

ZRANB1

Gene ID

10611

54764

Gene namePDZ and LIM domain 5zinc finger RANBP2-type containing 1
SynonymsENH|ENH1|L9|LIMTRABID
Cytomap

4q22.3

10q26.13

Type of geneprotein-codingprotein-coding
DescriptionPDZ and LIM domain protein 5enigma homologenigma-like LIM domain proteinenigma-like PDZ and LIM domains proteinubiquitin thioesterase ZRANB1TRAF-binding domain-containing proteinTRAF-binding protein domainhTrabidzinc finger Ran-binding domain-containing protein 1zinc finger, RAN-binding domain containing 1
Modification date2018052220180523
UniProtAcc

Q96HC4

Q9UGI0

Ensembl transtripts involved in fusion geneENST00000450793, ENST00000538141, 
ENST00000380180, ENST00000318007, 
ENST00000437932, ENST00000317968, 
ENST00000542407, ENST00000508216, 
ENST00000514743, ENST00000380176, 
ENST00000359265, ENST00000512274, 
ENST00000504489, 		ENST00000359653, 
ENST00000471421, 
Fusion gene scores* DoF score14 X 14 X 6=11763 X 3 X 2=18
# samples 153
** MAII scorelog2(15/1176*10)=-2.97085365434048
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PDLIM5 [Title/Abstract] AND ZRANB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneZRANB1

GO:0035523

protein K29-linked deubiquitination

23827681

TgeneZRANB1

GO:0070536

protein K63-linked deubiquitination

23827681

TgeneZRANB1

GO:1990168

protein K33-linked deubiquitination

23827681|24768539


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW803539PDLIM5chr4

95453230

-ZRANB1chr10

126666961

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000450793ENST00000359653PDLIM5chr4

95453230

-ZRANB1chr10

126666961

+
intron-intronENST00000450793ENST00000471421PDLIM5chr4

95453230

-ZRANB1chr10

126666961

+
intron-intronENST00000538141ENST00000359653PDLIM5chr4

95453230

-ZRANB1chr10

126666961

+
intron-intronENST00000538141ENST00000471421PDLIM5chr4

95453230

-ZRANB1chr10

126666961

+
intron-intronENST00000380180ENST00000359653PDLIM5chr4

95453230

-ZRANB1chr10

126666961

+
intron-intronENST00000380180ENST00000471421PDLIM5chr4

95453230

-ZRANB1chr10

126666961

+
intron-intronENST00000318007ENST00000359653PDLIM5chr4

95453230

-ZRANB1chr10

126666961

+
intron-intronENST00000318007ENST00000471421PDLIM5chr4

95453230

-ZRANB1chr10

126666961

+
intron-intronENST00000437932ENST00000359653PDLIM5chr4

95453230

-ZRANB1chr10

126666961

+
intron-intronENST00000437932ENST00000471421PDLIM5chr4

95453230

-ZRANB1chr10

126666961

+
intron-intronENST00000317968ENST00000359653PDLIM5chr4

95453230

-ZRANB1chr10

126666961

+
intron-intronENST00000317968ENST00000471421PDLIM5chr4

95453230

-ZRANB1chr10

126666961

+
intron-intronENST00000542407ENST00000359653PDLIM5chr4

95453230

-ZRANB1chr10

126666961

+
intron-intronENST00000542407ENST00000471421PDLIM5chr4

95453230

-ZRANB1chr10

126666961

+
intron-intronENST00000508216ENST00000359653PDLIM5chr4

95453230

-ZRANB1chr10

126666961

+
intron-intronENST00000508216ENST00000471421PDLIM5chr4

95453230

-ZRANB1chr10

126666961

+
intron-intronENST00000514743ENST00000359653PDLIM5chr4

95453230

-ZRANB1chr10

126666961

+
intron-intronENST00000514743ENST00000471421PDLIM5chr4

95453230

-ZRANB1chr10

126666961

+
intron-intronENST00000380176ENST00000359653PDLIM5chr4

95453230

-ZRANB1chr10

126666961

+
intron-intronENST00000380176ENST00000471421PDLIM5chr4

95453230

-ZRANB1chr10

126666961

+
intron-intronENST00000359265ENST00000359653PDLIM5chr4

95453230

-ZRANB1chr10

126666961

+
intron-intronENST00000359265ENST00000471421PDLIM5chr4

95453230

-ZRANB1chr10

126666961

+
intron-intronENST00000512274ENST00000359653PDLIM5chr4

95453230

-ZRANB1chr10

126666961

+
intron-intronENST00000512274ENST00000471421PDLIM5chr4

95453230

-ZRANB1chr10

126666961

+
intron-intronENST00000504489ENST00000359653PDLIM5chr4

95453230

-ZRANB1chr10

126666961

+
intron-intronENST00000504489ENST00000471421PDLIM5chr4

95453230

-ZRANB1chr10

126666961

+

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FusionProtFeatures for PDLIM5_ZRANB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PDLIM5

Q96HC4

ZRANB1

Q9UGI0

May play an important role in the heart development byscaffolding PKC to the Z-disk region. May play a role in theregulation of cardiomyocyte expansion. Overexpression promotes thedevelopment of heart hypertrophy. Contributes to the regulation ofdendritic spine morphogenesis in neurons. May restrainpostsynaptic growth of excitatory synapses (By similarity).{ECO:0000250}. Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with40-fold less efficiency compared to 'Lys-29'-linked ones. Positiveregulator of the Wnt signaling pathway that deubiquitinates APCprotein, a negative regulator of Wnt-mediated transcription. Playsa role in the regulation of cell morphology and cytoskeletalorganization. Required in the stress fiber dynamics and cellmigration. May also modulate TNF-alpha signaling.{ECO:0000269|PubMed:18281465, ECO:0000269|PubMed:21834987,ECO:0000269|PubMed:22157957, ECO:0000269|PubMed:23827681}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PDLIM5_ZRANB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PDLIM5_ZRANB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PDLIM5_ZRANB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PDLIM5_ZRANB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePDLIM5C0005586Bipolar Disorder5PSYGENET
HgenePDLIM5C0036341Schizophrenia4PSYGENET
HgenePDLIM5C0041696Unipolar Depression4PSYGENET
HgenePDLIM5C1269683Major Depressive Disorder4PSYGENET
HgenePDLIM5C0151744Myocardial Ischemia1CTD_human
HgenePDLIM5C0221765Chronic schizophrenia1PSYGENET