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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26538

FusionGeneSummary for PDLIM5_STPG2

check button Fusion gene summary
Fusion gene informationFusion gene name: PDLIM5_STPG2
Fusion gene ID: 26538
HgeneTgene
Gene symbol

PDLIM5

STPG2

Gene ID

10611

285555

Gene namePDZ and LIM domain 5sperm tail PG-rich repeat containing 2
SynonymsENH|ENH1|L9|LIMC4orf37
Cytomap

4q22.3

4q22.3-q23

Type of geneprotein-codingprotein-coding
DescriptionPDZ and LIM domain protein 5enigma homologenigma-like LIM domain proteinenigma-like PDZ and LIM domains proteinsperm-tail PG-rich repeat-containing protein 2
Modification date2018052220180519
UniProtAcc

Q96HC4

Q8N412

Ensembl transtripts involved in fusion geneENST00000450793, ENST00000538141, 
ENST00000380180, ENST00000318007, 
ENST00000437932, ENST00000317968, 
ENST00000542407, ENST00000508216, 
ENST00000514743, ENST00000380176, 
ENST00000359265, ENST00000512274, 
ENST00000504489, 
ENST00000506482, 
ENST00000295268, 
Fusion gene scores* DoF score14 X 14 X 6=11762 X 2 X 2=8
# samples 152
** MAII scorelog2(15/1176*10)=-2.97085365434048
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: PDLIM5 [Title/Abstract] AND STPG2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A8BU-01APDLIM5chr4

95561601

+STPG2chr4

98108984

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000450793ENST00000506482PDLIM5chr4

95561601

+STPG2chr4

98108984

-
intron-intronENST00000450793ENST00000295268PDLIM5chr4

95561601

+STPG2chr4

98108984

-
intron-intronENST00000538141ENST00000506482PDLIM5chr4

95561601

+STPG2chr4

98108984

-
intron-intronENST00000538141ENST00000295268PDLIM5chr4

95561601

+STPG2chr4

98108984

-
intron-intronENST00000380180ENST00000506482PDLIM5chr4

95561601

+STPG2chr4

98108984

-
intron-intronENST00000380180ENST00000295268PDLIM5chr4

95561601

+STPG2chr4

98108984

-
intron-intronENST00000318007ENST00000506482PDLIM5chr4

95561601

+STPG2chr4

98108984

-
intron-intronENST00000318007ENST00000295268PDLIM5chr4

95561601

+STPG2chr4

98108984

-
5CDS-intronENST00000437932ENST00000506482PDLIM5chr4

95561601

+STPG2chr4

98108984

-
5CDS-intronENST00000437932ENST00000295268PDLIM5chr4

95561601

+STPG2chr4

98108984

-
5CDS-intronENST00000317968ENST00000506482PDLIM5chr4

95561601

+STPG2chr4

98108984

-
5CDS-intronENST00000317968ENST00000295268PDLIM5chr4

95561601

+STPG2chr4

98108984

-
5CDS-intronENST00000542407ENST00000506482PDLIM5chr4

95561601

+STPG2chr4

98108984

-
5CDS-intronENST00000542407ENST00000295268PDLIM5chr4

95561601

+STPG2chr4

98108984

-
intron-intronENST00000508216ENST00000506482PDLIM5chr4

95561601

+STPG2chr4

98108984

-
intron-intronENST00000508216ENST00000295268PDLIM5chr4

95561601

+STPG2chr4

98108984

-
5CDS-intronENST00000514743ENST00000506482PDLIM5chr4

95561601

+STPG2chr4

98108984

-
5CDS-intronENST00000514743ENST00000295268PDLIM5chr4

95561601

+STPG2chr4

98108984

-
3UTR-intronENST00000380176ENST00000506482PDLIM5chr4

95561601

+STPG2chr4

98108984

-
3UTR-intronENST00000380176ENST00000295268PDLIM5chr4

95561601

+STPG2chr4

98108984

-
intron-intronENST00000359265ENST00000506482PDLIM5chr4

95561601

+STPG2chr4

98108984

-
intron-intronENST00000359265ENST00000295268PDLIM5chr4

95561601

+STPG2chr4

98108984

-
intron-intronENST00000512274ENST00000506482PDLIM5chr4

95561601

+STPG2chr4

98108984

-
intron-intronENST00000512274ENST00000295268PDLIM5chr4

95561601

+STPG2chr4

98108984

-
intron-intronENST00000504489ENST00000506482PDLIM5chr4

95561601

+STPG2chr4

98108984

-
intron-intronENST00000504489ENST00000295268PDLIM5chr4

95561601

+STPG2chr4

98108984

-

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FusionProtFeatures for PDLIM5_STPG2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PDLIM5

Q96HC4

STPG2

Q8N412

May play an important role in the heart development byscaffolding PKC to the Z-disk region. May play a role in theregulation of cardiomyocyte expansion. Overexpression promotes thedevelopment of heart hypertrophy. Contributes to the regulation ofdendritic spine morphogenesis in neurons. May restrainpostsynaptic growth of excitatory synapses (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PDLIM5_STPG2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PDLIM5_STPG2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PDLIM5TRIM39, CACNA1B, PRKCB, PRKCE, GFI1B, NDUFA7, SIN3A, ELMSAN1, DSTN, FN1, CALU, EIF4A3, METTL1, NPLOC4, PDE12, ANP32A, CBS, IPO11, PKM, PLIN3, SRP14, UBA2, RAD23B, TPD52, ZYX, COIL, CCDC136, KRT40, KRTAP10-7, SUZ12, RNF2, BMI1, SIRT6, ILK, METTL6, RWDD2B, SYT11, DNAJC8, MAP2K1, MAP2K2, ARFIP2, CAMK2G, NTRK1, BTRC, MED4, SSX2IP, CEP128, CEP19, XPO1, CDH1, PDLIM7, TULP3, PHF19, NFATC2IP, DENR, TPM2, EMILIN1, ATG14, G3BP1, BRCA1, TESSTPG2TF, TTC5, NYX


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PDLIM5_STPG2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PDLIM5_STPG2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePDLIM5C0005586Bipolar Disorder5PSYGENET
HgenePDLIM5C0036341Schizophrenia4PSYGENET
HgenePDLIM5C0041696Unipolar Depression4PSYGENET
HgenePDLIM5C1269683Major Depressive Disorder4PSYGENET
HgenePDLIM5C0151744Myocardial Ischemia1CTD_human
HgenePDLIM5C0221765Chronic schizophrenia1PSYGENET