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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 26536

FusionGeneSummary for PDLIM5_SHISA5

check button Fusion gene summary
Fusion gene informationFusion gene name: PDLIM5_SHISA5
Fusion gene ID: 26536
HgeneTgene
Gene symbol

PDLIM5

SHISA5

Gene ID

10611

51246

Gene namePDZ and LIM domain 5shisa family member 5
SynonymsENH|ENH1|L9|LIMSCOTIN
Cytomap

4q22.3

3p21.31

Type of geneprotein-codingprotein-coding
DescriptionPDZ and LIM domain protein 5enigma homologenigma-like LIM domain proteinenigma-like PDZ and LIM domains proteinprotein shisa-5putative NF-kappa-B-activating protein 120shisa homolog 5
Modification date2018052220180523
UniProtAcc

Q96HC4

Q8N114

Ensembl transtripts involved in fusion geneENST00000450793, ENST00000538141, 
ENST00000380180, ENST00000318007, 
ENST00000437932, ENST00000317968, 
ENST00000542407, ENST00000508216, 
ENST00000514743, ENST00000380176, 
ENST00000359265, ENST00000512274, 
ENST00000504489, 		ENST00000296444, 
ENST00000444115, ENST00000426002, 
ENST00000465449, ENST00000442747, 
ENST00000443308, 
Fusion gene scores* DoF score14 X 14 X 6=117613 X 10 X 7=910
# samples 1513
** MAII scorelog2(15/1176*10)=-2.97085365434048
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/910*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDLIM5 [Title/Abstract] AND SHISA5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-LL-A7T0-01APDLIM5chr4

95539342

+SHISA5chr3

48538726

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000450793ENST00000296444PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000450793ENST00000444115PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-intronENST00000450793ENST00000426002PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-intronENST00000450793ENST00000465449PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000450793ENST00000442747PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000450793ENST00000443308PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-3CDSENST00000538141ENST00000296444PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000538141ENST00000444115PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-intronENST00000538141ENST00000426002PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-intronENST00000538141ENST00000465449PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000538141ENST00000442747PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000538141ENST00000443308PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-3CDSENST00000380180ENST00000296444PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000380180ENST00000444115PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-intronENST00000380180ENST00000426002PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-intronENST00000380180ENST00000465449PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000380180ENST00000442747PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000380180ENST00000443308PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-3CDSENST00000318007ENST00000296444PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000318007ENST00000444115PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-intronENST00000318007ENST00000426002PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-intronENST00000318007ENST00000465449PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000318007ENST00000442747PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000318007ENST00000443308PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
In-frameENST00000437932ENST00000296444PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-5UTRENST00000437932ENST00000444115PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-intronENST00000437932ENST00000426002PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-intronENST00000437932ENST00000465449PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-5UTRENST00000437932ENST00000442747PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-5UTRENST00000437932ENST00000443308PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
In-frameENST00000317968ENST00000296444PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-5UTRENST00000317968ENST00000444115PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-intronENST00000317968ENST00000426002PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-intronENST00000317968ENST00000465449PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-5UTRENST00000317968ENST00000442747PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-5UTRENST00000317968ENST00000443308PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
In-frameENST00000542407ENST00000296444PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-5UTRENST00000542407ENST00000444115PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-intronENST00000542407ENST00000426002PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-intronENST00000542407ENST00000465449PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-5UTRENST00000542407ENST00000442747PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-5UTRENST00000542407ENST00000443308PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-3CDSENST00000508216ENST00000296444PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000508216ENST00000444115PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-intronENST00000508216ENST00000426002PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-intronENST00000508216ENST00000465449PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000508216ENST00000442747PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000508216ENST00000443308PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
In-frameENST00000514743ENST00000296444PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-5UTRENST00000514743ENST00000444115PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-intronENST00000514743ENST00000426002PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-intronENST00000514743ENST00000465449PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-5UTRENST00000514743ENST00000442747PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
5CDS-5UTRENST00000514743ENST00000443308PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
3UTR-3CDSENST00000380176ENST00000296444PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
3UTR-5UTRENST00000380176ENST00000444115PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
3UTR-intronENST00000380176ENST00000426002PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
3UTR-intronENST00000380176ENST00000465449PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
3UTR-5UTRENST00000380176ENST00000442747PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
3UTR-5UTRENST00000380176ENST00000443308PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-3CDSENST00000359265ENST00000296444PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000359265ENST00000444115PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-intronENST00000359265ENST00000426002PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-intronENST00000359265ENST00000465449PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000359265ENST00000442747PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000359265ENST00000443308PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-3CDSENST00000512274ENST00000296444PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000512274ENST00000444115PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-intronENST00000512274ENST00000426002PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-intronENST00000512274ENST00000465449PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000512274ENST00000442747PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000512274ENST00000443308PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-3CDSENST00000504489ENST00000296444PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000504489ENST00000444115PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-intronENST00000504489ENST00000426002PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-intronENST00000504489ENST00000465449PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000504489ENST00000442747PDLIM5chr4

95539342

+SHISA5chr3

48538726

-
intron-5UTRENST00000504489ENST00000443308PDLIM5chr4

95539342

+SHISA5chr3

48538726

-

Top

FusionProtFeatures for PDLIM5_SHISA5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PDLIM5

Q96HC4

SHISA5

Q8N114

May play an important role in the heart development byscaffolding PKC to the Z-disk region. May play a role in theregulation of cardiomyocyte expansion. Overexpression promotes thedevelopment of heart hypertrophy. Contributes to the regulation ofdendritic spine morphogenesis in neurons. May restrainpostsynaptic growth of excitatory synapses (By similarity).{ECO:0000250}. Can induce apoptosis in a caspase-dependent manner andplays a role in p53/TP53-dependent apoptosis.{ECO:0000269|PubMed:12135983}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PDLIM5_SHISA5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PDLIM5_ENST00000437932_chr4_95539342_+_SHISA5_ENST00000296444_chr3_48538726_-_476aa
MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMTHLEAQNKIKGCTGSLNMTLQRASAAPKP
EPVPVQKPTVTSVCSETSQELAEGQRRGSQGDSKQQNGPPRKHIVERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQI
TGTEHLKESEADNTKKANNSQEPSPQLASSVASTRSMPESLDSPTSGRPGVTSLTAAAAFKPVGSTGVIKSPSWQRPNQGARGEVCMASR
GLSLFPESCPDFCCGTCDDQYCCSDVLKKFVWSEERCAVPEASVPASVEPVEQLGSALRFRPGYNDPMSGFGATLAVGLTIFVLSVVTII
ICFTCSCCCLYKTCRRPRPVVTTTTSTTVVHAPYPQPPSVPPSYPGPSYQGYHTMPPQPGMPAAPYPMQYPPPYPAQPMGPPAYHETLAG

>In-frame_PDLIM5_ENST00000317968_chr4_95539342_+_SHISA5_ENST00000296444_chr3_48538726_-_585aa
MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMTHLEAQNKIKGCTGSLNMTLQRASAAPKP
EPVPVQKGEPKEVVKPVPITSPAVSKVTSTNNMAYNKAPRPFGSVSSPKVTSIPSPSSAFTPAHATTSSHASPSPVAAVTPPLFAASGLH
ANANLSADQSPSALSAGKTAVNVPRQPTVTSVCSETSQELAEGQRRGSQGDSKQQNGPPRKHIVERYTEFYHVPTHSDASKKRLIEDTED
WRPRTGTTQSRSFRILAQITGTEHLKESEADNTKKANNSQEPSPQLASSVASTRSMPESLDSPTSGRPGVTSLTAAAAFKPVGSTGVIKS
PSWQRPNQGARGEVCMASRGLSLFPESCPDFCCGTCDDQYCCSDVLKKFVWSEERCAVPEASVPASVEPVEQLGSALRFRPGYNDPMSGF
GATLAVGLTIFVLSVVTIIICFTCSCCCLYKTCRRPRPVVTTTTSTTVVHAPYPQPPSVPPSYPGPSYQGYHTMPPQPGMPAAPYPMQYP

>In-frame_PDLIM5_ENST00000542407_chr4_95539342_+_SHISA5_ENST00000296444_chr3_48538726_-_463aa
MAYNKAPRPFGSVSSPKVTSIPSPSSAFTPAHATTSSHASPSPVAAVTPPLFAASGLHANANLSADQSPSALSAGKTAVNVPRQPTVTSV
CSETSQELAEGQRRGSQGDSKQQNGPPRKHIVERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQITGTEHLKESEADN
TKKANNSQEPSPQLASSVASTRSMPESLDSPTSGRPGVTSLTAAAAFKPVGSTGVIKSPSWQRPNQGARGEVCMASRGLSLFPESCPDFC
CGTCDDQYCCSDVLKKFVWSEERCAVPEASVPASVEPVEQLGSALRFRPGYNDPMSGFGATLAVGLTIFVLSVVTIIICFTCSCCCLYKT
CRRPRPVVTTTTSTTVVHAPYPQPPSVPPSYPGPSYQGYHTMPPQPGMPAAPYPMQYPPPYPAQPMGPPAYHETLAGGAAAPYPASQPPY

>In-frame_PDLIM5_ENST00000514743_chr4_95539342_+_SHISA5_ENST00000296444_chr3_48538726_-_614aa
MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMTHLEAQNKIKGCTGSLNMTLQRASAAPKP
EPVPVQKPTVTSVCSETSQELAEGQRRGSQGDSKQQNGKIPPKRPPRKHIVERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSF
RILAQITGTEHLKESEADNTKKAKFDSALEDLPKSGPHPPATPQVLTIGSQVATLSKVATTYSSLSSSTGNVEDSFEGFRNFSTFSSPAR
YSAAVLSSAAATVSAVIATKTRLYTPERYHSLLDALCISPVSKPLAFSYLQSSRKSTGSIHVKKTSNSQEPSPQLASSVASTRSMPESLD
SPTSGRPGVTSLTAAAAFKPVGSTGVIKSPSWQRPNQGARGEVCMASRGLSLFPESCPDFCCGTCDDQYCCSDVLKKFVWSEERCAVPEA
SVPASVEPVEQLGSALRFRPGYNDPMSGFGATLAVGLTIFVLSVVTIIICFTCSCCCLYKTCRRPRPVVTTTTSTTVVHAPYPQPPSVPP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PDLIM5_ENST00000437932_chr4_95539342_+_SHISA5_ENST00000296444_chr3_48538726_-_1428nt
ATGAGCAACTACAGTGTGTCACTGGTTGGCCCAGCTCCTTGGGGTTTCCGGCTGCAGGGCGGTAAGGATTTCAACATGCCTCTGACAATC
TCTAGTCTAAAAGATGGCGGCAAGGCAGCCCAGGCAAATGTAAGAATAGGCGATGTGGTTCTCAGCATTGATGGAATAAATGCACAAGGA
ATGACTCATCTTGAAGCCCAGAATAAGATTAAGGGTTGTACAGGCTCTTTGAATATGACTCTGCAAAGAGCATCTGCTGCACCCAAGCCT
GAGCCGGTTCCTGTTCAAAAGCCCACAGTCACCAGCGTGTGTTCCGAGACTTCTCAGGAGCTAGCAGAGGGACAGAGAAGAGGATCCCAG
GGTGACAGTAAACAGCAAAATGGCCCACCAAGAAAACACATTGTGGAGCGCTATACAGAGTTTTATCATGTACCCACTCACAGTGATGCC
AGCAAGAAGAGACTGATTGAGGATACTGAAGACTGGCGTCCAAGGACTGGAACAACTCAGTCTCGCTCTTTCCGAATCCTTGCCCAGATC
ACTGGGACTGAACATTTGAAAGAATCTGAAGCCGATAATACAAAGAAGGCAAATAACTCTCAGGAGCCTTCTCCGCAGTTGGCTTCCTCG
GTAGCTTCCACACGGAGCATGCCCGAGAGCCTGGACAGCCCAACCTCTGGCAGACCAGGGGTTACCAGCCTCACAGCTGCAGCTGCCTTC
AAGCCTGTAGGATCCACTGGCGTCATCAAGTCACCAAGCTGGCAACGGCCAAACCAAGGAGCACGTGGTGAGGTGTGTATGGCTTCCCGT
GGACTCAGCCTCTTCCCCGAGTCCTGTCCAGATTTCTGCTGTGGTACCTGTGATGACCAATACTGCTGCTCTGACGTGCTGAAGAAATTT
GTGTGGAGCGAGGAAAGGTGTGCTGTGCCTGAGGCCAGCGTGCCTGCCAGTGTAGAGCCGGTGGAGCAGCTGGGCTCGGCGCTGAGGTTT
CGCCCTGGCTACAACGACCCCATGTCAGGGTTCGGAGCGACCTTGGCCGTTGGCCTGACCATCTTTGTGCTGTCTGTCGTCACTATCATC
ATCTGCTTCACCTGCTCCTGCTGCTGCCTTTACAAGACGTGCCGCCGACCACGTCCGGTTGTCACCACCACCACATCCACCACTGTGGTG
CATGCCCCTTATCCTCAGCCTCCAAGTGTGCCGCCCAGCTACCCTGGACCAAGCTACCAGGGCTACCACACCATGCCGCCTCAGCCAGGG
ATGCCAGCAGCACCCTACCCAATGCAGTACCCACCACCTTACCCAGCCCAGCCCATGGGCCCACCGGCCTACCACGAGACCCTGGCTGGA

>In-frame_PDLIM5_ENST00000317968_chr4_95539342_+_SHISA5_ENST00000296444_chr3_48538726_-_1755nt
ATGAGCAACTACAGTGTGTCACTGGTTGGCCCAGCTCCTTGGGGTTTCCGGCTGCAGGGCGGTAAGGATTTCAACATGCCTCTGACAATC
TCTAGTCTAAAAGATGGCGGCAAGGCAGCCCAGGCAAATGTAAGAATAGGCGATGTGGTTCTCAGCATTGATGGAATAAATGCACAAGGA
ATGACTCATCTTGAAGCCCAGAATAAGATTAAGGGTTGTACAGGCTCTTTGAATATGACTCTGCAAAGAGCATCTGCTGCACCCAAGCCT
GAGCCGGTTCCTGTTCAAAAGGGAGAACCTAAAGAAGTAGTTAAACCTGTGCCCATTACATCTCCTGCTGTGTCCAAAGTCACTTCCACA
AACAACATGGCCTACAATAAGGCACCACGGCCTTTTGGTTCTGTGTCTTCACCAAAAGTCACATCCATCCCATCACCATCGTCTGCCTTC
ACCCCAGCCCATGCGACCACCTCATCACATGCTTCCCCTTCACCCGTGGCTGCCGTCACTCCTCCCCTGTTCGCTGCATCTGGACTGCAT
GCTAATGCCAATCTTAGTGCTGACCAGTCTCCATCTGCACTGAGCGCTGGTAAAACTGCAGTTAATGTCCCACGGCAGCCCACAGTCACC
AGCGTGTGTTCCGAGACTTCTCAGGAGCTAGCAGAGGGACAGAGAAGAGGATCCCAGGGTGACAGTAAACAGCAAAATGGCCCACCAAGA
AAACACATTGTGGAGCGCTATACAGAGTTTTATCATGTACCCACTCACAGTGATGCCAGCAAGAAGAGACTGATTGAGGATACTGAAGAC
TGGCGTCCAAGGACTGGAACAACTCAGTCTCGCTCTTTCCGAATCCTTGCCCAGATCACTGGGACTGAACATTTGAAAGAATCTGAAGCC
GATAATACAAAGAAGGCAAATAACTCTCAGGAGCCTTCTCCGCAGTTGGCTTCCTCGGTAGCTTCCACACGGAGCATGCCCGAGAGCCTG
GACAGCCCAACCTCTGGCAGACCAGGGGTTACCAGCCTCACAGCTGCAGCTGCCTTCAAGCCTGTAGGATCCACTGGCGTCATCAAGTCA
CCAAGCTGGCAACGGCCAAACCAAGGAGCACGTGGTGAGGTGTGTATGGCTTCCCGTGGACTCAGCCTCTTCCCCGAGTCCTGTCCAGAT
TTCTGCTGTGGTACCTGTGATGACCAATACTGCTGCTCTGACGTGCTGAAGAAATTTGTGTGGAGCGAGGAAAGGTGTGCTGTGCCTGAG
GCCAGCGTGCCTGCCAGTGTAGAGCCGGTGGAGCAGCTGGGCTCGGCGCTGAGGTTTCGCCCTGGCTACAACGACCCCATGTCAGGGTTC
GGAGCGACCTTGGCCGTTGGCCTGACCATCTTTGTGCTGTCTGTCGTCACTATCATCATCTGCTTCACCTGCTCCTGCTGCTGCCTTTAC
AAGACGTGCCGCCGACCACGTCCGGTTGTCACCACCACCACATCCACCACTGTGGTGCATGCCCCTTATCCTCAGCCTCCAAGTGTGCCG
CCCAGCTACCCTGGACCAAGCTACCAGGGCTACCACACCATGCCGCCTCAGCCAGGGATGCCAGCAGCACCCTACCCAATGCAGTACCCA
CCACCTTACCCAGCCCAGCCCATGGGCCCACCGGCCTACCACGAGACCCTGGCTGGAGGAGCAGCCGCGCCCTACCCCGCCAGCCAGCCT

>In-frame_PDLIM5_ENST00000542407_chr4_95539342_+_SHISA5_ENST00000296444_chr3_48538726_-_1389nt
ATGGCCTACAATAAGGCACCACGGCCTTTTGGTTCTGTGTCTTCACCAAAAGTCACATCCATCCCATCACCATCGTCTGCCTTCACCCCA
GCCCATGCGACCACCTCATCACATGCTTCCCCTTCACCCGTGGCTGCCGTCACTCCTCCCCTGTTCGCTGCATCTGGACTGCATGCTAAT
GCCAATCTTAGTGCTGACCAGTCTCCATCTGCACTGAGCGCTGGTAAAACTGCAGTTAATGTCCCACGGCAGCCCACAGTCACCAGCGTG
TGTTCCGAGACTTCTCAGGAGCTAGCAGAGGGACAGAGAAGAGGATCCCAGGGTGACAGTAAACAGCAAAATGGCCCACCAAGAAAACAC
ATTGTGGAGCGCTATACAGAGTTTTATCATGTACCCACTCACAGTGATGCCAGCAAGAAGAGACTGATTGAGGATACTGAAGACTGGCGT
CCAAGGACTGGAACAACTCAGTCTCGCTCTTTCCGAATCCTTGCCCAGATCACTGGGACTGAACATTTGAAAGAATCTGAAGCCGATAAT
ACAAAGAAGGCAAATAACTCTCAGGAGCCTTCTCCGCAGTTGGCTTCCTCGGTAGCTTCCACACGGAGCATGCCCGAGAGCCTGGACAGC
CCAACCTCTGGCAGACCAGGGGTTACCAGCCTCACAGCTGCAGCTGCCTTCAAGCCTGTAGGATCCACTGGCGTCATCAAGTCACCAAGC
TGGCAACGGCCAAACCAAGGAGCACGTGGTGAGGTGTGTATGGCTTCCCGTGGACTCAGCCTCTTCCCCGAGTCCTGTCCAGATTTCTGC
TGTGGTACCTGTGATGACCAATACTGCTGCTCTGACGTGCTGAAGAAATTTGTGTGGAGCGAGGAAAGGTGTGCTGTGCCTGAGGCCAGC
GTGCCTGCCAGTGTAGAGCCGGTGGAGCAGCTGGGCTCGGCGCTGAGGTTTCGCCCTGGCTACAACGACCCCATGTCAGGGTTCGGAGCG
ACCTTGGCCGTTGGCCTGACCATCTTTGTGCTGTCTGTCGTCACTATCATCATCTGCTTCACCTGCTCCTGCTGCTGCCTTTACAAGACG
TGCCGCCGACCACGTCCGGTTGTCACCACCACCACATCCACCACTGTGGTGCATGCCCCTTATCCTCAGCCTCCAAGTGTGCCGCCCAGC
TACCCTGGACCAAGCTACCAGGGCTACCACACCATGCCGCCTCAGCCAGGGATGCCAGCAGCACCCTACCCAATGCAGTACCCACCACCT
TACCCAGCCCAGCCCATGGGCCCACCGGCCTACCACGAGACCCTGGCTGGAGGAGCAGCCGCGCCCTACCCCGCCAGCCAGCCTCCTTAC

>In-frame_PDLIM5_ENST00000514743_chr4_95539342_+_SHISA5_ENST00000296444_chr3_48538726_-_1842nt
ATGAGCAACTACAGTGTGTCACTGGTTGGCCCAGCTCCTTGGGGTTTCCGGCTGCAGGGCGGTAAGGATTTCAACATGCCTCTGACAATC
TCTAGTCTAAAAGATGGCGGCAAGGCAGCCCAGGCAAATGTAAGAATAGGCGATGTGGTTCTCAGCATTGATGGAATAAATGCACAAGGA
ATGACTCATCTTGAAGCCCAGAATAAGATTAAGGGTTGTACAGGCTCTTTGAATATGACTCTGCAAAGAGCATCTGCTGCACCCAAGCCT
GAGCCGGTTCCTGTTCAAAAGCCCACAGTCACCAGCGTGTGTTCCGAGACTTCTCAGGAGCTAGCAGAGGGACAGAGAAGAGGATCCCAG
GGTGACAGTAAACAGCAAAATGGGAAAATCCCACCTAAACGCCCACCAAGAAAACACATTGTGGAGCGCTATACAGAGTTTTATCATGTA
CCCACTCACAGTGATGCCAGCAAGAAGAGACTGATTGAGGATACTGAAGACTGGCGTCCAAGGACTGGAACAACTCAGTCTCGCTCTTTC
CGAATCCTTGCCCAGATCACTGGGACTGAACATTTGAAAGAATCTGAAGCCGATAATACAAAGAAGGCAAAGTTTGACAGTGCTCTGGAA
GACCTACCTAAGAGTGGACCTCACCCTCCTGCAACTCCTCAGGTGTTAACTATTGGTAGCCAAGTGGCCACACTTTCTAAAGTAGCAACT
ACTTATTCTAGTTTAAGCAGCTCCACAGGAAATGTGGAAGATTCTTTCGAAGGTTTTCGAAACTTTTCTACCTTCTCTTCTCCTGCTAGA
TATAGTGCTGCAGTTCTGAGCAGCGCAGCTGCTACTGTGTCTGCTGTTATTGCTACAAAAACCAGGCTCTACACTCCTGAAAGATATCAC
TCACTCCTGGATGCACTTTGCATCAGCCCTGTCTCCAAGCCTTTAGCTTTTTCCTATCTGCAGTCCTCAAGGAAATCAACTGGCTCTATC
CATGTTAAGAAAACAAGTAACTCTCAGGAGCCTTCTCCGCAGTTGGCTTCCTCGGTAGCTTCCACACGGAGCATGCCCGAGAGCCTGGAC
AGCCCAACCTCTGGCAGACCAGGGGTTACCAGCCTCACAGCTGCAGCTGCCTTCAAGCCTGTAGGATCCACTGGCGTCATCAAGTCACCA
AGCTGGCAACGGCCAAACCAAGGAGCACGTGGTGAGGTGTGTATGGCTTCCCGTGGACTCAGCCTCTTCCCCGAGTCCTGTCCAGATTTC
TGCTGTGGTACCTGTGATGACCAATACTGCTGCTCTGACGTGCTGAAGAAATTTGTGTGGAGCGAGGAAAGGTGTGCTGTGCCTGAGGCC
AGCGTGCCTGCCAGTGTAGAGCCGGTGGAGCAGCTGGGCTCGGCGCTGAGGTTTCGCCCTGGCTACAACGACCCCATGTCAGGGTTCGGA
GCGACCTTGGCCGTTGGCCTGACCATCTTTGTGCTGTCTGTCGTCACTATCATCATCTGCTTCACCTGCTCCTGCTGCTGCCTTTACAAG
ACGTGCCGCCGACCACGTCCGGTTGTCACCACCACCACATCCACCACTGTGGTGCATGCCCCTTATCCTCAGCCTCCAAGTGTGCCGCCC
AGCTACCCTGGACCAAGCTACCAGGGCTACCACACCATGCCGCCTCAGCCAGGGATGCCAGCAGCACCCTACCCAATGCAGTACCCACCA
CCTTACCCAGCCCAGCCCATGGGCCCACCGGCCTACCACGAGACCCTGGCTGGAGGAGCAGCCGCGCCCTACCCCGCCAGCCAGCCTCCT


* Fusion transcript sequences (Full-length transcript).
>In-frame_PDLIM5_ENST00000437932_chr4_95539342_+_SHISA5_ENST00000296444_chr3_48538726_-_2888nt
AGCCAGGAGGCGGAAGTTCCCGCGGGCGGTGGGGACGGCGCCCTCACCGCGAGTCACTTGTCAGCCCTTGTCTGAGGCGGAGGCAGCCCC
GCGCCGCGCCGGACCCGAGCATATTTCATTTTCTGTCATTGGACTTTGAGCCATTAGAACCATGAGCAACTACAGTGTGTCACTGGTTGG
CCCAGCTCCTTGGGGTTTCCGGCTGCAGGGCGGTAAGGATTTCAACATGCCTCTGACAATCTCTAGTCTAAAAGATGGCGGCAAGGCAGC
CCAGGCAAATGTAAGAATAGGCGATGTGGTTCTCAGCATTGATGGAATAAATGCACAAGGAATGACTCATCTTGAAGCCCAGAATAAGAT
TAAGGGTTGTACAGGCTCTTTGAATATGACTCTGCAAAGAGCATCTGCTGCACCCAAGCCTGAGCCGGTTCCTGTTCAAAAGCCCACAGT
CACCAGCGTGTGTTCCGAGACTTCTCAGGAGCTAGCAGAGGGACAGAGAAGAGGATCCCAGGGTGACAGTAAACAGCAAAATGGCCCACC
AAGAAAACACATTGTGGAGCGCTATACAGAGTTTTATCATGTACCCACTCACAGTGATGCCAGCAAGAAGAGACTGATTGAGGATACTGA
AGACTGGCGTCCAAGGACTGGAACAACTCAGTCTCGCTCTTTCCGAATCCTTGCCCAGATCACTGGGACTGAACATTTGAAAGAATCTGA
AGCCGATAATACAAAGAAGGCAAATAACTCTCAGGAGCCTTCTCCGCAGTTGGCTTCCTCGGTAGCTTCCACACGGAGCATGCCCGAGAG
CCTGGACAGCCCAACCTCTGGCAGACCAGGGGTTACCAGCCTCACAGCTGCAGCTGCCTTCAAGCCTGTAGGATCCACTGGCGTCATCAA
GTCACCAAGCTGGCAACGGCCAAACCAAGGAGCACGTGGTGAGGTGTGTATGGCTTCCCGTGGACTCAGCCTCTTCCCCGAGTCCTGTCC
AGATTTCTGCTGTGGTACCTGTGATGACCAATACTGCTGCTCTGACGTGCTGAAGAAATTTGTGTGGAGCGAGGAAAGGTGTGCTGTGCC
TGAGGCCAGCGTGCCTGCCAGTGTAGAGCCGGTGGAGCAGCTGGGCTCGGCGCTGAGGTTTCGCCCTGGCTACAACGACCCCATGTCAGG
GTTCGGAGCGACCTTGGCCGTTGGCCTGACCATCTTTGTGCTGTCTGTCGTCACTATCATCATCTGCTTCACCTGCTCCTGCTGCTGCCT
TTACAAGACGTGCCGCCGACCACGTCCGGTTGTCACCACCACCACATCCACCACTGTGGTGCATGCCCCTTATCCTCAGCCTCCAAGTGT
GCCGCCCAGCTACCCTGGACCAAGCTACCAGGGCTACCACACCATGCCGCCTCAGCCAGGGATGCCAGCAGCACCCTACCCAATGCAGTA
CCCACCACCTTACCCAGCCCAGCCCATGGGCCCACCGGCCTACCACGAGACCCTGGCTGGAGGAGCAGCCGCGCCCTACCCCGCCAGCCA
GCCTCCTTACAACCCGGCCTACATGGATGCCCCGAAGGCGGCCCTCTGAGCATTCCCTGGCCTCTCTGGCTGCCACTTGGTTATGTTGTG
TGTGTGCGTGAGTGGTGTGCAGGCGCGGTTCCTTACGCCCCATGTGTGCTGTGTGTGTCCAGGCACGGTTCCTTACGCCCCATGTGTGCT
GTGTGTGTCCTGCCTGTATATGTGGCTTCCTCTGATGCTGACAAGGTGGGGAACAATCCTTGCCAGAGTGGGCTGGGACCAGACTTTGTT
CTCTTCCTCACCTGAAATTATGCTTCCTAAAATCTCAAGCCAAACTCAAAGAATGGGGTGGTGGGGGGCACCCTGTGAGGTGGCCCCTGA
GAGGTGGGGGCCTCTCCAGGGCACATCTGGAGTTCTTCTCCAGCTTACCCTAGGGTGACCAAGTAGGGCCTGTCACACCAGGGTGGCGCA
GCTTTCTGTGTGATGCAGATGTGTCCTGGTTTCGGCAGCGTAGCCAGCTGCTGCTTGAGGCCATGGCTCGTCCCCGGAGTTGGGGGTACC
CGTTGCAGAGCCAGGGACATGATGCAGGCGAAGCTTGGGATCTGGCCAAGTTGGACTTTGATCCTTTGGGCAGATGTCCCATTGCTCCCT
GGAGCCTGTCATGCCTGTTGGGGATCAGGCAGCCTCCTGATGCCAGAACACCTCAGGCAGAGCCCTACTCAGCTGTACCTGTCTGCCTGG
ACTGTCCCCTGTCCCCGCATCTCCCCTGGGACCAGCTGGAGGGCCACATGCACACACAGCCTAGCTGCCCCCAGGGAGCTCTGCTGCCCT
TGCTGGCCCTGCCCTTCCCACAGGTGAGCAGGGCTCCTGTCCACCAGCACACTCAGTTCTCTTCCCTGCAGTGTTTTCATTTTATTTTAG
CCAAACATTTTGCCTGTTTTCTGTTTCAAACATGATAGTTGATATGAGACTGAAACCCCTGGGTTGTGGAGGGAAATTGGCTCAGAGATG
GACAACCTGGCAACTGTGAGTCCCTGCTTCCCGACACCAGCCTCATGGAATATGCAACAACTCCTGTACCCCAGTCCACGGTGTTCTGGC
AGCAGGGACACCTGGGCCAATGGGCCATCTGGACCAAAGGTGGGGTGTGGGGCCCTGGATGGCAGCTCTGGCCCAGACATGAATACCTCG
TGTTCCTCCTCCCTCTATTACTGTTTCACCAGAGCTGTCTTAGCTCAAATCTGTTGTGTTTCTGAGTCTAGGGTCTGTACACTTGTTTAT
AATAAATGCAATCGTTTGGAGCTGCTGCCCCCTTTCTTCCTGGCCTCGGCTGCTGGAATTGGAATCAGGCTGTACTCTTTCCATCCATTT

>In-frame_PDLIM5_ENST00000317968_chr4_95539342_+_SHISA5_ENST00000296444_chr3_48538726_-_3200nt
GTTCCCGCGGGCGGTGGGGACGGCGCCCTCACCGCGAGTCACTTGTCAGCCCTTGTCTGAGGCGGAGGCAGCCCCGCGCCGCGCCGGACC
CGAGCATATTTCATTTTCTGTCATTGGACTTTGAGCCATTAGAACCATGAGCAACTACAGTGTGTCACTGGTTGGCCCAGCTCCTTGGGG
TTTCCGGCTGCAGGGCGGTAAGGATTTCAACATGCCTCTGACAATCTCTAGTCTAAAAGATGGCGGCAAGGCAGCCCAGGCAAATGTAAG
AATAGGCGATGTGGTTCTCAGCATTGATGGAATAAATGCACAAGGAATGACTCATCTTGAAGCCCAGAATAAGATTAAGGGTTGTACAGG
CTCTTTGAATATGACTCTGCAAAGAGCATCTGCTGCACCCAAGCCTGAGCCGGTTCCTGTTCAAAAGGGAGAACCTAAAGAAGTAGTTAA
ACCTGTGCCCATTACATCTCCTGCTGTGTCCAAAGTCACTTCCACAAACAACATGGCCTACAATAAGGCACCACGGCCTTTTGGTTCTGT
GTCTTCACCAAAAGTCACATCCATCCCATCACCATCGTCTGCCTTCACCCCAGCCCATGCGACCACCTCATCACATGCTTCCCCTTCACC
CGTGGCTGCCGTCACTCCTCCCCTGTTCGCTGCATCTGGACTGCATGCTAATGCCAATCTTAGTGCTGACCAGTCTCCATCTGCACTGAG
CGCTGGTAAAACTGCAGTTAATGTCCCACGGCAGCCCACAGTCACCAGCGTGTGTTCCGAGACTTCTCAGGAGCTAGCAGAGGGACAGAG
AAGAGGATCCCAGGGTGACAGTAAACAGCAAAATGGCCCACCAAGAAAACACATTGTGGAGCGCTATACAGAGTTTTATCATGTACCCAC
TCACAGTGATGCCAGCAAGAAGAGACTGATTGAGGATACTGAAGACTGGCGTCCAAGGACTGGAACAACTCAGTCTCGCTCTTTCCGAAT
CCTTGCCCAGATCACTGGGACTGAACATTTGAAAGAATCTGAAGCCGATAATACAAAGAAGGCAAATAACTCTCAGGAGCCTTCTCCGCA
GTTGGCTTCCTCGGTAGCTTCCACACGGAGCATGCCCGAGAGCCTGGACAGCCCAACCTCTGGCAGACCAGGGGTTACCAGCCTCACAGC
TGCAGCTGCCTTCAAGCCTGTAGGATCCACTGGCGTCATCAAGTCACCAAGCTGGCAACGGCCAAACCAAGGAGCACGTGGTGAGGTGTG
TATGGCTTCCCGTGGACTCAGCCTCTTCCCCGAGTCCTGTCCAGATTTCTGCTGTGGTACCTGTGATGACCAATACTGCTGCTCTGACGT
GCTGAAGAAATTTGTGTGGAGCGAGGAAAGGTGTGCTGTGCCTGAGGCCAGCGTGCCTGCCAGTGTAGAGCCGGTGGAGCAGCTGGGCTC
GGCGCTGAGGTTTCGCCCTGGCTACAACGACCCCATGTCAGGGTTCGGAGCGACCTTGGCCGTTGGCCTGACCATCTTTGTGCTGTCTGT
CGTCACTATCATCATCTGCTTCACCTGCTCCTGCTGCTGCCTTTACAAGACGTGCCGCCGACCACGTCCGGTTGTCACCACCACCACATC
CACCACTGTGGTGCATGCCCCTTATCCTCAGCCTCCAAGTGTGCCGCCCAGCTACCCTGGACCAAGCTACCAGGGCTACCACACCATGCC
GCCTCAGCCAGGGATGCCAGCAGCACCCTACCCAATGCAGTACCCACCACCTTACCCAGCCCAGCCCATGGGCCCACCGGCCTACCACGA
GACCCTGGCTGGAGGAGCAGCCGCGCCCTACCCCGCCAGCCAGCCTCCTTACAACCCGGCCTACATGGATGCCCCGAAGGCGGCCCTCTG
AGCATTCCCTGGCCTCTCTGGCTGCCACTTGGTTATGTTGTGTGTGTGCGTGAGTGGTGTGCAGGCGCGGTTCCTTACGCCCCATGTGTG
CTGTGTGTGTCCAGGCACGGTTCCTTACGCCCCATGTGTGCTGTGTGTGTCCTGCCTGTATATGTGGCTTCCTCTGATGCTGACAAGGTG
GGGAACAATCCTTGCCAGAGTGGGCTGGGACCAGACTTTGTTCTCTTCCTCACCTGAAATTATGCTTCCTAAAATCTCAAGCCAAACTCA
AAGAATGGGGTGGTGGGGGGCACCCTGTGAGGTGGCCCCTGAGAGGTGGGGGCCTCTCCAGGGCACATCTGGAGTTCTTCTCCAGCTTAC
CCTAGGGTGACCAAGTAGGGCCTGTCACACCAGGGTGGCGCAGCTTTCTGTGTGATGCAGATGTGTCCTGGTTTCGGCAGCGTAGCCAGC
TGCTGCTTGAGGCCATGGCTCGTCCCCGGAGTTGGGGGTACCCGTTGCAGAGCCAGGGACATGATGCAGGCGAAGCTTGGGATCTGGCCA
AGTTGGACTTTGATCCTTTGGGCAGATGTCCCATTGCTCCCTGGAGCCTGTCATGCCTGTTGGGGATCAGGCAGCCTCCTGATGCCAGAA
CACCTCAGGCAGAGCCCTACTCAGCTGTACCTGTCTGCCTGGACTGTCCCCTGTCCCCGCATCTCCCCTGGGACCAGCTGGAGGGCCACA
TGCACACACAGCCTAGCTGCCCCCAGGGAGCTCTGCTGCCCTTGCTGGCCCTGCCCTTCCCACAGGTGAGCAGGGCTCCTGTCCACCAGC
ACACTCAGTTCTCTTCCCTGCAGTGTTTTCATTTTATTTTAGCCAAACATTTTGCCTGTTTTCTGTTTCAAACATGATAGTTGATATGAG
ACTGAAACCCCTGGGTTGTGGAGGGAAATTGGCTCAGAGATGGACAACCTGGCAACTGTGAGTCCCTGCTTCCCGACACCAGCCTCATGG
AATATGCAACAACTCCTGTACCCCAGTCCACGGTGTTCTGGCAGCAGGGACACCTGGGCCAATGGGCCATCTGGACCAAAGGTGGGGTGT
GGGGCCCTGGATGGCAGCTCTGGCCCAGACATGAATACCTCGTGTTCCTCCTCCCTCTATTACTGTTTCACCAGAGCTGTCTTAGCTCAA
ATCTGTTGTGTTTCTGAGTCTAGGGTCTGTACACTTGTTTATAATAAATGCAATCGTTTGGAGCTGCTGCCCCCTTTCTTCCTGGCCTCG

>In-frame_PDLIM5_ENST00000542407_chr4_95539342_+_SHISA5_ENST00000296444_chr3_48538726_-_3007nt
CTTGTCAGCCCTTGTCTGAGGCGGAGGCAGCCCCGCGCCGCGCCGGACCCGAGCATATTTCATTTTCTGTCATTGGACTTTGAGCCATTA
GAACCATGAGCAACTACAGTGTGTCACTGGTTGGCCCAGCTCCTTGGGGTTTCCGGCTGCAGGGCGGTAAGGATTTCAACATGCCTCTGA
CAATCTCTAGTAGCATCTGCTGCACCCAAGCCTGAGCCGGTTCCTGTTCAAAAGGGAGAACCTAAAGAAGTAGTTAAACCTGTGCCCATT
ACATCTCCTGCTGTGTCCAAAGTCACTTCCACAAACAACATGGCCTACAATAAGGCACCACGGCCTTTTGGTTCTGTGTCTTCACCAAAA
GTCACATCCATCCCATCACCATCGTCTGCCTTCACCCCAGCCCATGCGACCACCTCATCACATGCTTCCCCTTCACCCGTGGCTGCCGTC
ACTCCTCCCCTGTTCGCTGCATCTGGACTGCATGCTAATGCCAATCTTAGTGCTGACCAGTCTCCATCTGCACTGAGCGCTGGTAAAACT
GCAGTTAATGTCCCACGGCAGCCCACAGTCACCAGCGTGTGTTCCGAGACTTCTCAGGAGCTAGCAGAGGGACAGAGAAGAGGATCCCAG
GGTGACAGTAAACAGCAAAATGGCCCACCAAGAAAACACATTGTGGAGCGCTATACAGAGTTTTATCATGTACCCACTCACAGTGATGCC
AGCAAGAAGAGACTGATTGAGGATACTGAAGACTGGCGTCCAAGGACTGGAACAACTCAGTCTCGCTCTTTCCGAATCCTTGCCCAGATC
ACTGGGACTGAACATTTGAAAGAATCTGAAGCCGATAATACAAAGAAGGCAAATAACTCTCAGGAGCCTTCTCCGCAGTTGGCTTCCTCG
GTAGCTTCCACACGGAGCATGCCCGAGAGCCTGGACAGCCCAACCTCTGGCAGACCAGGGGTTACCAGCCTCACAGCTGCAGCTGCCTTC
AAGCCTGTAGGATCCACTGGCGTCATCAAGTCACCAAGCTGGCAACGGCCAAACCAAGGAGCACGTGGTGAGGTGTGTATGGCTTCCCGT
GGACTCAGCCTCTTCCCCGAGTCCTGTCCAGATTTCTGCTGTGGTACCTGTGATGACCAATACTGCTGCTCTGACGTGCTGAAGAAATTT
GTGTGGAGCGAGGAAAGGTGTGCTGTGCCTGAGGCCAGCGTGCCTGCCAGTGTAGAGCCGGTGGAGCAGCTGGGCTCGGCGCTGAGGTTT
CGCCCTGGCTACAACGACCCCATGTCAGGGTTCGGAGCGACCTTGGCCGTTGGCCTGACCATCTTTGTGCTGTCTGTCGTCACTATCATC
ATCTGCTTCACCTGCTCCTGCTGCTGCCTTTACAAGACGTGCCGCCGACCACGTCCGGTTGTCACCACCACCACATCCACCACTGTGGTG
CATGCCCCTTATCCTCAGCCTCCAAGTGTGCCGCCCAGCTACCCTGGACCAAGCTACCAGGGCTACCACACCATGCCGCCTCAGCCAGGG
ATGCCAGCAGCACCCTACCCAATGCAGTACCCACCACCTTACCCAGCCCAGCCCATGGGCCCACCGGCCTACCACGAGACCCTGGCTGGA
GGAGCAGCCGCGCCCTACCCCGCCAGCCAGCCTCCTTACAACCCGGCCTACATGGATGCCCCGAAGGCGGCCCTCTGAGCATTCCCTGGC
CTCTCTGGCTGCCACTTGGTTATGTTGTGTGTGTGCGTGAGTGGTGTGCAGGCGCGGTTCCTTACGCCCCATGTGTGCTGTGTGTGTCCA
GGCACGGTTCCTTACGCCCCATGTGTGCTGTGTGTGTCCTGCCTGTATATGTGGCTTCCTCTGATGCTGACAAGGTGGGGAACAATCCTT
GCCAGAGTGGGCTGGGACCAGACTTTGTTCTCTTCCTCACCTGAAATTATGCTTCCTAAAATCTCAAGCCAAACTCAAAGAATGGGGTGG
TGGGGGGCACCCTGTGAGGTGGCCCCTGAGAGGTGGGGGCCTCTCCAGGGCACATCTGGAGTTCTTCTCCAGCTTACCCTAGGGTGACCA
AGTAGGGCCTGTCACACCAGGGTGGCGCAGCTTTCTGTGTGATGCAGATGTGTCCTGGTTTCGGCAGCGTAGCCAGCTGCTGCTTGAGGC
CATGGCTCGTCCCCGGAGTTGGGGGTACCCGTTGCAGAGCCAGGGACATGATGCAGGCGAAGCTTGGGATCTGGCCAAGTTGGACTTTGA
TCCTTTGGGCAGATGTCCCATTGCTCCCTGGAGCCTGTCATGCCTGTTGGGGATCAGGCAGCCTCCTGATGCCAGAACACCTCAGGCAGA
GCCCTACTCAGCTGTACCTGTCTGCCTGGACTGTCCCCTGTCCCCGCATCTCCCCTGGGACCAGCTGGAGGGCCACATGCACACACAGCC
TAGCTGCCCCCAGGGAGCTCTGCTGCCCTTGCTGGCCCTGCCCTTCCCACAGGTGAGCAGGGCTCCTGTCCACCAGCACACTCAGTTCTC
TTCCCTGCAGTGTTTTCATTTTATTTTAGCCAAACATTTTGCCTGTTTTCTGTTTCAAACATGATAGTTGATATGAGACTGAAACCCCTG
GGTTGTGGAGGGAAATTGGCTCAGAGATGGACAACCTGGCAACTGTGAGTCCCTGCTTCCCGACACCAGCCTCATGGAATATGCAACAAC
TCCTGTACCCCAGTCCACGGTGTTCTGGCAGCAGGGACACCTGGGCCAATGGGCCATCTGGACCAAAGGTGGGGTGTGGGGCCCTGGATG
GCAGCTCTGGCCCAGACATGAATACCTCGTGTTCCTCCTCCCTCTATTACTGTTTCACCAGAGCTGTCTTAGCTCAAATCTGTTGTGTTT
CTGAGTCTAGGGTCTGTACACTTGTTTATAATAAATGCAATCGTTTGGAGCTGCTGCCCCCTTTCTTCCTGGCCTCGGCTGCTGGAATTG

>In-frame_PDLIM5_ENST00000514743_chr4_95539342_+_SHISA5_ENST00000296444_chr3_48538726_-_3195nt
AGCATATTTCATTTTCTGTCATTGGACTTTGAGCCATTAGAACCATGAGCAACTACAGTGTGTCACTGGTTGGCCCAGCTCCTTGGGGTT
TCCGGCTGCAGGGCGGTAAGGATTTCAACATGCCTCTGACAATCTCTAGTCTAAAAGATGGCGGCAAGGCAGCCCAGGCAAATGTAAGAA
TAGGCGATGTGGTTCTCAGCATTGATGGAATAAATGCACAAGGAATGACTCATCTTGAAGCCCAGAATAAGATTAAGGGTTGTACAGGCT
CTTTGAATATGACTCTGCAAAGAGCATCTGCTGCACCCAAGCCTGAGCCGGTTCCTGTTCAAAAGCCCACAGTCACCAGCGTGTGTTCCG
AGACTTCTCAGGAGCTAGCAGAGGGACAGAGAAGAGGATCCCAGGGTGACAGTAAACAGCAAAATGGGAAAATCCCACCTAAACGCCCAC
CAAGAAAACACATTGTGGAGCGCTATACAGAGTTTTATCATGTACCCACTCACAGTGATGCCAGCAAGAAGAGACTGATTGAGGATACTG
AAGACTGGCGTCCAAGGACTGGAACAACTCAGTCTCGCTCTTTCCGAATCCTTGCCCAGATCACTGGGACTGAACATTTGAAAGAATCTG
AAGCCGATAATACAAAGAAGGCAAAGTTTGACAGTGCTCTGGAAGACCTACCTAAGAGTGGACCTCACCCTCCTGCAACTCCTCAGGTGT
TAACTATTGGTAGCCAAGTGGCCACACTTTCTAAAGTAGCAACTACTTATTCTAGTTTAAGCAGCTCCACAGGAAATGTGGAAGATTCTT
TCGAAGGTTTTCGAAACTTTTCTACCTTCTCTTCTCCTGCTAGATATAGTGCTGCAGTTCTGAGCAGCGCAGCTGCTACTGTGTCTGCTG
TTATTGCTACAAAAACCAGGCTCTACACTCCTGAAAGATATCACTCACTCCTGGATGCACTTTGCATCAGCCCTGTCTCCAAGCCTTTAG
CTTTTTCCTATCTGCAGTCCTCAAGGAAATCAACTGGCTCTATCCATGTTAAGAAAACAAGTAACTCTCAGGAGCCTTCTCCGCAGTTGG
CTTCCTCGGTAGCTTCCACACGGAGCATGCCCGAGAGCCTGGACAGCCCAACCTCTGGCAGACCAGGGGTTACCAGCCTCACAGCTGCAG
CTGCCTTCAAGCCTGTAGGATCCACTGGCGTCATCAAGTCACCAAGCTGGCAACGGCCAAACCAAGGAGCACGTGGTGAGGTGTGTATGG
CTTCCCGTGGACTCAGCCTCTTCCCCGAGTCCTGTCCAGATTTCTGCTGTGGTACCTGTGATGACCAATACTGCTGCTCTGACGTGCTGA
AGAAATTTGTGTGGAGCGAGGAAAGGTGTGCTGTGCCTGAGGCCAGCGTGCCTGCCAGTGTAGAGCCGGTGGAGCAGCTGGGCTCGGCGC
TGAGGTTTCGCCCTGGCTACAACGACCCCATGTCAGGGTTCGGAGCGACCTTGGCCGTTGGCCTGACCATCTTTGTGCTGTCTGTCGTCA
CTATCATCATCTGCTTCACCTGCTCCTGCTGCTGCCTTTACAAGACGTGCCGCCGACCACGTCCGGTTGTCACCACCACCACATCCACCA
CTGTGGTGCATGCCCCTTATCCTCAGCCTCCAAGTGTGCCGCCCAGCTACCCTGGACCAAGCTACCAGGGCTACCACACCATGCCGCCTC
AGCCAGGGATGCCAGCAGCACCCTACCCAATGCAGTACCCACCACCTTACCCAGCCCAGCCCATGGGCCCACCGGCCTACCACGAGACCC
TGGCTGGAGGAGCAGCCGCGCCCTACCCCGCCAGCCAGCCTCCTTACAACCCGGCCTACATGGATGCCCCGAAGGCGGCCCTCTGAGCAT
TCCCTGGCCTCTCTGGCTGCCACTTGGTTATGTTGTGTGTGTGCGTGAGTGGTGTGCAGGCGCGGTTCCTTACGCCCCATGTGTGCTGTG
TGTGTCCAGGCACGGTTCCTTACGCCCCATGTGTGCTGTGTGTGTCCTGCCTGTATATGTGGCTTCCTCTGATGCTGACAAGGTGGGGAA
CAATCCTTGCCAGAGTGGGCTGGGACCAGACTTTGTTCTCTTCCTCACCTGAAATTATGCTTCCTAAAATCTCAAGCCAAACTCAAAGAA
TGGGGTGGTGGGGGGCACCCTGTGAGGTGGCCCCTGAGAGGTGGGGGCCTCTCCAGGGCACATCTGGAGTTCTTCTCCAGCTTACCCTAG
GGTGACCAAGTAGGGCCTGTCACACCAGGGTGGCGCAGCTTTCTGTGTGATGCAGATGTGTCCTGGTTTCGGCAGCGTAGCCAGCTGCTG
CTTGAGGCCATGGCTCGTCCCCGGAGTTGGGGGTACCCGTTGCAGAGCCAGGGACATGATGCAGGCGAAGCTTGGGATCTGGCCAAGTTG
GACTTTGATCCTTTGGGCAGATGTCCCATTGCTCCCTGGAGCCTGTCATGCCTGTTGGGGATCAGGCAGCCTCCTGATGCCAGAACACCT
CAGGCAGAGCCCTACTCAGCTGTACCTGTCTGCCTGGACTGTCCCCTGTCCCCGCATCTCCCCTGGGACCAGCTGGAGGGCCACATGCAC
ACACAGCCTAGCTGCCCCCAGGGAGCTCTGCTGCCCTTGCTGGCCCTGCCCTTCCCACAGGTGAGCAGGGCTCCTGTCCACCAGCACACT
CAGTTCTCTTCCCTGCAGTGTTTTCATTTTATTTTAGCCAAACATTTTGCCTGTTTTCTGTTTCAAACATGATAGTTGATATGAGACTGA
AACCCCTGGGTTGTGGAGGGAAATTGGCTCAGAGATGGACAACCTGGCAACTGTGAGTCCCTGCTTCCCGACACCAGCCTCATGGAATAT
GCAACAACTCCTGTACCCCAGTCCACGGTGTTCTGGCAGCAGGGACACCTGGGCCAATGGGCCATCTGGACCAAAGGTGGGGTGTGGGGC
CCTGGATGGCAGCTCTGGCCCAGACATGAATACCTCGTGTTCCTCCTCCCTCTATTACTGTTTCACCAGAGCTGTCTTAGCTCAAATCTG
TTGTGTTTCTGAGTCTAGGGTCTGTACACTTGTTTATAATAAATGCAATCGTTTGGAGCTGCTGCCCCCTTTCTTCCTGGCCTCGGCTGC


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FusionGenePPI for PDLIM5_SHISA5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PDLIM5TRIM39, CACNA1B, PRKCB, PRKCE, GFI1B, NDUFA7, SIN3A, ELMSAN1, DSTN, FN1, CALU, EIF4A3, METTL1, NPLOC4, PDE12, ANP32A, CBS, IPO11, PKM, PLIN3, SRP14, UBA2, RAD23B, TPD52, ZYX, COIL, CCDC136, KRT40, KRTAP10-7, SUZ12, RNF2, BMI1, SIRT6, ILK, METTL6, RWDD2B, SYT11, DNAJC8, MAP2K1, MAP2K2, ARFIP2, CAMK2G, NTRK1, BTRC, MED4, SSX2IP, CEP128, CEP19, XPO1, CDH1, PDLIM7, TULP3, PHF19, NFATC2IP, DENR, TPM2, EMILIN1, ATG14, G3BP1, BRCA1, TESSHISA5COPS5, ALG2, HNRNPD


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PDLIM5_SHISA5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PDLIM5_SHISA5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePDLIM5C0005586Bipolar Disorder5PSYGENET
HgenePDLIM5C0036341Schizophrenia4PSYGENET
HgenePDLIM5C0041696Unipolar Depression4PSYGENET
HgenePDLIM5C1269683Major Depressive Disorder4PSYGENET
HgenePDLIM5C0151744Myocardial Ischemia1CTD_human
HgenePDLIM5C0221765Chronic schizophrenia1PSYGENET