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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26529

FusionGeneSummary for PDLIM5_ART3

check button Fusion gene summary
Fusion gene informationFusion gene name: PDLIM5_ART3
Fusion gene ID: 26529
HgeneTgene
Gene symbol

PDLIM5

ART3

Gene ID

10611

419

Gene namePDZ and LIM domain 5ADP-ribosyltransferase 3
SynonymsENH|ENH1|L9|LIMARTC3
Cytomap

4q22.3

4q21.1|4p15.1-p14

Type of geneprotein-codingprotein-coding
DescriptionPDZ and LIM domain protein 5enigma homologenigma-like LIM domain proteinenigma-like PDZ and LIM domains proteinecto-ADP-ribosyltransferase 3ADP-ribosyltransferase C2 and C3 toxin-like 3NAD(P)(+)--arginine ADP-ribosyltransferase 3mono(ADP-ribosyl)transferase 3mono-ADP-ribosyltransferase
Modification date2018052220180523
UniProtAcc

Q96HC4

Q13508

Ensembl transtripts involved in fusion geneENST00000450793, ENST00000538141, 
ENST00000380180, ENST00000318007, 
ENST00000437932, ENST00000317968, 
ENST00000542407, ENST00000508216, 
ENST00000514743, ENST00000380176, 
ENST00000359265, ENST00000512274, 
ENST00000504489, 		ENST00000341029, 
ENST00000355810, ENST00000349321, 
ENST00000513494, 
Fusion gene scores* DoF score14 X 14 X 6=11763 X 2 X 3=18
# samples 153
** MAII scorelog2(15/1176*10)=-2.97085365434048
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PDLIM5 [Title/Abstract] AND ART3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-LL-A7T0-01APDLIM5chr4

95376535

+ART3chr4

76997034

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000450793ENST00000341029PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-5UTRENST00000450793ENST00000355810PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-5UTRENST00000450793ENST00000349321PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-3UTRENST00000450793ENST00000513494PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-5UTRENST00000538141ENST00000341029PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-5UTRENST00000538141ENST00000355810PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-5UTRENST00000538141ENST00000349321PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-3UTRENST00000538141ENST00000513494PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-5UTRENST00000380180ENST00000341029PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-5UTRENST00000380180ENST00000355810PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-5UTRENST00000380180ENST00000349321PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-3UTRENST00000380180ENST00000513494PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-5UTRENST00000318007ENST00000341029PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-5UTRENST00000318007ENST00000355810PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-5UTRENST00000318007ENST00000349321PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-3UTRENST00000318007ENST00000513494PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-5UTRENST00000437932ENST00000341029PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-5UTRENST00000437932ENST00000355810PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-5UTRENST00000437932ENST00000349321PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-3UTRENST00000437932ENST00000513494PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-5UTRENST00000317968ENST00000341029PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-5UTRENST00000317968ENST00000355810PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-5UTRENST00000317968ENST00000349321PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-3UTRENST00000317968ENST00000513494PDLIM5chr4

95376535

+ART3chr4

76997034

+
5UTR-5UTRENST00000542407ENST00000341029PDLIM5chr4

95376535

+ART3chr4

76997034

+
5UTR-5UTRENST00000542407ENST00000355810PDLIM5chr4

95376535

+ART3chr4

76997034

+
5UTR-5UTRENST00000542407ENST00000349321PDLIM5chr4

95376535

+ART3chr4

76997034

+
5UTR-3UTRENST00000542407ENST00000513494PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-5UTRENST00000508216ENST00000341029PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-5UTRENST00000508216ENST00000355810PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-5UTRENST00000508216ENST00000349321PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-3UTRENST00000508216ENST00000513494PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-5UTRENST00000514743ENST00000341029PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-5UTRENST00000514743ENST00000355810PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-5UTRENST00000514743ENST00000349321PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-3UTRENST00000514743ENST00000513494PDLIM5chr4

95376535

+ART3chr4

76997034

+
intron-5UTRENST00000380176ENST00000341029PDLIM5chr4

95376535

+ART3chr4

76997034

+
intron-5UTRENST00000380176ENST00000355810PDLIM5chr4

95376535

+ART3chr4

76997034

+
intron-5UTRENST00000380176ENST00000349321PDLIM5chr4

95376535

+ART3chr4

76997034

+
intron-3UTRENST00000380176ENST00000513494PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-5UTRENST00000359265ENST00000341029PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-5UTRENST00000359265ENST00000355810PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-5UTRENST00000359265ENST00000349321PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-3UTRENST00000359265ENST00000513494PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-5UTRENST00000512274ENST00000341029PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-5UTRENST00000512274ENST00000355810PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-5UTRENST00000512274ENST00000349321PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-3UTRENST00000512274ENST00000513494PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-5UTRENST00000504489ENST00000341029PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-5UTRENST00000504489ENST00000355810PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-5UTRENST00000504489ENST00000349321PDLIM5chr4

95376535

+ART3chr4

76997034

+
5CDS-3UTRENST00000504489ENST00000513494PDLIM5chr4

95376535

+ART3chr4

76997034

+

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FusionProtFeatures for PDLIM5_ART3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PDLIM5

Q96HC4

ART3

Q13508

May play an important role in the heart development byscaffolding PKC to the Z-disk region. May play a role in theregulation of cardiomyocyte expansion. Overexpression promotes thedevelopment of heart hypertrophy. Contributes to the regulation ofdendritic spine morphogenesis in neurons. May restrainpostsynaptic growth of excitatory synapses (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PDLIM5_ART3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PDLIM5_ART3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PDLIM5TRIM39, CACNA1B, PRKCB, PRKCE, GFI1B, NDUFA7, SIN3A, ELMSAN1, DSTN, FN1, CALU, EIF4A3, METTL1, NPLOC4, PDE12, ANP32A, CBS, IPO11, PKM, PLIN3, SRP14, UBA2, RAD23B, TPD52, ZYX, COIL, CCDC136, KRT40, KRTAP10-7, SUZ12, RNF2, BMI1, SIRT6, ILK, METTL6, RWDD2B, SYT11, DNAJC8, MAP2K1, MAP2K2, ARFIP2, CAMK2G, NTRK1, BTRC, MED4, SSX2IP, CEP128, CEP19, XPO1, CDH1, PDLIM7, TULP3, PHF19, NFATC2IP, DENR, TPM2, EMILIN1, ATG14, G3BP1, BRCA1, TESART3ALCAM, PRKCD, MDN1, ATP12A, PIGO, RAB39B, DDX19B, CHD1L, DYNC2LI1, PAM, NAGLU, ARSK, HSPA12A, GPD1L, ITGA7, MGAT5, CBWD3, POGLUT1, SPG7, PSEN2, MAP2K2, SCAMP2, GALNT7, ITGA8


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PDLIM5_ART3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PDLIM5_ART3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePDLIM5C0005586Bipolar Disorder5PSYGENET
HgenePDLIM5C0036341Schizophrenia4PSYGENET
HgenePDLIM5C0041696Unipolar Depression4PSYGENET
HgenePDLIM5C1269683Major Depressive Disorder4PSYGENET
HgenePDLIM5C0151744Myocardial Ischemia1CTD_human
HgenePDLIM5C0221765Chronic schizophrenia1PSYGENET