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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26527

FusionGeneSummary for PDLIM3_SORBS2

check button Fusion gene summary
Fusion gene informationFusion gene name: PDLIM3_SORBS2
Fusion gene ID: 26527
HgeneTgene
Gene symbol

PDLIM3

SORBS2

Gene ID

27295

8470

Gene namePDZ and LIM domain 3sorbin and SH3 domain containing 2
SynonymsALPARGBP2|PRO0618
Cytomap

4q35.1

4q35.1

Type of geneprotein-codingprotein-coding
DescriptionPDZ and LIM domain protein 3alpha-actinin-2-associated LIM proteinenigma homologsorbin and SH3 domain-containing protein 2Arg binding protein 2Arg/Abl-interacting protein 2arg-binding protein 2
Modification date2018051920180523
UniProtAcc

Q53GG5

O94875

Ensembl transtripts involved in fusion geneENST00000284770, ENST00000284771, 
ENST00000284767, 
ENST00000448662, 
ENST00000431808, ENST00000284776, 
ENST00000437304, ENST00000319471, 
ENST00000449407, ENST00000355634, 
ENST00000393528, ENST00000418609, 
ENST00000498125, 
Fusion gene scores* DoF score4 X 2 X 4=3211 X 12 X 7=924
# samples 415
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(15/924*10)=-2.62293035092018
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDLIM3 [Title/Abstract] AND SORBS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-E2-A14N-01APDLIM3chr4

186456496

-SORBS2chr4

186508842

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000284770ENST00000448662PDLIM3chr4

186456496

-SORBS2chr4

186508842

-
Frame-shiftENST00000284770ENST00000431808PDLIM3chr4

186456496

-SORBS2chr4

186508842

-
In-frameENST00000284770ENST00000284776PDLIM3chr4

186456496

-SORBS2chr4

186508842

-
In-frameENST00000284770ENST00000437304PDLIM3chr4

186456496

-SORBS2chr4

186508842

-
Frame-shiftENST00000284770ENST00000319471PDLIM3chr4

186456496

-SORBS2chr4

186508842

-
Frame-shiftENST00000284770ENST00000449407PDLIM3chr4

186456496

-SORBS2chr4

186508842

-
Frame-shiftENST00000284770ENST00000355634PDLIM3chr4

186456496

-SORBS2chr4

186508842

-
In-frameENST00000284770ENST00000393528PDLIM3chr4

186456496

-SORBS2chr4

186508842

-
Frame-shiftENST00000284770ENST00000418609PDLIM3chr4

186456496

-SORBS2chr4

186508842

-
5CDS-intronENST00000284770ENST00000498125PDLIM3chr4

186456496

-SORBS2chr4

186508842

-
Frame-shiftENST00000284771ENST00000448662PDLIM3chr4

186456496

-SORBS2chr4

186508842

-
Frame-shiftENST00000284771ENST00000431808PDLIM3chr4

186456496

-SORBS2chr4

186508842

-
In-frameENST00000284771ENST00000284776PDLIM3chr4

186456496

-SORBS2chr4

186508842

-
In-frameENST00000284771ENST00000437304PDLIM3chr4

186456496

-SORBS2chr4

186508842

-
Frame-shiftENST00000284771ENST00000319471PDLIM3chr4

186456496

-SORBS2chr4

186508842

-
Frame-shiftENST00000284771ENST00000449407PDLIM3chr4

186456496

-SORBS2chr4

186508842

-
Frame-shiftENST00000284771ENST00000355634PDLIM3chr4

186456496

-SORBS2chr4

186508842

-
In-frameENST00000284771ENST00000393528PDLIM3chr4

186456496

-SORBS2chr4

186508842

-
Frame-shiftENST00000284771ENST00000418609PDLIM3chr4

186456496

-SORBS2chr4

186508842

-
5CDS-intronENST00000284771ENST00000498125PDLIM3chr4

186456496

-SORBS2chr4

186508842

-
Frame-shiftENST00000284767ENST00000448662PDLIM3chr4

186456496

-SORBS2chr4

186508842

-
Frame-shiftENST00000284767ENST00000431808PDLIM3chr4

186456496

-SORBS2chr4

186508842

-
In-frameENST00000284767ENST00000284776PDLIM3chr4

186456496

-SORBS2chr4

186508842

-
In-frameENST00000284767ENST00000437304PDLIM3chr4

186456496

-SORBS2chr4

186508842

-
Frame-shiftENST00000284767ENST00000319471PDLIM3chr4

186456496

-SORBS2chr4

186508842

-
Frame-shiftENST00000284767ENST00000449407PDLIM3chr4

186456496

-SORBS2chr4

186508842

-
Frame-shiftENST00000284767ENST00000355634PDLIM3chr4

186456496

-SORBS2chr4

186508842

-
In-frameENST00000284767ENST00000393528PDLIM3chr4

186456496

-SORBS2chr4

186508842

-
Frame-shiftENST00000284767ENST00000418609PDLIM3chr4

186456496

-SORBS2chr4

186508842

-
5CDS-intronENST00000284767ENST00000498125PDLIM3chr4

186456496

-SORBS2chr4

186508842

-

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FusionProtFeatures for PDLIM3_SORBS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PDLIM3

Q53GG5

SORBS2

O94875

May play a role in the organization of actin filamentarrays within muscle cells. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PDLIM3_SORBS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PDLIM3_SORBS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PDLIM3LMNA, BAG3, ACTN2, ALK, RHOUSORBS2YWHAE, SFN, CBL, PTK2B, FLOT1, RPL9, DLGAP4, DLGAP1, VCL, MLLT4, ABL2, ABL1, EGFR, NR1H2, SEMA6A, PALLD, ACTN1, ADAM15, WASF1, PTPN12, BAG3, AKT2, MDM2, YWHAZ, YWHAB, WAS, NCK2, SORBS2, EFS, VPS37C, SH2D4A, ATPAF2, SUZ12, CAPZA2, CLTC, DBN1, FLNA, MYH9, MYO1C, PPP1CB, IQGAP1, SYNPO, MAPRE1, LIMA1, ANLN, MYO18A, FAT1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PDLIM3_SORBS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PDLIM3_SORBS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSORBS2C0043094Weight Gain1CTD_human