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Fusion gene ID: 26526 |
FusionGeneSummary for PDLIM3_PNOC |
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Fusion gene information | Fusion gene name: PDLIM3_PNOC | Fusion gene ID: 26526 | Hgene | Tgene | Gene symbol | PDLIM3 | PNOC | Gene ID | 27295 | 5368 |
Gene name | PDZ and LIM domain 3 | prepronociceptin | |
Synonyms | ALP | N/OFQ|NOP|OFQ|PPNOC|ppN/OFQ | |
Cytomap | 4q35.1 | 8p21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | PDZ and LIM domain protein 3alpha-actinin-2-associated LIM proteinenigma homolog | prepronociceptinnociceptinnocistatinorphanin FQpre-pro-N/OFQpronociceptin | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q53GG5 | Q13519 | |
Ensembl transtripts involved in fusion gene | ENST00000284770, ENST00000284771, ENST00000284767, | ENST00000301908, ENST00000522209, | |
Fusion gene scores | * DoF score | 4 X 2 X 4=32 | 5 X 3 X 5=75 |
# samples | 4 | 5 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PDLIM3 [Title/Abstract] AND PNOC [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW383368 | PDLIM3 | chr4 | 186453609 | + | PNOC | chr8 | 28200697 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000284770 | ENST00000301908 | PDLIM3 | chr4 | 186453609 | + | PNOC | chr8 | 28200697 | - |
intron-3UTR | ENST00000284770 | ENST00000522209 | PDLIM3 | chr4 | 186453609 | + | PNOC | chr8 | 28200697 | - |
intron-3UTR | ENST00000284771 | ENST00000301908 | PDLIM3 | chr4 | 186453609 | + | PNOC | chr8 | 28200697 | - |
intron-3UTR | ENST00000284771 | ENST00000522209 | PDLIM3 | chr4 | 186453609 | + | PNOC | chr8 | 28200697 | - |
intron-3UTR | ENST00000284767 | ENST00000301908 | PDLIM3 | chr4 | 186453609 | + | PNOC | chr8 | 28200697 | - |
intron-3UTR | ENST00000284767 | ENST00000522209 | PDLIM3 | chr4 | 186453609 | + | PNOC | chr8 | 28200697 | - |
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FusionProtFeatures for PDLIM3_PNOC |
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Hgene | Tgene |
PDLIM3 | PNOC |
May play a role in the organization of actin filamentarrays within muscle cells. {ECO:0000250}. | Nociceptin: Ligand of the opioid receptor-like receptorOPRL1. It may act as a transmitter in the brain by modulatingnociceptive and locomotor behavior. May be involved in neuronaldifferentiation and development. {ECO:0000250|UniProtKB:P55791}. Nocistatin: Blocks nociceptin action in paintransmission by inhibiting nociceptin-induced hyperalgesia andallodynia. {ECO:0000250|UniProtKB:O62647}. Orphanin FQ2: Has potent analgesic activity.{ECO:0000250|UniProtKB:Q64387}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PDLIM3_PNOC |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PDLIM3_PNOC |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PDLIM3_PNOC |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PDLIM3_PNOC |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PNOC | C0011570 | Mental Depression | 3 | PSYGENET |
Tgene | PNOC | C0011581 | Depressive disorder | 3 | PSYGENET |
Tgene | PNOC | C0020429 | Hyperalgesia | 2 | CTD_human |
Tgene | PNOC | C0036341 | Schizophrenia | 2 | PSYGENET |
Tgene | PNOC | C0020649 | Hypotension | 1 | CTD_human |
Tgene | PNOC | C0023186 | Learning Disorders | 1 | CTD_human |
Tgene | PNOC | C0025261 | Memory Disorders | 1 | CTD_human |
Tgene | PNOC | C0030193 | Pain | 1 | CTD_human |
Tgene | PNOC | C0038587 | Substance Withdrawal Syndrome | 1 | CTD_human |
Tgene | PNOC | C0525045 | Mood Disorders | 1 | PSYGENET |
Tgene | PNOC | C0600467 | Neurogenic Inflammation | 1 | CTD_human |