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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26526

FusionGeneSummary for PDLIM3_PNOC

check button Fusion gene summary
Fusion gene informationFusion gene name: PDLIM3_PNOC
Fusion gene ID: 26526
HgeneTgene
Gene symbol

PDLIM3

PNOC

Gene ID

27295

5368

Gene namePDZ and LIM domain 3prepronociceptin
SynonymsALPN/OFQ|NOP|OFQ|PPNOC|ppN/OFQ
Cytomap

4q35.1

8p21.1

Type of geneprotein-codingprotein-coding
DescriptionPDZ and LIM domain protein 3alpha-actinin-2-associated LIM proteinenigma homologprepronociceptinnociceptinnocistatinorphanin FQpre-pro-N/OFQpronociceptin
Modification date2018051920180523
UniProtAcc

Q53GG5

Q13519

Ensembl transtripts involved in fusion geneENST00000284770, ENST00000284771, 
ENST00000284767, 
ENST00000301908, 
ENST00000522209, 
Fusion gene scores* DoF score4 X 2 X 4=325 X 3 X 5=75
# samples 45
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDLIM3 [Title/Abstract] AND PNOC [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW383368PDLIM3chr4

186453609

+PNOCchr8

28200697

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000284770ENST00000301908PDLIM3chr4

186453609

+PNOCchr8

28200697

-
intron-3UTRENST00000284770ENST00000522209PDLIM3chr4

186453609

+PNOCchr8

28200697

-
intron-3UTRENST00000284771ENST00000301908PDLIM3chr4

186453609

+PNOCchr8

28200697

-
intron-3UTRENST00000284771ENST00000522209PDLIM3chr4

186453609

+PNOCchr8

28200697

-
intron-3UTRENST00000284767ENST00000301908PDLIM3chr4

186453609

+PNOCchr8

28200697

-
intron-3UTRENST00000284767ENST00000522209PDLIM3chr4

186453609

+PNOCchr8

28200697

-

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FusionProtFeatures for PDLIM3_PNOC


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PDLIM3

Q53GG5

PNOC

Q13519

May play a role in the organization of actin filamentarrays within muscle cells. {ECO:0000250}. Nociceptin: Ligand of the opioid receptor-like receptorOPRL1. It may act as a transmitter in the brain by modulatingnociceptive and locomotor behavior. May be involved in neuronaldifferentiation and development. {ECO:0000250|UniProtKB:P55791}. Nocistatin: Blocks nociceptin action in paintransmission by inhibiting nociceptin-induced hyperalgesia andallodynia. {ECO:0000250|UniProtKB:O62647}. Orphanin FQ2: Has potent analgesic activity.{ECO:0000250|UniProtKB:Q64387}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PDLIM3_PNOC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PDLIM3_PNOC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PDLIM3_PNOC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PDLIM3_PNOC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePNOCC0011570Mental Depression3PSYGENET
TgenePNOCC0011581Depressive disorder3PSYGENET
TgenePNOCC0020429Hyperalgesia2CTD_human
TgenePNOCC0036341Schizophrenia2PSYGENET
TgenePNOCC0020649Hypotension1CTD_human
TgenePNOCC0023186Learning Disorders1CTD_human
TgenePNOCC0025261Memory Disorders1CTD_human
TgenePNOCC0030193Pain1CTD_human
TgenePNOCC0038587Substance Withdrawal Syndrome1CTD_human
TgenePNOCC0525045Mood Disorders1PSYGENET
TgenePNOCC0600467Neurogenic Inflammation1CTD_human