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Fusion gene ID: 26525 |
FusionGeneSummary for PDLIM3_ENPP6 |
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Fusion gene information | Fusion gene name: PDLIM3_ENPP6 | Fusion gene ID: 26525 | Hgene | Tgene | Gene symbol | PDLIM3 | ENPP6 | Gene ID | 27295 | 133121 |
Gene name | PDZ and LIM domain 3 | ectonucleotide pyrophosphatase/phosphodiesterase 6 | |
Synonyms | ALP | NPP6 | |
Cytomap | 4q35.1 | 4q35.1 | |
Type of gene | protein-coding | protein-coding | |
Description | PDZ and LIM domain protein 3alpha-actinin-2-associated LIM proteinenigma homolog | ectonucleotide pyrophosphatase/phosphodiesterase family member 6B830047L21RikE-NPP 6GPC-CpdeNPP-6choline-specific glycerophosphodiester phosphodiesteraseglycerophosphocholine cholinephosphodiesterase | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q53GG5 | Q6UWR7 | |
Ensembl transtripts involved in fusion gene | ENST00000284770, ENST00000284771, ENST00000284767, | ENST00000296741, | |
Fusion gene scores | * DoF score | 4 X 2 X 4=32 | 2 X 3 X 3=18 |
# samples | 4 | 4 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PDLIM3 [Title/Abstract] AND ENPP6 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ENPP6 | GO:0006629 | lipid metabolic process | 15788404 |
Tgene | ENPP6 | GO:0019695 | choline metabolic process | 15788404 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | PRAD | TCGA-EJ-7794-01A | PDLIM3 | chr4 | 186456496 | - | ENPP6 | chr4 | 185074886 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000284770 | ENST00000296741 | PDLIM3 | chr4 | 186456496 | - | ENPP6 | chr4 | 185074886 | - |
Frame-shift | ENST00000284771 | ENST00000296741 | PDLIM3 | chr4 | 186456496 | - | ENPP6 | chr4 | 185074886 | - |
Frame-shift | ENST00000284767 | ENST00000296741 | PDLIM3 | chr4 | 186456496 | - | ENPP6 | chr4 | 185074886 | - |
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FusionProtFeatures for PDLIM3_ENPP6 |
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Hgene | Tgene |
PDLIM3 | ENPP6 |
May play a role in the organization of actin filamentarrays within muscle cells. {ECO:0000250}. | Choline-specific glycerophosphodiesterphosphodiesterase. The preferred substrate may belysosphingomyelin (By similarity). Hydrolyzeslysophosphatidylcholine (LPC) to form monoacylglycerol andphosphorylcholine but not lysophosphatidic acid, showing it has alysophospholipase C activity. Has a preference for LPC with short(12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids.Also hydrolyzes glycerophosphorylcholine andsphingosylphosphorylcholine efficiently. Hydrolyzes the classicalsubstrate for phospholipase C, p-nitrophenyl phosphorylcholine invitro, while it does not hydrolyze the classical nucleotidephosphodiesterase substrate, p-nitrophenyl thymidine 5'-monophosphate. Does not hydrolyze diacyl phospholipids such asphosphatidylethanolamine, phosphatidylinositol,phosphatidylserine, phosphatidylglycerol and phosphatidic acid.{ECO:0000250, ECO:0000269|PubMed:15788404}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PDLIM3_ENPP6 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PDLIM3_ENPP6 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PDLIM3 | LMNA, BAG3, ACTN2, ALK, RHOU | ENPP6 | CTPS2, OCRL, MEX3B, DIAPH3, SACS, NDUFA7, SCAMP1, PIGS, EMC3, NDUFB9, STX7, NUP85, ZBTB33, IMPAD1, PTPN1, RUNDC1, STEAP3, GLB1L2, CRLF3, NDUFB3, TMTC3, GNPAT, LMF1, VAMP3, RIPK4, SLC26A6, GLMN, NDUFB8, EMC7, ND5, LMF2, C14orf80, TMEM206, NDUFB4, NDUFB5, ALG9, EMC8, MKS1, USP22, AGTRAP |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PDLIM3_ENPP6 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PDLIM3_ENPP6 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |