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Fusion gene ID: 26508 |
FusionGeneSummary for PDIA6_BANP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PDIA6_BANP | Fusion gene ID: 26508 | Hgene | Tgene | Gene symbol | PDIA6 | BANP | Gene ID | 10130 | 54971 |
| Gene name | protein disulfide isomerase family A member 6 | BTG3 associated nuclear protein | |
| Synonyms | ERP5|P5|TXNDC7 | BEND1|SMAR1|SMARBP1 | |
| Cytomap | 2p25.1 | 16q24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein disulfide-isomerase A6ER protein 5endoplasmic reticulum protein 5protein disulfide isomerase P5protein disulfide isomerase-associated 6protein disulfide isomerase-related proteinthioredoxin domain containing 7 (protein disulfide isomerase)t | protein BANPBEN domain-containing protein 1scaffold/matrix-associated region-1-binding protein | |
| Modification date | 20180522 | 20180520 | |
| UniProtAcc | Q15084 | Q8N9N5 | |
| Ensembl transtripts involved in fusion gene | ENST00000272227, ENST00000404371, ENST00000404824, ENST00000540494, ENST00000381611, ENST00000489662, | ENST00000286122, ENST00000355163, ENST00000479780, ENST00000393208, ENST00000355022, ENST00000538234, ENST00000393207, ENST00000481948, | |
| Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 2 X 2 X 2=8 |
| # samples | 5 | 2 | |
| ** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: PDIA6 [Title/Abstract] AND BANP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BM852926 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000272227 | ENST00000286122 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000272227 | ENST00000355163 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000272227 | ENST00000479780 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000272227 | ENST00000393208 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000272227 | ENST00000355022 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000272227 | ENST00000538234 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000272227 | ENST00000393207 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000272227 | ENST00000481948 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000404371 | ENST00000286122 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000404371 | ENST00000355163 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000404371 | ENST00000479780 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000404371 | ENST00000393208 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000404371 | ENST00000355022 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000404371 | ENST00000538234 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000404371 | ENST00000393207 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000404371 | ENST00000481948 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000404824 | ENST00000286122 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000404824 | ENST00000355163 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000404824 | ENST00000479780 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000404824 | ENST00000393208 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000404824 | ENST00000355022 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000404824 | ENST00000538234 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000404824 | ENST00000393207 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000404824 | ENST00000481948 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000540494 | ENST00000286122 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000540494 | ENST00000355163 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000540494 | ENST00000479780 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000540494 | ENST00000393208 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000540494 | ENST00000355022 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000540494 | ENST00000538234 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000540494 | ENST00000393207 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000540494 | ENST00000481948 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000381611 | ENST00000286122 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000381611 | ENST00000355163 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000381611 | ENST00000479780 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000381611 | ENST00000393208 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000381611 | ENST00000355022 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000381611 | ENST00000538234 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000381611 | ENST00000393207 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000381611 | ENST00000481948 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000489662 | ENST00000286122 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000489662 | ENST00000355163 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000489662 | ENST00000479780 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000489662 | ENST00000393208 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000489662 | ENST00000355022 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000489662 | ENST00000538234 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000489662 | ENST00000393207 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
| intron-intron | ENST00000489662 | ENST00000481948 | PDIA6 | chr2 | 10929937 | - | BANP | chr16 | 87985724 | + |
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FusionProtFeatures for PDIA6_BANP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PDIA6 | BANP |
| Controls V(D)J recombination during T-cell developmentby repressing T-cell receptor (TCR) beta enhancer function. Bindsto scaffold/matrix attachment region beta (S/MARbeta), an ATC-richDNA sequence located upstream of the TCR beta enhancer. Repressescyclin D1 transcription by recruiting HDAC1 to its promoter,thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. PromotesTP53 'Ser-15' phosphorylation and nuclear accumulation, whichcauses cell cycle arrest (By similarity). {ECO:0000250,ECO:0000269|PubMed:16166625}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PDIA6_BANP |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PDIA6_BANP |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PDIA6_BANP |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PDIA6_BANP |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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