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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26508

FusionGeneSummary for PDIA6_BANP

check button Fusion gene summary
Fusion gene informationFusion gene name: PDIA6_BANP
Fusion gene ID: 26508
HgeneTgene
Gene symbol

PDIA6

BANP

Gene ID

10130

54971

Gene nameprotein disulfide isomerase family A member 6BTG3 associated nuclear protein
SynonymsERP5|P5|TXNDC7BEND1|SMAR1|SMARBP1
Cytomap

2p25.1

16q24.2

Type of geneprotein-codingprotein-coding
Descriptionprotein disulfide-isomerase A6ER protein 5endoplasmic reticulum protein 5protein disulfide isomerase P5protein disulfide isomerase-associated 6protein disulfide isomerase-related proteinthioredoxin domain containing 7 (protein disulfide isomerase)tprotein BANPBEN domain-containing protein 1scaffold/matrix-associated region-1-binding protein
Modification date2018052220180520
UniProtAcc

Q15084

Q8N9N5

Ensembl transtripts involved in fusion geneENST00000272227, ENST00000404371, 
ENST00000404824, ENST00000540494, 
ENST00000381611, ENST00000489662, 
ENST00000286122, ENST00000355163, 
ENST00000479780, ENST00000393208, 
ENST00000355022, ENST00000538234, 
ENST00000393207, ENST00000481948, 
Fusion gene scores* DoF score5 X 5 X 3=752 X 2 X 2=8
# samples 52
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: PDIA6 [Title/Abstract] AND BANP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM852926PDIA6chr2

10929937

-BANPchr16

87985724

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000272227ENST00000286122PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000272227ENST00000355163PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000272227ENST00000479780PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000272227ENST00000393208PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000272227ENST00000355022PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000272227ENST00000538234PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000272227ENST00000393207PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000272227ENST00000481948PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000404371ENST00000286122PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000404371ENST00000355163PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000404371ENST00000479780PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000404371ENST00000393208PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000404371ENST00000355022PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000404371ENST00000538234PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000404371ENST00000393207PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000404371ENST00000481948PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000404824ENST00000286122PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000404824ENST00000355163PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000404824ENST00000479780PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000404824ENST00000393208PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000404824ENST00000355022PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000404824ENST00000538234PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000404824ENST00000393207PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000404824ENST00000481948PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000540494ENST00000286122PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000540494ENST00000355163PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000540494ENST00000479780PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000540494ENST00000393208PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000540494ENST00000355022PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000540494ENST00000538234PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000540494ENST00000393207PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000540494ENST00000481948PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000381611ENST00000286122PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000381611ENST00000355163PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000381611ENST00000479780PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000381611ENST00000393208PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000381611ENST00000355022PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000381611ENST00000538234PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000381611ENST00000393207PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000381611ENST00000481948PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000489662ENST00000286122PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000489662ENST00000355163PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000489662ENST00000479780PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000489662ENST00000393208PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000489662ENST00000355022PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000489662ENST00000538234PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000489662ENST00000393207PDIA6chr2

10929937

-BANPchr16

87985724

+
intron-intronENST00000489662ENST00000481948PDIA6chr2

10929937

-BANPchr16

87985724

+

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FusionProtFeatures for PDIA6_BANP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PDIA6

Q15084

BANP

Q8N9N5

Controls V(D)J recombination during T-cell developmentby repressing T-cell receptor (TCR) beta enhancer function. Bindsto scaffold/matrix attachment region beta (S/MARbeta), an ATC-richDNA sequence located upstream of the TCR beta enhancer. Repressescyclin D1 transcription by recruiting HDAC1 to its promoter,thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. PromotesTP53 'Ser-15' phosphorylation and nuclear accumulation, whichcauses cell cycle arrest (By similarity). {ECO:0000250,ECO:0000269|PubMed:16166625}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PDIA6_BANP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PDIA6_BANP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PDIA6_BANP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PDIA6_BANP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource