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Fusion gene ID: 26490 |
FusionGeneSummary for PDIA3_RPAP1 |
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Fusion gene information | Fusion gene name: PDIA3_RPAP1 | Fusion gene ID: 26490 | Hgene | Tgene | Gene symbol | PDIA3 | RPAP1 | Gene ID | 2923 | 26015 |
Gene name | protein disulfide isomerase family A member 3 | RNA polymerase II associated protein 1 | |
Synonyms | ER60|ERp57|ERp60|ERp61|GRP57|GRP58|HEL-S-269|HEL-S-93n|HsT17083|P58|PI-PLC | - | |
Cytomap | 15q15.3 | 15q15.1 | |
Type of gene | protein-coding | protein-coding | |
Description | protein disulfide-isomerase A358 kDa glucose-regulated protein58 kDa microsomal proteinER protein 57ER protein 60disulfide isomerase ER-60endoplasmic reticulum P58endoplasmic reticulum resident protein 57endoplasmic reticulum resident protein 60e | RNA polymerase II-associated protein 1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P30101 | Q9BWH6 | |
Ensembl transtripts involved in fusion gene | ENST00000300289, ENST00000469684, ENST00000538521, | ENST00000561603, ENST00000304330, ENST00000568413, | |
Fusion gene scores | * DoF score | 9 X 8 X 4=288 | 2 X 1 X 2=4 |
# samples | 9 | 2 | |
** MAII score | log2(9/288*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: PDIA3 [Title/Abstract] AND RPAP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | PRAD | TCGA-J4-A83I-01A | PDIA3 | chr15 | 44038904 | + | RPAP1 | chr15 | 41829399 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000300289 | ENST00000561603 | PDIA3 | chr15 | 44038904 | + | RPAP1 | chr15 | 41829399 | - |
5CDS-5UTR | ENST00000300289 | ENST00000304330 | PDIA3 | chr15 | 44038904 | + | RPAP1 | chr15 | 41829399 | - |
5CDS-intron | ENST00000300289 | ENST00000568413 | PDIA3 | chr15 | 44038904 | + | RPAP1 | chr15 | 41829399 | - |
3UTR-5UTR | ENST00000469684 | ENST00000561603 | PDIA3 | chr15 | 44038904 | + | RPAP1 | chr15 | 41829399 | - |
3UTR-5UTR | ENST00000469684 | ENST00000304330 | PDIA3 | chr15 | 44038904 | + | RPAP1 | chr15 | 41829399 | - |
3UTR-intron | ENST00000469684 | ENST00000568413 | PDIA3 | chr15 | 44038904 | + | RPAP1 | chr15 | 41829399 | - |
5UTR-5UTR | ENST00000538521 | ENST00000561603 | PDIA3 | chr15 | 44038904 | + | RPAP1 | chr15 | 41829399 | - |
5UTR-5UTR | ENST00000538521 | ENST00000304330 | PDIA3 | chr15 | 44038904 | + | RPAP1 | chr15 | 41829399 | - |
5UTR-intron | ENST00000538521 | ENST00000568413 | PDIA3 | chr15 | 44038904 | + | RPAP1 | chr15 | 41829399 | - |
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FusionProtFeatures for PDIA3_RPAP1 |
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Hgene | Tgene |
PDIA3 | RPAP1 |
Forms an interface between the RNA polymerase II enzymeand chaperone/scaffolding protein, suggesting that it is requiredto connect RNA polymerase II to regulators of protein complexformation. Required for interaction of the RNA polymerase IIcomplex with acetylated histone H3. {ECO:0000269|PubMed:17643375}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PDIA3_RPAP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PDIA3_RPAP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PDIA3 | CALR, GYPC, SLC2A1, SLC12A3, TAP1, STAT3, HMGB1, PLAA, CAV1, CDK2, SEC61A1, APP, HSPA8, HSPA5, VIM, PPIB, GARS, RPN2, ITGA2, ITGA3, ITGA6, ITGB1, ITGB5, COL6A1, LAMB1, LAMB3, LAMC1, LAMC2, PLXNA1, AGRN, EFEMP1, LDLR, DCBLD1, CLU, LOXL2, ADAM17, ADAM10, MFI2, PLOD1, TAPBP, PDIA4, ERO1L, ERO1LB, ATF2, MTOR, RPTOR, RICTOR, CANX, HDAC10, EGFR, BCCIP, CNDP2, CSE1L, LDHA, MTPN, NANS, NPEPPS, ABCE1, ACOT7, ADSS, ATP6V1A, DAK, HSPD1, MTAP, RAB1A, RBBP4, PGD, RPL23, SLC9A3R1, SMS, FUS, CUL7, OBSL1, CCDC8, SUZ12, ESR1, INHA, LGALS9, UNK, ATP5O, DDX17, FLNA, HMBS, NMD3, P4HB, AARS, ANXA5, ARHGDIA, ATP5H, CORO1C, HNRNPK, PAK2, TARDBP, TXLNA, PSMB5, RAD23B, TAGLN2, XRCC6, NTRK1, MDM2, OFD1, TCTN3, CNTRL, FBF1, TCTN1, PPME1, ATP6AP2, GOLT1B, KBTBD7, UBE3A, MCM2, PES1, U2AF2, PTPRN, ACP5, DUSP13, JMJD8, PTPRO, PA2G4, TRAP1, SND1, SNRPB2, EIF5B, GPI, IDH2, UBE2N, MRPL12, CRNN, ZNF207, MTNR1B, DLST, PDHA1, SDHA, SOAT1, SOD1, EDEM3, HLA-B, YAP1 | RPAP1 | MEPCE, POLR2J, ARHGAP23, HNRNPA1, IGF2BP1, GPN1, POLR2B, HSPD1, POLR2C, SRP72, EFTUD2, ZFR, POLR3A, ELAVL1, CENPC, ILF3, POLR3B, HSPA8, BAG6, KIF11, CCT6A, DDX3Y, PHF8, NUMA1, IPO9, SLFN11, CSNK2B, MAGED2, HLTF, MCM10, SYTL2, ERBB2IP, ANAPC1, TERF2IP, POT1, LAGE3, IGBP1, PPIL3, PAICS, POLR2L, CCDC8, GPN2, POLR2M, NHP2L1, NTRK1, XPO1, POLK, C1orf94, POLR1C |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PDIA3_RPAP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | PDIA3 | P30101 | DB01593 | Zinc | Protein disulfide-isomerase A3 | small molecule | approved|investigational |
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RelatedDiseases for PDIA3_RPAP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PDIA3 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | PDIA3 | C0948089 | Acute Coronary Syndrome | 1 | CTD_human |
Hgene | PDIA3 | C1846707 | SPINOCEREBELLAR ATAXIA 17 | 1 | CTD_human |
Hgene | PDIA3 | C2239176 | Liver carcinoma | 1 | CTD_human |