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Fusion gene ID: 26480 |
FusionGeneSummary for PDHX_STK32B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PDHX_STK32B | Fusion gene ID: 26480 | Hgene | Tgene | Gene symbol | PDHX | STK32B | Gene ID | 8050 | 55351 |
| Gene name | pyruvate dehydrogenase complex component X | serine/threonine kinase 32B | |
| Synonyms | DLDBP|E3BP|OPDX|PDHXD|PDX1|proX | HSA250839|STK32|STKG6|YANK2 | |
| Cytomap | 11p13 | 4p16.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pyruvate dehydrogenase protein X component, mitochondrialdihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complexlipoyl-containing pyruvate dehydrogenase complex component Xpyruvate dehydrogenase complex, E3-binding protein subu | serine/threonine-protein kinase 32Bgene for serine/threonine protein kinaseyet another novel kinase 2 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | O00330 | Q9NY57 | |
| Ensembl transtripts involved in fusion gene | ENST00000448838, ENST00000227868, ENST00000430469, ENST00000477173, | ENST00000282908, ENST00000512636, ENST00000510398, ENST00000508728, | |
| Fusion gene scores | * DoF score | 9 X 9 X 5=405 | 2 X 2 X 2=8 |
| # samples | 12 | 2 | |
| ** MAII score | log2(12/405*10)=-1.75488750216347 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: PDHX [Title/Abstract] AND STK32B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | CESC | TCGA-JW-A5VJ-01A | PDHX | chr11 | 34953031 | + | STK32B | chr4 | 5418572 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000448838 | ENST00000282908 | PDHX | chr11 | 34953031 | + | STK32B | chr4 | 5418572 | + |
| 5CDS-intron | ENST00000448838 | ENST00000512636 | PDHX | chr11 | 34953031 | + | STK32B | chr4 | 5418572 | + |
| 5CDS-intron | ENST00000448838 | ENST00000510398 | PDHX | chr11 | 34953031 | + | STK32B | chr4 | 5418572 | + |
| 5CDS-intron | ENST00000448838 | ENST00000508728 | PDHX | chr11 | 34953031 | + | STK32B | chr4 | 5418572 | + |
| In-frame | ENST00000227868 | ENST00000282908 | PDHX | chr11 | 34953031 | + | STK32B | chr4 | 5418572 | + |
| 5CDS-intron | ENST00000227868 | ENST00000512636 | PDHX | chr11 | 34953031 | + | STK32B | chr4 | 5418572 | + |
| 5CDS-intron | ENST00000227868 | ENST00000510398 | PDHX | chr11 | 34953031 | + | STK32B | chr4 | 5418572 | + |
| 5CDS-intron | ENST00000227868 | ENST00000508728 | PDHX | chr11 | 34953031 | + | STK32B | chr4 | 5418572 | + |
| In-frame | ENST00000430469 | ENST00000282908 | PDHX | chr11 | 34953031 | + | STK32B | chr4 | 5418572 | + |
| 5CDS-intron | ENST00000430469 | ENST00000512636 | PDHX | chr11 | 34953031 | + | STK32B | chr4 | 5418572 | + |
| 5CDS-intron | ENST00000430469 | ENST00000510398 | PDHX | chr11 | 34953031 | + | STK32B | chr4 | 5418572 | + |
| 5CDS-intron | ENST00000430469 | ENST00000508728 | PDHX | chr11 | 34953031 | + | STK32B | chr4 | 5418572 | + |
| intron-3CDS | ENST00000477173 | ENST00000282908 | PDHX | chr11 | 34953031 | + | STK32B | chr4 | 5418572 | + |
| intron-intron | ENST00000477173 | ENST00000512636 | PDHX | chr11 | 34953031 | + | STK32B | chr4 | 5418572 | + |
| intron-intron | ENST00000477173 | ENST00000510398 | PDHX | chr11 | 34953031 | + | STK32B | chr4 | 5418572 | + |
| intron-intron | ENST00000477173 | ENST00000508728 | PDHX | chr11 | 34953031 | + | STK32B | chr4 | 5418572 | + |
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FusionProtFeatures for PDHX_STK32B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PDHX | STK32B |
| Required for anchoring dihydrolipoamide dehydrogenase(E3) to the dihydrolipoamide transacetylase (E2) core of thepyruvate dehydrogenase complexes of eukaryotes. This specificbinding is essential for a functional PDH complex. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PDHX | chr11:34953031 | chr4:5418572 | ENST00000227868 | + | 2 | 11 | 149_170 | 80 | 502 | Compositional bias | Note=Pro-rich |
| Hgene | >PDHX | chr11:34953031 | chr4:5418572 | ENST00000430469 | + | 2 | 6 | 149_170 | 80 | 275 | Compositional bias | Note=Pro-rich |
| Hgene | >PDHX | chr11:34953031 | chr4:5418572 | ENST00000227868 | + | 2 | 11 | 183_220 | 80 | 502 | Domain | Peripheral subunit-binding (PSBD) |
| Hgene | >PDHX | chr11:34953031 | chr4:5418572 | ENST00000227868 | + | 2 | 11 | 56_132 | 80 | 502 | Domain | Lipoyl-binding |
| Hgene | >PDHX | chr11:34953031 | chr4:5418572 | ENST00000430469 | + | 2 | 6 | 183_220 | 80 | 275 | Domain | Peripheral subunit-binding (PSBD) |
| Hgene | >PDHX | chr11:34953031 | chr4:5418572 | ENST00000430469 | + | 2 | 6 | 56_132 | 80 | 275 | Domain | Lipoyl-binding |
| Tgene | STK32B | chr11:34953031 | chr4:5418572 | ENST00000282908 | + | 4 | 12 | 23_283 | 157 | 415 | Domain | Protein kinase |
| Tgene | STK32B | chr11:34953031 | chr4:5418572 | ENST00000510398 | + | 4 | 12 | 23_283 | 110 | 368 | Domain | Protein kinase |
| Tgene | STK32B | chr11:34953031 | chr4:5418572 | ENST00000282908 | + | 4 | 12 | 29_37 | 157 | 415 | Nucleotide binding | ATP |
| Tgene | STK32B | chr11:34953031 | chr4:5418572 | ENST00000510398 | + | 4 | 12 | 29_37 | 110 | 368 | Nucleotide binding | ATP |
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FusionGeneSequence for PDHX_STK32B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PDHX_ENST00000448838_chr11_34953031_+_STK32B_ENST00000282908_chr4_5418572_+_323aa MQSGGAEGSPGAGRTGRGPGSGKAPPAEISSGAPDFPGGDPIKILMPSLSPTMEEGNIVKWLKKEGHVHITDFNIATVVKGAERASSMAG TKPYMAPEVFQVYMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEILNMFKVERVHYSSTWCKGMVALLRKLLTKDPESRVS SLHDIQSVPYLADMNWDAVFKKALMPGFVPNKGRLNCDPTFELEEMILESKPLHKKKKRLAKNRSRDGTKDSCPLNGHLQHCLETVREEF >In-frame_PDHX_ENST00000227868_chr11_34953031_+_STK32B_ENST00000282908_chr4_5418572_+_338aa MAASWRLGCDPRLLRYLVGFPGRRSVGLVKGALGWSVSRGANWRWFHSTQWLRGDPIKILMPSLSPTMEEGNIVKWLKKEGHVHITDFNI ATVVKGAERASSMAGTKPYMAPEVFQVYMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEILNMFKVERVHYSSTWCKGMVA LLRKLLTKDPESRVSSLHDIQSVPYLADMNWDAVFKKALMPGFVPNKGRLNCDPTFELEEMILESKPLHKKKKRLAKNRSRDGTKDSCPL >In-frame_PDHX_ENST00000430469_chr11_34953031_+_STK32B_ENST00000282908_chr4_5418572_+_338aa MAASWRLGCDPRLLRYLVGFPGRRSVGLVKGALGWSVSRGANWRWFHSTQWLRGDPIKILMPSLSPTMEEGNIVKWLKKEGHVHITDFNI ATVVKGAERASSMAGTKPYMAPEVFQVYMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEILNMFKVERVHYSSTWCKGMVA LLRKLLTKDPESRVSSLHDIQSVPYLADMNWDAVFKKALMPGFVPNKGRLNCDPTFELEEMILESKPLHKKKKRLAKNRSRDGTKDSCPL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PDHX_ENST00000448838_chr11_34953031_+_STK32B_ENST00000282908_chr4_5418572_+_969nt ATGCAATCAGGCGGCGCTGAGGGCAGCCCGGGGGCGGGGCGAACGGGGCGGGGGCCGGGGTCTGGTAAGGCCCCGCCGGCTGAGATATCC AGCGGCGCACCTGACTTCCCGGGAGGTGATCCCATTAAGATACTAATGCCATCACTGTCTCCTACAATGGAAGAAGGAAACATTGTGAAA TGGCTGAAAAAGGAAGGACATGTTCACATTACAGACTTCAACATAGCGACGGTAGTGAAAGGAGCAGAAAGGGCTTCCTCCATGGCTGGC ACCAAGCCCTACATGGCTCCAGAAGTATTCCAGGTGTACATGGACAGAGGCCCCGGATACTCGTACCCTGTCGACTGGTGGTCCCTGGGC ATCACAGCCTATGAGCTGCTGCGGGGCTGGAGGCCGTACGAAATCCACTCGGTCACGCCCATCGATGAAATCCTCAACATGTTCAAGGTG GAGCGTGTCCACTACTCCTCCACGTGGTGCAAGGGGATGGTGGCCCTGCTGAGGAAGCTCCTGACCAAGGATCCTGAGAGCCGCGTGTCC AGCCTTCATGACATACAGAGCGTGCCCTACTTGGCCGACATGAACTGGGACGCGGTGTTCAAGAAGGCACTGATGCCCGGCTTTGTGCCC AATAAAGGGAGGTTGAACTGCGATCCCACATTTGAGCTTGAAGAGATGATTCTAGAATCCAAGCCACTTCACAAAAAGAAGAAGCGATTG GCAAAGAACAGATCCAGGGATGGCACAAAGGACAGCTGCCCGCTGAATGGACACCTGCAGCACTGTTTGGAGACTGTCCGGGAGGAATTC ATCATATTCAACAGAGAGAAGCTCAGGAGGCAGCAGGGACAGGGCAGCCAGCTCTTGGACACCGACAGCCGAGGGGGAGGCCAGGCCCAA >In-frame_PDHX_ENST00000227868_chr11_34953031_+_STK32B_ENST00000282908_chr4_5418572_+_1014nt ATGGCGGCCTCCTGGAGGCTGGGCTGTGATCCGCGGCTGCTGCGTTATCTTGTGGGCTTCCCCGGCCGCCGAAGCGTAGGGCTGGTGAAG GGGGCTCTTGGGTGGTCTGTAAGCCGCGGAGCTAATTGGAGATGGTTTCACAGCACGCAGTGGCTTCGGGGTGATCCCATTAAGATACTA ATGCCATCACTGTCTCCTACAATGGAAGAAGGAAACATTGTGAAATGGCTGAAAAAGGAAGGACATGTTCACATTACAGACTTCAACATA GCGACGGTAGTGAAAGGAGCAGAAAGGGCTTCCTCCATGGCTGGCACCAAGCCCTACATGGCTCCAGAAGTATTCCAGGTGTACATGGAC AGAGGCCCCGGATACTCGTACCCTGTCGACTGGTGGTCCCTGGGCATCACAGCCTATGAGCTGCTGCGGGGCTGGAGGCCGTACGAAATC CACTCGGTCACGCCCATCGATGAAATCCTCAACATGTTCAAGGTGGAGCGTGTCCACTACTCCTCCACGTGGTGCAAGGGGATGGTGGCC CTGCTGAGGAAGCTCCTGACCAAGGATCCTGAGAGCCGCGTGTCCAGCCTTCATGACATACAGAGCGTGCCCTACTTGGCCGACATGAAC TGGGACGCGGTGTTCAAGAAGGCACTGATGCCCGGCTTTGTGCCCAATAAAGGGAGGTTGAACTGCGATCCCACATTTGAGCTTGAAGAG ATGATTCTAGAATCCAAGCCACTTCACAAAAAGAAGAAGCGATTGGCAAAGAACAGATCCAGGGATGGCACAAAGGACAGCTGCCCGCTG AATGGACACCTGCAGCACTGTTTGGAGACTGTCCGGGAGGAATTCATCATATTCAACAGAGAGAAGCTCAGGAGGCAGCAGGGACAGGGC AGCCAGCTCTTGGACACCGACAGCCGAGGGGGAGGCCAGGCCCAAAGCAAGCTCCAGGACGGGTGCAACAACAACCTCCTCACCCACACC >In-frame_PDHX_ENST00000430469_chr11_34953031_+_STK32B_ENST00000282908_chr4_5418572_+_1014nt ATGGCGGCCTCCTGGAGGCTGGGCTGTGATCCGCGGCTGCTGCGTTATCTTGTGGGCTTCCCCGGCCGCCGAAGCGTAGGGCTGGTGAAG GGGGCTCTTGGGTGGTCTGTAAGCCGCGGAGCTAATTGGAGATGGTTTCACAGCACGCAGTGGCTTCGGGGTGATCCCATTAAGATACTA ATGCCATCACTGTCTCCTACAATGGAAGAAGGAAACATTGTGAAATGGCTGAAAAAGGAAGGACATGTTCACATTACAGACTTCAACATA GCGACGGTAGTGAAAGGAGCAGAAAGGGCTTCCTCCATGGCTGGCACCAAGCCCTACATGGCTCCAGAAGTATTCCAGGTGTACATGGAC AGAGGCCCCGGATACTCGTACCCTGTCGACTGGTGGTCCCTGGGCATCACAGCCTATGAGCTGCTGCGGGGCTGGAGGCCGTACGAAATC CACTCGGTCACGCCCATCGATGAAATCCTCAACATGTTCAAGGTGGAGCGTGTCCACTACTCCTCCACGTGGTGCAAGGGGATGGTGGCC CTGCTGAGGAAGCTCCTGACCAAGGATCCTGAGAGCCGCGTGTCCAGCCTTCATGACATACAGAGCGTGCCCTACTTGGCCGACATGAAC TGGGACGCGGTGTTCAAGAAGGCACTGATGCCCGGCTTTGTGCCCAATAAAGGGAGGTTGAACTGCGATCCCACATTTGAGCTTGAAGAG ATGATTCTAGAATCCAAGCCACTTCACAAAAAGAAGAAGCGATTGGCAAAGAACAGATCCAGGGATGGCACAAAGGACAGCTGCCCGCTG AATGGACACCTGCAGCACTGTTTGGAGACTGTCCGGGAGGAATTCATCATATTCAACAGAGAGAAGCTCAGGAGGCAGCAGGGACAGGGC AGCCAGCTCTTGGACACCGACAGCCGAGGGGGAGGCCAGGCCCAAAGCAAGCTCCAGGACGGGTGCAACAACAACCTCCTCACCCACACC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PDHX_ENST00000448838_chr11_34953031_+_STK32B_ENST00000282908_chr4_5418572_+_3126nt AAACGCCCGGCCCGCTACCCTGCGCCCAGCTCCAGCCGCCGGGTCCCGCCTGGGCCTCTCCTCCTGGGAATACCGGGCACCGGTGGCCCC GCCCCTACCTGCGCGCCGCATCTCCGGGAACAACAGTCTCCCTCCCGAGCATCACAGCCAGACATGGCCCAGACCAGGGACCCGCGCGGC CTCCAATCTCCGCACGGCTTTGCGCGCGGCGCTTAGCCTGGGATACGGCAGCGAGGCCGCAAATGCAATCAGGCGGCGCTGAGGGCAGCC CGGGGGCGGGGCGAACGGGGCGGGGGCCGGGGTCTGGTAAGGCCCCGCCGGCTGAGATATCCAGCGGCGCACCTGACTTCCCGGGAGGTG ATCCCATTAAGATACTAATGCCATCACTGTCTCCTACAATGGAAGAAGGAAACATTGTGAAATGGCTGAAAAAGGAAGGACATGTTCACA TTACAGACTTCAACATAGCGACGGTAGTGAAAGGAGCAGAAAGGGCTTCCTCCATGGCTGGCACCAAGCCCTACATGGCTCCAGAAGTAT TCCAGGTGTACATGGACAGAGGCCCCGGATACTCGTACCCTGTCGACTGGTGGTCCCTGGGCATCACAGCCTATGAGCTGCTGCGGGGCT GGAGGCCGTACGAAATCCACTCGGTCACGCCCATCGATGAAATCCTCAACATGTTCAAGGTGGAGCGTGTCCACTACTCCTCCACGTGGT GCAAGGGGATGGTGGCCCTGCTGAGGAAGCTCCTGACCAAGGATCCTGAGAGCCGCGTGTCCAGCCTTCATGACATACAGAGCGTGCCCT ACTTGGCCGACATGAACTGGGACGCGGTGTTCAAGAAGGCACTGATGCCCGGCTTTGTGCCCAATAAAGGGAGGTTGAACTGCGATCCCA CATTTGAGCTTGAAGAGATGATTCTAGAATCCAAGCCACTTCACAAAAAGAAGAAGCGATTGGCAAAGAACAGATCCAGGGATGGCACAA AGGACAGCTGCCCGCTGAATGGACACCTGCAGCACTGTTTGGAGACTGTCCGGGAGGAATTCATCATATTCAACAGAGAGAAGCTCAGGA GGCAGCAGGGACAGGGCAGCCAGCTCTTGGACACCGACAGCCGAGGGGGAGGCCAGGCCCAAAGCAAGCTCCAGGACGGGTGCAACAACA ACCTCCTCACCCACACCTGCACCCGTGGCTGCAGCAGCTGAGCCCACACTTGTTGCTGCTCAACAGGACTGCACTCGTCTCTGCCCTGCC CACCCAGAGCCCCTCTTTGTGCCCTGATGGTCCCTGTCTCACCCCTGAAAACATCAGATGCAGAAAAAGCCCTGGACTTGGAGCTGGGAA GCCTGGGTTCTGGTCCCATCTCCATGACTGATTCACGTGTGACCTCAGACAAGTCACGCCCTCTCTGTGCCTCCGTTTTCTGCATCTGCC AAAGGGGTTAAACACTTCTGCCCCACTTCAAATTACAAGATTATGGGGAGAACCCAATTAGGTAGGAAACATGAAAAACCTTTGATATTT ATAAAATCATTTTTACGTGCAAAATATAACCTTAATATTTGAAGTGACCCCCATTCCCCAAAGCAATCAAACCGTCATGACTTTGCAATT TGGCACATCCTAGCTTGTTAGAGGGCACTTCCGAAAAACACAGCCCTGACAGCAAAATAAAGGTCTGATATGTTGGCCCCTTCTATGGAA ACAACGCTGCCAAATCCTGGAGCAAAACCTGAAGTGTCTTCATGTGCATTCTCTGGCAGGCCACAGTCCTGAGCTTGTAAGATGGTGCAG CATGCAGACCAGACTTGTCCCCAAGGTCTCAGCGCTGCGGTCTCACTCCTCCCCTCATTTAAGAAGACTATCCTTACCTTTTAGTTTCAG CAGTCCTCACCACCACCATATCCCCAGTGCTGGGATGGCACACAGGTGTCCATTCAGATGAGAGTTGGGTCGCTGAGCATTGGTTACTCC TGCAGAGTGTAATCAGCACCCCATCCAACTGGCCCGAAAGCCCAGACCTGCAGCAGAACTCTCCAACTCTCTATCAGCTTTCAGGGTTTT CTCTCCTGGGAAGGGTGTAAAATCAGCTTGTCAGATTCTTCTTACAGAGAGTATCCAATCGGTATTGGTGGAGCGGCTCCCTATTTATAC AATAGGAAGCATGGGTGCTTAGAAAGTTTATTTCAGGAGGAAAATGGGTTCACACAAAAAGCAAACTACATTCTGGTCTGCTCAGGGAGA AGCTTGCCTTTGAACTGGAAGATGTTGGGATGAGCAGGGAAAGCTTAGACTTTGGAGTCAGGTTTGTGTTCAGAATCCAGCCCTGCTGGC TACTAACTAACTGGGAGACCTTAGGCAAAGCATGCAATCGCTCTGAATGGCAGTTTCCTCATTTTTAAACAGGGATAATAAAACTAATAT TGCAGGGGAGTTACAGGGTTAAATAAGATCCTGTGTGTAACCCCAAGCATTGGATGACTCATAGAATGGCCTTTTTTGTCAGCATAATCG TCATCATTATTTAGATACTTTCTTCCTTCACTCACCCAGCAGGTCAGTTTTCTGTGCAAACAAACCTGTTTAGGATTCTTCCAAATGTTC TTCCTGGGGTCTTTGATATTTGTTTGTTACATCCTGCTGAAGTTCGACTGTGTTTTTATTTTTTCATCCAACTTCCATTTTTCACTTTTT ACATGATTACTCAATCCTTGGGGCTGTCCATGTCATCTCTTAGATTTCTTAAAAGACATTTTAATGTATGGTTAGGTTTTATATTTTTAT TTTTTAAAAAAGAAATAGTCAGTGTTTTCCTCCTTTCAACCGAGACTATTTCTGGATTGTGTGCTCCTCGTCAGTTGACTTGTTTTGCAC ACTTTTCTTTACTTCATGTCCCCATCAACAACCGTCCTGCTCCCCACCTCCCCCAGGAAATAAGGGGCCTGCTCCTCTCCCTACTGTGAC CCTGGAGGCTCTTAAGATGATGATGGTTTTTTTTATTGGGCTGAGTTCACGAATTAGGGGCAGGAGCTGGAAGTCGCCCTAGGAACACCA >In-frame_PDHX_ENST00000227868_chr11_34953031_+_STK32B_ENST00000282908_chr4_5418572_+_3013nt GGGCGTGGCCAACCATGCGGGAGGCGGGGCCTTGATGCTGGACATCAGGCTGTGCTGCGGGCAGCCAGTGAGAAGGCCGTCAAGATGGCG GCCTCCTGGAGGCTGGGCTGTGATCCGCGGCTGCTGCGTTATCTTGTGGGCTTCCCCGGCCGCCGAAGCGTAGGGCTGGTGAAGGGGGCT CTTGGGTGGTCTGTAAGCCGCGGAGCTAATTGGAGATGGTTTCACAGCACGCAGTGGCTTCGGGGTGATCCCATTAAGATACTAATGCCA TCACTGTCTCCTACAATGGAAGAAGGAAACATTGTGAAATGGCTGAAAAAGGAAGGACATGTTCACATTACAGACTTCAACATAGCGACG GTAGTGAAAGGAGCAGAAAGGGCTTCCTCCATGGCTGGCACCAAGCCCTACATGGCTCCAGAAGTATTCCAGGTGTACATGGACAGAGGC CCCGGATACTCGTACCCTGTCGACTGGTGGTCCCTGGGCATCACAGCCTATGAGCTGCTGCGGGGCTGGAGGCCGTACGAAATCCACTCG GTCACGCCCATCGATGAAATCCTCAACATGTTCAAGGTGGAGCGTGTCCACTACTCCTCCACGTGGTGCAAGGGGATGGTGGCCCTGCTG AGGAAGCTCCTGACCAAGGATCCTGAGAGCCGCGTGTCCAGCCTTCATGACATACAGAGCGTGCCCTACTTGGCCGACATGAACTGGGAC GCGGTGTTCAAGAAGGCACTGATGCCCGGCTTTGTGCCCAATAAAGGGAGGTTGAACTGCGATCCCACATTTGAGCTTGAAGAGATGATT CTAGAATCCAAGCCACTTCACAAAAAGAAGAAGCGATTGGCAAAGAACAGATCCAGGGATGGCACAAAGGACAGCTGCCCGCTGAATGGA CACCTGCAGCACTGTTTGGAGACTGTCCGGGAGGAATTCATCATATTCAACAGAGAGAAGCTCAGGAGGCAGCAGGGACAGGGCAGCCAG CTCTTGGACACCGACAGCCGAGGGGGAGGCCAGGCCCAAAGCAAGCTCCAGGACGGGTGCAACAACAACCTCCTCACCCACACCTGCACC CGTGGCTGCAGCAGCTGAGCCCACACTTGTTGCTGCTCAACAGGACTGCACTCGTCTCTGCCCTGCCCACCCAGAGCCCCTCTTTGTGCC CTGATGGTCCCTGTCTCACCCCTGAAAACATCAGATGCAGAAAAAGCCCTGGACTTGGAGCTGGGAAGCCTGGGTTCTGGTCCCATCTCC ATGACTGATTCACGTGTGACCTCAGACAAGTCACGCCCTCTCTGTGCCTCCGTTTTCTGCATCTGCCAAAGGGGTTAAACACTTCTGCCC CACTTCAAATTACAAGATTATGGGGAGAACCCAATTAGGTAGGAAACATGAAAAACCTTTGATATTTATAAAATCATTTTTACGTGCAAA ATATAACCTTAATATTTGAAGTGACCCCCATTCCCCAAAGCAATCAAACCGTCATGACTTTGCAATTTGGCACATCCTAGCTTGTTAGAG GGCACTTCCGAAAAACACAGCCCTGACAGCAAAATAAAGGTCTGATATGTTGGCCCCTTCTATGGAAACAACGCTGCCAAATCCTGGAGC AAAACCTGAAGTGTCTTCATGTGCATTCTCTGGCAGGCCACAGTCCTGAGCTTGTAAGATGGTGCAGCATGCAGACCAGACTTGTCCCCA AGGTCTCAGCGCTGCGGTCTCACTCCTCCCCTCATTTAAGAAGACTATCCTTACCTTTTAGTTTCAGCAGTCCTCACCACCACCATATCC CCAGTGCTGGGATGGCACACAGGTGTCCATTCAGATGAGAGTTGGGTCGCTGAGCATTGGTTACTCCTGCAGAGTGTAATCAGCACCCCA TCCAACTGGCCCGAAAGCCCAGACCTGCAGCAGAACTCTCCAACTCTCTATCAGCTTTCAGGGTTTTCTCTCCTGGGAAGGGTGTAAAAT CAGCTTGTCAGATTCTTCTTACAGAGAGTATCCAATCGGTATTGGTGGAGCGGCTCCCTATTTATACAATAGGAAGCATGGGTGCTTAGA AAGTTTATTTCAGGAGGAAAATGGGTTCACACAAAAAGCAAACTACATTCTGGTCTGCTCAGGGAGAAGCTTGCCTTTGAACTGGAAGAT GTTGGGATGAGCAGGGAAAGCTTAGACTTTGGAGTCAGGTTTGTGTTCAGAATCCAGCCCTGCTGGCTACTAACTAACTGGGAGACCTTA GGCAAAGCATGCAATCGCTCTGAATGGCAGTTTCCTCATTTTTAAACAGGGATAATAAAACTAATATTGCAGGGGAGTTACAGGGTTAAA TAAGATCCTGTGTGTAACCCCAAGCATTGGATGACTCATAGAATGGCCTTTTTTGTCAGCATAATCGTCATCATTATTTAGATACTTTCT TCCTTCACTCACCCAGCAGGTCAGTTTTCTGTGCAAACAAACCTGTTTAGGATTCTTCCAAATGTTCTTCCTGGGGTCTTTGATATTTGT TTGTTACATCCTGCTGAAGTTCGACTGTGTTTTTATTTTTTCATCCAACTTCCATTTTTCACTTTTTACATGATTACTCAATCCTTGGGG CTGTCCATGTCATCTCTTAGATTTCTTAAAAGACATTTTAATGTATGGTTAGGTTTTATATTTTTATTTTTTAAAAAAGAAATAGTCAGT GTTTTCCTCCTTTCAACCGAGACTATTTCTGGATTGTGTGCTCCTCGTCAGTTGACTTGTTTTGCACACTTTTCTTTACTTCATGTCCCC ATCAACAACCGTCCTGCTCCCCACCTCCCCCAGGAAATAAGGGGCCTGCTCCTCTCCCTACTGTGACCCTGGAGGCTCTTAAGATGATGA TGGTTTTTTTTATTGGGCTGAGTTCACGAATTAGGGGCAGGAGCTGGAAGTCGCCCTAGGAACACCAGATTTCCTGGTTCTGTTCAAGTT >In-frame_PDHX_ENST00000430469_chr11_34953031_+_STK32B_ENST00000282908_chr4_5418572_+_2953nt GCAGCCAGTGAGAAGGCCGTCAAGATGGCGGCCTCCTGGAGGCTGGGCTGTGATCCGCGGCTGCTGCGTTATCTTGTGGGCTTCCCCGGC CGCCGAAGCGTAGGGCTGGTGAAGGGGGCTCTTGGGTGGTCTGTAAGCCGCGGAGCTAATTGGAGATGGTTTCACAGCACGCAGTGGCTT CGGGGTGATCCCATTAAGATACTAATGCCATCACTGTCTCCTACAATGGAAGAAGGAAACATTGTGAAATGGCTGAAAAAGGAAGGACAT GTTCACATTACAGACTTCAACATAGCGACGGTAGTGAAAGGAGCAGAAAGGGCTTCCTCCATGGCTGGCACCAAGCCCTACATGGCTCCA GAAGTATTCCAGGTGTACATGGACAGAGGCCCCGGATACTCGTACCCTGTCGACTGGTGGTCCCTGGGCATCACAGCCTATGAGCTGCTG CGGGGCTGGAGGCCGTACGAAATCCACTCGGTCACGCCCATCGATGAAATCCTCAACATGTTCAAGGTGGAGCGTGTCCACTACTCCTCC ACGTGGTGCAAGGGGATGGTGGCCCTGCTGAGGAAGCTCCTGACCAAGGATCCTGAGAGCCGCGTGTCCAGCCTTCATGACATACAGAGC GTGCCCTACTTGGCCGACATGAACTGGGACGCGGTGTTCAAGAAGGCACTGATGCCCGGCTTTGTGCCCAATAAAGGGAGGTTGAACTGC GATCCCACATTTGAGCTTGAAGAGATGATTCTAGAATCCAAGCCACTTCACAAAAAGAAGAAGCGATTGGCAAAGAACAGATCCAGGGAT GGCACAAAGGACAGCTGCCCGCTGAATGGACACCTGCAGCACTGTTTGGAGACTGTCCGGGAGGAATTCATCATATTCAACAGAGAGAAG CTCAGGAGGCAGCAGGGACAGGGCAGCCAGCTCTTGGACACCGACAGCCGAGGGGGAGGCCAGGCCCAAAGCAAGCTCCAGGACGGGTGC AACAACAACCTCCTCACCCACACCTGCACCCGTGGCTGCAGCAGCTGAGCCCACACTTGTTGCTGCTCAACAGGACTGCACTCGTCTCTG CCCTGCCCACCCAGAGCCCCTCTTTGTGCCCTGATGGTCCCTGTCTCACCCCTGAAAACATCAGATGCAGAAAAAGCCCTGGACTTGGAG CTGGGAAGCCTGGGTTCTGGTCCCATCTCCATGACTGATTCACGTGTGACCTCAGACAAGTCACGCCCTCTCTGTGCCTCCGTTTTCTGC ATCTGCCAAAGGGGTTAAACACTTCTGCCCCACTTCAAATTACAAGATTATGGGGAGAACCCAATTAGGTAGGAAACATGAAAAACCTTT GATATTTATAAAATCATTTTTACGTGCAAAATATAACCTTAATATTTGAAGTGACCCCCATTCCCCAAAGCAATCAAACCGTCATGACTT TGCAATTTGGCACATCCTAGCTTGTTAGAGGGCACTTCCGAAAAACACAGCCCTGACAGCAAAATAAAGGTCTGATATGTTGGCCCCTTC TATGGAAACAACGCTGCCAAATCCTGGAGCAAAACCTGAAGTGTCTTCATGTGCATTCTCTGGCAGGCCACAGTCCTGAGCTTGTAAGAT GGTGCAGCATGCAGACCAGACTTGTCCCCAAGGTCTCAGCGCTGCGGTCTCACTCCTCCCCTCATTTAAGAAGACTATCCTTACCTTTTA GTTTCAGCAGTCCTCACCACCACCATATCCCCAGTGCTGGGATGGCACACAGGTGTCCATTCAGATGAGAGTTGGGTCGCTGAGCATTGG TTACTCCTGCAGAGTGTAATCAGCACCCCATCCAACTGGCCCGAAAGCCCAGACCTGCAGCAGAACTCTCCAACTCTCTATCAGCTTTCA GGGTTTTCTCTCCTGGGAAGGGTGTAAAATCAGCTTGTCAGATTCTTCTTACAGAGAGTATCCAATCGGTATTGGTGGAGCGGCTCCCTA TTTATACAATAGGAAGCATGGGTGCTTAGAAAGTTTATTTCAGGAGGAAAATGGGTTCACACAAAAAGCAAACTACATTCTGGTCTGCTC AGGGAGAAGCTTGCCTTTGAACTGGAAGATGTTGGGATGAGCAGGGAAAGCTTAGACTTTGGAGTCAGGTTTGTGTTCAGAATCCAGCCC TGCTGGCTACTAACTAACTGGGAGACCTTAGGCAAAGCATGCAATCGCTCTGAATGGCAGTTTCCTCATTTTTAAACAGGGATAATAAAA CTAATATTGCAGGGGAGTTACAGGGTTAAATAAGATCCTGTGTGTAACCCCAAGCATTGGATGACTCATAGAATGGCCTTTTTTGTCAGC ATAATCGTCATCATTATTTAGATACTTTCTTCCTTCACTCACCCAGCAGGTCAGTTTTCTGTGCAAACAAACCTGTTTAGGATTCTTCCA AATGTTCTTCCTGGGGTCTTTGATATTTGTTTGTTACATCCTGCTGAAGTTCGACTGTGTTTTTATTTTTTCATCCAACTTCCATTTTTC ACTTTTTACATGATTACTCAATCCTTGGGGCTGTCCATGTCATCTCTTAGATTTCTTAAAAGACATTTTAATGTATGGTTAGGTTTTATA TTTTTATTTTTTAAAAAAGAAATAGTCAGTGTTTTCCTCCTTTCAACCGAGACTATTTCTGGATTGTGTGCTCCTCGTCAGTTGACTTGT TTTGCACACTTTTCTTTACTTCATGTCCCCATCAACAACCGTCCTGCTCCCCACCTCCCCCAGGAAATAAGGGGCCTGCTCCTCTCCCTA CTGTGACCCTGGAGGCTCTTAAGATGATGATGGTTTTTTTTATTGGGCTGAGTTCACGAATTAGGGGCAGGAGCTGGAAGTCGCCCTAGG |
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FusionGenePPI for PDHX_STK32B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PDHX | EWSR1, DLAT, PDK2, PDHB, PDHA1, OGDH, EIF3C, SLC25A3, ABCC1, MARC1, ACTN1, LGR4, CDKN1A, AGTRAP, NXF1, EP300, NEUROD1, DLD, PDK1, LGALS3, CS, STAT5A, STAT5B, HDAC6, NF2, HSD17B10, PDK3, FOXD4, MTIF2, PREPL | STK32B | HSP90AA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PDHX_STK32B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PDHX_STK32B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PDHX | C3714756 | Intellectual Disability | 1 | CTD_human;HPO |
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