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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26453

FusionGeneSummary for PDGFC_G3BP2

check button Fusion gene summary
Fusion gene informationFusion gene name: PDGFC_G3BP2
Fusion gene ID: 26453
HgeneTgene
Gene symbol

PDGFC

G3BP2

Gene ID

56034

9908

Gene nameplatelet derived growth factor CG3BP stress granule assembly factor 2
SynonymsFALLOTEIN|SCDGF-
Cytomap

4q32.1

4q21.1

Type of geneprotein-codingprotein-coding
Descriptionplatelet-derived growth factor CPDGF-CVEGF-Esecretory growth factor-like proteinspinal cord-derived growth factorras GTPase-activating protein-binding protein 2G3BP-2GAP SH3 domain-binding protein 2GTPase activating protein (SH3 domain) binding protein 2Ras-GTPase activating protein SH3 domain-binding protein 2
Modification date2018052320180523
UniProtAcc

Q9NRA1

Q9UN86

Ensembl transtripts involved in fusion geneENST00000502773, ENST00000541126, 
ENST00000422544, ENST00000504672, 
ENST00000542208, 
ENST00000395719, 
ENST00000359707, ENST00000357854, 
ENST00000502654, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 2 X 2=12
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PDGFC [Title/Abstract] AND G3BP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePDGFC

GO:0008284

positive regulation of cell proliferation

10806482

HgenePDGFC

GO:0048008

platelet-derived growth factor receptor signaling pathway

10806482

HgenePDGFC

GO:0048146

positive regulation of fibroblast proliferation

10806482


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-86-A4D0-01APDGFCchr4

157891938

-G3BP2chr4

76587233

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000502773ENST00000395719PDGFCchr4

157891938

-G3BP2chr4

76587233

-
5CDS-5UTRENST00000502773ENST00000359707PDGFCchr4

157891938

-G3BP2chr4

76587233

-
5CDS-5UTRENST00000502773ENST00000357854PDGFCchr4

157891938

-G3BP2chr4

76587233

-
5CDS-intronENST00000502773ENST00000502654PDGFCchr4

157891938

-G3BP2chr4

76587233

-
5UTR-5UTRENST00000541126ENST00000395719PDGFCchr4

157891938

-G3BP2chr4

76587233

-
5UTR-5UTRENST00000541126ENST00000359707PDGFCchr4

157891938

-G3BP2chr4

76587233

-
5UTR-5UTRENST00000541126ENST00000357854PDGFCchr4

157891938

-G3BP2chr4

76587233

-
5UTR-intronENST00000541126ENST00000502654PDGFCchr4

157891938

-G3BP2chr4

76587233

-
5CDS-5UTRENST00000422544ENST00000395719PDGFCchr4

157891938

-G3BP2chr4

76587233

-
5CDS-5UTRENST00000422544ENST00000359707PDGFCchr4

157891938

-G3BP2chr4

76587233

-
5CDS-5UTRENST00000422544ENST00000357854PDGFCchr4

157891938

-G3BP2chr4

76587233

-
5CDS-intronENST00000422544ENST00000502654PDGFCchr4

157891938

-G3BP2chr4

76587233

-
intron-5UTRENST00000504672ENST00000395719PDGFCchr4

157891938

-G3BP2chr4

76587233

-
intron-5UTRENST00000504672ENST00000359707PDGFCchr4

157891938

-G3BP2chr4

76587233

-
intron-5UTRENST00000504672ENST00000357854PDGFCchr4

157891938

-G3BP2chr4

76587233

-
intron-intronENST00000504672ENST00000502654PDGFCchr4

157891938

-G3BP2chr4

76587233

-
intron-5UTRENST00000542208ENST00000395719PDGFCchr4

157891938

-G3BP2chr4

76587233

-
intron-5UTRENST00000542208ENST00000359707PDGFCchr4

157891938

-G3BP2chr4

76587233

-
intron-5UTRENST00000542208ENST00000357854PDGFCchr4

157891938

-G3BP2chr4

76587233

-
intron-intronENST00000542208ENST00000502654PDGFCchr4

157891938

-G3BP2chr4

76587233

-

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FusionProtFeatures for PDGFC_G3BP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PDGFC

Q9NRA1

G3BP2

Q9UN86

Growth factor that plays an essential role in theregulation of embryonic development, cell proliferation, cellmigration, survival and chemotaxis. Potent mitogen andchemoattractant for cells of mesenchymal origin. Required fornormal skeleton formation during embryonic development, especiallyfor normal development of the craniofacial skeleton and for normaldevelopment of the palate. Required for normal skin morphogenesisduring embryonic development. Plays an important role in woundhealing, where it appears to be involved in three stages:inflammation, proliferation and remodeling. Plays an importantrole in angiogenesis and blood vessel development. Involved infibrotic processes, in which transformation of interstitialfibroblasts into myofibroblasts plus collagen deposition occurs.The CUB domain has mitogenic activity in coronary artery smoothmuscle cells, suggesting a role beyond the maintenance of thelatency of the PDGF domain. In the nucleus, PDGFC seems to haveadditional function. {ECO:0000269|PubMed:10806482,ECO:0000269|PubMed:10858496, ECO:0000269|PubMed:11297552,ECO:0000269|PubMed:11854040, ECO:0000269|PubMed:12032822,ECO:0000269|PubMed:15061151, ECO:0000269|PubMed:15372073,ECO:0000269|PubMed:15389578, ECO:0000269|PubMed:15728360,ECO:0000269|PubMed:15911618, ECO:0000269|PubMed:16439802,ECO:0000269|PubMed:18055825}. Probable scaffold protein that may be involved in mRNAtransport. {ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PDGFC_G3BP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PDGFC_G3BP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PDGFCPDGFRA, PLAT, PLAU, ST14, BAG3, CREB3G3BP2STK24, NFKBIA, DDX10, RNH1, RPL3L, NUP214, USP10, FARS2, ASCC3, ATXN2L, NUP62, C3orf17, GNL2, UIMC1, UBAP2, DDX24, NUFIP2, RPF2, WDR36, RPL22L1, ING4, TERF2, TP53, MDM2, UBC, PTEN, ELAVL1, ARRB2, CUL3, CDK2, CUL1, COPS5, CAND1, ESR1, CA9, VCP, TARDBP, PIN1, DDX6, FXR2, IVNS1ABP, SUZ12, RNF2, BMI1, G3BP1, POM121, NUP153, NUP88, HNRNPA1, ADSL, IFI30, IGF2BP3, PABPC1, PABPC4, PRPF8, YARS, SFN, NTRK1, RPL10, NF2, SNW1, WWP2, TRIM25, KLHDC3, CYLD, LASP1, RPS6, CAPRIN1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PDGFC_G3BP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PDGFC_G3BP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePDGFCC0025500Mesothelioma1CTD_human