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Fusion gene ID: 26424 |
FusionGeneSummary for PDE6B_INO80 |
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Fusion gene information | Fusion gene name: PDE6B_INO80 | Fusion gene ID: 26424 | Hgene | Tgene | Gene symbol | PDE6B | INO80 | Gene ID | 5158 | 54617 |
Gene name | phosphodiesterase 6B | INO80 complex subunit | |
Synonyms | CSNB3|CSNBAD2|GMP-PDEbeta|PDEB|RP40|rd1 | INO80A|INOC1|hINO80 | |
Cytomap | 4p16.3 | 15q15.1 | |
Type of gene | protein-coding | protein-coding | |
Description | rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit betaGMP-PDE betaphosphodiesterase 6B, cGMP-specific, rod, betarod cGMP-phosphodiesterase beta-subunit | DNA helicase INO80INO80 complex subunit AINO80 homologhomolog of yeast INO80putative DNA helicase INO80 complex homolog 1 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | P35913 | Q9ULG1 | |
Ensembl transtripts involved in fusion gene | ENST00000255622, ENST00000496514, ENST00000429163, | ENST00000361937, ENST00000401393, ENST00000561244, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 6 X 3=108 |
# samples | 1 | 7 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(7/108*10)=-0.625604485218502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PDE6B [Title/Abstract] AND INO80 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BU741962 | PDE6B | chr4 | 664297 | - | INO80 | chr15 | 41291127 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000255622 | ENST00000361937 | PDE6B | chr4 | 664297 | - | INO80 | chr15 | 41291127 | + |
3UTR-intron | ENST00000255622 | ENST00000401393 | PDE6B | chr4 | 664297 | - | INO80 | chr15 | 41291127 | + |
3UTR-intron | ENST00000255622 | ENST00000561244 | PDE6B | chr4 | 664297 | - | INO80 | chr15 | 41291127 | + |
3UTR-intron | ENST00000496514 | ENST00000361937 | PDE6B | chr4 | 664297 | - | INO80 | chr15 | 41291127 | + |
3UTR-intron | ENST00000496514 | ENST00000401393 | PDE6B | chr4 | 664297 | - | INO80 | chr15 | 41291127 | + |
3UTR-intron | ENST00000496514 | ENST00000561244 | PDE6B | chr4 | 664297 | - | INO80 | chr15 | 41291127 | + |
intron-intron | ENST00000429163 | ENST00000361937 | PDE6B | chr4 | 664297 | - | INO80 | chr15 | 41291127 | + |
intron-intron | ENST00000429163 | ENST00000401393 | PDE6B | chr4 | 664297 | - | INO80 | chr15 | 41291127 | + |
intron-intron | ENST00000429163 | ENST00000561244 | PDE6B | chr4 | 664297 | - | INO80 | chr15 | 41291127 | + |
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FusionProtFeatures for PDE6B_INO80 |
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Hgene | Tgene |
PDE6B | INO80 |
This protein participates in processes of transmissionand amplification of the visual signal. Necessary for theformation of a functional phosphodiesterase holoenzyme. | ATPase component of the chromatin remodeling INO80complex which is involved in transcriptional regulation, DNAreplication and DNA repair (PubMed:16230350, PubMed:16298340,PubMed:17721549, PubMed:20855601, PubMed:20237820). Binds DNA(PubMed:16298340, PubMed:21303910). As part of the INO80 complex,remodels chromatin by shifting nucleosomes (PubMed:16230350,PubMed:21303910). Regulates transcription upon recruitment by YY1to YY1-activated genes, where it acts as an essential coactivator(PubMed:17721549). Involved in UV-damage excision DNA repair(PubMed:20855601). The contribution to DNA double-strand breakrepair appears to be largely indirect through transcriptionalregulation (PubMed:20687897). Involved in DNA replication(PubMed:20237820). Required for microtubule assembly duringmitosis thereby regulating chromosome segregation cycle(PubMed:20237820). {ECO:0000269|PubMed:16230350,ECO:0000269|PubMed:16298340, ECO:0000269|PubMed:17721549,ECO:0000269|PubMed:20237820, ECO:0000269|PubMed:20687897,ECO:0000269|PubMed:20855601, ECO:0000269|PubMed:21303910}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PDE6B_INO80 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PDE6B_INO80 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PDE6B_INO80 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PDE6B_INO80 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PDE6B | C3151107 | RETINITIS PIGMENTOSA 40 (disorder) | 7 | UNIPROT |
Hgene | PDE6B | C0035304 | Retinal Degeneration | 4 | CTD_human |
Hgene | PDE6B | C0035334 | Retinitis Pigmentosa | 1 | CTD_human;HPO;ORPHANET |
Hgene | PDE6B | C0339535 | Night blindness, congenital stationary | 1 | CTD_human;HPO;ORPHANET |
Hgene | PDE6B | C1876182 | NIGHT BLINDNESS, CONGENITAL STATIONARY, AUTOSOMAL DOMINANT 2 | 1 | CTD_human;UNIPROT |