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Fusion gene ID: 26422 |
FusionGeneSummary for PDE5A_EHBP1 |
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Fusion gene information | Fusion gene name: PDE5A_EHBP1 | Fusion gene ID: 26422 | Hgene | Tgene | Gene symbol | PDE5A | EHBP1 | Gene ID | 8654 | 23301 |
Gene name | phosphodiesterase 5A | EH domain binding protein 1 | |
Synonyms | CGB-PDE|CN5A|PDE5 | HPC12|NACSIN | |
Cytomap | 4q26 | 2p15 | |
Type of gene | protein-coding | protein-coding | |
Description | cGMP-specific 3',5'-cyclic phosphodiesterasecGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterasecGMP-specific phosphodiesterase PDE5A2cGMP-specific phosphodiesterase type 5Aphosphodiesterase 5A, cGMP-specificphosphodiesterase isozyme | EH domain-binding protein 1NPF calponin-like proteintestis tissue sperm-binding protein Li 50e | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | O76074 | Q8NDI1 | |
Ensembl transtripts involved in fusion gene | ENST00000354960, ENST00000394439, ENST00000264805, ENST00000512739, | ENST00000405015, ENST00000431489, ENST00000354487, ENST00000263991, ENST00000405289, ENST00000496857, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 7 X 7 X 5=245 |
# samples | 3 | 7 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/245*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PDE5A [Title/Abstract] AND EHBP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PDE5A | GO:0046069 | cGMP catabolic process | 14687666 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW102720 | PDE5A | chr4 | 120420968 | - | EHBP1 | chr2 | 63251232 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000354960 | ENST00000405015 | PDE5A | chr4 | 120420968 | - | EHBP1 | chr2 | 63251232 | - |
intron-intron | ENST00000354960 | ENST00000431489 | PDE5A | chr4 | 120420968 | - | EHBP1 | chr2 | 63251232 | - |
intron-intron | ENST00000354960 | ENST00000354487 | PDE5A | chr4 | 120420968 | - | EHBP1 | chr2 | 63251232 | - |
intron-intron | ENST00000354960 | ENST00000263991 | PDE5A | chr4 | 120420968 | - | EHBP1 | chr2 | 63251232 | - |
intron-intron | ENST00000354960 | ENST00000405289 | PDE5A | chr4 | 120420968 | - | EHBP1 | chr2 | 63251232 | - |
intron-intron | ENST00000354960 | ENST00000496857 | PDE5A | chr4 | 120420968 | - | EHBP1 | chr2 | 63251232 | - |
intron-intron | ENST00000394439 | ENST00000405015 | PDE5A | chr4 | 120420968 | - | EHBP1 | chr2 | 63251232 | - |
intron-intron | ENST00000394439 | ENST00000431489 | PDE5A | chr4 | 120420968 | - | EHBP1 | chr2 | 63251232 | - |
intron-intron | ENST00000394439 | ENST00000354487 | PDE5A | chr4 | 120420968 | - | EHBP1 | chr2 | 63251232 | - |
intron-intron | ENST00000394439 | ENST00000263991 | PDE5A | chr4 | 120420968 | - | EHBP1 | chr2 | 63251232 | - |
intron-intron | ENST00000394439 | ENST00000405289 | PDE5A | chr4 | 120420968 | - | EHBP1 | chr2 | 63251232 | - |
intron-intron | ENST00000394439 | ENST00000496857 | PDE5A | chr4 | 120420968 | - | EHBP1 | chr2 | 63251232 | - |
intron-intron | ENST00000264805 | ENST00000405015 | PDE5A | chr4 | 120420968 | - | EHBP1 | chr2 | 63251232 | - |
intron-intron | ENST00000264805 | ENST00000431489 | PDE5A | chr4 | 120420968 | - | EHBP1 | chr2 | 63251232 | - |
intron-intron | ENST00000264805 | ENST00000354487 | PDE5A | chr4 | 120420968 | - | EHBP1 | chr2 | 63251232 | - |
intron-intron | ENST00000264805 | ENST00000263991 | PDE5A | chr4 | 120420968 | - | EHBP1 | chr2 | 63251232 | - |
intron-intron | ENST00000264805 | ENST00000405289 | PDE5A | chr4 | 120420968 | - | EHBP1 | chr2 | 63251232 | - |
intron-intron | ENST00000264805 | ENST00000496857 | PDE5A | chr4 | 120420968 | - | EHBP1 | chr2 | 63251232 | - |
intron-intron | ENST00000512739 | ENST00000405015 | PDE5A | chr4 | 120420968 | - | EHBP1 | chr2 | 63251232 | - |
intron-intron | ENST00000512739 | ENST00000431489 | PDE5A | chr4 | 120420968 | - | EHBP1 | chr2 | 63251232 | - |
intron-intron | ENST00000512739 | ENST00000354487 | PDE5A | chr4 | 120420968 | - | EHBP1 | chr2 | 63251232 | - |
intron-intron | ENST00000512739 | ENST00000263991 | PDE5A | chr4 | 120420968 | - | EHBP1 | chr2 | 63251232 | - |
intron-intron | ENST00000512739 | ENST00000405289 | PDE5A | chr4 | 120420968 | - | EHBP1 | chr2 | 63251232 | - |
intron-intron | ENST00000512739 | ENST00000496857 | PDE5A | chr4 | 120420968 | - | EHBP1 | chr2 | 63251232 | - |
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FusionProtFeatures for PDE5A_EHBP1 |
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Hgene | Tgene |
PDE5A | EHBP1 |
Plays a role in signal transduction by regulating theintracellular concentration of cyclic nucleotides. Thisphosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:9714779, PubMed:15489334). Specifically regulatesnitric-oxide-generated cGMP (PubMed:15489334).{ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:9714779}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PDE5A_EHBP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PDE5A_EHBP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PDE5A_EHBP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | PDE5A | O76074 | DB00277 | Theophylline | cGMP-specific 3',5'-cyclic phosphodiesterase | small molecule | approved |
Hgene | PDE5A | O76074 | DB00862 | Vardenafil | cGMP-specific 3',5'-cyclic phosphodiesterase | small molecule | approved |
Hgene | PDE5A | O76074 | DB00975 | Dipyridamole | cGMP-specific 3',5'-cyclic phosphodiesterase | small molecule | approved |
Hgene | PDE5A | O76074 | DB06237 | Avanafil | cGMP-specific 3',5'-cyclic phosphodiesterase | small molecule | approved |
Hgene | PDE5A | O76074 | DB00203 | Sildenafil | cGMP-specific 3',5'-cyclic phosphodiesterase | small molecule | approved|investigational |
Hgene | PDE5A | O76074 | DB00806 | Pentoxifylline | cGMP-specific 3',5'-cyclic phosphodiesterase | small molecule | approved|investigational |
Hgene | PDE5A | O76074 | DB00820 | Tadalafil | cGMP-specific 3',5'-cyclic phosphodiesterase | small molecule | approved|investigational |
Hgene | PDE5A | O76074 | DB06267 | Udenafil | cGMP-specific 3',5'-cyclic phosphodiesterase | small molecule | approved|investigational |
Hgene | PDE5A | O76074 | DB04272 | Citric Acid | cGMP-specific 3',5'-cyclic phosphodiesterase | small molecule | approved|nutraceutical|vet_approved |
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RelatedDiseases for PDE5A_EHBP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PDE5A | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Tgene | EHBP1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |