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Fusion gene ID: 26421 |
FusionGeneSummary for PDE5A_C4orf3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PDE5A_C4orf3 | Fusion gene ID: 26421 | Hgene | Tgene | Gene symbol | PDE5A | C4orf3 | Gene ID | 8654 | 401152 |
| Gene name | phosphodiesterase 5A | chromosome 4 open reading frame 3 | |
| Synonyms | CGB-PDE|CN5A|PDE5 | ALN|HCVFTP1 | |
| Cytomap | 4q26 | 4q26 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cGMP-specific 3',5'-cyclic phosphodiesterasecGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterasecGMP-specific phosphodiesterase PDE5A2cGMP-specific phosphodiesterase type 5Aphosphodiesterase 5A, cGMP-specificphosphodiesterase isozyme | uncharacterized protein C4orf3HCV F-transactivated protein 1another-regulinhepatitis C virus F protein-transactivated protein 1 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | O76074 | Q8WVX3 | |
| Ensembl transtripts involved in fusion gene | ENST00000354960, ENST00000394439, ENST00000264805, ENST00000512739, | ENST00000399075, ENST00000504110, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 1 X 1 X 1=1 |
| # samples | 3 | 1 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: PDE5A [Title/Abstract] AND C4orf3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PDE5A | GO:0046069 | cGMP catabolic process | 14687666 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | HNSC | TCGA-CV-7406-01A | PDE5A | chr4 | 120517678 | - | C4orf3 | chr4 | 120219934 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000354960 | ENST00000399075 | PDE5A | chr4 | 120517678 | - | C4orf3 | chr4 | 120219934 | - |
| Frame-shift | ENST00000354960 | ENST00000504110 | PDE5A | chr4 | 120517678 | - | C4orf3 | chr4 | 120219934 | - |
| In-frame | ENST00000394439 | ENST00000399075 | PDE5A | chr4 | 120517678 | - | C4orf3 | chr4 | 120219934 | - |
| Frame-shift | ENST00000394439 | ENST00000504110 | PDE5A | chr4 | 120517678 | - | C4orf3 | chr4 | 120219934 | - |
| In-frame | ENST00000264805 | ENST00000399075 | PDE5A | chr4 | 120517678 | - | C4orf3 | chr4 | 120219934 | - |
| Frame-shift | ENST00000264805 | ENST00000504110 | PDE5A | chr4 | 120517678 | - | C4orf3 | chr4 | 120219934 | - |
| intron-3CDS | ENST00000512739 | ENST00000399075 | PDE5A | chr4 | 120517678 | - | C4orf3 | chr4 | 120219934 | - |
| intron-3CDS | ENST00000512739 | ENST00000504110 | PDE5A | chr4 | 120517678 | - | C4orf3 | chr4 | 120219934 | - |
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FusionProtFeatures for PDE5A_C4orf3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PDE5A | C4orf3 |
| Plays a role in signal transduction by regulating theintracellular concentration of cyclic nucleotides. Thisphosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:9714779, PubMed:15489334). Specifically regulatesnitric-oxide-generated cGMP (PubMed:15489334).{ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:9714779}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PDE5A | chr4:120517678 | chr4:120219934 | ENST00000264805 | - | 3 | 21 | 10_24 | 235 | 834 | Compositional bias | Note=Poly-Gln |
| Hgene | PDE5A | chr4:120517678 | chr4:120219934 | ENST00000354960 | - | 3 | 21 | 10_24 | 277 | 876 | Compositional bias | Note=Poly-Gln |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PDE5A | chr4:120517678 | chr4:120219934 | ENST00000264805 | - | 3 | 21 | 164_314 | 235 | 834 | Domain | Note=GAF 1 |
| Hgene | >PDE5A | chr4:120517678 | chr4:120219934 | ENST00000264805 | - | 3 | 21 | 346_503 | 235 | 834 | Domain | Note=GAF 2 |
| Hgene | >PDE5A | chr4:120517678 | chr4:120219934 | ENST00000264805 | - | 3 | 21 | 536_860 | 235 | 834 | Domain | PDEase |
| Hgene | >PDE5A | chr4:120517678 | chr4:120219934 | ENST00000354960 | - | 3 | 21 | 164_314 | 277 | 876 | Domain | Note=GAF 1 |
| Hgene | >PDE5A | chr4:120517678 | chr4:120219934 | ENST00000354960 | - | 3 | 21 | 346_503 | 277 | 876 | Domain | Note=GAF 2 |
| Hgene | >PDE5A | chr4:120517678 | chr4:120219934 | ENST00000354960 | - | 3 | 21 | 536_860 | 277 | 876 | Domain | PDEase |
| Tgene | C4orf3 | chr4:120517678 | chr4:120219934 | ENST00000399075 | - | 1 | 3 | 45_65 | 199 | 200 | Transmembrane | Helical |
| Tgene | C4orf3 | chr4:120517678 | chr4:120219934 | ENST00000504110 | - | 0 | 2 | 45_65 | 66 | 67 | Transmembrane | Helical |
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FusionGeneSequence for PDE5A_C4orf3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PDE5A_ENST00000354960_chr4_120517678_-_C4orf3_ENST00000399075_chr4_120219934_-_277aa MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAERVHTIPVCKEGIRGHTESCSCPLQQSPRAD NSAPGTPTRKISASEFDRPLRPIVVKDSEGTVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLI SADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMP >In-frame_PDE5A_ENST00000394439_chr4_120517678_-_C4orf3_ENST00000399075_chr4_120219934_-_225aa MVNAWFAERVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEGTVSFLSDSEKKEQMPLTPPRFD HDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGH >In-frame_PDE5A_ENST00000264805_chr4_120517678_-_C4orf3_ENST00000399075_chr4_120219934_-_235aa MLPFGDKTREMVNAWFAERVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEGTVSFLSDSEKKE QMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PDE5A_ENST00000354960_chr4_120517678_-_C4orf3_ENST00000399075_chr4_120219934_-_832nt ATGGAGCGGGCCGGCCCCAGCTTCGGGCAGCAGCGACAGCAGCAGCAGCCCCAGCAGCAGAAGCAGCAGCAGAGGGATCAGGACTCGGTC GAAGCATGGCTGGACGATCACTGGGACTTTACCTTCTCATACTTTGTTAGAAAAGCCACCAGAGAAATGGTCAATGCATGGTTTGCTGAG AGAGTTCACACCATCCCTGTGTGCAAGGAAGGTATCAGAGGCCACACCGAATCTTGCTCTTGTCCCTTGCAGCAGAGTCCTCGTGCAGAT AACAGTGCCCCTGGAACACCAACCAGGAAAATCTCTGCCTCTGAATTTGACCGGCCTCTTAGACCCATTGTTGTCAAGGATTCTGAGGGA ACTGTGAGCTTCCTCTCTGACTCAGAAAAGAAGGAACAGATGCCTCTAACCCCTCCAAGGTTTGATCATGATGAAGGGGACCAGTGCTCA AGACTCTTGGAATTAGTGAAGGATATTTCTAGTCATTTGGATGTCACAGCCTTATGTCACAAAATTTTCTTGCATATCCATGGACTGATA TCTGCTGACCGCTATTCCCTGTTCCTTGTCTGTGAAGACAGCTCCAATGACAAGTTTCTTATCAGCCGCCTCTTTGATGTTGCTGAAGGT TCAACACTGGAAGAAGTTTCAAATAACTGTATCCGCTTAGAATGGAACAAAGGCATTGTGGGACATGTGGCAGCGCTTGGTGAGCCCTTG AACATCAAAGATGCATATGAGGATCCTCGGTTCAATGCAGAAGTTGACCAAATTACAGGCTACAAGACACAAAGCATTCTTTGTATGCCA >In-frame_PDE5A_ENST00000394439_chr4_120517678_-_C4orf3_ENST00000399075_chr4_120219934_-_676nt ATGGTCAATGCATGGTTTGCTGAGAGAGTTCACACCATCCCTGTGTGCAAGGAAGGTATCAGAGGCCACACCGAATCTTGCTCTTGTCCC TTGCAGCAGAGTCCTCGTGCAGATAACAGTGCCCCTGGAACACCAACCAGGAAAATCTCTGCCTCTGAATTTGACCGGCCTCTTAGACCC ATTGTTGTCAAGGATTCTGAGGGAACTGTGAGCTTCCTCTCTGACTCAGAAAAGAAGGAACAGATGCCTCTAACCCCTCCAAGGTTTGAT CATGATGAAGGGGACCAGTGCTCAAGACTCTTGGAATTAGTGAAGGATATTTCTAGTCATTTGGATGTCACAGCCTTATGTCACAAAATT TTCTTGCATATCCATGGACTGATATCTGCTGACCGCTATTCCCTGTTCCTTGTCTGTGAAGACAGCTCCAATGACAAGTTTCTTATCAGC CGCCTCTTTGATGTTGCTGAAGGTTCAACACTGGAAGAAGTTTCAAATAACTGTATCCGCTTAGAATGGAACAAAGGCATTGTGGGACAT GTGGCAGCGCTTGGTGAGCCCTTGAACATCAAAGATGCATATGAGGATCCTCGGTTCAATGCAGAAGTTGACCAAATTACAGGCTACAAG >In-frame_PDE5A_ENST00000264805_chr4_120517678_-_C4orf3_ENST00000399075_chr4_120219934_-_706nt ATGTTGCCCTTTGGAGACAAAACAAGAGAAATGGTCAATGCATGGTTTGCTGAGAGAGTTCACACCATCCCTGTGTGCAAGGAAGGTATC AGAGGCCACACCGAATCTTGCTCTTGTCCCTTGCAGCAGAGTCCTCGTGCAGATAACAGTGCCCCTGGAACACCAACCAGGAAAATCTCT GCCTCTGAATTTGACCGGCCTCTTAGACCCATTGTTGTCAAGGATTCTGAGGGAACTGTGAGCTTCCTCTCTGACTCAGAAAAGAAGGAA CAGATGCCTCTAACCCCTCCAAGGTTTGATCATGATGAAGGGGACCAGTGCTCAAGACTCTTGGAATTAGTGAAGGATATTTCTAGTCAT TTGGATGTCACAGCCTTATGTCACAAAATTTTCTTGCATATCCATGGACTGATATCTGCTGACCGCTATTCCCTGTTCCTTGTCTGTGAA GACAGCTCCAATGACAAGTTTCTTATCAGCCGCCTCTTTGATGTTGCTGAAGGTTCAACACTGGAAGAAGTTTCAAATAACTGTATCCGC TTAGAATGGAACAAAGGCATTGTGGGACATGTGGCAGCGCTTGGTGAGCCCTTGAACATCAAAGATGCATATGAGGATCCTCGGTTCAAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PDE5A_ENST00000354960_chr4_120517678_-_C4orf3_ENST00000399075_chr4_120219934_-_2879nt GCTGCCGCCGCCGCCGCCGCCTCCTGGGAACCAGGGGACTGAAGAGCCTGCGAGAGCGGAACACTGCCGGACCCCGGGTGGGGGGGGCGC AGCAGCTGCGCCTGGCCCCGCCCACCACACCTGGGCGCCCGTAGAACCGCGCGGGGCGGGGCGGGGCAGGAGGCTGGCCTGGCGCTCCGG CCGCTTTGTCGAAAGCCGGCCCGACTGGAGCAGGACGAAGGGGGAGGGTCTCGAGGCCGAGTCCTGTTCTTCTGAGGGACGGACCCCAGC TGGGGTGGAAAAGCAGTACCAGAGAGCCTCCGAGGCGCGCGGTGCCAACCATGGAGCGGGCCGGCCCCAGCTTCGGGCAGCAGCGACAGC AGCAGCAGCCCCAGCAGCAGAAGCAGCAGCAGAGGGATCAGGACTCGGTCGAAGCATGGCTGGACGATCACTGGGACTTTACCTTCTCAT ACTTTGTTAGAAAAGCCACCAGAGAAATGGTCAATGCATGGTTTGCTGAGAGAGTTCACACCATCCCTGTGTGCAAGGAAGGTATCAGAG GCCACACCGAATCTTGCTCTTGTCCCTTGCAGCAGAGTCCTCGTGCAGATAACAGTGCCCCTGGAACACCAACCAGGAAAATCTCTGCCT CTGAATTTGACCGGCCTCTTAGACCCATTGTTGTCAAGGATTCTGAGGGAACTGTGAGCTTCCTCTCTGACTCAGAAAAGAAGGAACAGA TGCCTCTAACCCCTCCAAGGTTTGATCATGATGAAGGGGACCAGTGCTCAAGACTCTTGGAATTAGTGAAGGATATTTCTAGTCATTTGG ATGTCACAGCCTTATGTCACAAAATTTTCTTGCATATCCATGGACTGATATCTGCTGACCGCTATTCCCTGTTCCTTGTCTGTGAAGACA GCTCCAATGACAAGTTTCTTATCAGCCGCCTCTTTGATGTTGCTGAAGGTTCAACACTGGAAGAAGTTTCAAATAACTGTATCCGCTTAG AATGGAACAAAGGCATTGTGGGACATGTGGCAGCGCTTGGTGAGCCCTTGAACATCAAAGATGCATATGAGGATCCTCGGTTCAATGCAG AAGTTGACCAAATTACAGGCTACAAGACACAAAGCATTCTTTGTATGCCAATTAAGAATCATAGGGAAGAGACTTGTTCGCTGATATCTA AATTAAGAAGTTGGTTCTTGAGTGAATTCTGAAAATGGCTACAAACTTCTTGAATAAAGAAGACAGGACTCTCAATAGAAGAATTTCACA TCTCCAAGGGACCCTTCCTTTCATTTTACACTTTGTTACTAATTTGCAGAACTCTATTAATTGGGTAGGATTTCACCCATTCCTAGCTAA GTTCTTAAAATTAAACCCTTTGGTTCGTGTTTAAAAACTTTCAAACATCTGATGGCTTTACAGGGGCTGAATATAAAAGCATTTGTACTT AAAGGTCTTGTGTATTCATTAAGAAATATAGTAATGTCTTTTAATGTTTTAAGAGTTGATCAGGGTTTACTATGATGCAAGTAATAGGAT GATTAATAAGGGAAGGTTTTTATGAATTCAAAAGTCAATTATTCAAAAGCAGGGAAAGATTTTGAGAGAGGGAACAAAGTATTCTTAGAT TGCGTAGAAGCTGCTAGGTTCCAGTTTTAATTTTTAGGTTTAGTTGGACTCTGTTATGAAAAGATAGGTTATGGGTGGGCGACAGGTTGA TACAGTCTTAGAAAAAGCAGGTAATATCAAAGTATTGGAAAGCTAGCATGCATGCCCTCTTACCTGGGTATCTTCCCCCTTTTTTCCTTT TAAACTCTTGAGCCTCCTATAACGAAGGATTATGTGTTTCAAACCTATTTTTTTTTTACTGTTTCATTAAGTGTGCTTGTGCCCAAAATA TTTACTTGTATAATATCTGTAACTTGCTTAAATACTTCAGCAAAGTCAGCATATTTACTCATTCAACAAATATTTGAGCCAGGCATTATT TTAGACACAGCAGTGAACAAAACAAAAAGGCATTCTTGCCTTCATGGAGCTTACATTCTTATTGTTATTTAAATCTAAATGTTATAAAAC AAGAATTTATATTCTAGGGTTGATCAGCTAGTATTTAATCAAAAAGGCCACACTCCCATAGCAGCTACTCTAAGCTGTAGTAGCTAATAA AAAATATTAATGTTGGCCGGGCACAGTGGCTCACGCCTATAATCCCAGCACTTTGGGAGGCCAAGGGTGGTAGATCACTTGAGGTCAAGA GTTGTGACACCAGCCTGGCCAACCTGGTGAAACCCTATCTCTATTAAAAAATACAAAAAAATACAAAAAAATTAGCTGGGCATGTTGGCA TGCACCTGTAGTCCCAGCTATTTGGGAGGCTGAGGCACGAGAATTGCTTGAATCCGGGAGGTGGAGGTTGCAGTGAGCCAAGATGGGGCC ACTGCACTCTAACGTGGGCAACAGAGACCCTGTCTCAAAAAGAAAATATTCCTGTTAGCCCTAAAGGCTTTACATGAGGAATGGTAGAAG TGGTCTTTTGTTTAAATTAGTTGCATTCAGCATATATGAATTGTCTTAAATATTTTGGGGATACTCCCCCGCCTTTTAAACAGGGCATAA GATCTGGTAAACTCTCTGTATATCTTCCTACCTTTCAAAATCGTTCTTAGGGTTAGTCAAGTCTGGAATATAATTGCTGACTATAAAGTT AGCAATTATGCTTTTAAGGTGTTGTCACATCAACCTAAAGAGAACCATCTATGGAAGGTATGGTTGAAACATCTGTAGGAACACAGAACT >In-frame_PDE5A_ENST00000394439_chr4_120517678_-_C4orf3_ENST00000399075_chr4_120219934_-_2460nt GAGGGACGAGTCCACGGGACAGCCCAAAGGCAACATGACGGAACCTTGCCAAAAGAAATGGTCAATGCATGGTTTGCTGAGAGAGTTCAC ACCATCCCTGTGTGCAAGGAAGGTATCAGAGGCCACACCGAATCTTGCTCTTGTCCCTTGCAGCAGAGTCCTCGTGCAGATAACAGTGCC CCTGGAACACCAACCAGGAAAATCTCTGCCTCTGAATTTGACCGGCCTCTTAGACCCATTGTTGTCAAGGATTCTGAGGGAACTGTGAGC TTCCTCTCTGACTCAGAAAAGAAGGAACAGATGCCTCTAACCCCTCCAAGGTTTGATCATGATGAAGGGGACCAGTGCTCAAGACTCTTG GAATTAGTGAAGGATATTTCTAGTCATTTGGATGTCACAGCCTTATGTCACAAAATTTTCTTGCATATCCATGGACTGATATCTGCTGAC CGCTATTCCCTGTTCCTTGTCTGTGAAGACAGCTCCAATGACAAGTTTCTTATCAGCCGCCTCTTTGATGTTGCTGAAGGTTCAACACTG GAAGAAGTTTCAAATAACTGTATCCGCTTAGAATGGAACAAAGGCATTGTGGGACATGTGGCAGCGCTTGGTGAGCCCTTGAACATCAAA GATGCATATGAGGATCCTCGGTTCAATGCAGAAGTTGACCAAATTACAGGCTACAAGACACAAAGCATTCTTTGTATGCCAATTAAGAAT CATAGGGAAGAGACTTGTTCGCTGATATCTAAATTAAGAAGTTGGTTCTTGAGTGAATTCTGAAAATGGCTACAAACTTCTTGAATAAAG AAGACAGGACTCTCAATAGAAGAATTTCACATCTCCAAGGGACCCTTCCTTTCATTTTACACTTTGTTACTAATTTGCAGAACTCTATTA ATTGGGTAGGATTTCACCCATTCCTAGCTAAGTTCTTAAAATTAAACCCTTTGGTTCGTGTTTAAAAACTTTCAAACATCTGATGGCTTT ACAGGGGCTGAATATAAAAGCATTTGTACTTAAAGGTCTTGTGTATTCATTAAGAAATATAGTAATGTCTTTTAATGTTTTAAGAGTTGA TCAGGGTTTACTATGATGCAAGTAATAGGATGATTAATAAGGGAAGGTTTTTATGAATTCAAAAGTCAATTATTCAAAAGCAGGGAAAGA TTTTGAGAGAGGGAACAAAGTATTCTTAGATTGCGTAGAAGCTGCTAGGTTCCAGTTTTAATTTTTAGGTTTAGTTGGACTCTGTTATGA AAAGATAGGTTATGGGTGGGCGACAGGTTGATACAGTCTTAGAAAAAGCAGGTAATATCAAAGTATTGGAAAGCTAGCATGCATGCCCTC TTACCTGGGTATCTTCCCCCTTTTTTCCTTTTAAACTCTTGAGCCTCCTATAACGAAGGATTATGTGTTTCAAACCTATTTTTTTTTTAC TGTTTCATTAAGTGTGCTTGTGCCCAAAATATTTACTTGTATAATATCTGTAACTTGCTTAAATACTTCAGCAAAGTCAGCATATTTACT CATTCAACAAATATTTGAGCCAGGCATTATTTTAGACACAGCAGTGAACAAAACAAAAAGGCATTCTTGCCTTCATGGAGCTTACATTCT TATTGTTATTTAAATCTAAATGTTATAAAACAAGAATTTATATTCTAGGGTTGATCAGCTAGTATTTAATCAAAAAGGCCACACTCCCAT AGCAGCTACTCTAAGCTGTAGTAGCTAATAAAAAATATTAATGTTGGCCGGGCACAGTGGCTCACGCCTATAATCCCAGCACTTTGGGAG GCCAAGGGTGGTAGATCACTTGAGGTCAAGAGTTGTGACACCAGCCTGGCCAACCTGGTGAAACCCTATCTCTATTAAAAAATACAAAAA AATACAAAAAAATTAGCTGGGCATGTTGGCATGCACCTGTAGTCCCAGCTATTTGGGAGGCTGAGGCACGAGAATTGCTTGAATCCGGGA GGTGGAGGTTGCAGTGAGCCAAGATGGGGCCACTGCACTCTAACGTGGGCAACAGAGACCCTGTCTCAAAAAGAAAATATTCCTGTTAGC CCTAAAGGCTTTACATGAGGAATGGTAGAAGTGGTCTTTTGTTTAAATTAGTTGCATTCAGCATATATGAATTGTCTTAAATATTTTGGG GATACTCCCCCGCCTTTTAAACAGGGCATAAGATCTGGTAAACTCTCTGTATATCTTCCTACCTTTCAAAATCGTTCTTAGGGTTAGTCA AGTCTGGAATATAATTGCTGACTATAAAGTTAGCAATTATGCTTTTAAGGTGTTGTCACATCAACCTAAAGAGAACCATCTATGGAAGGT ATGGTTGAAACATCTGTAGGAACACAGAACTGGGATTTCACTGAGTTTACCAAATCAACTGTGTGAACTGTTTCTGCACTGCTTGCTAAT >In-frame_PDE5A_ENST00000264805_chr4_120517678_-_C4orf3_ENST00000399075_chr4_120219934_-_2891nt GTGGAGCAGAGAGTGCTTGGCGGGCGGGTGCCCCGAAGCCTGAGGAATTGATGCATAGTCGGGGTGCGTGGACTCCAGGACGCGCCCCTT TGCAGAAAGAGTCCGTGCCCCGCTGCCGCCTGCTCTGGGCAGCGGCCGTCGGGCAGCGGGTGCTGGCCGTCTTGGCCGGGAGGGTGACAC ACGCCCGGCAGTGATGGTCGAGGAGCCCGCCCGGGTTCGACGCCCGGGTCCCACTCGCCGGCGCGCGGCCGCGGCTCTGCCGGTCGCTCC CCGCCAGGGGGCGGCGCAGCGCGGGGCGAGCGGGAGGCGACGGGCGGCGGCGCGGAGGCCGGGGCCGTGAGGGAGCTGGTTCTGAGTCGC CGACCTCACCTCACCTCACCTGCGCGCGTTGTTGCCCCTACGGAGCCTCCTGGAGTCCAGGATCGGCGGAGTTCGAAAACGAACTTCCCA CGTTTGCTATGTTGCCCTTTGGAGACAAAACAAGAGAAATGGTCAATGCATGGTTTGCTGAGAGAGTTCACACCATCCCTGTGTGCAAGG AAGGTATCAGAGGCCACACCGAATCTTGCTCTTGTCCCTTGCAGCAGAGTCCTCGTGCAGATAACAGTGCCCCTGGAACACCAACCAGGA AAATCTCTGCCTCTGAATTTGACCGGCCTCTTAGACCCATTGTTGTCAAGGATTCTGAGGGAACTGTGAGCTTCCTCTCTGACTCAGAAA AGAAGGAACAGATGCCTCTAACCCCTCCAAGGTTTGATCATGATGAAGGGGACCAGTGCTCAAGACTCTTGGAATTAGTGAAGGATATTT CTAGTCATTTGGATGTCACAGCCTTATGTCACAAAATTTTCTTGCATATCCATGGACTGATATCTGCTGACCGCTATTCCCTGTTCCTTG TCTGTGAAGACAGCTCCAATGACAAGTTTCTTATCAGCCGCCTCTTTGATGTTGCTGAAGGTTCAACACTGGAAGAAGTTTCAAATAACT GTATCCGCTTAGAATGGAACAAAGGCATTGTGGGACATGTGGCAGCGCTTGGTGAGCCCTTGAACATCAAAGATGCATATGAGGATCCTC GGTTCAATGCAGAAGTTGACCAAATTACAGGCTACAAGACACAAAGCATTCTTTGTATGCCAATTAAGAATCATAGGGAAGAGACTTGTT CGCTGATATCTAAATTAAGAAGTTGGTTCTTGAGTGAATTCTGAAAATGGCTACAAACTTCTTGAATAAAGAAGACAGGACTCTCAATAG AAGAATTTCACATCTCCAAGGGACCCTTCCTTTCATTTTACACTTTGTTACTAATTTGCAGAACTCTATTAATTGGGTAGGATTTCACCC ATTCCTAGCTAAGTTCTTAAAATTAAACCCTTTGGTTCGTGTTTAAAAACTTTCAAACATCTGATGGCTTTACAGGGGCTGAATATAAAA GCATTTGTACTTAAAGGTCTTGTGTATTCATTAAGAAATATAGTAATGTCTTTTAATGTTTTAAGAGTTGATCAGGGTTTACTATGATGC AAGTAATAGGATGATTAATAAGGGAAGGTTTTTATGAATTCAAAAGTCAATTATTCAAAAGCAGGGAAAGATTTTGAGAGAGGGAACAAA GTATTCTTAGATTGCGTAGAAGCTGCTAGGTTCCAGTTTTAATTTTTAGGTTTAGTTGGACTCTGTTATGAAAAGATAGGTTATGGGTGG GCGACAGGTTGATACAGTCTTAGAAAAAGCAGGTAATATCAAAGTATTGGAAAGCTAGCATGCATGCCCTCTTACCTGGGTATCTTCCCC CTTTTTTCCTTTTAAACTCTTGAGCCTCCTATAACGAAGGATTATGTGTTTCAAACCTATTTTTTTTTTACTGTTTCATTAAGTGTGCTT GTGCCCAAAATATTTACTTGTATAATATCTGTAACTTGCTTAAATACTTCAGCAAAGTCAGCATATTTACTCATTCAACAAATATTTGAG CCAGGCATTATTTTAGACACAGCAGTGAACAAAACAAAAAGGCATTCTTGCCTTCATGGAGCTTACATTCTTATTGTTATTTAAATCTAA ATGTTATAAAACAAGAATTTATATTCTAGGGTTGATCAGCTAGTATTTAATCAAAAAGGCCACACTCCCATAGCAGCTACTCTAAGCTGT AGTAGCTAATAAAAAATATTAATGTTGGCCGGGCACAGTGGCTCACGCCTATAATCCCAGCACTTTGGGAGGCCAAGGGTGGTAGATCAC TTGAGGTCAAGAGTTGTGACACCAGCCTGGCCAACCTGGTGAAACCCTATCTCTATTAAAAAATACAAAAAAATACAAAAAAATTAGCTG GGCATGTTGGCATGCACCTGTAGTCCCAGCTATTTGGGAGGCTGAGGCACGAGAATTGCTTGAATCCGGGAGGTGGAGGTTGCAGTGAGC CAAGATGGGGCCACTGCACTCTAACGTGGGCAACAGAGACCCTGTCTCAAAAAGAAAATATTCCTGTTAGCCCTAAAGGCTTTACATGAG GAATGGTAGAAGTGGTCTTTTGTTTAAATTAGTTGCATTCAGCATATATGAATTGTCTTAAATATTTTGGGGATACTCCCCCGCCTTTTA AACAGGGCATAAGATCTGGTAAACTCTCTGTATATCTTCCTACCTTTCAAAATCGTTCTTAGGGTTAGTCAAGTCTGGAATATAATTGCT GACTATAAAGTTAGCAATTATGCTTTTAAGGTGTTGTCACATCAACCTAAAGAGAACCATCTATGGAAGGTATGGTTGAAACATCTGTAG GAACACAGAACTGGGATTTCACTGAGTTTACCAAATCAACTGTGTGAACTGTTTCTGCACTGCTTGCTAATGGTTTCATCTAATAAATGT |
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FusionGenePPI for PDE5A_C4orf3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PDE5A | AIPL1, MIOS, FGFR1OP, BLM, SUPT5H, WDR24, PATZ1, FKBP15 | C4orf3 | GCN1L1, PANX1, EDC4, DEGS1, ERMP1, CALM1, GLP1R, LMNA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PDE5A_C4orf3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | PDE5A | O76074 | DB00277 | Theophylline | cGMP-specific 3',5'-cyclic phosphodiesterase | small molecule | approved |
| Hgene | PDE5A | O76074 | DB00862 | Vardenafil | cGMP-specific 3',5'-cyclic phosphodiesterase | small molecule | approved |
| Hgene | PDE5A | O76074 | DB00975 | Dipyridamole | cGMP-specific 3',5'-cyclic phosphodiesterase | small molecule | approved |
| Hgene | PDE5A | O76074 | DB06237 | Avanafil | cGMP-specific 3',5'-cyclic phosphodiesterase | small molecule | approved |
| Hgene | PDE5A | O76074 | DB00203 | Sildenafil | cGMP-specific 3',5'-cyclic phosphodiesterase | small molecule | approved|investigational |
| Hgene | PDE5A | O76074 | DB00806 | Pentoxifylline | cGMP-specific 3',5'-cyclic phosphodiesterase | small molecule | approved|investigational |
| Hgene | PDE5A | O76074 | DB00820 | Tadalafil | cGMP-specific 3',5'-cyclic phosphodiesterase | small molecule | approved|investigational |
| Hgene | PDE5A | O76074 | DB06267 | Udenafil | cGMP-specific 3',5'-cyclic phosphodiesterase | small molecule | approved|investigational |
| Hgene | PDE5A | O76074 | DB04272 | Citric Acid | cGMP-specific 3',5'-cyclic phosphodiesterase | small molecule | approved|nutraceutical|vet_approved |
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RelatedDiseases for PDE5A_C4orf3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PDE5A | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
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