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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26417

FusionGeneSummary for PDE4D_RGS7BP

check button Fusion gene summary
Fusion gene informationFusion gene name: PDE4D_RGS7BP
Fusion gene ID: 26417
HgeneTgene
Gene symbol

PDE4D

RGS7BP

Gene ID

5144

401190

Gene namephosphodiesterase 4Dregulator of G protein signaling 7 binding protein
SynonymsACRDYS2|DPDE3|HSPDE4D|PDE43|PDE4DN2|STRK1R7BP
Cytomap

5q11.2-q12.1

5q12.3

Type of geneprotein-codingprotein-coding
DescriptioncAMP-specific 3',5'-cyclic phosphodiesterase 4DcAMP-specific phosphodiesterase PDE4D6phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)testicular tissue protein Li 136regulator of G-protein signaling 7-binding proteinR7 family-binding protein
Modification date2018051920180519
UniProtAcc

Q08499

Q6MZT1

Ensembl transtripts involved in fusion geneENST00000340635, ENST00000360047, 
ENST00000507116, ENST00000502484, 
ENST00000546160, ENST00000502575, 
ENST00000358923, ENST00000503258, 
ENST00000405755, ENST00000317118, 
ENST00000503947, 		ENST00000508162, 
ENST00000334025, 
Fusion gene scores* DoF score23 X 14 X 10=32201 X 1 X 1=1
# samples 341
** MAII scorelog2(34/3220*10)=-3.24345403686428
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: PDE4D [Title/Abstract] AND RGS7BP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePDE4D

GO:0006198

cAMP catabolic process

9371713|17404263


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-66-2778-01APDE4Dchr5

59783769

-RGS7BPchr5

63871601

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000340635ENST00000508162PDE4Dchr5

59783769

-RGS7BPchr5

63871601

+
intron-3UTRENST00000340635ENST00000334025PDE4Dchr5

59783769

-RGS7BPchr5

63871601

+
intron-3UTRENST00000360047ENST00000508162PDE4Dchr5

59783769

-RGS7BPchr5

63871601

+
intron-3UTRENST00000360047ENST00000334025PDE4Dchr5

59783769

-RGS7BPchr5

63871601

+
intron-3UTRENST00000507116ENST00000508162PDE4Dchr5

59783769

-RGS7BPchr5

63871601

+
intron-3UTRENST00000507116ENST00000334025PDE4Dchr5

59783769

-RGS7BPchr5

63871601

+
5UTR-3UTRENST00000502484ENST00000508162PDE4Dchr5

59783769

-RGS7BPchr5

63871601

+
5UTR-3UTRENST00000502484ENST00000334025PDE4Dchr5

59783769

-RGS7BPchr5

63871601

+
intron-3UTRENST00000546160ENST00000508162PDE4Dchr5

59783769

-RGS7BPchr5

63871601

+
intron-3UTRENST00000546160ENST00000334025PDE4Dchr5

59783769

-RGS7BPchr5

63871601

+
intron-3UTRENST00000502575ENST00000508162PDE4Dchr5

59783769

-RGS7BPchr5

63871601

+
intron-3UTRENST00000502575ENST00000334025PDE4Dchr5

59783769

-RGS7BPchr5

63871601

+
intron-3UTRENST00000358923ENST00000508162PDE4Dchr5

59783769

-RGS7BPchr5

63871601

+
intron-3UTRENST00000358923ENST00000334025PDE4Dchr5

59783769

-RGS7BPchr5

63871601

+
intron-3UTRENST00000503258ENST00000508162PDE4Dchr5

59783769

-RGS7BPchr5

63871601

+
intron-3UTRENST00000503258ENST00000334025PDE4Dchr5

59783769

-RGS7BPchr5

63871601

+
intron-3UTRENST00000405755ENST00000508162PDE4Dchr5

59783769

-RGS7BPchr5

63871601

+
intron-3UTRENST00000405755ENST00000334025PDE4Dchr5

59783769

-RGS7BPchr5

63871601

+
intron-3UTRENST00000317118ENST00000508162PDE4Dchr5

59783769

-RGS7BPchr5

63871601

+
intron-3UTRENST00000317118ENST00000334025PDE4Dchr5

59783769

-RGS7BPchr5

63871601

+
intron-3UTRENST00000503947ENST00000508162PDE4Dchr5

59783769

-RGS7BPchr5

63871601

+
intron-3UTRENST00000503947ENST00000334025PDE4Dchr5

59783769

-RGS7BPchr5

63871601

+

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FusionProtFeatures for PDE4D_RGS7BP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PDE4D

Q08499

RGS7BP

Q6MZT1

Regulator of G protein-coupled receptor (GPCR)signaling. Regulatory subunit of the R7-Gbeta5 complexes that actsby controlling the subcellular location of the R7-Gbeta5complexes. When palmitoylated, it targets the R7-Gbeta5 complexesto the plasma membrane, leading to inhibit G protein alphasubunits. When it is unpalmitoylated, the R7-Gbeta5 complexesundergo a nuclear/cytoplasmic shuttling. May also act bycontrolling the proteolytic stability of R7 proteins, probably byprotecting them from degradation. {ECO:0000250|UniProtKB:Q8BQP9}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PDE4D_RGS7BP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PDE4D_RGS7BP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PDE4DPDE4DIP, PDE4D, AKAP6, GNB2L1, ARRB1, MDM2, ITSN1, ARRB2, PPP3CA, PPP3CB, PPP3R1, GSK3B, CSNK1A1, CDK2, PAFAH1B1, PRKACA, APP, LYN, SRC, FYN, ABL1, GRB2, PIAS4, MAPK1, BIN1, HDGFRP2, ZBTB1, MAGEA6, TRAF1, COIL, GOLGA8EP, GOLGA8F, ZDHHC17, SPTAN1, PIK3R1, TRIM23, ITPKB, PFKFB2, AKAP12, ATOH1, DUSP13, PDE4B, TRIM25RGS7BPRGS9, GNB5, MCM2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PDE4D_RGS7BP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePDE4DQ08499DB00651DyphyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Dsmall moleculeapproved
HgenePDE4DQ08499DB01656RoflumilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Dsmall moleculeapproved
HgenePDE4DQ08499DB01088IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Dsmall moleculeapproved|investigational
HgenePDE4DQ08499DB05266IbudilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Dsmall moleculeapproved|investigational
HgenePDE4DQ08499DB05676ApremilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Dsmall moleculeapproved|investigational

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RelatedDiseases for PDE4D_RGS7BP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePDE4DC3553250ACRODYSOSTOSIS 2 WITH OR WITHOUT HORMONE RESISTANCE4UNIPROT
HgenePDE4DC0011581Depressive disorder3PSYGENET
HgenePDE4DC0004096Asthma2CTD_human
HgenePDE4DC0011570Mental Depression2PSYGENET
HgenePDE4DC0033578Prostatic Neoplasms1CTD_human
HgenePDE4DC0036341Schizophrenia1PSYGENET
HgenePDE4DC0236733Amphetamine-Related Disorders1CTD_human