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Fusion gene ID: 26413 |
FusionGeneSummary for PDE4D_PLK2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PDE4D_PLK2 | Fusion gene ID: 26413 | Hgene | Tgene | Gene symbol | PDE4D | PLK2 | Gene ID | 5144 | 10769 |
| Gene name | phosphodiesterase 4D | polo like kinase 2 | |
| Synonyms | ACRDYS2|DPDE3|HSPDE4D|PDE43|PDE4DN2|STRK1 | SNK|hPlk2|hSNK | |
| Cytomap | 5q11.2-q12.1 | 5q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cAMP-specific 3',5'-cyclic phosphodiesterase 4DcAMP-specific phosphodiesterase PDE4D6phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)testicular tissue protein Li 136 | serine/threonine-protein kinase PLK2PLK-2serine/threonine-protein kinase SNKserum-inducible kinase | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q08499 | Q9NYY3 | |
| Ensembl transtripts involved in fusion gene | ENST00000340635, ENST00000360047, ENST00000507116, ENST00000502484, ENST00000546160, ENST00000502575, ENST00000358923, ENST00000503258, ENST00000405755, ENST00000317118, ENST00000503947, | ENST00000274289, ENST00000502671, | |
| Fusion gene scores | * DoF score | 23 X 14 X 10=3220 | 1 X 1 X 1=1 |
| # samples | 34 | 1 | |
| ** MAII score | log2(34/3220*10)=-3.24345403686428 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: PDE4D [Title/Abstract] AND PLK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PDE4D | GO:0006198 | cAMP catabolic process | 9371713|17404263 |
| Tgene | PLK2 | GO:0006468 | protein phosphorylation | 20352051 |
| Tgene | PLK2 | GO:0007052 | mitotic spindle organization | 19001868 |
| Tgene | PLK2 | GO:0010508 | positive regulation of autophagy | 23983262 |
| Tgene | PLK2 | GO:0018105 | peptidyl-serine phosphorylation | 23983262 |
| Tgene | PLK2 | GO:0045732 | positive regulation of protein catabolic process | 23983262 |
| Tgene | PLK2 | GO:0046599 | regulation of centriole replication | 19001868|20352051|20531387 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | MESO | TCGA-TS-A7OY-01A | PDE4D | chr5 | 58334686 | - | PLK2 | chr5 | 57754919 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000340635 | ENST00000274289 | PDE4D | chr5 | 58334686 | - | PLK2 | chr5 | 57754919 | - |
| 5CDS-intron | ENST00000340635 | ENST00000502671 | PDE4D | chr5 | 58334686 | - | PLK2 | chr5 | 57754919 | - |
| In-frame | ENST00000360047 | ENST00000274289 | PDE4D | chr5 | 58334686 | - | PLK2 | chr5 | 57754919 | - |
| 5CDS-intron | ENST00000360047 | ENST00000502671 | PDE4D | chr5 | 58334686 | - | PLK2 | chr5 | 57754919 | - |
| In-frame | ENST00000507116 | ENST00000274289 | PDE4D | chr5 | 58334686 | - | PLK2 | chr5 | 57754919 | - |
| 5CDS-intron | ENST00000507116 | ENST00000502671 | PDE4D | chr5 | 58334686 | - | PLK2 | chr5 | 57754919 | - |
| Frame-shift | ENST00000502484 | ENST00000274289 | PDE4D | chr5 | 58334686 | - | PLK2 | chr5 | 57754919 | - |
| 5CDS-intron | ENST00000502484 | ENST00000502671 | PDE4D | chr5 | 58334686 | - | PLK2 | chr5 | 57754919 | - |
| In-frame | ENST00000546160 | ENST00000274289 | PDE4D | chr5 | 58334686 | - | PLK2 | chr5 | 57754919 | - |
| 5CDS-intron | ENST00000546160 | ENST00000502671 | PDE4D | chr5 | 58334686 | - | PLK2 | chr5 | 57754919 | - |
| intron-3CDS | ENST00000502575 | ENST00000274289 | PDE4D | chr5 | 58334686 | - | PLK2 | chr5 | 57754919 | - |
| intron-intron | ENST00000502575 | ENST00000502671 | PDE4D | chr5 | 58334686 | - | PLK2 | chr5 | 57754919 | - |
| Frame-shift | ENST00000358923 | ENST00000274289 | PDE4D | chr5 | 58334686 | - | PLK2 | chr5 | 57754919 | - |
| 5CDS-intron | ENST00000358923 | ENST00000502671 | PDE4D | chr5 | 58334686 | - | PLK2 | chr5 | 57754919 | - |
| In-frame | ENST00000503258 | ENST00000274289 | PDE4D | chr5 | 58334686 | - | PLK2 | chr5 | 57754919 | - |
| 5CDS-intron | ENST00000503258 | ENST00000502671 | PDE4D | chr5 | 58334686 | - | PLK2 | chr5 | 57754919 | - |
| In-frame | ENST00000405755 | ENST00000274289 | PDE4D | chr5 | 58334686 | - | PLK2 | chr5 | 57754919 | - |
| 5CDS-intron | ENST00000405755 | ENST00000502671 | PDE4D | chr5 | 58334686 | - | PLK2 | chr5 | 57754919 | - |
| intron-3CDS | ENST00000317118 | ENST00000274289 | PDE4D | chr5 | 58334686 | - | PLK2 | chr5 | 57754919 | - |
| intron-intron | ENST00000317118 | ENST00000502671 | PDE4D | chr5 | 58334686 | - | PLK2 | chr5 | 57754919 | - |
| intron-3CDS | ENST00000503947 | ENST00000274289 | PDE4D | chr5 | 58334686 | - | PLK2 | chr5 | 57754919 | - |
| intron-intron | ENST00000503947 | ENST00000502671 | PDE4D | chr5 | 58334686 | - | PLK2 | chr5 | 57754919 | - |
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FusionProtFeatures for PDE4D_PLK2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PDE4D | PLK2 |
| Tumor suppressor serine/threonine-protein kinaseinvolved in synaptic plasticity, centriole duplication and G1/Sphase transition. Polo-like kinases act by binding andphosphorylating proteins are that already phosphorylated on aspecific motif recognized by the POLO box domains. PhosphorylatesCENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays akey role in synaptic plasticity and memory by regulating the Rasand Rap protein signaling: required for overactivity-dependentspine remodeling by phosphorylating the Ras activator RASGRF1 andthe Rap inhibitor SIPA1L1 leading to their degradation by theproteasome. Conversely, phosphorylates the Rap activator RAPGEF2and the Ras inhibitor SYNGAP1, promoting their activity. Alsoregulates synaptic plasticity independently of kinase activity,via its interaction with NSF that disrupts the interaction betweenNSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown ofAMPAR-mediated current that occludes long term depression.Required for procentriole formation and centriole duplication byphosphorylating CENPJ and NPM1, respectively. Its induction byp53/TP53 suggests that it may participate in the mitoticcheckpoint following stress. {ECO:0000269|PubMed:15242618,ECO:0000269|PubMed:19001868, ECO:0000269|PubMed:20352051,ECO:0000269|PubMed:20531387}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PDE4D | chr5:58334686 | chr5:57754919 | ENST00000340635 | - | 6 | 15 | 42_88 | 307 | 810 | Compositional bias | Note=Pro-rich |
| Hgene | PDE4D | chr5:58334686 | chr5:57754919 | ENST00000360047 | - | 6 | 15 | 42_88 | 171 | 674 | Compositional bias | Note=Pro-rich |
| Hgene | PDE4D | chr5:58334686 | chr5:57754919 | ENST00000405755 | - | 6 | 15 | 42_88 | 185 | 688 | Compositional bias | Note=Pro-rich |
| Hgene | PDE4D | chr5:58334686 | chr5:57754919 | ENST00000502484 | - | 8 | 17 | 42_88 | 246 | 749 | Compositional bias | Note=Pro-rich |
| Hgene | PDE4D | chr5:58334686 | chr5:57754919 | ENST00000503258 | - | 6 | 15 | 42_88 | 177 | 680 | Compositional bias | Note=Pro-rich |
| Hgene | PDE4D | chr5:58334686 | chr5:57754919 | ENST00000507116 | - | 6 | 15 | 42_88 | 243 | 746 | Compositional bias | Note=Pro-rich |
| Hgene | PDE4D | chr5:58334686 | chr5:57754919 | ENST00000546160 | - | 7 | 16 | 42_88 | 246 | 749 | Compositional bias | Note=Pro-rich |
| Tgene | >PLK2 | chr5:58334686 | chr5:57754919 | ENST00000274289 | - | 0 | 14 | 510_573 | 90 | 686 | Domain | POLO box 1 |
| Tgene | >PLK2 | chr5:58334686 | chr5:57754919 | ENST00000274289 | - | 0 | 14 | 606_677 | 90 | 686 | Domain | POLO box 2 |
| Tgene | >PLK2 | chr5:58334686 | chr5:57754919 | ENST00000274289 | - | 0 | 14 | 88_96 | 90 | 686 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PDE4D | chr5:58334686 | chr5:57754919 | ENST00000317118 | - | 1 | 10 | 42_88 | -132 | 519 | Compositional bias | Note=Pro-rich |
| Hgene | >PDE4D | chr5:58334686 | chr5:57754919 | ENST00000358923 | - | 2 | 11 | 42_88 | 5 | 508 | Compositional bias | Note=Pro-rich |
| Hgene | >PDE4D | chr5:58334686 | chr5:57754919 | ENST00000502575 | - | 1 | 6 | 42_88 | -43 | 220 | Compositional bias | Note=Pro-rich |
| Hgene | >PDE4D | chr5:58334686 | chr5:57754919 | ENST00000317118 | - | 1 | 10 | 386_715 | -132 | 519 | Domain | PDEase |
| Hgene | >PDE4D | chr5:58334686 | chr5:57754919 | ENST00000340635 | - | 6 | 15 | 386_715 | 307 | 810 | Domain | PDEase |
| Hgene | >PDE4D | chr5:58334686 | chr5:57754919 | ENST00000358923 | - | 2 | 11 | 386_715 | 5 | 508 | Domain | PDEase |
| Hgene | >PDE4D | chr5:58334686 | chr5:57754919 | ENST00000360047 | - | 6 | 15 | 386_715 | 171 | 674 | Domain | PDEase |
| Hgene | >PDE4D | chr5:58334686 | chr5:57754919 | ENST00000405755 | - | 6 | 15 | 386_715 | 185 | 688 | Domain | PDEase |
| Hgene | >PDE4D | chr5:58334686 | chr5:57754919 | ENST00000502484 | - | 8 | 17 | 386_715 | 246 | 749 | Domain | PDEase |
| Hgene | >PDE4D | chr5:58334686 | chr5:57754919 | ENST00000502575 | - | 1 | 6 | 386_715 | -43 | 220 | Domain | PDEase |
| Hgene | >PDE4D | chr5:58334686 | chr5:57754919 | ENST00000503258 | - | 6 | 15 | 386_715 | 177 | 680 | Domain | PDEase |
| Hgene | >PDE4D | chr5:58334686 | chr5:57754919 | ENST00000507116 | - | 6 | 15 | 386_715 | 243 | 746 | Domain | PDEase |
| Hgene | >PDE4D | chr5:58334686 | chr5:57754919 | ENST00000546160 | - | 7 | 16 | 386_715 | 246 | 749 | Domain | PDEase |
| Hgene | >PDE4D | chr5:58334686 | chr5:57754919 | ENST00000317118 | - | 1 | 10 | 462_466 | -132 | 519 | Nucleotide binding | cAMP |
| Hgene | >PDE4D | chr5:58334686 | chr5:57754919 | ENST00000340635 | - | 6 | 15 | 462_466 | 307 | 810 | Nucleotide binding | cAMP |
| Hgene | >PDE4D | chr5:58334686 | chr5:57754919 | ENST00000358923 | - | 2 | 11 | 462_466 | 5 | 508 | Nucleotide binding | cAMP |
| Hgene | >PDE4D | chr5:58334686 | chr5:57754919 | ENST00000360047 | - | 6 | 15 | 462_466 | 171 | 674 | Nucleotide binding | cAMP |
| Hgene | >PDE4D | chr5:58334686 | chr5:57754919 | ENST00000405755 | - | 6 | 15 | 462_466 | 185 | 688 | Nucleotide binding | cAMP |
| Hgene | >PDE4D | chr5:58334686 | chr5:57754919 | ENST00000502484 | - | 8 | 17 | 462_466 | 246 | 749 | Nucleotide binding | cAMP |
| Hgene | >PDE4D | chr5:58334686 | chr5:57754919 | ENST00000502575 | - | 1 | 6 | 462_466 | -43 | 220 | Nucleotide binding | cAMP |
| Hgene | >PDE4D | chr5:58334686 | chr5:57754919 | ENST00000503258 | - | 6 | 15 | 462_466 | 177 | 680 | Nucleotide binding | cAMP |
| Hgene | >PDE4D | chr5:58334686 | chr5:57754919 | ENST00000507116 | - | 6 | 15 | 462_466 | 243 | 746 | Nucleotide binding | cAMP |
| Hgene | >PDE4D | chr5:58334686 | chr5:57754919 | ENST00000546160 | - | 7 | 16 | 462_466 | 246 | 749 | Nucleotide binding | cAMP |
| Tgene | PLK2 | chr5:58334686 | chr5:57754919 | ENST00000274289 | - | 0 | 14 | 57_64 | 90 | 686 | Compositional bias | Note=Poly-His |
| Tgene | PLK2 | chr5:58334686 | chr5:57754919 | ENST00000274289 | - | 0 | 14 | 82_334 | 90 | 686 | Domain | Protein kinase |
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FusionGeneSequence for PDE4D_PLK2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PDE4D_ENST00000340635_chr5_58334686_-_PLK2_ENST00000274289_chr5_57754919_-_903aa MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPPPPPSPQPQPQCPLQPPPPPPLPPPPPPPGA ARGRYASSGATGRVRHRGYSDTERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQA NFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITE EAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVV QFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPL EHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRP SLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKTSITQQPSK HRTDEELQPPTTTVARSGTPAVENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTSFQW VTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVT DIRRPRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICSQNEEYLLTYINEDRISTTFRLTTLLMSGCSSELKNRMEYALNMLLQR >In-frame_PDE4D_ENST00000360047_chr5_58334686_-_PLK2_ENST00000274289_chr5_57754919_-_767aa MMHVNNFPFRRHSWICFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPF AQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKGGFAKCYEM TDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQI VSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPP FETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPAKNFFKKAAA ALFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEELQPPTTTVARSGTPAVENKQQIGDAIRMIVRGTLGSCSSS SECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAE LGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICSQNE >In-frame_PDE4D_ENST00000507116_chr5_58334686_-_PLK2_ENST00000274289_chr5_57754919_-_839aa MAQQTSPDTLTVPEVDNPHCPNPWLNEDLVKSLRENLLQHEKSKTARKSVSPKLSPVISPRNSPRLLRRMLLSSNIPKQRRFTVAHTCFD VDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALT NLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKGGFAKCYEMTDLTNNKVYAAKIIPHSR VAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLK LGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARY TMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYIDTHNR VSKEDEDIYKLRHDLKKTSITQQPSKHRTDEELQPPTTTVARSGTPAVENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVAR VLRGCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFIS QVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICSQNEEYLLTYINEDRISTTFRL >In-frame_PDE4D_ENST00000546160_chr5_58334686_-_PLK2_ENST00000274289_chr5_57754919_-_842aa MKRNTCDLLSRSKSASEETLHSSNEEEDPFRGMEPYLVRRLSCRNIQLPPLAFRQLEQADLKSESENIQRPTSLPLKILPLIAITSAESS GFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFA ALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKGGFAKCYEMTDLTNNKVYAAKIIP HSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHR DLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIRE ARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYIDT HNRVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEELQPPTTTVARSGTPAVENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADT VARVLRGCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQ FISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICSQNEEYLLTYINEDRISTT >In-frame_PDE4D_ENST00000503258_chr5_58334686_-_PLK2_ENST00000274289_chr5_57754919_-_773aa MSIIMKPRSRSTSSLRTAEAVCFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDD LIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKGGF AKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVR YYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTM LLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPAKNF FKKAAAALFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEELQPPTTTVARSGTPAVENKQQIGDAIRMIVRGTL GSCSSSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKT VHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKII >In-frame_PDE4D_ENST00000405755_chr5_58334686_-_PLK2_ENST00000274289_chr5_57754919_-_781aa MAFVWDPLGATVPGPSTRAKSRLRFSKSYSFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSI ASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSE MASNKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARK VLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWA LGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFH LSSPAKNFFKKAAAALFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEELQPPTTTVARSGTPAVENKQQIGDAI RMIVRGTLGSCSSSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHM SLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRLYLLQWLKSDKALMMLFNDGTFQVNF |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PDE4D_ENST00000340635_chr5_58334686_-_PLK2_ENST00000274289_chr5_57754919_-_2709nt ATGGAGGCAGAGGGCAGCAGCGCGCCGGCCCGGGCGGGCAGCGGAGAGGGCAGCGACAGCGCCGGCGGGGCCACGCTCAAAGCCCCCAAG CATCTCTGGAGGCACGAGCAGCACCACCAGTACCCGCTCCGGCAGCCCCAGTTCCGCCTCCTGCATCCCCATCACCACCTGCCCCCGCCG CCGCCACCCTCGCCCCAGCCCCAGCCCCAGTGTCCGCTACAGCCGCCGCCGCCGCCCCCCCTGCCGCCGCCCCCGCCGCCGCCCGGGGCT GCCCGCGGCCGCTACGCCTCGAGCGGGGCCACCGGCCGCGTCCGGCATCGCGGCTACTCGGACACCGAGCGCTACCTGTACTGTCGCGCC ATGGACCGCACCTCCTACGCGGTGGAGACCGGCCACCGGCCCGGCCTGAAGAAATCCAGGATGTCCTGGCCCTCCTCGTTCCAGGGACTC AGGCGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCA AATTTTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCC TCCATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTT GCTGCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGAG GAGGCCTACCAGAAACTGGCCAGCGAGACCCTGGAGGAGCTGGACTGGTGTCTGGACCAGCTAGAGACCCTACAGACCAGGCACTCCGTC AGTGAGATGGCCTCCAACAAGGGTGGCTTTGCAAAATGTTACGAGATGACAGATTTGACAAATAACAAAGTCTACGCCGCAAAAATTATT CCTCACAGCAGAGTAGCTAAACCTCATCAAAGGGAAAAGATTGACAAAGAAATAGAGCTTCACAGAATTCTTCATCATAAGCATGTAGTG CAGTTTTACCACTACTTCGAGGACAAAGAAAACATTTACATTCTCTTGGAATACTGCAGTAGAAGGTCAATGGCTCATATTTTGAAAGCA AGAAAGGTGTTGACAGAGCCAGAAGTTCGATACTACCTCAGGCAGATTGTGTCTGGACTGAAATACCTTCATGAACAAGAAATCTTGCAC AGAGATCTCAAACTAGGGAACTTTTTTATTAATGAAGCCATGGAACTAAAAGTTGGGGACTTCGGTCTGGCAGCCAGGCTAGAACCCTTG GAACACAGAAGGAGAACGATATGTGGTACCCCAAATTATCTCTCTCCTGAAGTCCTCAACAAACAAGGACATGGCTGTGAATCAGACATT TGGGCCCTGGGCTGTGTAATGTATACAATGTTACTAGGGAGGCCCCCATTTGAAACTACAAATCTCAAAGAAACTTATAGGTGCATAAGG GAAGCAAGGTATACAATGCCGTCCTCATTGCTGGCTCCTGCCAAGCACTTAATTGCTAGTATGTTGTCCAAAAACCCAGAGGATCGTCCC AGTTTGGATGACATCATTCGACATGACTTTTTTTTGCAGGGCTTCACTCCGGACAGACTGTCTTCTAGCTGTTGTCATACAGTTCCAGAT TTCCACTTATCAAGCCCAGCTAAGAATTTCTTTAAGAAAGCAGCTGCTGCTCTTTTTGGTGGCAAAAAAGACAAAGCAAGATATATTGAC ACACATAATAGAGTGTCTAAAGAAGATGAAGACATCTACAAGCTTAGGCATGATTTGAAAAAGACTTCAATAACTCAGCAACCCAGCAAA CACAGGACAGATGAGGAGCTCCAGCCACCTACCACCACAGTTGCCAGGTCTGGAACACCCGCAGTAGAAAACAAGCAGCAGATTGGGGAT GCTATTCGGATGATAGTCAGAGGGACTCTTGGCAGCTGTAGCAGCAGCAGTGAATGCCTTGAAGACAGTACCATGGGAAGTGTTGCAGAC ACAGTGGCAAGGGTTCTTCGGGGATGTCTGGAAAACATGCCGGAAGCTGATTGCATTCCCAAAGAGCAGCTGAGCACATCATTTCAGTGG GTCACCAAATGGGTTGATTACTCTAACAAATATGGCTTTGGGTACCAGCTCTCAGACCACACCGTCGGTGTCCTTTTCAACAATGGTGCT CACATGAGCCTCCTTCCAGACAAAAAAACAGTTCACTATTACGCAGAGCTTGGCCAATGCTCAGTTTTCCCAGCAACAGATGCTCCTGAG CAATTTATTAGTCAAGTGACGGTGCTGAAATACTTTTCTCATTACATGGAGGAGAACCTCATGGATGGTGGAGATCTGCCTAGTGTTACT GATATTCGAAGACCTCGGCTCTACCTCCTTCAGTGGCTAAAATCTGATAAGGCCCTAATGATGCTCTTTAATGATGGCACCTTTCAGGTG AATTTCTACCATGATCATACAAAAATCATCATCTGTAGCCAAAATGAAGAATACCTTCTCACCTACATCAATGAGGATAGGATATCTACA ACTTTCAGGCTGACAACTCTGCTGATGTCTGGCTGTTCATCAGAATTAAAAAATCGAATGGAATATGCCCTGAACATGCTCTTACAAAGA >In-frame_PDE4D_ENST00000360047_chr5_58334686_-_PLK2_ENST00000274289_chr5_57754919_-_2301nt ATGATGCACGTGAATAATTTTCCCTTTAGAAGGCATTCCTGGATATGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTG GATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGAC AGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTT GCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCC ATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGAGGAGGCCTACCAGAAACTGGCCAGCGAGACCCTGGAGGAGCTGGACTGG TGTCTGGACCAGCTAGAGACCCTACAGACCAGGCACTCCGTCAGTGAGATGGCCTCCAACAAGGGTGGCTTTGCAAAATGTTACGAGATG ACAGATTTGACAAATAACAAAGTCTACGCCGCAAAAATTATTCCTCACAGCAGAGTAGCTAAACCTCATCAAAGGGAAAAGATTGACAAA GAAATAGAGCTTCACAGAATTCTTCATCATAAGCATGTAGTGCAGTTTTACCACTACTTCGAGGACAAAGAAAACATTTACATTCTCTTG GAATACTGCAGTAGAAGGTCAATGGCTCATATTTTGAAAGCAAGAAAGGTGTTGACAGAGCCAGAAGTTCGATACTACCTCAGGCAGATT GTGTCTGGACTGAAATACCTTCATGAACAAGAAATCTTGCACAGAGATCTCAAACTAGGGAACTTTTTTATTAATGAAGCCATGGAACTA AAAGTTGGGGACTTCGGTCTGGCAGCCAGGCTAGAACCCTTGGAACACAGAAGGAGAACGATATGTGGTACCCCAAATTATCTCTCTCCT GAAGTCCTCAACAAACAAGGACATGGCTGTGAATCAGACATTTGGGCCCTGGGCTGTGTAATGTATACAATGTTACTAGGGAGGCCCCCA TTTGAAACTACAAATCTCAAAGAAACTTATAGGTGCATAAGGGAAGCAAGGTATACAATGCCGTCCTCATTGCTGGCTCCTGCCAAGCAC TTAATTGCTAGTATGTTGTCCAAAAACCCAGAGGATCGTCCCAGTTTGGATGACATCATTCGACATGACTTTTTTTTGCAGGGCTTCACT CCGGACAGACTGTCTTCTAGCTGTTGTCATACAGTTCCAGATTTCCACTTATCAAGCCCAGCTAAGAATTTCTTTAAGAAAGCAGCTGCT GCTCTTTTTGGTGGCAAAAAAGACAAAGCAAGATATATTGACACACATAATAGAGTGTCTAAAGAAGATGAAGACATCTACAAGCTTAGG CATGATTTGAAAAAGACTTCAATAACTCAGCAACCCAGCAAACACAGGACAGATGAGGAGCTCCAGCCACCTACCACCACAGTTGCCAGG TCTGGAACACCCGCAGTAGAAAACAAGCAGCAGATTGGGGATGCTATTCGGATGATAGTCAGAGGGACTCTTGGCAGCTGTAGCAGCAGC AGTGAATGCCTTGAAGACAGTACCATGGGAAGTGTTGCAGACACAGTGGCAAGGGTTCTTCGGGGATGTCTGGAAAACATGCCGGAAGCT GATTGCATTCCCAAAGAGCAGCTGAGCACATCATTTCAGTGGGTCACCAAATGGGTTGATTACTCTAACAAATATGGCTTTGGGTACCAG CTCTCAGACCACACCGTCGGTGTCCTTTTCAACAATGGTGCTCACATGAGCCTCCTTCCAGACAAAAAAACAGTTCACTATTACGCAGAG CTTGGCCAATGCTCAGTTTTCCCAGCAACAGATGCTCCTGAGCAATTTATTAGTCAAGTGACGGTGCTGAAATACTTTTCTCATTACATG GAGGAGAACCTCATGGATGGTGGAGATCTGCCTAGTGTTACTGATATTCGAAGACCTCGGCTCTACCTCCTTCAGTGGCTAAAATCTGAT AAGGCCCTAATGATGCTCTTTAATGATGGCACCTTTCAGGTGAATTTCTACCATGATCATACAAAAATCATCATCTGTAGCCAAAATGAA GAATACCTTCTCACCTACATCAATGAGGATAGGATATCTACAACTTTCAGGCTGACAACTCTGCTGATGTCTGGCTGTTCATCAGAATTA >In-frame_PDE4D_ENST00000507116_chr5_58334686_-_PLK2_ENST00000274289_chr5_57754919_-_2517nt ATGGCTCAGCAGACAAGCCCGGACACTTTAACAGTACCTGAAGTGGATAATCCGCATTGTCCAAACCCGTGGCTGAACGAAGACCTTGTG AAATCCTTGCGAGAAAACCTGTTGCAGCATGAGAAGTCCAAGACAGCGAGGAAATCGGTTTCTCCCAAGCTCTCTCCAGTGATCTCTCCG AGAAATTCCCCCAGGCTTCTGCGCAGAATGCTTCTCAGCAGCAACATCCCCAAACAGCGGCGTTTCACGGTGGCACATACATGTTTTGAT GTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCCAC AGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGT GATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCATTAACT AATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGAGGAGGCCTACCAG AAACTGGCCAGCGAGACCCTGGAGGAGCTGGACTGGTGTCTGGACCAGCTAGAGACCCTACAGACCAGGCACTCCGTCAGTGAGATGGCC TCCAACAAGGGTGGCTTTGCAAAATGTTACGAGATGACAGATTTGACAAATAACAAAGTCTACGCCGCAAAAATTATTCCTCACAGCAGA GTAGCTAAACCTCATCAAAGGGAAAAGATTGACAAAGAAATAGAGCTTCACAGAATTCTTCATCATAAGCATGTAGTGCAGTTTTACCAC TACTTCGAGGACAAAGAAAACATTTACATTCTCTTGGAATACTGCAGTAGAAGGTCAATGGCTCATATTTTGAAAGCAAGAAAGGTGTTG ACAGAGCCAGAAGTTCGATACTACCTCAGGCAGATTGTGTCTGGACTGAAATACCTTCATGAACAAGAAATCTTGCACAGAGATCTCAAA CTAGGGAACTTTTTTATTAATGAAGCCATGGAACTAAAAGTTGGGGACTTCGGTCTGGCAGCCAGGCTAGAACCCTTGGAACACAGAAGG AGAACGATATGTGGTACCCCAAATTATCTCTCTCCTGAAGTCCTCAACAAACAAGGACATGGCTGTGAATCAGACATTTGGGCCCTGGGC TGTGTAATGTATACAATGTTACTAGGGAGGCCCCCATTTGAAACTACAAATCTCAAAGAAACTTATAGGTGCATAAGGGAAGCAAGGTAT ACAATGCCGTCCTCATTGCTGGCTCCTGCCAAGCACTTAATTGCTAGTATGTTGTCCAAAAACCCAGAGGATCGTCCCAGTTTGGATGAC ATCATTCGACATGACTTTTTTTTGCAGGGCTTCACTCCGGACAGACTGTCTTCTAGCTGTTGTCATACAGTTCCAGATTTCCACTTATCA AGCCCAGCTAAGAATTTCTTTAAGAAAGCAGCTGCTGCTCTTTTTGGTGGCAAAAAAGACAAAGCAAGATATATTGACACACATAATAGA GTGTCTAAAGAAGATGAAGACATCTACAAGCTTAGGCATGATTTGAAAAAGACTTCAATAACTCAGCAACCCAGCAAACACAGGACAGAT GAGGAGCTCCAGCCACCTACCACCACAGTTGCCAGGTCTGGAACACCCGCAGTAGAAAACAAGCAGCAGATTGGGGATGCTATTCGGATG ATAGTCAGAGGGACTCTTGGCAGCTGTAGCAGCAGCAGTGAATGCCTTGAAGACAGTACCATGGGAAGTGTTGCAGACACAGTGGCAAGG GTTCTTCGGGGATGTCTGGAAAACATGCCGGAAGCTGATTGCATTCCCAAAGAGCAGCTGAGCACATCATTTCAGTGGGTCACCAAATGG GTTGATTACTCTAACAAATATGGCTTTGGGTACCAGCTCTCAGACCACACCGTCGGTGTCCTTTTCAACAATGGTGCTCACATGAGCCTC CTTCCAGACAAAAAAACAGTTCACTATTACGCAGAGCTTGGCCAATGCTCAGTTTTCCCAGCAACAGATGCTCCTGAGCAATTTATTAGT CAAGTGACGGTGCTGAAATACTTTTCTCATTACATGGAGGAGAACCTCATGGATGGTGGAGATCTGCCTAGTGTTACTGATATTCGAAGA CCTCGGCTCTACCTCCTTCAGTGGCTAAAATCTGATAAGGCCCTAATGATGCTCTTTAATGATGGCACCTTTCAGGTGAATTTCTACCAT GATCATACAAAAATCATCATCTGTAGCCAAAATGAAGAATACCTTCTCACCTACATCAATGAGGATAGGATATCTACAACTTTCAGGCTG >In-frame_PDE4D_ENST00000546160_chr5_58334686_-_PLK2_ENST00000274289_chr5_57754919_-_2526nt ATGAAAAGAAATACCTGTGATTTGCTTTCTCGGAGCAAAAGTGCCTCTGAGGAAACACTACATTCCAGTAATGAAGAGGAAGACCCTTTC CGCGGAATGGAACCCTATCTTGTCCGGAGACTTTCATGTCGCAATATTCAGCTTCCCCCTCTCGCCTTCAGACAGTTGGAACAAGCTGAC TTGAAAAGTGAATCAGAGAACATTCAACGACCAACCAGCCTCCCCCTGAAGATTCTGCCGCTGATTGCTATCACTTCTGCAGAATCCAGT GGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAAT TTTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCC ATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCT GCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGAGGAG GCCTACCAGAAACTGGCCAGCGAGACCCTGGAGGAGCTGGACTGGTGTCTGGACCAGCTAGAGACCCTACAGACCAGGCACTCCGTCAGT GAGATGGCCTCCAACAAGGGTGGCTTTGCAAAATGTTACGAGATGACAGATTTGACAAATAACAAAGTCTACGCCGCAAAAATTATTCCT CACAGCAGAGTAGCTAAACCTCATCAAAGGGAAAAGATTGACAAAGAAATAGAGCTTCACAGAATTCTTCATCATAAGCATGTAGTGCAG TTTTACCACTACTTCGAGGACAAAGAAAACATTTACATTCTCTTGGAATACTGCAGTAGAAGGTCAATGGCTCATATTTTGAAAGCAAGA AAGGTGTTGACAGAGCCAGAAGTTCGATACTACCTCAGGCAGATTGTGTCTGGACTGAAATACCTTCATGAACAAGAAATCTTGCACAGA GATCTCAAACTAGGGAACTTTTTTATTAATGAAGCCATGGAACTAAAAGTTGGGGACTTCGGTCTGGCAGCCAGGCTAGAACCCTTGGAA CACAGAAGGAGAACGATATGTGGTACCCCAAATTATCTCTCTCCTGAAGTCCTCAACAAACAAGGACATGGCTGTGAATCAGACATTTGG GCCCTGGGCTGTGTAATGTATACAATGTTACTAGGGAGGCCCCCATTTGAAACTACAAATCTCAAAGAAACTTATAGGTGCATAAGGGAA GCAAGGTATACAATGCCGTCCTCATTGCTGGCTCCTGCCAAGCACTTAATTGCTAGTATGTTGTCCAAAAACCCAGAGGATCGTCCCAGT TTGGATGACATCATTCGACATGACTTTTTTTTGCAGGGCTTCACTCCGGACAGACTGTCTTCTAGCTGTTGTCATACAGTTCCAGATTTC CACTTATCAAGCCCAGCTAAGAATTTCTTTAAGAAAGCAGCTGCTGCTCTTTTTGGTGGCAAAAAAGACAAAGCAAGATATATTGACACA CATAATAGAGTGTCTAAAGAAGATGAAGACATCTACAAGCTTAGGCATGATTTGAAAAAGACTTCAATAACTCAGCAACCCAGCAAACAC AGGACAGATGAGGAGCTCCAGCCACCTACCACCACAGTTGCCAGGTCTGGAACACCCGCAGTAGAAAACAAGCAGCAGATTGGGGATGCT ATTCGGATGATAGTCAGAGGGACTCTTGGCAGCTGTAGCAGCAGCAGTGAATGCCTTGAAGACAGTACCATGGGAAGTGTTGCAGACACA GTGGCAAGGGTTCTTCGGGGATGTCTGGAAAACATGCCGGAAGCTGATTGCATTCCCAAAGAGCAGCTGAGCACATCATTTCAGTGGGTC ACCAAATGGGTTGATTACTCTAACAAATATGGCTTTGGGTACCAGCTCTCAGACCACACCGTCGGTGTCCTTTTCAACAATGGTGCTCAC ATGAGCCTCCTTCCAGACAAAAAAACAGTTCACTATTACGCAGAGCTTGGCCAATGCTCAGTTTTCCCAGCAACAGATGCTCCTGAGCAA TTTATTAGTCAAGTGACGGTGCTGAAATACTTTTCTCATTACATGGAGGAGAACCTCATGGATGGTGGAGATCTGCCTAGTGTTACTGAT ATTCGAAGACCTCGGCTCTACCTCCTTCAGTGGCTAAAATCTGATAAGGCCCTAATGATGCTCTTTAATGATGGCACCTTTCAGGTGAAT TTCTACCATGATCATACAAAAATCATCATCTGTAGCCAAAATGAAGAATACCTTCTCACCTACATCAATGAGGATAGGATATCTACAACT TTCAGGCTGACAACTCTGCTGATGTCTGGCTGTTCATCAGAATTAAAAAATCGAATGGAATATGCCCTGAACATGCTCTTACAAAGATGT >In-frame_PDE4D_ENST00000503258_chr5_58334686_-_PLK2_ENST00000274289_chr5_57754919_-_2319nt ATGAGCATTATTATGAAGCCAAGATCCCGATCTACAAGTTCCCTAAGGACTGCAGAGGCAGTTTGTTTTGATGTGGACAATGGCACATCT GCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCCACAGTCAACGACGGGAGTCC TTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGAC TTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCA CCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGAGGAGGCCTACCAGAAACTGGCCAGCGAGACC CTGGAGGAGCTGGACTGGTGTCTGGACCAGCTAGAGACCCTACAGACCAGGCACTCCGTCAGTGAGATGGCCTCCAACAAGGGTGGCTTT GCAAAATGTTACGAGATGACAGATTTGACAAATAACAAAGTCTACGCCGCAAAAATTATTCCTCACAGCAGAGTAGCTAAACCTCATCAA AGGGAAAAGATTGACAAAGAAATAGAGCTTCACAGAATTCTTCATCATAAGCATGTAGTGCAGTTTTACCACTACTTCGAGGACAAAGAA AACATTTACATTCTCTTGGAATACTGCAGTAGAAGGTCAATGGCTCATATTTTGAAAGCAAGAAAGGTGTTGACAGAGCCAGAAGTTCGA TACTACCTCAGGCAGATTGTGTCTGGACTGAAATACCTTCATGAACAAGAAATCTTGCACAGAGATCTCAAACTAGGGAACTTTTTTATT AATGAAGCCATGGAACTAAAAGTTGGGGACTTCGGTCTGGCAGCCAGGCTAGAACCCTTGGAACACAGAAGGAGAACGATATGTGGTACC CCAAATTATCTCTCTCCTGAAGTCCTCAACAAACAAGGACATGGCTGTGAATCAGACATTTGGGCCCTGGGCTGTGTAATGTATACAATG TTACTAGGGAGGCCCCCATTTGAAACTACAAATCTCAAAGAAACTTATAGGTGCATAAGGGAAGCAAGGTATACAATGCCGTCCTCATTG CTGGCTCCTGCCAAGCACTTAATTGCTAGTATGTTGTCCAAAAACCCAGAGGATCGTCCCAGTTTGGATGACATCATTCGACATGACTTT TTTTTGCAGGGCTTCACTCCGGACAGACTGTCTTCTAGCTGTTGTCATACAGTTCCAGATTTCCACTTATCAAGCCCAGCTAAGAATTTC TTTAAGAAAGCAGCTGCTGCTCTTTTTGGTGGCAAAAAAGACAAAGCAAGATATATTGACACACATAATAGAGTGTCTAAAGAAGATGAA GACATCTACAAGCTTAGGCATGATTTGAAAAAGACTTCAATAACTCAGCAACCCAGCAAACACAGGACAGATGAGGAGCTCCAGCCACCT ACCACCACAGTTGCCAGGTCTGGAACACCCGCAGTAGAAAACAAGCAGCAGATTGGGGATGCTATTCGGATGATAGTCAGAGGGACTCTT GGCAGCTGTAGCAGCAGCAGTGAATGCCTTGAAGACAGTACCATGGGAAGTGTTGCAGACACAGTGGCAAGGGTTCTTCGGGGATGTCTG GAAAACATGCCGGAAGCTGATTGCATTCCCAAAGAGCAGCTGAGCACATCATTTCAGTGGGTCACCAAATGGGTTGATTACTCTAACAAA TATGGCTTTGGGTACCAGCTCTCAGACCACACCGTCGGTGTCCTTTTCAACAATGGTGCTCACATGAGCCTCCTTCCAGACAAAAAAACA GTTCACTATTACGCAGAGCTTGGCCAATGCTCAGTTTTCCCAGCAACAGATGCTCCTGAGCAATTTATTAGTCAAGTGACGGTGCTGAAA TACTTTTCTCATTACATGGAGGAGAACCTCATGGATGGTGGAGATCTGCCTAGTGTTACTGATATTCGAAGACCTCGGCTCTACCTCCTT CAGTGGCTAAAATCTGATAAGGCCCTAATGATGCTCTTTAATGATGGCACCTTTCAGGTGAATTTCTACCATGATCATACAAAAATCATC ATCTGTAGCCAAAATGAAGAATACCTTCTCACCTACATCAATGAGGATAGGATATCTACAACTTTCAGGCTGACAACTCTGCTGATGTCT >In-frame_PDE4D_ENST00000405755_chr5_58334686_-_PLK2_ENST00000274289_chr5_57754919_-_2343nt ATGGCTTTTGTTTGGGATCCTCTGGGAGCCACGGTGCCAGGACCATCTACAAGAGCCAAATCAAGATTGCGTTTCTCAAAGTCCTACAGT TTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTT GTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATT GCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCA TTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGAGGAGGCC TACCAGAAACTGGCCAGCGAGACCCTGGAGGAGCTGGACTGGTGTCTGGACCAGCTAGAGACCCTACAGACCAGGCACTCCGTCAGTGAG ATGGCCTCCAACAAGGGTGGCTTTGCAAAATGTTACGAGATGACAGATTTGACAAATAACAAAGTCTACGCCGCAAAAATTATTCCTCAC AGCAGAGTAGCTAAACCTCATCAAAGGGAAAAGATTGACAAAGAAATAGAGCTTCACAGAATTCTTCATCATAAGCATGTAGTGCAGTTT TACCACTACTTCGAGGACAAAGAAAACATTTACATTCTCTTGGAATACTGCAGTAGAAGGTCAATGGCTCATATTTTGAAAGCAAGAAAG GTGTTGACAGAGCCAGAAGTTCGATACTACCTCAGGCAGATTGTGTCTGGACTGAAATACCTTCATGAACAAGAAATCTTGCACAGAGAT CTCAAACTAGGGAACTTTTTTATTAATGAAGCCATGGAACTAAAAGTTGGGGACTTCGGTCTGGCAGCCAGGCTAGAACCCTTGGAACAC AGAAGGAGAACGATATGTGGTACCCCAAATTATCTCTCTCCTGAAGTCCTCAACAAACAAGGACATGGCTGTGAATCAGACATTTGGGCC CTGGGCTGTGTAATGTATACAATGTTACTAGGGAGGCCCCCATTTGAAACTACAAATCTCAAAGAAACTTATAGGTGCATAAGGGAAGCA AGGTATACAATGCCGTCCTCATTGCTGGCTCCTGCCAAGCACTTAATTGCTAGTATGTTGTCCAAAAACCCAGAGGATCGTCCCAGTTTG GATGACATCATTCGACATGACTTTTTTTTGCAGGGCTTCACTCCGGACAGACTGTCTTCTAGCTGTTGTCATACAGTTCCAGATTTCCAC TTATCAAGCCCAGCTAAGAATTTCTTTAAGAAAGCAGCTGCTGCTCTTTTTGGTGGCAAAAAAGACAAAGCAAGATATATTGACACACAT AATAGAGTGTCTAAAGAAGATGAAGACATCTACAAGCTTAGGCATGATTTGAAAAAGACTTCAATAACTCAGCAACCCAGCAAACACAGG ACAGATGAGGAGCTCCAGCCACCTACCACCACAGTTGCCAGGTCTGGAACACCCGCAGTAGAAAACAAGCAGCAGATTGGGGATGCTATT CGGATGATAGTCAGAGGGACTCTTGGCAGCTGTAGCAGCAGCAGTGAATGCCTTGAAGACAGTACCATGGGAAGTGTTGCAGACACAGTG GCAAGGGTTCTTCGGGGATGTCTGGAAAACATGCCGGAAGCTGATTGCATTCCCAAAGAGCAGCTGAGCACATCATTTCAGTGGGTCACC AAATGGGTTGATTACTCTAACAAATATGGCTTTGGGTACCAGCTCTCAGACCACACCGTCGGTGTCCTTTTCAACAATGGTGCTCACATG AGCCTCCTTCCAGACAAAAAAACAGTTCACTATTACGCAGAGCTTGGCCAATGCTCAGTTTTCCCAGCAACAGATGCTCCTGAGCAATTT ATTAGTCAAGTGACGGTGCTGAAATACTTTTCTCATTACATGGAGGAGAACCTCATGGATGGTGGAGATCTGCCTAGTGTTACTGATATT CGAAGACCTCGGCTCTACCTCCTTCAGTGGCTAAAATCTGATAAGGCCCTAATGATGCTCTTTAATGATGGCACCTTTCAGGTGAATTTC TACCATGATCATACAAAAATCATCATCTGTAGCCAAAATGAAGAATACCTTCTCACCTACATCAATGAGGATAGGATATCTACAACTTTC AGGCTGACAACTCTGCTGATGTCTGGCTGTTCATCAGAATTAAAAAATCGAATGGAATATGCCCTGAACATGCTCTTACAAAGATGTAAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PDE4D_ENST00000340635_chr5_58334686_-_PLK2_ENST00000274289_chr5_57754919_-_3486nt GGGCCCCCTCTCGGTAGCCCTGAGGCTCTGGCGCCTTCAAGTGAGAAGCTAAGCACCAGCCTCTGCTGGGCTGCAGAAGCGGCGGCGGCG GCAGCAGCAGCAGCAGCATCAGGAAGGCGCTCGGGCCAGCGCGGTGAACCCGGGCTGGGCAGCAGGTCGCGGAGCCGCGAGCCAGGATGG AGGCAGAGGGCAGCAGCGCGCCGGCCCGGGCGGGCAGCGGAGAGGGCAGCGACAGCGCCGGCGGGGCCACGCTCAAAGCCCCCAAGCATC TCTGGAGGCACGAGCAGCACCACCAGTACCCGCTCCGGCAGCCCCAGTTCCGCCTCCTGCATCCCCATCACCACCTGCCCCCGCCGCCGC CACCCTCGCCCCAGCCCCAGCCCCAGTGTCCGCTACAGCCGCCGCCGCCGCCCCCCCTGCCGCCGCCCCCGCCGCCGCCCGGGGCTGCCC GCGGCCGCTACGCCTCGAGCGGGGCCACCGGCCGCGTCCGGCATCGCGGCTACTCGGACACCGAGCGCTACCTGTACTGTCGCGCCATGG ACCGCACCTCCTACGCGGTGGAGACCGGCCACCGGCCCGGCCTGAAGAAATCCAGGATGTCCTGGCCCTCCTCGTTCCAGGGACTCAGGC GTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATT TTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCA TTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTG CATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGAGGAGG CCTACCAGAAACTGGCCAGCGAGACCCTGGAGGAGCTGGACTGGTGTCTGGACCAGCTAGAGACCCTACAGACCAGGCACTCCGTCAGTG AGATGGCCTCCAACAAGGGTGGCTTTGCAAAATGTTACGAGATGACAGATTTGACAAATAACAAAGTCTACGCCGCAAAAATTATTCCTC ACAGCAGAGTAGCTAAACCTCATCAAAGGGAAAAGATTGACAAAGAAATAGAGCTTCACAGAATTCTTCATCATAAGCATGTAGTGCAGT TTTACCACTACTTCGAGGACAAAGAAAACATTTACATTCTCTTGGAATACTGCAGTAGAAGGTCAATGGCTCATATTTTGAAAGCAAGAA AGGTGTTGACAGAGCCAGAAGTTCGATACTACCTCAGGCAGATTGTGTCTGGACTGAAATACCTTCATGAACAAGAAATCTTGCACAGAG ATCTCAAACTAGGGAACTTTTTTATTAATGAAGCCATGGAACTAAAAGTTGGGGACTTCGGTCTGGCAGCCAGGCTAGAACCCTTGGAAC ACAGAAGGAGAACGATATGTGGTACCCCAAATTATCTCTCTCCTGAAGTCCTCAACAAACAAGGACATGGCTGTGAATCAGACATTTGGG CCCTGGGCTGTGTAATGTATACAATGTTACTAGGGAGGCCCCCATTTGAAACTACAAATCTCAAAGAAACTTATAGGTGCATAAGGGAAG CAAGGTATACAATGCCGTCCTCATTGCTGGCTCCTGCCAAGCACTTAATTGCTAGTATGTTGTCCAAAAACCCAGAGGATCGTCCCAGTT TGGATGACATCATTCGACATGACTTTTTTTTGCAGGGCTTCACTCCGGACAGACTGTCTTCTAGCTGTTGTCATACAGTTCCAGATTTCC ACTTATCAAGCCCAGCTAAGAATTTCTTTAAGAAAGCAGCTGCTGCTCTTTTTGGTGGCAAAAAAGACAAAGCAAGATATATTGACACAC ATAATAGAGTGTCTAAAGAAGATGAAGACATCTACAAGCTTAGGCATGATTTGAAAAAGACTTCAATAACTCAGCAACCCAGCAAACACA GGACAGATGAGGAGCTCCAGCCACCTACCACCACAGTTGCCAGGTCTGGAACACCCGCAGTAGAAAACAAGCAGCAGATTGGGGATGCTA TTCGGATGATAGTCAGAGGGACTCTTGGCAGCTGTAGCAGCAGCAGTGAATGCCTTGAAGACAGTACCATGGGAAGTGTTGCAGACACAG TGGCAAGGGTTCTTCGGGGATGTCTGGAAAACATGCCGGAAGCTGATTGCATTCCCAAAGAGCAGCTGAGCACATCATTTCAGTGGGTCA CCAAATGGGTTGATTACTCTAACAAATATGGCTTTGGGTACCAGCTCTCAGACCACACCGTCGGTGTCCTTTTCAACAATGGTGCTCACA TGAGCCTCCTTCCAGACAAAAAAACAGTTCACTATTACGCAGAGCTTGGCCAATGCTCAGTTTTCCCAGCAACAGATGCTCCTGAGCAAT TTATTAGTCAAGTGACGGTGCTGAAATACTTTTCTCATTACATGGAGGAGAACCTCATGGATGGTGGAGATCTGCCTAGTGTTACTGATA TTCGAAGACCTCGGCTCTACCTCCTTCAGTGGCTAAAATCTGATAAGGCCCTAATGATGCTCTTTAATGATGGCACCTTTCAGGTGAATT TCTACCATGATCATACAAAAATCATCATCTGTAGCCAAAATGAAGAATACCTTCTCACCTACATCAATGAGGATAGGATATCTACAACTT TCAGGCTGACAACTCTGCTGATGTCTGGCTGTTCATCAGAATTAAAAAATCGAATGGAATATGCCCTGAACATGCTCTTACAAAGATGTA ACTGAAAGACTTTTCGAATGGACCCTATGGGACTCCTCTTTTCCACTGTGAGATCTACAGGGAAGCCAAAAGAATGATCTAGAGTATGTT GAAGAAGATGGACATGTGGTGGTACGAAAACAATTCCCCTGTGGCCTGCTGGACTGGTTGGAACCAGAACAGGCTAAGGCATACAGTTCT TGACTTTGGACAATCCAAGAGTGAACCAGAATGCAGTTTTCCTTGAGATACCTGTTTTAAAAGGTTTTTCAGACAATTTTGCAGAAAGGT GCATTGATTCTTAAATTCTCTCTGTTGAGAGCATTTCAGCCAGAGGACTTTGGAACTGTGAATATACTTCCTGAAGGGGAGGGAGAAGGG AGGAAGCTCCCATGTTGTTTAAAGGCTGTAATTGGAGCAGCTTTTGGCTGCGTAACTGTGAACTATGGCCATATATAATTTTTTTTCATT AATTTTTGAAGATACTTGTGGCTGGAAAAGTGCATTCCTTGTTAATAAACTTTTTATTTATTACAGCCCAAAGAGCAGTATTTATTATCA >In-frame_PDE4D_ENST00000360047_chr5_58334686_-_PLK2_ENST00000274289_chr5_57754919_-_3026nt CAATACTTGTTGCAATAATTGCCCACGATAGCTGCTCAAACAAGAGAGTTGGAATTCATCTGTAAAAATCACTACATGTAACGTAGGAGA CAAGAAAAATATTAATGACAGAAGATCTGCGAACATGATGCACGTGAATAATTTTCCCTTTAGAAGGCATTCCTGGATATGTTTTGATGT GGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCCACAG TCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGA TATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCATTAACTAA TTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGAGGAGGCCTACCAGAA ACTGGCCAGCGAGACCCTGGAGGAGCTGGACTGGTGTCTGGACCAGCTAGAGACCCTACAGACCAGGCACTCCGTCAGTGAGATGGCCTC CAACAAGGGTGGCTTTGCAAAATGTTACGAGATGACAGATTTGACAAATAACAAAGTCTACGCCGCAAAAATTATTCCTCACAGCAGAGT AGCTAAACCTCATCAAAGGGAAAAGATTGACAAAGAAATAGAGCTTCACAGAATTCTTCATCATAAGCATGTAGTGCAGTTTTACCACTA CTTCGAGGACAAAGAAAACATTTACATTCTCTTGGAATACTGCAGTAGAAGGTCAATGGCTCATATTTTGAAAGCAAGAAAGGTGTTGAC AGAGCCAGAAGTTCGATACTACCTCAGGCAGATTGTGTCTGGACTGAAATACCTTCATGAACAAGAAATCTTGCACAGAGATCTCAAACT AGGGAACTTTTTTATTAATGAAGCCATGGAACTAAAAGTTGGGGACTTCGGTCTGGCAGCCAGGCTAGAACCCTTGGAACACAGAAGGAG AACGATATGTGGTACCCCAAATTATCTCTCTCCTGAAGTCCTCAACAAACAAGGACATGGCTGTGAATCAGACATTTGGGCCCTGGGCTG TGTAATGTATACAATGTTACTAGGGAGGCCCCCATTTGAAACTACAAATCTCAAAGAAACTTATAGGTGCATAAGGGAAGCAAGGTATAC AATGCCGTCCTCATTGCTGGCTCCTGCCAAGCACTTAATTGCTAGTATGTTGTCCAAAAACCCAGAGGATCGTCCCAGTTTGGATGACAT CATTCGACATGACTTTTTTTTGCAGGGCTTCACTCCGGACAGACTGTCTTCTAGCTGTTGTCATACAGTTCCAGATTTCCACTTATCAAG CCCAGCTAAGAATTTCTTTAAGAAAGCAGCTGCTGCTCTTTTTGGTGGCAAAAAAGACAAAGCAAGATATATTGACACACATAATAGAGT GTCTAAAGAAGATGAAGACATCTACAAGCTTAGGCATGATTTGAAAAAGACTTCAATAACTCAGCAACCCAGCAAACACAGGACAGATGA GGAGCTCCAGCCACCTACCACCACAGTTGCCAGGTCTGGAACACCCGCAGTAGAAAACAAGCAGCAGATTGGGGATGCTATTCGGATGAT AGTCAGAGGGACTCTTGGCAGCTGTAGCAGCAGCAGTGAATGCCTTGAAGACAGTACCATGGGAAGTGTTGCAGACACAGTGGCAAGGGT TCTTCGGGGATGTCTGGAAAACATGCCGGAAGCTGATTGCATTCCCAAAGAGCAGCTGAGCACATCATTTCAGTGGGTCACCAAATGGGT TGATTACTCTAACAAATATGGCTTTGGGTACCAGCTCTCAGACCACACCGTCGGTGTCCTTTTCAACAATGGTGCTCACATGAGCCTCCT TCCAGACAAAAAAACAGTTCACTATTACGCAGAGCTTGGCCAATGCTCAGTTTTCCCAGCAACAGATGCTCCTGAGCAATTTATTAGTCA AGTGACGGTGCTGAAATACTTTTCTCATTACATGGAGGAGAACCTCATGGATGGTGGAGATCTGCCTAGTGTTACTGATATTCGAAGACC TCGGCTCTACCTCCTTCAGTGGCTAAAATCTGATAAGGCCCTAATGATGCTCTTTAATGATGGCACCTTTCAGGTGAATTTCTACCATGA TCATACAAAAATCATCATCTGTAGCCAAAATGAAGAATACCTTCTCACCTACATCAATGAGGATAGGATATCTACAACTTTCAGGCTGAC AACTCTGCTGATGTCTGGCTGTTCATCAGAATTAAAAAATCGAATGGAATATGCCCTGAACATGCTCTTACAAAGATGTAACTGAAAGAC TTTTCGAATGGACCCTATGGGACTCCTCTTTTCCACTGTGAGATCTACAGGGAAGCCAAAAGAATGATCTAGAGTATGTTGAAGAAGATG GACATGTGGTGGTACGAAAACAATTCCCCTGTGGCCTGCTGGACTGGTTGGAACCAGAACAGGCTAAGGCATACAGTTCTTGACTTTGGA CAATCCAAGAGTGAACCAGAATGCAGTTTTCCTTGAGATACCTGTTTTAAAAGGTTTTTCAGACAATTTTGCAGAAAGGTGCATTGATTC TTAAATTCTCTCTGTTGAGAGCATTTCAGCCAGAGGACTTTGGAACTGTGAATATACTTCCTGAAGGGGAGGGAGAAGGGAGGAAGCTCC CATGTTGTTTAAAGGCTGTAATTGGAGCAGCTTTTGGCTGCGTAACTGTGAACTATGGCCATATATAATTTTTTTTCATTAATTTTTGAA GATACTTGTGGCTGGAAAAGTGCATTCCTTGTTAATAAACTTTTTATTTATTACAGCCCAAAGAGCAGTATTTATTATCAAAATGTCTTT >In-frame_PDE4D_ENST00000507116_chr5_58334686_-_PLK2_ENST00000274289_chr5_57754919_-_3254nt AGAGAGACTGAGGCAGGCGACTGAATGCACTAACAGCAGCAGGCTCAGACCTGCTTCCCTGGACATTTCCGGGACCGTGAGCGAGGGAAC CACGTTGCCCTGGATTCTTGCCAGCTGTACAAAGTTGACCAGGAAAATGGCTCAGCAGACAAGCCCGGACACTTTAACAGTACCTGAAGT GGATAATCCGCATTGTCCAAACCCGTGGCTGAACGAAGACCTTGTGAAATCCTTGCGAGAAAACCTGTTGCAGCATGAGAAGTCCAAGAC AGCGAGGAAATCGGTTTCTCCCAAGCTCTCTCCAGTGATCTCTCCGAGAAATTCCCCCAGGCTTCTGCGCAGAATGCTTCTCAGCAGCAA CATCCCCAAACAGCGGCGTTTCACGGTGGCACATACATGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCAT GACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTA TGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGT CTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAA CCAACCATCCATCAACAAAGCCACCATAACAGAGGAGGCCTACCAGAAACTGGCCAGCGAGACCCTGGAGGAGCTGGACTGGTGTCTGGA CCAGCTAGAGACCCTACAGACCAGGCACTCCGTCAGTGAGATGGCCTCCAACAAGGGTGGCTTTGCAAAATGTTACGAGATGACAGATTT GACAAATAACAAAGTCTACGCCGCAAAAATTATTCCTCACAGCAGAGTAGCTAAACCTCATCAAAGGGAAAAGATTGACAAAGAAATAGA GCTTCACAGAATTCTTCATCATAAGCATGTAGTGCAGTTTTACCACTACTTCGAGGACAAAGAAAACATTTACATTCTCTTGGAATACTG CAGTAGAAGGTCAATGGCTCATATTTTGAAAGCAAGAAAGGTGTTGACAGAGCCAGAAGTTCGATACTACCTCAGGCAGATTGTGTCTGG ACTGAAATACCTTCATGAACAAGAAATCTTGCACAGAGATCTCAAACTAGGGAACTTTTTTATTAATGAAGCCATGGAACTAAAAGTTGG GGACTTCGGTCTGGCAGCCAGGCTAGAACCCTTGGAACACAGAAGGAGAACGATATGTGGTACCCCAAATTATCTCTCTCCTGAAGTCCT CAACAAACAAGGACATGGCTGTGAATCAGACATTTGGGCCCTGGGCTGTGTAATGTATACAATGTTACTAGGGAGGCCCCCATTTGAAAC TACAAATCTCAAAGAAACTTATAGGTGCATAAGGGAAGCAAGGTATACAATGCCGTCCTCATTGCTGGCTCCTGCCAAGCACTTAATTGC TAGTATGTTGTCCAAAAACCCAGAGGATCGTCCCAGTTTGGATGACATCATTCGACATGACTTTTTTTTGCAGGGCTTCACTCCGGACAG ACTGTCTTCTAGCTGTTGTCATACAGTTCCAGATTTCCACTTATCAAGCCCAGCTAAGAATTTCTTTAAGAAAGCAGCTGCTGCTCTTTT TGGTGGCAAAAAAGACAAAGCAAGATATATTGACACACATAATAGAGTGTCTAAAGAAGATGAAGACATCTACAAGCTTAGGCATGATTT GAAAAAGACTTCAATAACTCAGCAACCCAGCAAACACAGGACAGATGAGGAGCTCCAGCCACCTACCACCACAGTTGCCAGGTCTGGAAC ACCCGCAGTAGAAAACAAGCAGCAGATTGGGGATGCTATTCGGATGATAGTCAGAGGGACTCTTGGCAGCTGTAGCAGCAGCAGTGAATG CCTTGAAGACAGTACCATGGGAAGTGTTGCAGACACAGTGGCAAGGGTTCTTCGGGGATGTCTGGAAAACATGCCGGAAGCTGATTGCAT TCCCAAAGAGCAGCTGAGCACATCATTTCAGTGGGTCACCAAATGGGTTGATTACTCTAACAAATATGGCTTTGGGTACCAGCTCTCAGA CCACACCGTCGGTGTCCTTTTCAACAATGGTGCTCACATGAGCCTCCTTCCAGACAAAAAAACAGTTCACTATTACGCAGAGCTTGGCCA ATGCTCAGTTTTCCCAGCAACAGATGCTCCTGAGCAATTTATTAGTCAAGTGACGGTGCTGAAATACTTTTCTCATTACATGGAGGAGAA CCTCATGGATGGTGGAGATCTGCCTAGTGTTACTGATATTCGAAGACCTCGGCTCTACCTCCTTCAGTGGCTAAAATCTGATAAGGCCCT AATGATGCTCTTTAATGATGGCACCTTTCAGGTGAATTTCTACCATGATCATACAAAAATCATCATCTGTAGCCAAAATGAAGAATACCT TCTCACCTACATCAATGAGGATAGGATATCTACAACTTTCAGGCTGACAACTCTGCTGATGTCTGGCTGTTCATCAGAATTAAAAAATCG AATGGAATATGCCCTGAACATGCTCTTACAAAGATGTAACTGAAAGACTTTTCGAATGGACCCTATGGGACTCCTCTTTTCCACTGTGAG ATCTACAGGGAAGCCAAAAGAATGATCTAGAGTATGTTGAAGAAGATGGACATGTGGTGGTACGAAAACAATTCCCCTGTGGCCTGCTGG ACTGGTTGGAACCAGAACAGGCTAAGGCATACAGTTCTTGACTTTGGACAATCCAAGAGTGAACCAGAATGCAGTTTTCCTTGAGATACC TGTTTTAAAAGGTTTTTCAGACAATTTTGCAGAAAGGTGCATTGATTCTTAAATTCTCTCTGTTGAGAGCATTTCAGCCAGAGGACTTTG GAACTGTGAATATACTTCCTGAAGGGGAGGGAGAAGGGAGGAAGCTCCCATGTTGTTTAAAGGCTGTAATTGGAGCAGCTTTTGGCTGCG TAACTGTGAACTATGGCCATATATAATTTTTTTTCATTAATTTTTGAAGATACTTGTGGCTGGAAAAGTGCATTCCTTGTTAATAAACTT TTTATTTATTACAGCCCAAAGAGCAGTATTTATTATCAAAATGTCTTTTTTTTTATGTTGACCATTTTAAACCGTTGGCAATAAAGAGTA >In-frame_PDE4D_ENST00000546160_chr5_58334686_-_PLK2_ENST00000274289_chr5_57754919_-_3127nt ATGAAAAGAAATACCTGTGATTTGCTTTCTCGGAGCAAAAGTGCCTCTGAGGAAACACTACATTCCAGTAATGAAGAGGAAGACCCTTTC CGCGGAATGGAACCCTATCTTGTCCGGAGACTTTCATGTCGCAATATTCAGCTTCCCCCTCTCGCCTTCAGACAGTTGGAACAAGCTGAC TTGAAAAGTGAATCAGAGAACATTCAACGACCAACCAGCCTCCCCCTGAAGATTCTGCCGCTGATTGCTATCACTTCTGCAGAATCCAGT GGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAAT TTTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCC ATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCT GCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGAGGAG GCCTACCAGAAACTGGCCAGCGAGACCCTGGAGGAGCTGGACTGGTGTCTGGACCAGCTAGAGACCCTACAGACCAGGCACTCCGTCAGT GAGATGGCCTCCAACAAGGGTGGCTTTGCAAAATGTTACGAGATGACAGATTTGACAAATAACAAAGTCTACGCCGCAAAAATTATTCCT CACAGCAGAGTAGCTAAACCTCATCAAAGGGAAAAGATTGACAAAGAAATAGAGCTTCACAGAATTCTTCATCATAAGCATGTAGTGCAG TTTTACCACTACTTCGAGGACAAAGAAAACATTTACATTCTCTTGGAATACTGCAGTAGAAGGTCAATGGCTCATATTTTGAAAGCAAGA AAGGTGTTGACAGAGCCAGAAGTTCGATACTACCTCAGGCAGATTGTGTCTGGACTGAAATACCTTCATGAACAAGAAATCTTGCACAGA GATCTCAAACTAGGGAACTTTTTTATTAATGAAGCCATGGAACTAAAAGTTGGGGACTTCGGTCTGGCAGCCAGGCTAGAACCCTTGGAA CACAGAAGGAGAACGATATGTGGTACCCCAAATTATCTCTCTCCTGAAGTCCTCAACAAACAAGGACATGGCTGTGAATCAGACATTTGG GCCCTGGGCTGTGTAATGTATACAATGTTACTAGGGAGGCCCCCATTTGAAACTACAAATCTCAAAGAAACTTATAGGTGCATAAGGGAA GCAAGGTATACAATGCCGTCCTCATTGCTGGCTCCTGCCAAGCACTTAATTGCTAGTATGTTGTCCAAAAACCCAGAGGATCGTCCCAGT TTGGATGACATCATTCGACATGACTTTTTTTTGCAGGGCTTCACTCCGGACAGACTGTCTTCTAGCTGTTGTCATACAGTTCCAGATTTC CACTTATCAAGCCCAGCTAAGAATTTCTTTAAGAAAGCAGCTGCTGCTCTTTTTGGTGGCAAAAAAGACAAAGCAAGATATATTGACACA CATAATAGAGTGTCTAAAGAAGATGAAGACATCTACAAGCTTAGGCATGATTTGAAAAAGACTTCAATAACTCAGCAACCCAGCAAACAC AGGACAGATGAGGAGCTCCAGCCACCTACCACCACAGTTGCCAGGTCTGGAACACCCGCAGTAGAAAACAAGCAGCAGATTGGGGATGCT ATTCGGATGATAGTCAGAGGGACTCTTGGCAGCTGTAGCAGCAGCAGTGAATGCCTTGAAGACAGTACCATGGGAAGTGTTGCAGACACA GTGGCAAGGGTTCTTCGGGGATGTCTGGAAAACATGCCGGAAGCTGATTGCATTCCCAAAGAGCAGCTGAGCACATCATTTCAGTGGGTC ACCAAATGGGTTGATTACTCTAACAAATATGGCTTTGGGTACCAGCTCTCAGACCACACCGTCGGTGTCCTTTTCAACAATGGTGCTCAC ATGAGCCTCCTTCCAGACAAAAAAACAGTTCACTATTACGCAGAGCTTGGCCAATGCTCAGTTTTCCCAGCAACAGATGCTCCTGAGCAA TTTATTAGTCAAGTGACGGTGCTGAAATACTTTTCTCATTACATGGAGGAGAACCTCATGGATGGTGGAGATCTGCCTAGTGTTACTGAT ATTCGAAGACCTCGGCTCTACCTCCTTCAGTGGCTAAAATCTGATAAGGCCCTAATGATGCTCTTTAATGATGGCACCTTTCAGGTGAAT TTCTACCATGATCATACAAAAATCATCATCTGTAGCCAAAATGAAGAATACCTTCTCACCTACATCAATGAGGATAGGATATCTACAACT TTCAGGCTGACAACTCTGCTGATGTCTGGCTGTTCATCAGAATTAAAAAATCGAATGGAATATGCCCTGAACATGCTCTTACAAAGATGT AACTGAAAGACTTTTCGAATGGACCCTATGGGACTCCTCTTTTCCACTGTGAGATCTACAGGGAAGCCAAAAGAATGATCTAGAGTATGT TGAAGAAGATGGACATGTGGTGGTACGAAAACAATTCCCCTGTGGCCTGCTGGACTGGTTGGAACCAGAACAGGCTAAGGCATACAGTTC TTGACTTTGGACAATCCAAGAGTGAACCAGAATGCAGTTTTCCTTGAGATACCTGTTTTAAAAGGTTTTTCAGACAATTTTGCAGAAAGG TGCATTGATTCTTAAATTCTCTCTGTTGAGAGCATTTCAGCCAGAGGACTTTGGAACTGTGAATATACTTCCTGAAGGGGAGGGAGAAGG GAGGAAGCTCCCATGTTGTTTAAAGGCTGTAATTGGAGCAGCTTTTGGCTGCGTAACTGTGAACTATGGCCATATATAATTTTTTTTCAT TAATTTTTGAAGATACTTGTGGCTGGAAAAGTGCATTCCTTGTTAATAAACTTTTTATTTATTACAGCCCAAAGAGCAGTATTTATTATC >In-frame_PDE4D_ENST00000503258_chr5_58334686_-_PLK2_ENST00000274289_chr5_57754919_-_3637nt TTCTCACTGCCCTGCGGTGTTTTGAACTGCCTTCTTACAGACGTCATACAGCCCTTGAGGAATAGTTTCTGCCTGGTGAGATTGAATGAT AGTTCTCATTCACAAAACCCTGGATTCTAAGCAGGGACACACAGAAATTACTTTCGCAGGTAAATCAGCCCACCCAGCCAAAGTGTGGAG AGATTTGTTCCTTGGCTGACTTCTTTGCTCCACGGAGAGGAGTGTTTTCCTGTGCTTGCCCTGAAATGGAACTTCCTTGACAGCTCTCCC GTGTTACAGTACCTCCCGGTCATTTTCTTTTTCTCTCTCTCTACCTGCGCTCTTCGAGTGTCAGAAACCTTTAAAGCTGTTACTATGGAA TTGCAAAAAAGAGATCAAGTGACTCTTTCACTATGCTGGTTTCCCTTGTGACCCAGATGAAGAATCAATTCAGAATTCAGTTCCTCCCTT GGCATTGCAAGACACAGAAGAAACTGTCACTTCCTAACAGCCTAGTACTGGAGTAAATTCAGTATGAAGGAAGAAAGCGCTCCTGCGTGT TAGAACCTTGCCCATGAGCTGGACCGAGGACAGGAGATGGACTCCAGGAAAATTGGATTTCTTCAAGCAGCCTCCCTTGGAAATGGAATA TCTTTAAAATCTTCTTTGCAGAAAGACAGTTAGAATGTATTAATCAGAATAGTTGAAGACTTATTTTCCTTTTTATTTTTTTTCAAAATG AGCATTATTATGAAGCCAAGATCCCGATCTACAAGTTCCCTAAGGACTGCAGAGGCAGTTTGTTTTGATGTGGACAATGGCACATCTGCG GGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCCACAGTCAACGACGGGAGTCCTTC CTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGACTTG ATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCT AGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGAGGAGGCCTACCAGAAACTGGCCAGCGAGACCCTG GAGGAGCTGGACTGGTGTCTGGACCAGCTAGAGACCCTACAGACCAGGCACTCCGTCAGTGAGATGGCCTCCAACAAGGGTGGCTTTGCA AAATGTTACGAGATGACAGATTTGACAAATAACAAAGTCTACGCCGCAAAAATTATTCCTCACAGCAGAGTAGCTAAACCTCATCAAAGG GAAAAGATTGACAAAGAAATAGAGCTTCACAGAATTCTTCATCATAAGCATGTAGTGCAGTTTTACCACTACTTCGAGGACAAAGAAAAC ATTTACATTCTCTTGGAATACTGCAGTAGAAGGTCAATGGCTCATATTTTGAAAGCAAGAAAGGTGTTGACAGAGCCAGAAGTTCGATAC TACCTCAGGCAGATTGTGTCTGGACTGAAATACCTTCATGAACAAGAAATCTTGCACAGAGATCTCAAACTAGGGAACTTTTTTATTAAT GAAGCCATGGAACTAAAAGTTGGGGACTTCGGTCTGGCAGCCAGGCTAGAACCCTTGGAACACAGAAGGAGAACGATATGTGGTACCCCA AATTATCTCTCTCCTGAAGTCCTCAACAAACAAGGACATGGCTGTGAATCAGACATTTGGGCCCTGGGCTGTGTAATGTATACAATGTTA CTAGGGAGGCCCCCATTTGAAACTACAAATCTCAAAGAAACTTATAGGTGCATAAGGGAAGCAAGGTATACAATGCCGTCCTCATTGCTG GCTCCTGCCAAGCACTTAATTGCTAGTATGTTGTCCAAAAACCCAGAGGATCGTCCCAGTTTGGATGACATCATTCGACATGACTTTTTT TTGCAGGGCTTCACTCCGGACAGACTGTCTTCTAGCTGTTGTCATACAGTTCCAGATTTCCACTTATCAAGCCCAGCTAAGAATTTCTTT AAGAAAGCAGCTGCTGCTCTTTTTGGTGGCAAAAAAGACAAAGCAAGATATATTGACACACATAATAGAGTGTCTAAAGAAGATGAAGAC ATCTACAAGCTTAGGCATGATTTGAAAAAGACTTCAATAACTCAGCAACCCAGCAAACACAGGACAGATGAGGAGCTCCAGCCACCTACC ACCACAGTTGCCAGGTCTGGAACACCCGCAGTAGAAAACAAGCAGCAGATTGGGGATGCTATTCGGATGATAGTCAGAGGGACTCTTGGC AGCTGTAGCAGCAGCAGTGAATGCCTTGAAGACAGTACCATGGGAAGTGTTGCAGACACAGTGGCAAGGGTTCTTCGGGGATGTCTGGAA AACATGCCGGAAGCTGATTGCATTCCCAAAGAGCAGCTGAGCACATCATTTCAGTGGGTCACCAAATGGGTTGATTACTCTAACAAATAT GGCTTTGGGTACCAGCTCTCAGACCACACCGTCGGTGTCCTTTTCAACAATGGTGCTCACATGAGCCTCCTTCCAGACAAAAAAACAGTT CACTATTACGCAGAGCTTGGCCAATGCTCAGTTTTCCCAGCAACAGATGCTCCTGAGCAATTTATTAGTCAAGTGACGGTGCTGAAATAC TTTTCTCATTACATGGAGGAGAACCTCATGGATGGTGGAGATCTGCCTAGTGTTACTGATATTCGAAGACCTCGGCTCTACCTCCTTCAG TGGCTAAAATCTGATAAGGCCCTAATGATGCTCTTTAATGATGGCACCTTTCAGGTGAATTTCTACCATGATCATACAAAAATCATCATC TGTAGCCAAAATGAAGAATACCTTCTCACCTACATCAATGAGGATAGGATATCTACAACTTTCAGGCTGACAACTCTGCTGATGTCTGGC TGTTCATCAGAATTAAAAAATCGAATGGAATATGCCCTGAACATGCTCTTACAAAGATGTAACTGAAAGACTTTTCGAATGGACCCTATG GGACTCCTCTTTTCCACTGTGAGATCTACAGGGAAGCCAAAAGAATGATCTAGAGTATGTTGAAGAAGATGGACATGTGGTGGTACGAAA ACAATTCCCCTGTGGCCTGCTGGACTGGTTGGAACCAGAACAGGCTAAGGCATACAGTTCTTGACTTTGGACAATCCAAGAGTGAACCAG AATGCAGTTTTCCTTGAGATACCTGTTTTAAAAGGTTTTTCAGACAATTTTGCAGAAAGGTGCATTGATTCTTAAATTCTCTCTGTTGAG AGCATTTCAGCCAGAGGACTTTGGAACTGTGAATATACTTCCTGAAGGGGAGGGAGAAGGGAGGAAGCTCCCATGTTGTTTAAAGGCTGT AATTGGAGCAGCTTTTGGCTGCGTAACTGTGAACTATGGCCATATATAATTTTTTTTCATTAATTTTTGAAGATACTTGTGGCTGGAAAA GTGCATTCCTTGTTAATAAACTTTTTATTTATTACAGCCCAAAGAGCAGTATTTATTATCAAAATGTCTTTTTTTTTATGTTGACCATTT >In-frame_PDE4D_ENST00000405755_chr5_58334686_-_PLK2_ENST00000274289_chr5_57754919_-_3073nt ACTGCACAAAGGAAATGCCCTCACTCAGCTACAAGTGCCTCCTGCTCCGTGCGGGGCCTCAGGGCCCCAGAGCCCCGCACCAGCTCTGAC TTCTCGTGGTTCCTGGGGATCTTGGCATCGTCCTTAAAAATGGCTTTTGTTTGGGATCCTCTGGGAGCCACGGTGCCAGGACCATCTACA AGAGCCAAATCAAGATTGCGTTTCTCAAAGTCCTACAGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATG ACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTAT GACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTC TTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAAC CAACCATCCATCAACAAAGCCACCATAACAGAGGAGGCCTACCAGAAACTGGCCAGCGAGACCCTGGAGGAGCTGGACTGGTGTCTGGAC CAGCTAGAGACCCTACAGACCAGGCACTCCGTCAGTGAGATGGCCTCCAACAAGGGTGGCTTTGCAAAATGTTACGAGATGACAGATTTG ACAAATAACAAAGTCTACGCCGCAAAAATTATTCCTCACAGCAGAGTAGCTAAACCTCATCAAAGGGAAAAGATTGACAAAGAAATAGAG CTTCACAGAATTCTTCATCATAAGCATGTAGTGCAGTTTTACCACTACTTCGAGGACAAAGAAAACATTTACATTCTCTTGGAATACTGC AGTAGAAGGTCAATGGCTCATATTTTGAAAGCAAGAAAGGTGTTGACAGAGCCAGAAGTTCGATACTACCTCAGGCAGATTGTGTCTGGA CTGAAATACCTTCATGAACAAGAAATCTTGCACAGAGATCTCAAACTAGGGAACTTTTTTATTAATGAAGCCATGGAACTAAAAGTTGGG GACTTCGGTCTGGCAGCCAGGCTAGAACCCTTGGAACACAGAAGGAGAACGATATGTGGTACCCCAAATTATCTCTCTCCTGAAGTCCTC AACAAACAAGGACATGGCTGTGAATCAGACATTTGGGCCCTGGGCTGTGTAATGTATACAATGTTACTAGGGAGGCCCCCATTTGAAACT ACAAATCTCAAAGAAACTTATAGGTGCATAAGGGAAGCAAGGTATACAATGCCGTCCTCATTGCTGGCTCCTGCCAAGCACTTAATTGCT AGTATGTTGTCCAAAAACCCAGAGGATCGTCCCAGTTTGGATGACATCATTCGACATGACTTTTTTTTGCAGGGCTTCACTCCGGACAGA CTGTCTTCTAGCTGTTGTCATACAGTTCCAGATTTCCACTTATCAAGCCCAGCTAAGAATTTCTTTAAGAAAGCAGCTGCTGCTCTTTTT GGTGGCAAAAAAGACAAAGCAAGATATATTGACACACATAATAGAGTGTCTAAAGAAGATGAAGACATCTACAAGCTTAGGCATGATTTG AAAAAGACTTCAATAACTCAGCAACCCAGCAAACACAGGACAGATGAGGAGCTCCAGCCACCTACCACCACAGTTGCCAGGTCTGGAACA CCCGCAGTAGAAAACAAGCAGCAGATTGGGGATGCTATTCGGATGATAGTCAGAGGGACTCTTGGCAGCTGTAGCAGCAGCAGTGAATGC CTTGAAGACAGTACCATGGGAAGTGTTGCAGACACAGTGGCAAGGGTTCTTCGGGGATGTCTGGAAAACATGCCGGAAGCTGATTGCATT CCCAAAGAGCAGCTGAGCACATCATTTCAGTGGGTCACCAAATGGGTTGATTACTCTAACAAATATGGCTTTGGGTACCAGCTCTCAGAC CACACCGTCGGTGTCCTTTTCAACAATGGTGCTCACATGAGCCTCCTTCCAGACAAAAAAACAGTTCACTATTACGCAGAGCTTGGCCAA TGCTCAGTTTTCCCAGCAACAGATGCTCCTGAGCAATTTATTAGTCAAGTGACGGTGCTGAAATACTTTTCTCATTACATGGAGGAGAAC CTCATGGATGGTGGAGATCTGCCTAGTGTTACTGATATTCGAAGACCTCGGCTCTACCTCCTTCAGTGGCTAAAATCTGATAAGGCCCTA ATGATGCTCTTTAATGATGGCACCTTTCAGGTGAATTTCTACCATGATCATACAAAAATCATCATCTGTAGCCAAAATGAAGAATACCTT CTCACCTACATCAATGAGGATAGGATATCTACAACTTTCAGGCTGACAACTCTGCTGATGTCTGGCTGTTCATCAGAATTAAAAAATCGA ATGGAATATGCCCTGAACATGCTCTTACAAAGATGTAACTGAAAGACTTTTCGAATGGACCCTATGGGACTCCTCTTTTCCACTGTGAGA TCTACAGGGAAGCCAAAAGAATGATCTAGAGTATGTTGAAGAAGATGGACATGTGGTGGTACGAAAACAATTCCCCTGTGGCCTGCTGGA CTGGTTGGAACCAGAACAGGCTAAGGCATACAGTTCTTGACTTTGGACAATCCAAGAGTGAACCAGAATGCAGTTTTCCTTGAGATACCT GTTTTAAAAGGTTTTTCAGACAATTTTGCAGAAAGGTGCATTGATTCTTAAATTCTCTCTGTTGAGAGCATTTCAGCCAGAGGACTTTGG AACTGTGAATATACTTCCTGAAGGGGAGGGAGAAGGGAGGAAGCTCCCATGTTGTTTAAAGGCTGTAATTGGAGCAGCTTTTGGCTGCGT AACTGTGAACTATGGCCATATATAATTTTTTTTCATTAATTTTTGAAGATACTTGTGGCTGGAAAAGTGCATTCCTTGTTAATAAACTTT TTATTTATTACAGCCCAAAGAGCAGTATTTATTATCAAAATGTCTTTTTTTTTATGTTGACCATTTTAAACCGTTGGCAATAAAGAGTAT |
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FusionGenePPI for PDE4D_PLK2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PDE4D | PDE4DIP, PDE4D, AKAP6, GNB2L1, ARRB1, MDM2, ITSN1, ARRB2, PPP3CA, PPP3CB, PPP3R1, GSK3B, CSNK1A1, CDK2, PAFAH1B1, PRKACA, APP, LYN, SRC, FYN, ABL1, GRB2, PIAS4, MAPK1, BIN1, HDGFRP2, ZBTB1, MAGEA6, TRAF1, COIL, GOLGA8EP, GOLGA8F, ZDHHC17, SPTAN1, PIK3R1, TRIM23, ITPKB, PFKFB2, AKAP12, ATOH1, DUSP13, PDE4B, TRIM25 | PLK2 | CIB1, MPP3, NEDD4, SNCA, APP, CENPU, CASK, CDC20B, KLK7, IGKC, IGHG2, CTSV, RNASE7, POF1B, EIF5B, SUGP1, TAF8, CCDC12, EEF1A2, RABL6, ANKRD44, ANKRD28, PAK2, SERPINA12, SAR1B, CPA4, CSTF1, SDR9C7, SERPINA1, SERPINB7, UNK, XPO1, CTSZ, ITPR1, FXR1, THRAP3, MFN1, FGD6, LENG1, PCGF5, RTN4IP1, DNTTIP1, IRGQ, MYO18A, C1orf226, ALAD, FBXW7 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PDE4D_PLK2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | PDE4D | Q08499 | DB00651 | Dyphylline | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | small molecule | approved |
| Hgene | PDE4D | Q08499 | DB01656 | Roflumilast | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | small molecule | approved |
| Hgene | PDE4D | Q08499 | DB01088 | Iloprost | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | small molecule | approved|investigational |
| Hgene | PDE4D | Q08499 | DB05266 | Ibudilast | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | small molecule | approved|investigational |
| Hgene | PDE4D | Q08499 | DB05676 | Apremilast | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | small molecule | approved|investigational |
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RelatedDiseases for PDE4D_PLK2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PDE4D | C3553250 | ACRODYSOSTOSIS 2 WITH OR WITHOUT HORMONE RESISTANCE | 4 | UNIPROT |
| Hgene | PDE4D | C0011581 | Depressive disorder | 3 | PSYGENET |
| Hgene | PDE4D | C0004096 | Asthma | 2 | CTD_human |
| Hgene | PDE4D | C0011570 | Mental Depression | 2 | PSYGENET |
| Hgene | PDE4D | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | PDE4D | C0036341 | Schizophrenia | 1 | PSYGENET |
| Hgene | PDE4D | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
| Tgene | PLK2 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Tgene | PLK2 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Tgene | PLK2 | C0041755 | Adverse reaction to drug | 1 | CTD_human |
| Tgene | PLK2 | C3495559 | Juvenile arthritis | 1 | CTD_human |
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