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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 26410

FusionGeneSummary for PDE4D_NOA1

check button Fusion gene summary
Fusion gene informationFusion gene name: PDE4D_NOA1
Fusion gene ID: 26410
HgeneTgene
Gene symbol

PDE4D

NOA1

Gene ID

5144

84273

Gene namephosphodiesterase 4Dnitric oxide associated 1
SynonymsACRDYS2|DPDE3|HSPDE4D|PDE43|PDE4DN2|STRK1C4orf14|MTG3|hAtNOS1|hNOA1|mAtNOS1
Cytomap

5q11.2-q12.1

4q12

Type of geneprotein-codingprotein-coding
DescriptioncAMP-specific 3',5'-cyclic phosphodiesterase 4DcAMP-specific phosphodiesterase PDE4D6phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)testicular tissue protein Li 136nitric oxide-associated protein 1mitochondrial GTPase 3 homolognitric oxide synthase, mitochondrial (putative)putative ortholog of Arabidopsis mitochondrial nitric oxide synthase
Modification date2018051920180522
UniProtAcc

Q08499

Q8NC60

Ensembl transtripts involved in fusion geneENST00000340635, ENST00000360047, 
ENST00000507116, ENST00000502484, 
ENST00000546160, ENST00000502575, 
ENST00000358923, ENST00000503258, 
ENST00000405755, ENST00000317118, 
ENST00000503947, 
ENST00000264230, 
Fusion gene scores* DoF score23 X 14 X 10=32202 X 1 X 2=4
# samples 342
** MAII scorelog2(34/3220*10)=-3.24345403686428
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: PDE4D [Title/Abstract] AND NOA1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePDE4D

GO:0006198

cAMP catabolic process

9371713|17404263


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-KD-A5QU-01APDE4Dchr5

58476421

-NOA1chr4

57840188

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000340635ENST00000264230PDE4Dchr5

58476421

-NOA1chr4

57840188

-
In-frameENST00000360047ENST00000264230PDE4Dchr5

58476421

-NOA1chr4

57840188

-
In-frameENST00000507116ENST00000264230PDE4Dchr5

58476421

-NOA1chr4

57840188

-
Frame-shiftENST00000502484ENST00000264230PDE4Dchr5

58476421

-NOA1chr4

57840188

-
In-frameENST00000546160ENST00000264230PDE4Dchr5

58476421

-NOA1chr4

57840188

-
In-frameENST00000502575ENST00000264230PDE4Dchr5

58476421

-NOA1chr4

57840188

-
intron-3CDSENST00000358923ENST00000264230PDE4Dchr5

58476421

-NOA1chr4

57840188

-
In-frameENST00000503258ENST00000264230PDE4Dchr5

58476421

-NOA1chr4

57840188

-
In-frameENST00000405755ENST00000264230PDE4Dchr5

58476421

-NOA1chr4

57840188

-
intron-3CDSENST00000317118ENST00000264230PDE4Dchr5

58476421

-NOA1chr4

57840188

-
5UTR-3CDSENST00000503947ENST00000264230PDE4Dchr5

58476421

-NOA1chr4

57840188

-

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FusionProtFeatures for PDE4D_NOA1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PDE4D

Q08499

NOA1

Q8NC60

Involved in regulation of mitochondrial proteintranslation and respiration. Plays a role in mitochondria-mediatedcell death. May act as a scaffolding protein or stabilizer ofrespiratory chain supercomplexes. Binds GTP.{ECO:0000269|PubMed:19103604}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDE4Dchr5:58476421chr4:57840188ENST00000340635-51542_88269810Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58476421chr4:57840188ENST00000360047-51542_88133674Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58476421chr4:57840188ENST00000405755-51542_88147688Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58476421chr4:57840188ENST00000502484-71742_88208749Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58476421chr4:57840188ENST00000502575-5642_88205220Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58476421chr4:57840188ENST00000503258-51542_88139680Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58476421chr4:57840188ENST00000507116-51542_88205746Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58476421chr4:57840188ENST00000546160-61642_88208749Compositional biasNote=Pro-rich

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDE4Dchr5:58476421chr4:57840188ENST00000317118-11042_88-132519Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58476421chr4:57840188ENST00000358923-11142_88-185508Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58476421chr4:57840188ENST00000317118-110386_715-132519DomainPDEase
HgenePDE4Dchr5:58476421chr4:57840188ENST00000340635-515386_715269810DomainPDEase
HgenePDE4Dchr5:58476421chr4:57840188ENST00000358923-111386_715-185508DomainPDEase
HgenePDE4Dchr5:58476421chr4:57840188ENST00000360047-515386_715133674DomainPDEase
HgenePDE4Dchr5:58476421chr4:57840188ENST00000405755-515386_715147688DomainPDEase
HgenePDE4Dchr5:58476421chr4:57840188ENST00000502484-717386_715208749DomainPDEase
HgenePDE4Dchr5:58476421chr4:57840188ENST00000502575-56386_715205220DomainPDEase
HgenePDE4Dchr5:58476421chr4:57840188ENST00000503258-515386_715139680DomainPDEase
HgenePDE4Dchr5:58476421chr4:57840188ENST00000507116-515386_715205746DomainPDEase
HgenePDE4Dchr5:58476421chr4:57840188ENST00000546160-616386_715208749DomainPDEase
HgenePDE4Dchr5:58476421chr4:57840188ENST00000317118-110462_466-132519Nucleotide bindingcAMP
HgenePDE4Dchr5:58476421chr4:57840188ENST00000340635-515462_466269810Nucleotide bindingcAMP
HgenePDE4Dchr5:58476421chr4:57840188ENST00000358923-111462_466-185508Nucleotide bindingcAMP
HgenePDE4Dchr5:58476421chr4:57840188ENST00000360047-515462_466133674Nucleotide bindingcAMP
HgenePDE4Dchr5:58476421chr4:57840188ENST00000405755-515462_466147688Nucleotide bindingcAMP
HgenePDE4Dchr5:58476421chr4:57840188ENST00000502484-717462_466208749Nucleotide bindingcAMP
HgenePDE4Dchr5:58476421chr4:57840188ENST00000502575-56462_466205220Nucleotide bindingcAMP
HgenePDE4Dchr5:58476421chr4:57840188ENST00000503258-515462_466139680Nucleotide bindingcAMP
HgenePDE4Dchr5:58476421chr4:57840188ENST00000507116-515462_466205746Nucleotide bindingcAMP
HgenePDE4Dchr5:58476421chr4:57840188ENST00000546160-616462_466208749Nucleotide bindingcAMP
TgeneNOA1chr5:58476421chr4:57840188ENST00000264230-07202_503381699DomainCP-type G


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FusionGeneSequence for PDE4D_NOA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PDE4D_ENST00000340635_chr5_58476421_-_NOA1_ENST00000264230_chr4_57840188_-_587aa
MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPPPPPSPQPQPQCPLQPPPPPPLPPPPPPPGA
ARGRYASSGATGRVRHRGYSDTERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQA
NFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITG
TTLNLLKFPICNPTPYRMFKRHQRLKKDSTQAEEDLSEQEQNQLNVLKKHGYVVGRVGRTFLYSEEQKDNIPFEFDADSLAFDMENDPVM
GTHKSTKQVELTAQDVKDAHWFYDTPGITKENCILNLLTEKEVNIVLPTQSIVPRTFVLKPGMVLFLGAIGRIDFLQGNQSAWFTVVASN
ILPVHITSLDRADALYQKHAGHTLLQIPMGGKERMAGFPPLVAEDIMLKEGLGASEAVADIKFSSAGWVSVTPNFKDRLHLRGYTPEGTV

>In-frame_PDE4D_ENST00000360047_chr5_58476421_-_NOA1_ENST00000264230_chr4_57840188_-_451aa
MMHVNNFPFRRHSWICFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPF
AQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITGTTLNLLKFPICNPTPYRMFKRHQRLKKDSTQAEEDLSEQEQNQLNV
LKKHGYVVGRVGRTFLYSEEQKDNIPFEFDADSLAFDMENDPVMGTHKSTKQVELTAQDVKDAHWFYDTPGITKENCILNLLTEKEVNIV
LPTQSIVPRTFVLKPGMVLFLGAIGRIDFLQGNQSAWFTVVASNILPVHITSLDRADALYQKHAGHTLLQIPMGGKERMAGFPPLVAEDI
MLKEGLGASEAVADIKFSSAGWVSVTPNFKDRLHLRGYTPEGTVLTVRPPLLPYIVNIKGQRIKKSVAYKTKKPPSLMYNVRKKKGKINV

>In-frame_PDE4D_ENST00000507116_chr5_58476421_-_NOA1_ENST00000264230_chr4_57840188_-_523aa
MAQQTSPDTLTVPEVDNPHCPNPWLNEDLVKSLRENLLQHEKSKTARKSVSPKLSPVISPRNSPRLLRRMLLSSNIPKQRRFTVAHTCFD
VDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALT
NLQDRAPSKRSPMCNQPSINKATITGTTLNLLKFPICNPTPYRMFKRHQRLKKDSTQAEEDLSEQEQNQLNVLKKHGYVVGRVGRTFLYS
EEQKDNIPFEFDADSLAFDMENDPVMGTHKSTKQVELTAQDVKDAHWFYDTPGITKENCILNLLTEKEVNIVLPTQSIVPRTFVLKPGMV
LFLGAIGRIDFLQGNQSAWFTVVASNILPVHITSLDRADALYQKHAGHTLLQIPMGGKERMAGFPPLVAEDIMLKEGLGASEAVADIKFS

>In-frame_PDE4D_ENST00000546160_chr5_58476421_-_NOA1_ENST00000264230_chr4_57840188_-_526aa
MKRNTCDLLSRSKSASEETLHSSNEEEDPFRGMEPYLVRRLSCRNIQLPPLAFRQLEQADLKSESENIQRPTSLPLKILPLIAITSAESS
GFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFA
ALTNLQDRAPSKRSPMCNQPSINKATITGTTLNLLKFPICNPTPYRMFKRHQRLKKDSTQAEEDLSEQEQNQLNVLKKHGYVVGRVGRTF
LYSEEQKDNIPFEFDADSLAFDMENDPVMGTHKSTKQVELTAQDVKDAHWFYDTPGITKENCILNLLTEKEVNIVLPTQSIVPRTFVLKP
GMVLFLGAIGRIDFLQGNQSAWFTVVASNILPVHITSLDRADALYQKHAGHTLLQIPMGGKERMAGFPPLVAEDIMLKEGLGASEAVADI

>In-frame_PDE4D_ENST00000502575_chr5_58476421_-_NOA1_ENST00000264230_chr4_57840188_-_523aa
MAQQTSPDTLTVPEVDNPHCPNPWLNEDLVKSLRENLLQHEKSKTARKSVSPKLSPVISPRNSPRLLRRMLLSSNIPKQRRFTVAHTCFD
VDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALT
NLQDRAPSKRSPMCNQPSINKATITGTTLNLLKFPICNPTPYRMFKRHQRLKKDSTQAEEDLSEQEQNQLNVLKKHGYVVGRVGRTFLYS
EEQKDNIPFEFDADSLAFDMENDPVMGTHKSTKQVELTAQDVKDAHWFYDTPGITKENCILNLLTEKEVNIVLPTQSIVPRTFVLKPGMV
LFLGAIGRIDFLQGNQSAWFTVVASNILPVHITSLDRADALYQKHAGHTLLQIPMGGKERMAGFPPLVAEDIMLKEGLGASEAVADIKFS

>In-frame_PDE4D_ENST00000503258_chr5_58476421_-_NOA1_ENST00000264230_chr4_57840188_-_457aa
MSIIMKPRSRSTSSLRTAEAVCFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDD
LIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITGTTLNLLKFPICNPTPYRMFKRHQRLKKDSTQAEEDLSEQE
QNQLNVLKKHGYVVGRVGRTFLYSEEQKDNIPFEFDADSLAFDMENDPVMGTHKSTKQVELTAQDVKDAHWFYDTPGITKENCILNLLTE
KEVNIVLPTQSIVPRTFVLKPGMVLFLGAIGRIDFLQGNQSAWFTVVASNILPVHITSLDRADALYQKHAGHTLLQIPMGGKERMAGFPP
LVAEDIMLKEGLGASEAVADIKFSSAGWVSVTPNFKDRLHLRGYTPEGTVLTVRPPLLPYIVNIKGQRIKKSVAYKTKKPPSLMYNVRKK

>In-frame_PDE4D_ENST00000405755_chr5_58476421_-_NOA1_ENST00000264230_chr4_57840188_-_465aa
MAFVWDPLGATVPGPSTRAKSRLRFSKSYSFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSI
ASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITGTTLNLLKFPICNPTPYRMFKRHQRLKKDSTQA
EEDLSEQEQNQLNVLKKHGYVVGRVGRTFLYSEEQKDNIPFEFDADSLAFDMENDPVMGTHKSTKQVELTAQDVKDAHWFYDTPGITKEN
CILNLLTEKEVNIVLPTQSIVPRTFVLKPGMVLFLGAIGRIDFLQGNQSAWFTVVASNILPVHITSLDRADALYQKHAGHTLLQIPMGGK
ERMAGFPPLVAEDIMLKEGLGASEAVADIKFSSAGWVSVTPNFKDRLHLRGYTPEGTVLTVRPPLLPYIVNIKGQRIKKSVAYKTKKPPS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PDE4D_ENST00000340635_chr5_58476421_-_NOA1_ENST00000264230_chr4_57840188_-_1761nt
ATGGAGGCAGAGGGCAGCAGCGCGCCGGCCCGGGCGGGCAGCGGAGAGGGCAGCGACAGCGCCGGCGGGGCCACGCTCAAAGCCCCCAAG
CATCTCTGGAGGCACGAGCAGCACCACCAGTACCCGCTCCGGCAGCCCCAGTTCCGCCTCCTGCATCCCCATCACCACCTGCCCCCGCCG
CCGCCACCCTCGCCCCAGCCCCAGCCCCAGTGTCCGCTACAGCCGCCGCCGCCGCCCCCCCTGCCGCCGCCCCCGCCGCCGCCCGGGGCT
GCCCGCGGCCGCTACGCCTCGAGCGGGGCCACCGGCCGCGTCCGGCATCGCGGCTACTCGGACACCGAGCGCTACCTGTACTGTCGCGCC
ATGGACCGCACCTCCTACGCGGTGGAGACCGGCCACCGGCCCGGCCTGAAGAAATCCAGGATGTCCTGGCCCTCCTCGTTCCAGGGACTC
AGGCGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCA
AATTTTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCC
TCCATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTT
GCTGCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGGT
ACTACATTAAACCTTCTGAAGTTTCCTATTTGCAACCCAACTCCTTACAGAATGTTTAAAAGGCATCAAAGACTTAAAAAAGATTCAACT
CAAGCTGAAGAAGATCTTAGTGAGCAAGAACAAAATCAGCTTAATGTCCTCAAAAAGCATGGTTATGTCGTAGGAAGAGTTGGAAGGACA
TTCTTGTATTCAGAAGAACAGAAGGATAACATTCCCTTTGAGTTTGATGCTGATTCACTTGCCTTTGACATGGAAAATGACCCTGTTATG
GGTACACACAAATCCACCAAACAAGTAGAATTGACTGCACAAGATGTGAAAGATGCCCACTGGTTTTATGACACCCCTGGAATTACAAAA
GAAAATTGTATTTTAAATCTTCTAACAGAAAAAGAAGTAAATATTGTTTTGCCAACACAGTCCATTGTTCCAAGAACTTTTGTGCTTAAA
CCAGGAATGGTTCTGTTTTTGGGTGCTATAGGCCGCATAGATTTCCTGCAGGGAAATCAGTCAGCTTGGTTTACAGTCGTGGCTTCCAAC
ATCCTCCCTGTGCATATCACCTCCTTGGACAGGGCAGACGCTCTGTATCAGAAGCATGCAGGTCATACGTTACTCCAGATTCCAATGGGT
GGAAAAGAACGAATGGCAGGATTTCCTCCTCTTGTTGCTGAAGACATTATGTTAAAAGAAGGACTGGGGGCATCTGAAGCAGTGGCCGAC
ATCAAGTTTTCCTCTGCAGGTTGGGTTTCAGTAACACCTAATTTTAAGGACAGACTGCATCTCCGAGGCTATACACCTGAAGGAACAGTT
TTGACCGTCCGGCCCCCTCTCTTGCCATATATTGTTAACATCAAAGGACAGCGCATCAAGAAAAGTGTGGCCTATAAAACCAAGAAGCCT

>In-frame_PDE4D_ENST00000360047_chr5_58476421_-_NOA1_ENST00000264230_chr4_57840188_-_1353nt
ATGATGCACGTGAATAATTTTCCCTTTAGAAGGCATTCCTGGATATGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTG
GATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGAC
AGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTT
GCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCC
ATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGGTACTACATTAAACCTTCTGAAGTTTCCTATTTGCAACCCAACTCCTTAC
AGAATGTTTAAAAGGCATCAAAGACTTAAAAAAGATTCAACTCAAGCTGAAGAAGATCTTAGTGAGCAAGAACAAAATCAGCTTAATGTC
CTCAAAAAGCATGGTTATGTCGTAGGAAGAGTTGGAAGGACATTCTTGTATTCAGAAGAACAGAAGGATAACATTCCCTTTGAGTTTGAT
GCTGATTCACTTGCCTTTGACATGGAAAATGACCCTGTTATGGGTACACACAAATCCACCAAACAAGTAGAATTGACTGCACAAGATGTG
AAAGATGCCCACTGGTTTTATGACACCCCTGGAATTACAAAAGAAAATTGTATTTTAAATCTTCTAACAGAAAAAGAAGTAAATATTGTT
TTGCCAACACAGTCCATTGTTCCAAGAACTTTTGTGCTTAAACCAGGAATGGTTCTGTTTTTGGGTGCTATAGGCCGCATAGATTTCCTG
CAGGGAAATCAGTCAGCTTGGTTTACAGTCGTGGCTTCCAACATCCTCCCTGTGCATATCACCTCCTTGGACAGGGCAGACGCTCTGTAT
CAGAAGCATGCAGGTCATACGTTACTCCAGATTCCAATGGGTGGAAAAGAACGAATGGCAGGATTTCCTCCTCTTGTTGCTGAAGACATT
ATGTTAAAAGAAGGACTGGGGGCATCTGAAGCAGTGGCCGACATCAAGTTTTCCTCTGCAGGTTGGGTTTCAGTAACACCTAATTTTAAG
GACAGACTGCATCTCCGAGGCTATACACCTGAAGGAACAGTTTTGACCGTCCGGCCCCCTCTCTTGCCATATATTGTTAACATCAAAGGA
CAGCGCATCAAGAAAAGTGTGGCCTATAAAACCAAGAAGCCTCCTTCCCTTATGTACAACGTGAGGAAGAAGAAAGGAAAGATAAATGTA

>In-frame_PDE4D_ENST00000507116_chr5_58476421_-_NOA1_ENST00000264230_chr4_57840188_-_1569nt
ATGGCTCAGCAGACAAGCCCGGACACTTTAACAGTACCTGAAGTGGATAATCCGCATTGTCCAAACCCGTGGCTGAACGAAGACCTTGTG
AAATCCTTGCGAGAAAACCTGTTGCAGCATGAGAAGTCCAAGACAGCGAGGAAATCGGTTTCTCCCAAGCTCTCTCCAGTGATCTCTCCG
AGAAATTCCCCCAGGCTTCTGCGCAGAATGCTTCTCAGCAGCAACATCCCCAAACAGCGGCGTTTCACGGTGGCACATACATGTTTTGAT
GTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCCAC
AGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGT
GATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCATTAACT
AATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGGTACTACATTAAAC
CTTCTGAAGTTTCCTATTTGCAACCCAACTCCTTACAGAATGTTTAAAAGGCATCAAAGACTTAAAAAAGATTCAACTCAAGCTGAAGAA
GATCTTAGTGAGCAAGAACAAAATCAGCTTAATGTCCTCAAAAAGCATGGTTATGTCGTAGGAAGAGTTGGAAGGACATTCTTGTATTCA
GAAGAACAGAAGGATAACATTCCCTTTGAGTTTGATGCTGATTCACTTGCCTTTGACATGGAAAATGACCCTGTTATGGGTACACACAAA
TCCACCAAACAAGTAGAATTGACTGCACAAGATGTGAAAGATGCCCACTGGTTTTATGACACCCCTGGAATTACAAAAGAAAATTGTATT
TTAAATCTTCTAACAGAAAAAGAAGTAAATATTGTTTTGCCAACACAGTCCATTGTTCCAAGAACTTTTGTGCTTAAACCAGGAATGGTT
CTGTTTTTGGGTGCTATAGGCCGCATAGATTTCCTGCAGGGAAATCAGTCAGCTTGGTTTACAGTCGTGGCTTCCAACATCCTCCCTGTG
CATATCACCTCCTTGGACAGGGCAGACGCTCTGTATCAGAAGCATGCAGGTCATACGTTACTCCAGATTCCAATGGGTGGAAAAGAACGA
ATGGCAGGATTTCCTCCTCTTGTTGCTGAAGACATTATGTTAAAAGAAGGACTGGGGGCATCTGAAGCAGTGGCCGACATCAAGTTTTCC
TCTGCAGGTTGGGTTTCAGTAACACCTAATTTTAAGGACAGACTGCATCTCCGAGGCTATACACCTGAAGGAACAGTTTTGACCGTCCGG
CCCCCTCTCTTGCCATATATTGTTAACATCAAAGGACAGCGCATCAAGAAAAGTGTGGCCTATAAAACCAAGAAGCCTCCTTCCCTTATG

>In-frame_PDE4D_ENST00000546160_chr5_58476421_-_NOA1_ENST00000264230_chr4_57840188_-_1578nt
ATGAAAAGAAATACCTGTGATTTGCTTTCTCGGAGCAAAAGTGCCTCTGAGGAAACACTACATTCCAGTAATGAAGAGGAAGACCCTTTC
CGCGGAATGGAACCCTATCTTGTCCGGAGACTTTCATGTCGCAATATTCAGCTTCCCCCTCTCGCCTTCAGACAGTTGGAACAAGCTGAC
TTGAAAAGTGAATCAGAGAACATTCAACGACCAACCAGCCTCCCCCTGAAGATTCTGCCGCTGATTGCTATCACTTCTGCAGAATCCAGT
GGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAAT
TTTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCC
ATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCT
GCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGGTACT
ACATTAAACCTTCTGAAGTTTCCTATTTGCAACCCAACTCCTTACAGAATGTTTAAAAGGCATCAAAGACTTAAAAAAGATTCAACTCAA
GCTGAAGAAGATCTTAGTGAGCAAGAACAAAATCAGCTTAATGTCCTCAAAAAGCATGGTTATGTCGTAGGAAGAGTTGGAAGGACATTC
TTGTATTCAGAAGAACAGAAGGATAACATTCCCTTTGAGTTTGATGCTGATTCACTTGCCTTTGACATGGAAAATGACCCTGTTATGGGT
ACACACAAATCCACCAAACAAGTAGAATTGACTGCACAAGATGTGAAAGATGCCCACTGGTTTTATGACACCCCTGGAATTACAAAAGAA
AATTGTATTTTAAATCTTCTAACAGAAAAAGAAGTAAATATTGTTTTGCCAACACAGTCCATTGTTCCAAGAACTTTTGTGCTTAAACCA
GGAATGGTTCTGTTTTTGGGTGCTATAGGCCGCATAGATTTCCTGCAGGGAAATCAGTCAGCTTGGTTTACAGTCGTGGCTTCCAACATC
CTCCCTGTGCATATCACCTCCTTGGACAGGGCAGACGCTCTGTATCAGAAGCATGCAGGTCATACGTTACTCCAGATTCCAATGGGTGGA
AAAGAACGAATGGCAGGATTTCCTCCTCTTGTTGCTGAAGACATTATGTTAAAAGAAGGACTGGGGGCATCTGAAGCAGTGGCCGACATC
AAGTTTTCCTCTGCAGGTTGGGTTTCAGTAACACCTAATTTTAAGGACAGACTGCATCTCCGAGGCTATACACCTGAAGGAACAGTTTTG
ACCGTCCGGCCCCCTCTCTTGCCATATATTGTTAACATCAAAGGACAGCGCATCAAGAAAAGTGTGGCCTATAAAACCAAGAAGCCTCCT

>In-frame_PDE4D_ENST00000502575_chr5_58476421_-_NOA1_ENST00000264230_chr4_57840188_-_1569nt
ATGGCTCAGCAGACAAGCCCGGACACTTTAACAGTACCTGAAGTGGATAATCCGCATTGTCCAAACCCGTGGCTGAACGAAGACCTTGTG
AAATCCTTGCGAGAAAACCTGTTGCAGCATGAGAAGTCCAAGACAGCGAGGAAATCGGTTTCTCCCAAGCTCTCTCCAGTGATCTCTCCG
AGAAATTCCCCCAGGCTTCTGCGCAGAATGCTTCTCAGCAGCAACATCCCCAAACAGCGGCGTTTCACGGTGGCACATACATGTTTTGAT
GTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCCAC
AGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGT
GATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCATTAACT
AATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGGTACTACATTAAAC
CTTCTGAAGTTTCCTATTTGCAACCCAACTCCTTACAGAATGTTTAAAAGGCATCAAAGACTTAAAAAAGATTCAACTCAAGCTGAAGAA
GATCTTAGTGAGCAAGAACAAAATCAGCTTAATGTCCTCAAAAAGCATGGTTATGTCGTAGGAAGAGTTGGAAGGACATTCTTGTATTCA
GAAGAACAGAAGGATAACATTCCCTTTGAGTTTGATGCTGATTCACTTGCCTTTGACATGGAAAATGACCCTGTTATGGGTACACACAAA
TCCACCAAACAAGTAGAATTGACTGCACAAGATGTGAAAGATGCCCACTGGTTTTATGACACCCCTGGAATTACAAAAGAAAATTGTATT
TTAAATCTTCTAACAGAAAAAGAAGTAAATATTGTTTTGCCAACACAGTCCATTGTTCCAAGAACTTTTGTGCTTAAACCAGGAATGGTT
CTGTTTTTGGGTGCTATAGGCCGCATAGATTTCCTGCAGGGAAATCAGTCAGCTTGGTTTACAGTCGTGGCTTCCAACATCCTCCCTGTG
CATATCACCTCCTTGGACAGGGCAGACGCTCTGTATCAGAAGCATGCAGGTCATACGTTACTCCAGATTCCAATGGGTGGAAAAGAACGA
ATGGCAGGATTTCCTCCTCTTGTTGCTGAAGACATTATGTTAAAAGAAGGACTGGGGGCATCTGAAGCAGTGGCCGACATCAAGTTTTCC
TCTGCAGGTTGGGTTTCAGTAACACCTAATTTTAAGGACAGACTGCATCTCCGAGGCTATACACCTGAAGGAACAGTTTTGACCGTCCGG
CCCCCTCTCTTGCCATATATTGTTAACATCAAAGGACAGCGCATCAAGAAAAGTGTGGCCTATAAAACCAAGAAGCCTCCTTCCCTTATG

>In-frame_PDE4D_ENST00000503258_chr5_58476421_-_NOA1_ENST00000264230_chr4_57840188_-_1371nt
ATGAGCATTATTATGAAGCCAAGATCCCGATCTACAAGTTCCCTAAGGACTGCAGAGGCAGTTTGTTTTGATGTGGACAATGGCACATCT
GCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCCACAGTCAACGACGGGAGTCC
TTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGAC
TTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCA
CCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGGTACTACATTAAACCTTCTGAAGTTTCCTATT
TGCAACCCAACTCCTTACAGAATGTTTAAAAGGCATCAAAGACTTAAAAAAGATTCAACTCAAGCTGAAGAAGATCTTAGTGAGCAAGAA
CAAAATCAGCTTAATGTCCTCAAAAAGCATGGTTATGTCGTAGGAAGAGTTGGAAGGACATTCTTGTATTCAGAAGAACAGAAGGATAAC
ATTCCCTTTGAGTTTGATGCTGATTCACTTGCCTTTGACATGGAAAATGACCCTGTTATGGGTACACACAAATCCACCAAACAAGTAGAA
TTGACTGCACAAGATGTGAAAGATGCCCACTGGTTTTATGACACCCCTGGAATTACAAAAGAAAATTGTATTTTAAATCTTCTAACAGAA
AAAGAAGTAAATATTGTTTTGCCAACACAGTCCATTGTTCCAAGAACTTTTGTGCTTAAACCAGGAATGGTTCTGTTTTTGGGTGCTATA
GGCCGCATAGATTTCCTGCAGGGAAATCAGTCAGCTTGGTTTACAGTCGTGGCTTCCAACATCCTCCCTGTGCATATCACCTCCTTGGAC
AGGGCAGACGCTCTGTATCAGAAGCATGCAGGTCATACGTTACTCCAGATTCCAATGGGTGGAAAAGAACGAATGGCAGGATTTCCTCCT
CTTGTTGCTGAAGACATTATGTTAAAAGAAGGACTGGGGGCATCTGAAGCAGTGGCCGACATCAAGTTTTCCTCTGCAGGTTGGGTTTCA
GTAACACCTAATTTTAAGGACAGACTGCATCTCCGAGGCTATACACCTGAAGGAACAGTTTTGACCGTCCGGCCCCCTCTCTTGCCATAT
ATTGTTAACATCAAAGGACAGCGCATCAAGAAAAGTGTGGCCTATAAAACCAAGAAGCCTCCTTCCCTTATGTACAACGTGAGGAAGAAG

>In-frame_PDE4D_ENST00000405755_chr5_58476421_-_NOA1_ENST00000264230_chr4_57840188_-_1395nt
ATGGCTTTTGTTTGGGATCCTCTGGGAGCCACGGTGCCAGGACCATCTACAAGAGCCAAATCAAGATTGCGTTTCTCAAAGTCCTACAGT
TTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTT
GTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATT
GCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCA
TTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGGTACTACA
TTAAACCTTCTGAAGTTTCCTATTTGCAACCCAACTCCTTACAGAATGTTTAAAAGGCATCAAAGACTTAAAAAAGATTCAACTCAAGCT
GAAGAAGATCTTAGTGAGCAAGAACAAAATCAGCTTAATGTCCTCAAAAAGCATGGTTATGTCGTAGGAAGAGTTGGAAGGACATTCTTG
TATTCAGAAGAACAGAAGGATAACATTCCCTTTGAGTTTGATGCTGATTCACTTGCCTTTGACATGGAAAATGACCCTGTTATGGGTACA
CACAAATCCACCAAACAAGTAGAATTGACTGCACAAGATGTGAAAGATGCCCACTGGTTTTATGACACCCCTGGAATTACAAAAGAAAAT
TGTATTTTAAATCTTCTAACAGAAAAAGAAGTAAATATTGTTTTGCCAACACAGTCCATTGTTCCAAGAACTTTTGTGCTTAAACCAGGA
ATGGTTCTGTTTTTGGGTGCTATAGGCCGCATAGATTTCCTGCAGGGAAATCAGTCAGCTTGGTTTACAGTCGTGGCTTCCAACATCCTC
CCTGTGCATATCACCTCCTTGGACAGGGCAGACGCTCTGTATCAGAAGCATGCAGGTCATACGTTACTCCAGATTCCAATGGGTGGAAAA
GAACGAATGGCAGGATTTCCTCCTCTTGTTGCTGAAGACATTATGTTAAAAGAAGGACTGGGGGCATCTGAAGCAGTGGCCGACATCAAG
TTTTCCTCTGCAGGTTGGGTTTCAGTAACACCTAATTTTAAGGACAGACTGCATCTCCGAGGCTATACACCTGAAGGAACAGTTTTGACC
GTCCGGCCCCCTCTCTTGCCATATATTGTTAACATCAAAGGACAGCGCATCAAGAAAAGTGTGGCCTATAAAACCAAGAAGCCTCCTTCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_PDE4D_ENST00000340635_chr5_58476421_-_NOA1_ENST00000264230_chr4_57840188_-_2017nt
GGGCCCCCTCTCGGTAGCCCTGAGGCTCTGGCGCCTTCAAGTGAGAAGCTAAGCACCAGCCTCTGCTGGGCTGCAGAAGCGGCGGCGGCG
GCAGCAGCAGCAGCAGCATCAGGAAGGCGCTCGGGCCAGCGCGGTGAACCCGGGCTGGGCAGCAGGTCGCGGAGCCGCGAGCCAGGATGG
AGGCAGAGGGCAGCAGCGCGCCGGCCCGGGCGGGCAGCGGAGAGGGCAGCGACAGCGCCGGCGGGGCCACGCTCAAAGCCCCCAAGCATC
TCTGGAGGCACGAGCAGCACCACCAGTACCCGCTCCGGCAGCCCCAGTTCCGCCTCCTGCATCCCCATCACCACCTGCCCCCGCCGCCGC
CACCCTCGCCCCAGCCCCAGCCCCAGTGTCCGCTACAGCCGCCGCCGCCGCCCCCCCTGCCGCCGCCCCCGCCGCCGCCCGGGGCTGCCC
GCGGCCGCTACGCCTCGAGCGGGGCCACCGGCCGCGTCCGGCATCGCGGCTACTCGGACACCGAGCGCTACCTGTACTGTCGCGCCATGG
ACCGCACCTCCTACGCGGTGGAGACCGGCCACCGGCCCGGCCTGAAGAAATCCAGGATGTCCTGGCCCTCCTCGTTCCAGGGACTCAGGC
GTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATT
TTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCA
TTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTG
CATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGGTACTA
CATTAAACCTTCTGAAGTTTCCTATTTGCAACCCAACTCCTTACAGAATGTTTAAAAGGCATCAAAGACTTAAAAAAGATTCAACTCAAG
CTGAAGAAGATCTTAGTGAGCAAGAACAAAATCAGCTTAATGTCCTCAAAAAGCATGGTTATGTCGTAGGAAGAGTTGGAAGGACATTCT
TGTATTCAGAAGAACAGAAGGATAACATTCCCTTTGAGTTTGATGCTGATTCACTTGCCTTTGACATGGAAAATGACCCTGTTATGGGTA
CACACAAATCCACCAAACAAGTAGAATTGACTGCACAAGATGTGAAAGATGCCCACTGGTTTTATGACACCCCTGGAATTACAAAAGAAA
ATTGTATTTTAAATCTTCTAACAGAAAAAGAAGTAAATATTGTTTTGCCAACACAGTCCATTGTTCCAAGAACTTTTGTGCTTAAACCAG
GAATGGTTCTGTTTTTGGGTGCTATAGGCCGCATAGATTTCCTGCAGGGAAATCAGTCAGCTTGGTTTACAGTCGTGGCTTCCAACATCC
TCCCTGTGCATATCACCTCCTTGGACAGGGCAGACGCTCTGTATCAGAAGCATGCAGGTCATACGTTACTCCAGATTCCAATGGGTGGAA
AAGAACGAATGGCAGGATTTCCTCCTCTTGTTGCTGAAGACATTATGTTAAAAGAAGGACTGGGGGCATCTGAAGCAGTGGCCGACATCA
AGTTTTCCTCTGCAGGTTGGGTTTCAGTAACACCTAATTTTAAGGACAGACTGCATCTCCGAGGCTATACACCTGAAGGAACAGTTTTGA
CCGTCCGGCCCCCTCTCTTGCCATATATTGTTAACATCAAAGGACAGCGCATCAAGAAAAGTGTGGCCTATAAAACCAAGAAGCCTCCTT
CCCTTATGTACAACGTGAGGAAGAAGAAAGGAAAGATAAATGTATGAGACCGACCTTGTTCACTCCAGATATTAACTGTATTGAACACAA

>In-frame_PDE4D_ENST00000360047_chr5_58476421_-_NOA1_ENST00000264230_chr4_57840188_-_1557nt
CAATACTTGTTGCAATAATTGCCCACGATAGCTGCTCAAACAAGAGAGTTGGAATTCATCTGTAAAAATCACTACATGTAACGTAGGAGA
CAAGAAAAATATTAATGACAGAAGATCTGCGAACATGATGCACGTGAATAATTTTCCCTTTAGAAGGCATTCCTGGATATGTTTTGATGT
GGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCCACAG
TCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGA
TATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCATTAACTAA
TTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGGTACTACATTAAACCT
TCTGAAGTTTCCTATTTGCAACCCAACTCCTTACAGAATGTTTAAAAGGCATCAAAGACTTAAAAAAGATTCAACTCAAGCTGAAGAAGA
TCTTAGTGAGCAAGAACAAAATCAGCTTAATGTCCTCAAAAAGCATGGTTATGTCGTAGGAAGAGTTGGAAGGACATTCTTGTATTCAGA
AGAACAGAAGGATAACATTCCCTTTGAGTTTGATGCTGATTCACTTGCCTTTGACATGGAAAATGACCCTGTTATGGGTACACACAAATC
CACCAAACAAGTAGAATTGACTGCACAAGATGTGAAAGATGCCCACTGGTTTTATGACACCCCTGGAATTACAAAAGAAAATTGTATTTT
AAATCTTCTAACAGAAAAAGAAGTAAATATTGTTTTGCCAACACAGTCCATTGTTCCAAGAACTTTTGTGCTTAAACCAGGAATGGTTCT
GTTTTTGGGTGCTATAGGCCGCATAGATTTCCTGCAGGGAAATCAGTCAGCTTGGTTTACAGTCGTGGCTTCCAACATCCTCCCTGTGCA
TATCACCTCCTTGGACAGGGCAGACGCTCTGTATCAGAAGCATGCAGGTCATACGTTACTCCAGATTCCAATGGGTGGAAAAGAACGAAT
GGCAGGATTTCCTCCTCTTGTTGCTGAAGACATTATGTTAAAAGAAGGACTGGGGGCATCTGAAGCAGTGGCCGACATCAAGTTTTCCTC
TGCAGGTTGGGTTTCAGTAACACCTAATTTTAAGGACAGACTGCATCTCCGAGGCTATACACCTGAAGGAACAGTTTTGACCGTCCGGCC
CCCTCTCTTGCCATATATTGTTAACATCAAAGGACAGCGCATCAAGAAAAGTGTGGCCTATAAAACCAAGAAGCCTCCTTCCCTTATGTA
CAACGTGAGGAAGAAGAAAGGAAAGATAAATGTATGAGACCGACCTTGTTCACTCCAGATATTAACTGTATTGAACACAACAAAATACAT

>In-frame_PDE4D_ENST00000507116_chr5_58476421_-_NOA1_ENST00000264230_chr4_57840188_-_1785nt
AGAGAGACTGAGGCAGGCGACTGAATGCACTAACAGCAGCAGGCTCAGACCTGCTTCCCTGGACATTTCCGGGACCGTGAGCGAGGGAAC
CACGTTGCCCTGGATTCTTGCCAGCTGTACAAAGTTGACCAGGAAAATGGCTCAGCAGACAAGCCCGGACACTTTAACAGTACCTGAAGT
GGATAATCCGCATTGTCCAAACCCGTGGCTGAACGAAGACCTTGTGAAATCCTTGCGAGAAAACCTGTTGCAGCATGAGAAGTCCAAGAC
AGCGAGGAAATCGGTTTCTCCCAAGCTCTCTCCAGTGATCTCTCCGAGAAATTCCCCCAGGCTTCTGCGCAGAATGCTTCTCAGCAGCAA
CATCCCCAAACAGCGGCGTTTCACGGTGGCACATACATGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCAT
GACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTA
TGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGT
CTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAA
CCAACCATCCATCAACAAAGCCACCATAACAGGTACTACATTAAACCTTCTGAAGTTTCCTATTTGCAACCCAACTCCTTACAGAATGTT
TAAAAGGCATCAAAGACTTAAAAAAGATTCAACTCAAGCTGAAGAAGATCTTAGTGAGCAAGAACAAAATCAGCTTAATGTCCTCAAAAA
GCATGGTTATGTCGTAGGAAGAGTTGGAAGGACATTCTTGTATTCAGAAGAACAGAAGGATAACATTCCCTTTGAGTTTGATGCTGATTC
ACTTGCCTTTGACATGGAAAATGACCCTGTTATGGGTACACACAAATCCACCAAACAAGTAGAATTGACTGCACAAGATGTGAAAGATGC
CCACTGGTTTTATGACACCCCTGGAATTACAAAAGAAAATTGTATTTTAAATCTTCTAACAGAAAAAGAAGTAAATATTGTTTTGCCAAC
ACAGTCCATTGTTCCAAGAACTTTTGTGCTTAAACCAGGAATGGTTCTGTTTTTGGGTGCTATAGGCCGCATAGATTTCCTGCAGGGAAA
TCAGTCAGCTTGGTTTACAGTCGTGGCTTCCAACATCCTCCCTGTGCATATCACCTCCTTGGACAGGGCAGACGCTCTGTATCAGAAGCA
TGCAGGTCATACGTTACTCCAGATTCCAATGGGTGGAAAAGAACGAATGGCAGGATTTCCTCCTCTTGTTGCTGAAGACATTATGTTAAA
AGAAGGACTGGGGGCATCTGAAGCAGTGGCCGACATCAAGTTTTCCTCTGCAGGTTGGGTTTCAGTAACACCTAATTTTAAGGACAGACT
GCATCTCCGAGGCTATACACCTGAAGGAACAGTTTTGACCGTCCGGCCCCCTCTCTTGCCATATATTGTTAACATCAAAGGACAGCGCAT
CAAGAAAAGTGTGGCCTATAAAACCAAGAAGCCTCCTTCCCTTATGTACAACGTGAGGAAGAAGAAAGGAAAGATAAATGTATGAGACCG

>In-frame_PDE4D_ENST00000546160_chr5_58476421_-_NOA1_ENST00000264230_chr4_57840188_-_1658nt
ATGAAAAGAAATACCTGTGATTTGCTTTCTCGGAGCAAAAGTGCCTCTGAGGAAACACTACATTCCAGTAATGAAGAGGAAGACCCTTTC
CGCGGAATGGAACCCTATCTTGTCCGGAGACTTTCATGTCGCAATATTCAGCTTCCCCCTCTCGCCTTCAGACAGTTGGAACAAGCTGAC
TTGAAAAGTGAATCAGAGAACATTCAACGACCAACCAGCCTCCCCCTGAAGATTCTGCCGCTGATTGCTATCACTTCTGCAGAATCCAGT
GGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAAT
TTTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCC
ATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCT
GCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGGTACT
ACATTAAACCTTCTGAAGTTTCCTATTTGCAACCCAACTCCTTACAGAATGTTTAAAAGGCATCAAAGACTTAAAAAAGATTCAACTCAA
GCTGAAGAAGATCTTAGTGAGCAAGAACAAAATCAGCTTAATGTCCTCAAAAAGCATGGTTATGTCGTAGGAAGAGTTGGAAGGACATTC
TTGTATTCAGAAGAACAGAAGGATAACATTCCCTTTGAGTTTGATGCTGATTCACTTGCCTTTGACATGGAAAATGACCCTGTTATGGGT
ACACACAAATCCACCAAACAAGTAGAATTGACTGCACAAGATGTGAAAGATGCCCACTGGTTTTATGACACCCCTGGAATTACAAAAGAA
AATTGTATTTTAAATCTTCTAACAGAAAAAGAAGTAAATATTGTTTTGCCAACACAGTCCATTGTTCCAAGAACTTTTGTGCTTAAACCA
GGAATGGTTCTGTTTTTGGGTGCTATAGGCCGCATAGATTTCCTGCAGGGAAATCAGTCAGCTTGGTTTACAGTCGTGGCTTCCAACATC
CTCCCTGTGCATATCACCTCCTTGGACAGGGCAGACGCTCTGTATCAGAAGCATGCAGGTCATACGTTACTCCAGATTCCAATGGGTGGA
AAAGAACGAATGGCAGGATTTCCTCCTCTTGTTGCTGAAGACATTATGTTAAAAGAAGGACTGGGGGCATCTGAAGCAGTGGCCGACATC
AAGTTTTCCTCTGCAGGTTGGGTTTCAGTAACACCTAATTTTAAGGACAGACTGCATCTCCGAGGCTATACACCTGAAGGAACAGTTTTG
ACCGTCCGGCCCCCTCTCTTGCCATATATTGTTAACATCAAAGGACAGCGCATCAAGAAAAGTGTGGCCTATAAAACCAAGAAGCCTCCT
TCCCTTATGTACAACGTGAGGAAGAAGAAAGGAAAGATAAATGTATGAGACCGACCTTGTTCACTCCAGATATTAACTGTATTGAACACA

>In-frame_PDE4D_ENST00000502575_chr5_58476421_-_NOA1_ENST00000264230_chr4_57840188_-_1776nt
GAGGCAGGCGACTGAATGCACTAACAGCAGCAGGCTCAGACCTGCTTCCCTGGACATTTCCGGGACCGTGAGCGAGGGAACCACGTTGCC
CTGGATTCTTGCCAGCTGTACAAAGTTGACCAGGAAAATGGCTCAGCAGACAAGCCCGGACACTTTAACAGTACCTGAAGTGGATAATCC
GCATTGTCCAAACCCGTGGCTGAACGAAGACCTTGTGAAATCCTTGCGAGAAAACCTGTTGCAGCATGAGAAGTCCAAGACAGCGAGGAA
ATCGGTTTCTCCCAAGCTCTCTCCAGTGATCTCTCCGAGAAATTCCCCCAGGCTTCTGCGCAGAATGCTTCTCAGCAGCAACATCCCCAA
ACAGCGGCGTTTCACGGTGGCACATACATGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCC
AGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTC
TCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAG
TCTGCGAACTGTACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATC
CATCAACAAAGCCACCATAACAGGTACTACATTAAACCTTCTGAAGTTTCCTATTTGCAACCCAACTCCTTACAGAATGTTTAAAAGGCA
TCAAAGACTTAAAAAAGATTCAACTCAAGCTGAAGAAGATCTTAGTGAGCAAGAACAAAATCAGCTTAATGTCCTCAAAAAGCATGGTTA
TGTCGTAGGAAGAGTTGGAAGGACATTCTTGTATTCAGAAGAACAGAAGGATAACATTCCCTTTGAGTTTGATGCTGATTCACTTGCCTT
TGACATGGAAAATGACCCTGTTATGGGTACACACAAATCCACCAAACAAGTAGAATTGACTGCACAAGATGTGAAAGATGCCCACTGGTT
TTATGACACCCCTGGAATTACAAAAGAAAATTGTATTTTAAATCTTCTAACAGAAAAAGAAGTAAATATTGTTTTGCCAACACAGTCCAT
TGTTCCAAGAACTTTTGTGCTTAAACCAGGAATGGTTCTGTTTTTGGGTGCTATAGGCCGCATAGATTTCCTGCAGGGAAATCAGTCAGC
TTGGTTTACAGTCGTGGCTTCCAACATCCTCCCTGTGCATATCACCTCCTTGGACAGGGCAGACGCTCTGTATCAGAAGCATGCAGGTCA
TACGTTACTCCAGATTCCAATGGGTGGAAAAGAACGAATGGCAGGATTTCCTCCTCTTGTTGCTGAAGACATTATGTTAAAAGAAGGACT
GGGGGCATCTGAAGCAGTGGCCGACATCAAGTTTTCCTCTGCAGGTTGGGTTTCAGTAACACCTAATTTTAAGGACAGACTGCATCTCCG
AGGCTATACACCTGAAGGAACAGTTTTGACCGTCCGGCCCCCTCTCTTGCCATATATTGTTAACATCAAAGGACAGCGCATCAAGAAAAG
TGTGGCCTATAAAACCAAGAAGCCTCCTTCCCTTATGTACAACGTGAGGAAGAAGAAAGGAAAGATAAATGTATGAGACCGACCTTGTTC

>In-frame_PDE4D_ENST00000503258_chr5_58476421_-_NOA1_ENST00000264230_chr4_57840188_-_2168nt
TTCTCACTGCCCTGCGGTGTTTTGAACTGCCTTCTTACAGACGTCATACAGCCCTTGAGGAATAGTTTCTGCCTGGTGAGATTGAATGAT
AGTTCTCATTCACAAAACCCTGGATTCTAAGCAGGGACACACAGAAATTACTTTCGCAGGTAAATCAGCCCACCCAGCCAAAGTGTGGAG
AGATTTGTTCCTTGGCTGACTTCTTTGCTCCACGGAGAGGAGTGTTTTCCTGTGCTTGCCCTGAAATGGAACTTCCTTGACAGCTCTCCC
GTGTTACAGTACCTCCCGGTCATTTTCTTTTTCTCTCTCTCTACCTGCGCTCTTCGAGTGTCAGAAACCTTTAAAGCTGTTACTATGGAA
TTGCAAAAAAGAGATCAAGTGACTCTTTCACTATGCTGGTTTCCCTTGTGACCCAGATGAAGAATCAATTCAGAATTCAGTTCCTCCCTT
GGCATTGCAAGACACAGAAGAAACTGTCACTTCCTAACAGCCTAGTACTGGAGTAAATTCAGTATGAAGGAAGAAAGCGCTCCTGCGTGT
TAGAACCTTGCCCATGAGCTGGACCGAGGACAGGAGATGGACTCCAGGAAAATTGGATTTCTTCAAGCAGCCTCCCTTGGAAATGGAATA
TCTTTAAAATCTTCTTTGCAGAAAGACAGTTAGAATGTATTAATCAGAATAGTTGAAGACTTATTTTCCTTTTTATTTTTTTTCAAAATG
AGCATTATTATGAAGCCAAGATCCCGATCTACAAGTTCCCTAAGGACTGCAGAGGCAGTTTGTTTTGATGTGGACAATGGCACATCTGCG
GGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCCACAGTCAACGACGGGAGTCCTTC
CTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGACTTG
ATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCT
AGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGGTACTACATTAAACCTTCTGAAGTTTCCTATTTGC
AACCCAACTCCTTACAGAATGTTTAAAAGGCATCAAAGACTTAAAAAAGATTCAACTCAAGCTGAAGAAGATCTTAGTGAGCAAGAACAA
AATCAGCTTAATGTCCTCAAAAAGCATGGTTATGTCGTAGGAAGAGTTGGAAGGACATTCTTGTATTCAGAAGAACAGAAGGATAACATT
CCCTTTGAGTTTGATGCTGATTCACTTGCCTTTGACATGGAAAATGACCCTGTTATGGGTACACACAAATCCACCAAACAAGTAGAATTG
ACTGCACAAGATGTGAAAGATGCCCACTGGTTTTATGACACCCCTGGAATTACAAAAGAAAATTGTATTTTAAATCTTCTAACAGAAAAA
GAAGTAAATATTGTTTTGCCAACACAGTCCATTGTTCCAAGAACTTTTGTGCTTAAACCAGGAATGGTTCTGTTTTTGGGTGCTATAGGC
CGCATAGATTTCCTGCAGGGAAATCAGTCAGCTTGGTTTACAGTCGTGGCTTCCAACATCCTCCCTGTGCATATCACCTCCTTGGACAGG
GCAGACGCTCTGTATCAGAAGCATGCAGGTCATACGTTACTCCAGATTCCAATGGGTGGAAAAGAACGAATGGCAGGATTTCCTCCTCTT
GTTGCTGAAGACATTATGTTAAAAGAAGGACTGGGGGCATCTGAAGCAGTGGCCGACATCAAGTTTTCCTCTGCAGGTTGGGTTTCAGTA
ACACCTAATTTTAAGGACAGACTGCATCTCCGAGGCTATACACCTGAAGGAACAGTTTTGACCGTCCGGCCCCCTCTCTTGCCATATATT
GTTAACATCAAAGGACAGCGCATCAAGAAAAGTGTGGCCTATAAAACCAAGAAGCCTCCTTCCCTTATGTACAACGTGAGGAAGAAGAAA
GGAAAGATAAATGTATGAGACCGACCTTGTTCACTCCAGATATTAACTGTATTGAACACAACAAAATACATTGAATTTGTATTAAACATA

>In-frame_PDE4D_ENST00000405755_chr5_58476421_-_NOA1_ENST00000264230_chr4_57840188_-_1604nt
ACTGCACAAAGGAAATGCCCTCACTCAGCTACAAGTGCCTCCTGCTCCGTGCGGGGCCTCAGGGCCCCAGAGCCCCGCACCAGCTCTGAC
TTCTCGTGGTTCCTGGGGATCTTGGCATCGTCCTTAAAAATGGCTTTTGTTTGGGATCCTCTGGGAGCCACGGTGCCAGGACCATCTACA
AGAGCCAAATCAAGATTGCGTTTCTCAAAGTCCTACAGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATG
ACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTAT
GACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTC
TTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAAC
CAACCATCCATCAACAAAGCCACCATAACAGGTACTACATTAAACCTTCTGAAGTTTCCTATTTGCAACCCAACTCCTTACAGAATGTTT
AAAAGGCATCAAAGACTTAAAAAAGATTCAACTCAAGCTGAAGAAGATCTTAGTGAGCAAGAACAAAATCAGCTTAATGTCCTCAAAAAG
CATGGTTATGTCGTAGGAAGAGTTGGAAGGACATTCTTGTATTCAGAAGAACAGAAGGATAACATTCCCTTTGAGTTTGATGCTGATTCA
CTTGCCTTTGACATGGAAAATGACCCTGTTATGGGTACACACAAATCCACCAAACAAGTAGAATTGACTGCACAAGATGTGAAAGATGCC
CACTGGTTTTATGACACCCCTGGAATTACAAAAGAAAATTGTATTTTAAATCTTCTAACAGAAAAAGAAGTAAATATTGTTTTGCCAACA
CAGTCCATTGTTCCAAGAACTTTTGTGCTTAAACCAGGAATGGTTCTGTTTTTGGGTGCTATAGGCCGCATAGATTTCCTGCAGGGAAAT
CAGTCAGCTTGGTTTACAGTCGTGGCTTCCAACATCCTCCCTGTGCATATCACCTCCTTGGACAGGGCAGACGCTCTGTATCAGAAGCAT
GCAGGTCATACGTTACTCCAGATTCCAATGGGTGGAAAAGAACGAATGGCAGGATTTCCTCCTCTTGTTGCTGAAGACATTATGTTAAAA
GAAGGACTGGGGGCATCTGAAGCAGTGGCCGACATCAAGTTTTCCTCTGCAGGTTGGGTTTCAGTAACACCTAATTTTAAGGACAGACTG
CATCTCCGAGGCTATACACCTGAAGGAACAGTTTTGACCGTCCGGCCCCCTCTCTTGCCATATATTGTTAACATCAAAGGACAGCGCATC
AAGAAAAGTGTGGCCTATAAAACCAAGAAGCCTCCTTCCCTTATGTACAACGTGAGGAAGAAGAAAGGAAAGATAAATGTATGAGACCGA


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FusionGenePPI for PDE4D_NOA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PDE4DPDE4DIP, PDE4D, AKAP6, GNB2L1, ARRB1, MDM2, ITSN1, ARRB2, PPP3CA, PPP3CB, PPP3R1, GSK3B, CSNK1A1, CDK2, PAFAH1B1, PRKACA, APP, LYN, SRC, FYN, ABL1, GRB2, PIAS4, MAPK1, BIN1, HDGFRP2, ZBTB1, MAGEA6, TRAF1, COIL, GOLGA8EP, GOLGA8F, ZDHHC17, SPTAN1, PIK3R1, TRIM23, ITPKB, PFKFB2, AKAP12, ATOH1, DUSP13, PDE4B, TRIM25NOA1ARF1, COL9A2, HSPA8, MPP3, ICT1, GRB10, BOK, LIN28A, ZNF346, TRA2A, TRMT10B, MRPS11, MRPS27, MRPS34, AURKAIP1, FGF8, MRPS15, KLHL22, CCDC59


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PDE4D_NOA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePDE4DQ08499DB00651DyphyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Dsmall moleculeapproved
HgenePDE4DQ08499DB01656RoflumilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Dsmall moleculeapproved
HgenePDE4DQ08499DB01088IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Dsmall moleculeapproved|investigational
HgenePDE4DQ08499DB05266IbudilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Dsmall moleculeapproved|investigational
HgenePDE4DQ08499DB05676ApremilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Dsmall moleculeapproved|investigational

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RelatedDiseases for PDE4D_NOA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePDE4DC3553250ACRODYSOSTOSIS 2 WITH OR WITHOUT HORMONE RESISTANCE4UNIPROT
HgenePDE4DC0011581Depressive disorder3PSYGENET
HgenePDE4DC0004096Asthma2CTD_human
HgenePDE4DC0011570Mental Depression2PSYGENET
HgenePDE4DC0033578Prostatic Neoplasms1CTD_human
HgenePDE4DC0036341Schizophrenia1PSYGENET
HgenePDE4DC0236733Amphetamine-Related Disorders1CTD_human