![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 26402 |
FusionGeneSummary for PDE4D_ERCC8 |
![]() |
Fusion gene information | Fusion gene name: PDE4D_ERCC8 | Fusion gene ID: 26402 | Hgene | Tgene | Gene symbol | PDE4D | ERCC8 | Gene ID | 5144 | 1161 |
Gene name | phosphodiesterase 4D | ERCC excision repair 8, CSA ubiquitin ligase complex subunit | |
Synonyms | ACRDYS2|DPDE3|HSPDE4D|PDE43|PDE4DN2|STRK1 | CKN1|CSA|UVSS2 | |
Cytomap | 5q11.2-q12.1 | 5q12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | cAMP-specific 3',5'-cyclic phosphodiesterase 4DcAMP-specific phosphodiesterase PDE4D6phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)testicular tissue protein Li 136 | DNA excision repair protein ERCC-8Cockayne syndrome WD-repeat protein CSAcockayne syndrome WD repeat protein CSAexcision repair cross-complementation group 8excision repair cross-complementing rodent repair deficiency, complementation group 8 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q08499 | Q13216 | |
Ensembl transtripts involved in fusion gene | ENST00000340635, ENST00000360047, ENST00000507116, ENST00000502484, ENST00000546160, ENST00000502575, ENST00000358923, ENST00000503258, ENST00000405755, ENST00000317118, ENST00000503947, | ENST00000426742, ENST00000265038, ENST00000462279, ENST00000543101, | |
Fusion gene scores | * DoF score | 23 X 14 X 10=3220 | 4 X 4 X 5=80 |
# samples | 34 | 6 | |
** MAII score | log2(34/3220*10)=-3.24345403686428 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/80*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PDE4D [Title/Abstract] AND ERCC8 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | DDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PDE4D | GO:0006198 | cAMP catabolic process | 9371713|17404263 |
Tgene | ERCC8 | GO:0000209 | protein polyubiquitination | 12732143 |
Tgene | ERCC8 | GO:0006283 | transcription-coupled nucleotide-excision repair | 12732143 |
Tgene | ERCC8 | GO:0006974 | cellular response to DNA damage stimulus | 11782547 |
Tgene | ERCC8 | GO:0006979 | response to oxidative stress | 11782547 |
Tgene | ERCC8 | GO:0009411 | response to UV | 12732143 |
Tgene | ERCC8 | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 16751180 |
Tgene | ERCC8 | GO:0051865 | protein autoubiquitination | 12732143 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-HN-A2NL-01A | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
TCGA | RV | PRAD | TCGA-ZG-A8QY-01A | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
TCGA | RV | STAD | TCGA-VQ-A92D-01A | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000340635 | ENST00000426742 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-3CDS | ENST00000340635 | ENST00000265038 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-5UTR | ENST00000340635 | ENST00000462279 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-5UTR | ENST00000340635 | ENST00000543101 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-3CDS | ENST00000360047 | ENST00000426742 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-3CDS | ENST00000360047 | ENST00000265038 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-5UTR | ENST00000360047 | ENST00000462279 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-5UTR | ENST00000360047 | ENST00000543101 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-3CDS | ENST00000507116 | ENST00000426742 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-3CDS | ENST00000507116 | ENST00000265038 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-5UTR | ENST00000507116 | ENST00000462279 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-5UTR | ENST00000507116 | ENST00000543101 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
5UTR-3CDS | ENST00000502484 | ENST00000426742 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
5UTR-3CDS | ENST00000502484 | ENST00000265038 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
5UTR-5UTR | ENST00000502484 | ENST00000462279 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
5UTR-5UTR | ENST00000502484 | ENST00000543101 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-3CDS | ENST00000546160 | ENST00000426742 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-3CDS | ENST00000546160 | ENST00000265038 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-5UTR | ENST00000546160 | ENST00000462279 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-5UTR | ENST00000546160 | ENST00000543101 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-3CDS | ENST00000502575 | ENST00000426742 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-3CDS | ENST00000502575 | ENST00000265038 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-5UTR | ENST00000502575 | ENST00000462279 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-5UTR | ENST00000502575 | ENST00000543101 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-3CDS | ENST00000358923 | ENST00000426742 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-3CDS | ENST00000358923 | ENST00000265038 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-5UTR | ENST00000358923 | ENST00000462279 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-5UTR | ENST00000358923 | ENST00000543101 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-3CDS | ENST00000503258 | ENST00000426742 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-3CDS | ENST00000503258 | ENST00000265038 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-5UTR | ENST00000503258 | ENST00000462279 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-5UTR | ENST00000503258 | ENST00000543101 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-3CDS | ENST00000405755 | ENST00000426742 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-3CDS | ENST00000405755 | ENST00000265038 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-5UTR | ENST00000405755 | ENST00000462279 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-5UTR | ENST00000405755 | ENST00000543101 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-3CDS | ENST00000317118 | ENST00000426742 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-3CDS | ENST00000317118 | ENST00000265038 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-5UTR | ENST00000317118 | ENST00000462279 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-5UTR | ENST00000317118 | ENST00000543101 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-3CDS | ENST00000503947 | ENST00000426742 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-3CDS | ENST00000503947 | ENST00000265038 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-5UTR | ENST00000503947 | ENST00000462279 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-5UTR | ENST00000503947 | ENST00000543101 | PDE4D | chr5 | 59783769 | - | ERCC8 | chr5 | 60198335 | - |
intron-3CDS | ENST00000340635 | ENST00000426742 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-3CDS | ENST00000340635 | ENST00000265038 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-5UTR | ENST00000340635 | ENST00000462279 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-intron | ENST00000340635 | ENST00000543101 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-3CDS | ENST00000360047 | ENST00000426742 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-3CDS | ENST00000360047 | ENST00000265038 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-5UTR | ENST00000360047 | ENST00000462279 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-intron | ENST00000360047 | ENST00000543101 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-3CDS | ENST00000507116 | ENST00000426742 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-3CDS | ENST00000507116 | ENST00000265038 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-5UTR | ENST00000507116 | ENST00000462279 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-intron | ENST00000507116 | ENST00000543101 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
Frame-shift | ENST00000502484 | ENST00000426742 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
Frame-shift | ENST00000502484 | ENST00000265038 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
5CDS-5UTR | ENST00000502484 | ENST00000462279 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
5CDS-intron | ENST00000502484 | ENST00000543101 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
In-frame | ENST00000546160 | ENST00000426742 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
In-frame | ENST00000546160 | ENST00000265038 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
5CDS-5UTR | ENST00000546160 | ENST00000462279 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
5CDS-intron | ENST00000546160 | ENST00000543101 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-3CDS | ENST00000502575 | ENST00000426742 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-3CDS | ENST00000502575 | ENST00000265038 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-5UTR | ENST00000502575 | ENST00000462279 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-intron | ENST00000502575 | ENST00000543101 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-3CDS | ENST00000358923 | ENST00000426742 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-3CDS | ENST00000358923 | ENST00000265038 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-5UTR | ENST00000358923 | ENST00000462279 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-intron | ENST00000358923 | ENST00000543101 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-3CDS | ENST00000503258 | ENST00000426742 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-3CDS | ENST00000503258 | ENST00000265038 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-5UTR | ENST00000503258 | ENST00000462279 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-intron | ENST00000503258 | ENST00000543101 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-3CDS | ENST00000405755 | ENST00000426742 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-3CDS | ENST00000405755 | ENST00000265038 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-5UTR | ENST00000405755 | ENST00000462279 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-intron | ENST00000405755 | ENST00000543101 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-3CDS | ENST00000317118 | ENST00000426742 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-3CDS | ENST00000317118 | ENST00000265038 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-5UTR | ENST00000317118 | ENST00000462279 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-intron | ENST00000317118 | ENST00000543101 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-3CDS | ENST00000503947 | ENST00000426742 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-3CDS | ENST00000503947 | ENST00000265038 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-5UTR | ENST00000503947 | ENST00000462279 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
intron-intron | ENST00000503947 | ENST00000543101 | PDE4D | chr5 | 59481384 | - | ERCC8 | chr5 | 60200700 | - |
Frame-shift | ENST00000340635 | ENST00000426742 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
Frame-shift | ENST00000340635 | ENST00000265038 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
5CDS-5UTR | ENST00000340635 | ENST00000462279 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
5CDS-5UTR | ENST00000340635 | ENST00000543101 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
Frame-shift | ENST00000360047 | ENST00000426742 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
Frame-shift | ENST00000360047 | ENST00000265038 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
5CDS-5UTR | ENST00000360047 | ENST00000462279 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
5CDS-5UTR | ENST00000360047 | ENST00000543101 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
Frame-shift | ENST00000507116 | ENST00000426742 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
Frame-shift | ENST00000507116 | ENST00000265038 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
5CDS-5UTR | ENST00000507116 | ENST00000462279 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
5CDS-5UTR | ENST00000507116 | ENST00000543101 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
Frame-shift | ENST00000502484 | ENST00000426742 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
Frame-shift | ENST00000502484 | ENST00000265038 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
5CDS-5UTR | ENST00000502484 | ENST00000462279 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
5CDS-5UTR | ENST00000502484 | ENST00000543101 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
Frame-shift | ENST00000546160 | ENST00000426742 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
Frame-shift | ENST00000546160 | ENST00000265038 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
5CDS-5UTR | ENST00000546160 | ENST00000462279 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
5CDS-5UTR | ENST00000546160 | ENST00000543101 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
Frame-shift | ENST00000502575 | ENST00000426742 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
Frame-shift | ENST00000502575 | ENST00000265038 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
5CDS-5UTR | ENST00000502575 | ENST00000462279 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
5CDS-5UTR | ENST00000502575 | ENST00000543101 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
intron-3CDS | ENST00000358923 | ENST00000426742 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
intron-3CDS | ENST00000358923 | ENST00000265038 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
intron-5UTR | ENST00000358923 | ENST00000462279 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
intron-5UTR | ENST00000358923 | ENST00000543101 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
Frame-shift | ENST00000503258 | ENST00000426742 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
Frame-shift | ENST00000503258 | ENST00000265038 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
5CDS-5UTR | ENST00000503258 | ENST00000462279 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
5CDS-5UTR | ENST00000503258 | ENST00000543101 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
Frame-shift | ENST00000405755 | ENST00000426742 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
Frame-shift | ENST00000405755 | ENST00000265038 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
5CDS-5UTR | ENST00000405755 | ENST00000462279 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
5CDS-5UTR | ENST00000405755 | ENST00000543101 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
intron-3CDS | ENST00000317118 | ENST00000426742 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
intron-3CDS | ENST00000317118 | ENST00000265038 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
intron-5UTR | ENST00000317118 | ENST00000462279 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
intron-5UTR | ENST00000317118 | ENST00000543101 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
5UTR-3CDS | ENST00000503947 | ENST00000426742 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
5UTR-3CDS | ENST00000503947 | ENST00000265038 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
5UTR-5UTR | ENST00000503947 | ENST00000462279 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
5UTR-5UTR | ENST00000503947 | ENST00000543101 | PDE4D | chr5 | 58511603 | - | ERCC8 | chr5 | 60170510 | - |
Top |
FusionProtFeatures for PDE4D_ERCC8 |
![]() |
Hgene | Tgene |
PDE4D | ERCC8 |
Substrate-recognition component of the CSA complex, aDCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex,involved in transcription-coupled nucleotide excision repair. TheCSA complex (DCX(ERCC8) complex) promotes the ubiquitination andsubsequent proteasomal degradation of ERCC6 in a UV-dependentmanner; ERCC6 degradation is essential for the recovery of RNAsynthesis after transcription-coupled repair. It is required forthe recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blockinglesions from the transcribed strand of active genes.{ECO:0000269|PubMed:16751180, ECO:0000269|PubMed:16916636,ECO:0000269|PubMed:16964240}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for PDE4D_ERCC8 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_PDE4D_ENST00000546160_chr5_59481384_-_ERCC8_ENST00000426742_chr5_60200700_-_278aa MKRNTCDLLSRSKSTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADS RVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTV SCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDAW >In-frame_PDE4D_ENST00000546160_chr5_59481384_-_ERCC8_ENST00000265038_chr5_60200700_-_278aa MKRNTCDLLSRSKSTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADS RVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTV SCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDAW |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_PDE4D_ENST00000546160_chr5_59481384_-_ERCC8_ENST00000426742_chr5_60200700_-_834nt ATGAAAAGAAATACCTGTGATTTGCTTTCTCGGAGCAAAAGTACTGCAGATGTATTTAATTTTGAGGAAACAGTTTATAGTCATCATATG TCTCCAGTCTCCACCAAGCACTGTTTGGTAGCAGTTGGTACTAGAGGACCCAAAGTACAACTTTGTGACTTGAAGTCTGGATCCTGTTCT CACATTCTACAGGGTCACAGACAAGAAATATTAGCAGTTTCCTGGTCTCCACGTTATGACTATATCTTGGCAACAGCAAGTGCTGACAGT AGAGTAAAATTATGGGATGTGAGAAGAGCATCAGGATGTTTGATTACTCTTGATCAACATAATGGGAAAAAGTCACAAGCTGTTGAATCA GCAAACACTGCTCATAATGGGAAAGTTAATGGCTTATGTTTTACAAGTGATGGACTTCACCTCCTCACTGTTGGTACAGATAATCGAATG AGGCTCTGGAATAGTTCCAATGGAGAAAACACACTTGTGAACTATGGAAAAGTTTGTAATAACAGTAAAAAAGGATTGAAATTCACTGTC TCCTGTGGCTGCAGTTCAGAATTTGTTTTTGTACCATATGGTAGCACCATTGCTGTTTATACAGTTTACTCAGGAGAACAGATAACTATG CTTAAGGGACATTATAAAACTGTTGACTGCTGTGTATTTCAGTCAAATTTCCAGGAACTTTATAGTGGTAGCAGAGACTGCAACATTCTG GCTTGGGTTCCATCCTTATATGAACCAGTTCCTGATGATGATGAGACTACAACAAAATCACAATTAAATCCGGCCTTTGAAGATGCCTGG >In-frame_PDE4D_ENST00000546160_chr5_59481384_-_ERCC8_ENST00000265038_chr5_60200700_-_834nt ATGAAAAGAAATACCTGTGATTTGCTTTCTCGGAGCAAAAGTACTGCAGATGTATTTAATTTTGAGGAAACAGTTTATAGTCATCATATG TCTCCAGTCTCCACCAAGCACTGTTTGGTAGCAGTTGGTACTAGAGGACCCAAAGTACAACTTTGTGACTTGAAGTCTGGATCCTGTTCT CACATTCTACAGGGTCACAGACAAGAAATATTAGCAGTTTCCTGGTCTCCACGTTATGACTATATCTTGGCAACAGCAAGTGCTGACAGT AGAGTAAAATTATGGGATGTGAGAAGAGCATCAGGATGTTTGATTACTCTTGATCAACATAATGGGAAAAAGTCACAAGCTGTTGAATCA GCAAACACTGCTCATAATGGGAAAGTTAATGGCTTATGTTTTACAAGTGATGGACTTCACCTCCTCACTGTTGGTACAGATAATCGAATG AGGCTCTGGAATAGTTCCAATGGAGAAAACACACTTGTGAACTATGGAAAAGTTTGTAATAACAGTAAAAAAGGATTGAAATTCACTGTC TCCTGTGGCTGCAGTTCAGAATTTGTTTTTGTACCATATGGTAGCACCATTGCTGTTTATACAGTTTACTCAGGAGAACAGATAACTATG CTTAAGGGACATTATAAAACTGTTGACTGCTGTGTATTTCAGTCAAATTTCCAGGAACTTTATAGTGGTAGCAGAGACTGCAACATTCTG GCTTGGGTTCCATCCTTATATGAACCAGTTCCTGATGATGATGAGACTACAACAAAATCACAATTAAATCCGGCCTTTGAAGATGCCTGG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_PDE4D_ENST00000546160_chr5_59481384_-_ERCC8_ENST00000426742_chr5_60200700_-_1618nt ATGAAAAGAAATACCTGTGATTTGCTTTCTCGGAGCAAAAGTACTGCAGATGTATTTAATTTTGAGGAAACAGTTTATAGTCATCATATG TCTCCAGTCTCCACCAAGCACTGTTTGGTAGCAGTTGGTACTAGAGGACCCAAAGTACAACTTTGTGACTTGAAGTCTGGATCCTGTTCT CACATTCTACAGGGTCACAGACAAGAAATATTAGCAGTTTCCTGGTCTCCACGTTATGACTATATCTTGGCAACAGCAAGTGCTGACAGT AGAGTAAAATTATGGGATGTGAGAAGAGCATCAGGATGTTTGATTACTCTTGATCAACATAATGGGAAAAAGTCACAAGCTGTTGAATCA GCAAACACTGCTCATAATGGGAAAGTTAATGGCTTATGTTTTACAAGTGATGGACTTCACCTCCTCACTGTTGGTACAGATAATCGAATG AGGCTCTGGAATAGTTCCAATGGAGAAAACACACTTGTGAACTATGGAAAAGTTTGTAATAACAGTAAAAAAGGATTGAAATTCACTGTC TCCTGTGGCTGCAGTTCAGAATTTGTTTTTGTACCATATGGTAGCACCATTGCTGTTTATACAGTTTACTCAGGAGAACAGATAACTATG CTTAAGGGACATTATAAAACTGTTGACTGCTGTGTATTTCAGTCAAATTTCCAGGAACTTTATAGTGGTAGCAGAGACTGCAACATTCTG GCTTGGGTTCCATCCTTATATGAACCAGTTCCTGATGATGATGAGACTACAACAAAATCACAATTAAATCCGGCCTTTGAAGATGCCTGG AGCAGCAGTGATGAAGAAGGATGAATATCATCTTTAGTACCTTTTTGTCTCTGCTGAAACTTTTTAAATGAGACTGTGTTTTTTTCAACT GTATGGTCTATTCCTGACAGCTAAATTAGCCCTAAATGTGGGTAATATTTTTCCTCATGTTTTAAAATGAGGTTAATATTTGCATAAAAT CCTAAAACAGACTTCTGTATAGTTTATTTAGTCAAAATGTGTTCCTTGATCCCAGATGTTGTGGCCTGGGAAAGCCCTCATTGCTACAGT ACAAGTAACACAAGTCGTTGTACCTCAGTTGTGACCTTCAGCAGATTTTATGAACTATAAGATGCAGTCTCAGAGGATCAGCAAGTGGAG GCCATCAGTATTGACTTTCTCTTACTTGCTGTACTATCAGCCTGCTCGTTTCCACCTTTAAGAATGATTTTGCCAAGAATGATTATATCA AAAATAGTAGTTGAAATGGTAACATCAAAATTATTTTATTCTTTCTTCTTCATGTATTCACATTTTTCAGTGGTTTCATTTAATTAACCA TGCTTTATGTTAAACATTTTGGGGCTCAATGTCTCCTACTATCCAAAATGTGCATCACAGGAGGCTTTTAACTTTGTGAAAATCCCATGT TTGCTTTATTTTATTTTAATGTCAGAAGGCAGTTTGCGCTAATGCTTGAACTCTTTTTCTGTGAAACTCATTAAGGTATGACCAAATCCT >In-frame_PDE4D_ENST00000546160_chr5_59481384_-_ERCC8_ENST00000265038_chr5_60200700_-_1617nt ATGAAAAGAAATACCTGTGATTTGCTTTCTCGGAGCAAAAGTACTGCAGATGTATTTAATTTTGAGGAAACAGTTTATAGTCATCATATG TCTCCAGTCTCCACCAAGCACTGTTTGGTAGCAGTTGGTACTAGAGGACCCAAAGTACAACTTTGTGACTTGAAGTCTGGATCCTGTTCT CACATTCTACAGGGTCACAGACAAGAAATATTAGCAGTTTCCTGGTCTCCACGTTATGACTATATCTTGGCAACAGCAAGTGCTGACAGT AGAGTAAAATTATGGGATGTGAGAAGAGCATCAGGATGTTTGATTACTCTTGATCAACATAATGGGAAAAAGTCACAAGCTGTTGAATCA GCAAACACTGCTCATAATGGGAAAGTTAATGGCTTATGTTTTACAAGTGATGGACTTCACCTCCTCACTGTTGGTACAGATAATCGAATG AGGCTCTGGAATAGTTCCAATGGAGAAAACACACTTGTGAACTATGGAAAAGTTTGTAATAACAGTAAAAAAGGATTGAAATTCACTGTC TCCTGTGGCTGCAGTTCAGAATTTGTTTTTGTACCATATGGTAGCACCATTGCTGTTTATACAGTTTACTCAGGAGAACAGATAACTATG CTTAAGGGACATTATAAAACTGTTGACTGCTGTGTATTTCAGTCAAATTTCCAGGAACTTTATAGTGGTAGCAGAGACTGCAACATTCTG GCTTGGGTTCCATCCTTATATGAACCAGTTCCTGATGATGATGAGACTACAACAAAATCACAATTAAATCCGGCCTTTGAAGATGCCTGG AGCAGCAGTGATGAAGAAGGATGAATATCATCTTTAGTACCTTTTTGTCTCTGCTGAAACTTTTTAAATGAGACTGTGTTTTTTTCAACT GTATGGTCTATTCCTGACAGCTAAATTAGCCCTAAATGTGGGTAATATTTTTCCTCATGTTTTAAAATGAGGTTAATATTTGCATAAAAT CCTAAAACAGACTTCTGTATAGTTTATTTAGTCAAAATGTGTTCCTTGATCCCAGATGTTGTGGCCTGGGAAAGCCCTCATTGCTACAGT ACAAGTAACACAAGTCGTTGTACCTCAGTTGTGACCTTCAGCAGATTTTATGAACTATAAGATGCAGTCTCAGAGGATCAGCAAGTGGAG GCCATCAGTATTGACTTTCTCTTACTTGCTGTACTATCAGCCTGCTCGTTTCCACCTTTAAGAATGATTTTGCCAAGAATGATTATATCA AAAATAGTAGTTGAAATGGTAACATCAAAATTATTTTATTCTTTCTTCTTCATGTATTCACATTTTTCAGTGGTTTCATTTAATTAACCA TGCTTTATGTTAAACATTTTGGGGCTCAATGTCTCCTACTATCCAAAATGTGCATCACAGGAGGCTTTTAACTTTGTGAAAATCCCATGT TTGCTTTATTTTATTTTAATGTCAGAAGGCAGTTTGCGCTAATGCTTGAACTCTTTTTCTGTGAAACTCATTAAGGTATGACCAAATCCT |
Top |
FusionGenePPI for PDE4D_ERCC8 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PDE4D | PDE4DIP, PDE4D, AKAP6, GNB2L1, ARRB1, MDM2, ITSN1, ARRB2, PPP3CA, PPP3CB, PPP3R1, GSK3B, CSNK1A1, CDK2, PAFAH1B1, PRKACA, APP, LYN, SRC, FYN, ABL1, GRB2, PIAS4, MAPK1, BIN1, HDGFRP2, ZBTB1, MAGEA6, TRAF1, COIL, GOLGA8EP, GOLGA8F, ZDHHC17, SPTAN1, PIK3R1, TRIM23, ITPKB, PFKFB2, AKAP12, ATOH1, DUSP13, PDE4B, TRIM25 | ERCC8 | XAB2, COPS5, COPS6, DDB1, ERCC6, CSNK2B, POLR2A, EP300, HMGN1, DDB2, CUL4A, GPS1, RBX1, COPS2, COPS3, COPS4, COPS7A, COPS8, CUL4B, CUL5, GTF2H2, TP53, MDM2, OGG1, SSBP1, DDA1, RFWD2, TOP1, ZNF24, RUVBL2, UVSSA, PCNA, H1F0, VCP, UBXN7, PCGF1, DPPA4, BCOR, NANOG, POU5F1, PFDN4, TRIM25 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for PDE4D_ERCC8 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | PDE4D | Q08499 | DB00651 | Dyphylline | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | small molecule | approved |
Hgene | PDE4D | Q08499 | DB01656 | Roflumilast | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | small molecule | approved |
Hgene | PDE4D | Q08499 | DB01088 | Iloprost | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | small molecule | approved|investigational |
Hgene | PDE4D | Q08499 | DB05266 | Ibudilast | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | small molecule | approved|investigational |
Hgene | PDE4D | Q08499 | DB05676 | Apremilast | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | small molecule | approved|investigational |
Top |
RelatedDiseases for PDE4D_ERCC8 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PDE4D | C3553250 | ACRODYSOSTOSIS 2 WITH OR WITHOUT HORMONE RESISTANCE | 4 | UNIPROT |
Hgene | PDE4D | C0011581 | Depressive disorder | 3 | PSYGENET |
Hgene | PDE4D | C0004096 | Asthma | 2 | CTD_human |
Hgene | PDE4D | C0011570 | Mental Depression | 2 | PSYGENET |
Hgene | PDE4D | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | PDE4D | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | PDE4D | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
Tgene | ERCC8 | C0751039 | Cockayne Syndrome, Type I | 3 | ORPHANET;UNIPROT |
Tgene | ERCC8 | C0009207 | Cockayne Syndrome | 2 | CTD_human |
Tgene | ERCC8 | C3553298 | UV-SENSITIVE SYNDROME 2 | 1 | UNIPROT |