FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 26402

FusionGeneSummary for PDE4D_ERCC8

check button Fusion gene summary
Fusion gene informationFusion gene name: PDE4D_ERCC8
Fusion gene ID: 26402
HgeneTgene
Gene symbol

PDE4D

ERCC8

Gene ID

5144

1161

Gene namephosphodiesterase 4DERCC excision repair 8, CSA ubiquitin ligase complex subunit
SynonymsACRDYS2|DPDE3|HSPDE4D|PDE43|PDE4DN2|STRK1CKN1|CSA|UVSS2
Cytomap

5q11.2-q12.1

5q12.1

Type of geneprotein-codingprotein-coding
DescriptioncAMP-specific 3',5'-cyclic phosphodiesterase 4DcAMP-specific phosphodiesterase PDE4D6phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)testicular tissue protein Li 136DNA excision repair protein ERCC-8Cockayne syndrome WD-repeat protein CSAcockayne syndrome WD repeat protein CSAexcision repair cross-complementation group 8excision repair cross-complementing rodent repair deficiency, complementation group 8
Modification date2018051920180519
UniProtAcc

Q08499

Q13216

Ensembl transtripts involved in fusion geneENST00000340635, ENST00000360047, 
ENST00000507116, ENST00000502484, 
ENST00000546160, ENST00000502575, 
ENST00000358923, ENST00000503258, 
ENST00000405755, ENST00000317118, 
ENST00000503947, 		ENST00000426742, 
ENST00000265038, ENST00000462279, 
ENST00000543101, 
Fusion gene scores* DoF score23 X 14 X 10=32204 X 4 X 5=80
# samples 346
** MAII scorelog2(34/3220*10)=-3.24345403686428
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDE4D [Title/Abstract] AND ERCC8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationDDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePDE4D

GO:0006198

cAMP catabolic process

9371713|17404263

TgeneERCC8

GO:0000209

protein polyubiquitination

12732143

TgeneERCC8

GO:0006283

transcription-coupled nucleotide-excision repair

12732143

TgeneERCC8

GO:0006974

cellular response to DNA damage stimulus

11782547

TgeneERCC8

GO:0006979

response to oxidative stress

11782547

TgeneERCC8

GO:0009411

response to UV

12732143

TgeneERCC8

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

16751180

TgeneERCC8

GO:0051865

protein autoubiquitination

12732143


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-HN-A2NL-01APDE4Dchr5

59783769

-ERCC8chr5

60198335

-
TCGARVPRADTCGA-ZG-A8QY-01APDE4Dchr5

59481384

-ERCC8chr5

60200700

-
TCGARVSTADTCGA-VQ-A92D-01APDE4Dchr5

58511603

-ERCC8chr5

60170510

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000340635ENST00000426742PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-3CDSENST00000340635ENST00000265038PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-5UTRENST00000340635ENST00000462279PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-5UTRENST00000340635ENST00000543101PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-3CDSENST00000360047ENST00000426742PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-3CDSENST00000360047ENST00000265038PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-5UTRENST00000360047ENST00000462279PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-5UTRENST00000360047ENST00000543101PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-3CDSENST00000507116ENST00000426742PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-3CDSENST00000507116ENST00000265038PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-5UTRENST00000507116ENST00000462279PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-5UTRENST00000507116ENST00000543101PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
5UTR-3CDSENST00000502484ENST00000426742PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
5UTR-3CDSENST00000502484ENST00000265038PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
5UTR-5UTRENST00000502484ENST00000462279PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
5UTR-5UTRENST00000502484ENST00000543101PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-3CDSENST00000546160ENST00000426742PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-3CDSENST00000546160ENST00000265038PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-5UTRENST00000546160ENST00000462279PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-5UTRENST00000546160ENST00000543101PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-3CDSENST00000502575ENST00000426742PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-3CDSENST00000502575ENST00000265038PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-5UTRENST00000502575ENST00000462279PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-5UTRENST00000502575ENST00000543101PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-3CDSENST00000358923ENST00000426742PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-3CDSENST00000358923ENST00000265038PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-5UTRENST00000358923ENST00000462279PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-5UTRENST00000358923ENST00000543101PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-3CDSENST00000503258ENST00000426742PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-3CDSENST00000503258ENST00000265038PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-5UTRENST00000503258ENST00000462279PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-5UTRENST00000503258ENST00000543101PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-3CDSENST00000405755ENST00000426742PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-3CDSENST00000405755ENST00000265038PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-5UTRENST00000405755ENST00000462279PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-5UTRENST00000405755ENST00000543101PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-3CDSENST00000317118ENST00000426742PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-3CDSENST00000317118ENST00000265038PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-5UTRENST00000317118ENST00000462279PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-5UTRENST00000317118ENST00000543101PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-3CDSENST00000503947ENST00000426742PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-3CDSENST00000503947ENST00000265038PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-5UTRENST00000503947ENST00000462279PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-5UTRENST00000503947ENST00000543101PDE4Dchr5

59783769

-ERCC8chr5

60198335

-
intron-3CDSENST00000340635ENST00000426742PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-3CDSENST00000340635ENST00000265038PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-5UTRENST00000340635ENST00000462279PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-intronENST00000340635ENST00000543101PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-3CDSENST00000360047ENST00000426742PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-3CDSENST00000360047ENST00000265038PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-5UTRENST00000360047ENST00000462279PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-intronENST00000360047ENST00000543101PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-3CDSENST00000507116ENST00000426742PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-3CDSENST00000507116ENST00000265038PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-5UTRENST00000507116ENST00000462279PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-intronENST00000507116ENST00000543101PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
Frame-shiftENST00000502484ENST00000426742PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
Frame-shiftENST00000502484ENST00000265038PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
5CDS-5UTRENST00000502484ENST00000462279PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
5CDS-intronENST00000502484ENST00000543101PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
In-frameENST00000546160ENST00000426742PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
In-frameENST00000546160ENST00000265038PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
5CDS-5UTRENST00000546160ENST00000462279PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
5CDS-intronENST00000546160ENST00000543101PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-3CDSENST00000502575ENST00000426742PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-3CDSENST00000502575ENST00000265038PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-5UTRENST00000502575ENST00000462279PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-intronENST00000502575ENST00000543101PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-3CDSENST00000358923ENST00000426742PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-3CDSENST00000358923ENST00000265038PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-5UTRENST00000358923ENST00000462279PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-intronENST00000358923ENST00000543101PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-3CDSENST00000503258ENST00000426742PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-3CDSENST00000503258ENST00000265038PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-5UTRENST00000503258ENST00000462279PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-intronENST00000503258ENST00000543101PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-3CDSENST00000405755ENST00000426742PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-3CDSENST00000405755ENST00000265038PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-5UTRENST00000405755ENST00000462279PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-intronENST00000405755ENST00000543101PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-3CDSENST00000317118ENST00000426742PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-3CDSENST00000317118ENST00000265038PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-5UTRENST00000317118ENST00000462279PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-intronENST00000317118ENST00000543101PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-3CDSENST00000503947ENST00000426742PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-3CDSENST00000503947ENST00000265038PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-5UTRENST00000503947ENST00000462279PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
intron-intronENST00000503947ENST00000543101PDE4Dchr5

59481384

-ERCC8chr5

60200700

-
Frame-shiftENST00000340635ENST00000426742PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
Frame-shiftENST00000340635ENST00000265038PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
5CDS-5UTRENST00000340635ENST00000462279PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
5CDS-5UTRENST00000340635ENST00000543101PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
Frame-shiftENST00000360047ENST00000426742PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
Frame-shiftENST00000360047ENST00000265038PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
5CDS-5UTRENST00000360047ENST00000462279PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
5CDS-5UTRENST00000360047ENST00000543101PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
Frame-shiftENST00000507116ENST00000426742PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
Frame-shiftENST00000507116ENST00000265038PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
5CDS-5UTRENST00000507116ENST00000462279PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
5CDS-5UTRENST00000507116ENST00000543101PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
Frame-shiftENST00000502484ENST00000426742PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
Frame-shiftENST00000502484ENST00000265038PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
5CDS-5UTRENST00000502484ENST00000462279PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
5CDS-5UTRENST00000502484ENST00000543101PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
Frame-shiftENST00000546160ENST00000426742PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
Frame-shiftENST00000546160ENST00000265038PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
5CDS-5UTRENST00000546160ENST00000462279PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
5CDS-5UTRENST00000546160ENST00000543101PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
Frame-shiftENST00000502575ENST00000426742PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
Frame-shiftENST00000502575ENST00000265038PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
5CDS-5UTRENST00000502575ENST00000462279PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
5CDS-5UTRENST00000502575ENST00000543101PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
intron-3CDSENST00000358923ENST00000426742PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
intron-3CDSENST00000358923ENST00000265038PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
intron-5UTRENST00000358923ENST00000462279PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
intron-5UTRENST00000358923ENST00000543101PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
Frame-shiftENST00000503258ENST00000426742PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
Frame-shiftENST00000503258ENST00000265038PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
5CDS-5UTRENST00000503258ENST00000462279PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
5CDS-5UTRENST00000503258ENST00000543101PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
Frame-shiftENST00000405755ENST00000426742PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
Frame-shiftENST00000405755ENST00000265038PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
5CDS-5UTRENST00000405755ENST00000462279PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
5CDS-5UTRENST00000405755ENST00000543101PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
intron-3CDSENST00000317118ENST00000426742PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
intron-3CDSENST00000317118ENST00000265038PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
intron-5UTRENST00000317118ENST00000462279PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
intron-5UTRENST00000317118ENST00000543101PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
5UTR-3CDSENST00000503947ENST00000426742PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
5UTR-3CDSENST00000503947ENST00000265038PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
5UTR-5UTRENST00000503947ENST00000462279PDE4Dchr5

58511603

-ERCC8chr5

60170510

-
5UTR-5UTRENST00000503947ENST00000543101PDE4Dchr5

58511603

-ERCC8chr5

60170510

-

Top

FusionProtFeatures for PDE4D_ERCC8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PDE4D

Q08499

ERCC8

Q13216

Substrate-recognition component of the CSA complex, aDCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex,involved in transcription-coupled nucleotide excision repair. TheCSA complex (DCX(ERCC8) complex) promotes the ubiquitination andsubsequent proteasomal degradation of ERCC6 in a UV-dependentmanner; ERCC6 degradation is essential for the recovery of RNAsynthesis after transcription-coupled repair. It is required forthe recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blockinglesions from the transcribed strand of active genes.{ECO:0000269|PubMed:16751180, ECO:0000269|PubMed:16916636,ECO:0000269|PubMed:16964240}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PDE4D_ERCC8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PDE4D_ENST00000546160_chr5_59481384_-_ERCC8_ENST00000426742_chr5_60200700_-_278aa
MKRNTCDLLSRSKSTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADS
RVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTV
SCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDAW

>In-frame_PDE4D_ENST00000546160_chr5_59481384_-_ERCC8_ENST00000265038_chr5_60200700_-_278aa
MKRNTCDLLSRSKSTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADS
RVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTV
SCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDAW


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PDE4D_ENST00000546160_chr5_59481384_-_ERCC8_ENST00000426742_chr5_60200700_-_834nt
ATGAAAAGAAATACCTGTGATTTGCTTTCTCGGAGCAAAAGTACTGCAGATGTATTTAATTTTGAGGAAACAGTTTATAGTCATCATATG
TCTCCAGTCTCCACCAAGCACTGTTTGGTAGCAGTTGGTACTAGAGGACCCAAAGTACAACTTTGTGACTTGAAGTCTGGATCCTGTTCT
CACATTCTACAGGGTCACAGACAAGAAATATTAGCAGTTTCCTGGTCTCCACGTTATGACTATATCTTGGCAACAGCAAGTGCTGACAGT
AGAGTAAAATTATGGGATGTGAGAAGAGCATCAGGATGTTTGATTACTCTTGATCAACATAATGGGAAAAAGTCACAAGCTGTTGAATCA
GCAAACACTGCTCATAATGGGAAAGTTAATGGCTTATGTTTTACAAGTGATGGACTTCACCTCCTCACTGTTGGTACAGATAATCGAATG
AGGCTCTGGAATAGTTCCAATGGAGAAAACACACTTGTGAACTATGGAAAAGTTTGTAATAACAGTAAAAAAGGATTGAAATTCACTGTC
TCCTGTGGCTGCAGTTCAGAATTTGTTTTTGTACCATATGGTAGCACCATTGCTGTTTATACAGTTTACTCAGGAGAACAGATAACTATG
CTTAAGGGACATTATAAAACTGTTGACTGCTGTGTATTTCAGTCAAATTTCCAGGAACTTTATAGTGGTAGCAGAGACTGCAACATTCTG
GCTTGGGTTCCATCCTTATATGAACCAGTTCCTGATGATGATGAGACTACAACAAAATCACAATTAAATCCGGCCTTTGAAGATGCCTGG

>In-frame_PDE4D_ENST00000546160_chr5_59481384_-_ERCC8_ENST00000265038_chr5_60200700_-_834nt
ATGAAAAGAAATACCTGTGATTTGCTTTCTCGGAGCAAAAGTACTGCAGATGTATTTAATTTTGAGGAAACAGTTTATAGTCATCATATG
TCTCCAGTCTCCACCAAGCACTGTTTGGTAGCAGTTGGTACTAGAGGACCCAAAGTACAACTTTGTGACTTGAAGTCTGGATCCTGTTCT
CACATTCTACAGGGTCACAGACAAGAAATATTAGCAGTTTCCTGGTCTCCACGTTATGACTATATCTTGGCAACAGCAAGTGCTGACAGT
AGAGTAAAATTATGGGATGTGAGAAGAGCATCAGGATGTTTGATTACTCTTGATCAACATAATGGGAAAAAGTCACAAGCTGTTGAATCA
GCAAACACTGCTCATAATGGGAAAGTTAATGGCTTATGTTTTACAAGTGATGGACTTCACCTCCTCACTGTTGGTACAGATAATCGAATG
AGGCTCTGGAATAGTTCCAATGGAGAAAACACACTTGTGAACTATGGAAAAGTTTGTAATAACAGTAAAAAAGGATTGAAATTCACTGTC
TCCTGTGGCTGCAGTTCAGAATTTGTTTTTGTACCATATGGTAGCACCATTGCTGTTTATACAGTTTACTCAGGAGAACAGATAACTATG
CTTAAGGGACATTATAAAACTGTTGACTGCTGTGTATTTCAGTCAAATTTCCAGGAACTTTATAGTGGTAGCAGAGACTGCAACATTCTG
GCTTGGGTTCCATCCTTATATGAACCAGTTCCTGATGATGATGAGACTACAACAAAATCACAATTAAATCCGGCCTTTGAAGATGCCTGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_PDE4D_ENST00000546160_chr5_59481384_-_ERCC8_ENST00000426742_chr5_60200700_-_1618nt
ATGAAAAGAAATACCTGTGATTTGCTTTCTCGGAGCAAAAGTACTGCAGATGTATTTAATTTTGAGGAAACAGTTTATAGTCATCATATG
TCTCCAGTCTCCACCAAGCACTGTTTGGTAGCAGTTGGTACTAGAGGACCCAAAGTACAACTTTGTGACTTGAAGTCTGGATCCTGTTCT
CACATTCTACAGGGTCACAGACAAGAAATATTAGCAGTTTCCTGGTCTCCACGTTATGACTATATCTTGGCAACAGCAAGTGCTGACAGT
AGAGTAAAATTATGGGATGTGAGAAGAGCATCAGGATGTTTGATTACTCTTGATCAACATAATGGGAAAAAGTCACAAGCTGTTGAATCA
GCAAACACTGCTCATAATGGGAAAGTTAATGGCTTATGTTTTACAAGTGATGGACTTCACCTCCTCACTGTTGGTACAGATAATCGAATG
AGGCTCTGGAATAGTTCCAATGGAGAAAACACACTTGTGAACTATGGAAAAGTTTGTAATAACAGTAAAAAAGGATTGAAATTCACTGTC
TCCTGTGGCTGCAGTTCAGAATTTGTTTTTGTACCATATGGTAGCACCATTGCTGTTTATACAGTTTACTCAGGAGAACAGATAACTATG
CTTAAGGGACATTATAAAACTGTTGACTGCTGTGTATTTCAGTCAAATTTCCAGGAACTTTATAGTGGTAGCAGAGACTGCAACATTCTG
GCTTGGGTTCCATCCTTATATGAACCAGTTCCTGATGATGATGAGACTACAACAAAATCACAATTAAATCCGGCCTTTGAAGATGCCTGG
AGCAGCAGTGATGAAGAAGGATGAATATCATCTTTAGTACCTTTTTGTCTCTGCTGAAACTTTTTAAATGAGACTGTGTTTTTTTCAACT
GTATGGTCTATTCCTGACAGCTAAATTAGCCCTAAATGTGGGTAATATTTTTCCTCATGTTTTAAAATGAGGTTAATATTTGCATAAAAT
CCTAAAACAGACTTCTGTATAGTTTATTTAGTCAAAATGTGTTCCTTGATCCCAGATGTTGTGGCCTGGGAAAGCCCTCATTGCTACAGT
ACAAGTAACACAAGTCGTTGTACCTCAGTTGTGACCTTCAGCAGATTTTATGAACTATAAGATGCAGTCTCAGAGGATCAGCAAGTGGAG
GCCATCAGTATTGACTTTCTCTTACTTGCTGTACTATCAGCCTGCTCGTTTCCACCTTTAAGAATGATTTTGCCAAGAATGATTATATCA
AAAATAGTAGTTGAAATGGTAACATCAAAATTATTTTATTCTTTCTTCTTCATGTATTCACATTTTTCAGTGGTTTCATTTAATTAACCA
TGCTTTATGTTAAACATTTTGGGGCTCAATGTCTCCTACTATCCAAAATGTGCATCACAGGAGGCTTTTAACTTTGTGAAAATCCCATGT
TTGCTTTATTTTATTTTAATGTCAGAAGGCAGTTTGCGCTAATGCTTGAACTCTTTTTCTGTGAAACTCATTAAGGTATGACCAAATCCT

>In-frame_PDE4D_ENST00000546160_chr5_59481384_-_ERCC8_ENST00000265038_chr5_60200700_-_1617nt
ATGAAAAGAAATACCTGTGATTTGCTTTCTCGGAGCAAAAGTACTGCAGATGTATTTAATTTTGAGGAAACAGTTTATAGTCATCATATG
TCTCCAGTCTCCACCAAGCACTGTTTGGTAGCAGTTGGTACTAGAGGACCCAAAGTACAACTTTGTGACTTGAAGTCTGGATCCTGTTCT
CACATTCTACAGGGTCACAGACAAGAAATATTAGCAGTTTCCTGGTCTCCACGTTATGACTATATCTTGGCAACAGCAAGTGCTGACAGT
AGAGTAAAATTATGGGATGTGAGAAGAGCATCAGGATGTTTGATTACTCTTGATCAACATAATGGGAAAAAGTCACAAGCTGTTGAATCA
GCAAACACTGCTCATAATGGGAAAGTTAATGGCTTATGTTTTACAAGTGATGGACTTCACCTCCTCACTGTTGGTACAGATAATCGAATG
AGGCTCTGGAATAGTTCCAATGGAGAAAACACACTTGTGAACTATGGAAAAGTTTGTAATAACAGTAAAAAAGGATTGAAATTCACTGTC
TCCTGTGGCTGCAGTTCAGAATTTGTTTTTGTACCATATGGTAGCACCATTGCTGTTTATACAGTTTACTCAGGAGAACAGATAACTATG
CTTAAGGGACATTATAAAACTGTTGACTGCTGTGTATTTCAGTCAAATTTCCAGGAACTTTATAGTGGTAGCAGAGACTGCAACATTCTG
GCTTGGGTTCCATCCTTATATGAACCAGTTCCTGATGATGATGAGACTACAACAAAATCACAATTAAATCCGGCCTTTGAAGATGCCTGG
AGCAGCAGTGATGAAGAAGGATGAATATCATCTTTAGTACCTTTTTGTCTCTGCTGAAACTTTTTAAATGAGACTGTGTTTTTTTCAACT
GTATGGTCTATTCCTGACAGCTAAATTAGCCCTAAATGTGGGTAATATTTTTCCTCATGTTTTAAAATGAGGTTAATATTTGCATAAAAT
CCTAAAACAGACTTCTGTATAGTTTATTTAGTCAAAATGTGTTCCTTGATCCCAGATGTTGTGGCCTGGGAAAGCCCTCATTGCTACAGT
ACAAGTAACACAAGTCGTTGTACCTCAGTTGTGACCTTCAGCAGATTTTATGAACTATAAGATGCAGTCTCAGAGGATCAGCAAGTGGAG
GCCATCAGTATTGACTTTCTCTTACTTGCTGTACTATCAGCCTGCTCGTTTCCACCTTTAAGAATGATTTTGCCAAGAATGATTATATCA
AAAATAGTAGTTGAAATGGTAACATCAAAATTATTTTATTCTTTCTTCTTCATGTATTCACATTTTTCAGTGGTTTCATTTAATTAACCA
TGCTTTATGTTAAACATTTTGGGGCTCAATGTCTCCTACTATCCAAAATGTGCATCACAGGAGGCTTTTAACTTTGTGAAAATCCCATGT
TTGCTTTATTTTATTTTAATGTCAGAAGGCAGTTTGCGCTAATGCTTGAACTCTTTTTCTGTGAAACTCATTAAGGTATGACCAAATCCT


Top

FusionGenePPI for PDE4D_ERCC8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PDE4DPDE4DIP, PDE4D, AKAP6, GNB2L1, ARRB1, MDM2, ITSN1, ARRB2, PPP3CA, PPP3CB, PPP3R1, GSK3B, CSNK1A1, CDK2, PAFAH1B1, PRKACA, APP, LYN, SRC, FYN, ABL1, GRB2, PIAS4, MAPK1, BIN1, HDGFRP2, ZBTB1, MAGEA6, TRAF1, COIL, GOLGA8EP, GOLGA8F, ZDHHC17, SPTAN1, PIK3R1, TRIM23, ITPKB, PFKFB2, AKAP12, ATOH1, DUSP13, PDE4B, TRIM25ERCC8XAB2, COPS5, COPS6, DDB1, ERCC6, CSNK2B, POLR2A, EP300, HMGN1, DDB2, CUL4A, GPS1, RBX1, COPS2, COPS3, COPS4, COPS7A, COPS8, CUL4B, CUL5, GTF2H2, TP53, MDM2, OGG1, SSBP1, DDA1, RFWD2, TOP1, ZNF24, RUVBL2, UVSSA, PCNA, H1F0, VCP, UBXN7, PCGF1, DPPA4, BCOR, NANOG, POU5F1, PFDN4, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PDE4D_ERCC8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePDE4DQ08499DB00651DyphyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Dsmall moleculeapproved
HgenePDE4DQ08499DB01656RoflumilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Dsmall moleculeapproved
HgenePDE4DQ08499DB01088IloprostcAMP-specific 3',5'-cyclic phosphodiesterase 4Dsmall moleculeapproved|investigational
HgenePDE4DQ08499DB05266IbudilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Dsmall moleculeapproved|investigational
HgenePDE4DQ08499DB05676ApremilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Dsmall moleculeapproved|investigational

Top

RelatedDiseases for PDE4D_ERCC8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePDE4DC3553250ACRODYSOSTOSIS 2 WITH OR WITHOUT HORMONE RESISTANCE4UNIPROT
HgenePDE4DC0011581Depressive disorder3PSYGENET
HgenePDE4DC0004096Asthma2CTD_human
HgenePDE4DC0011570Mental Depression2PSYGENET
HgenePDE4DC0033578Prostatic Neoplasms1CTD_human
HgenePDE4DC0036341Schizophrenia1PSYGENET
HgenePDE4DC0236733Amphetamine-Related Disorders1CTD_human
TgeneERCC8C0751039Cockayne Syndrome, Type I3ORPHANET;UNIPROT
TgeneERCC8C0009207Cockayne Syndrome2CTD_human
TgeneERCC8C3553298UV-SENSITIVE SYNDROME 21UNIPROT