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Fusion gene ID: 26398 |
FusionGeneSummary for PDE4D_CRABP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PDE4D_CRABP1 | Fusion gene ID: 26398 | Hgene | Tgene | Gene symbol | PDE4D | CRABP1 | Gene ID | 5144 | 1381 |
| Gene name | phosphodiesterase 4D | cellular retinoic acid binding protein 1 | |
| Synonyms | ACRDYS2|DPDE3|HSPDE4D|PDE43|PDE4DN2|STRK1 | CRABP|CRABP-I|CRABPI|RBP5 | |
| Cytomap | 5q11.2-q12.1 | 15q25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cAMP-specific 3',5'-cyclic phosphodiesterase 4DcAMP-specific phosphodiesterase PDE4D6phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)testicular tissue protein Li 136 | cellular retinoic acid-binding protein 1cellular retinoic acid-binding protein I | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q08499 | P29762 | |
| Ensembl transtripts involved in fusion gene | ENST00000340635, ENST00000360047, ENST00000507116, ENST00000502484, ENST00000546160, ENST00000502575, ENST00000358923, ENST00000503258, ENST00000405755, ENST00000317118, ENST00000503947, | ENST00000299529, | |
| Fusion gene scores | * DoF score | 23 X 14 X 10=3220 | 1 X 1 X 1=1 |
| # samples | 34 | 1 | |
| ** MAII score | log2(34/3220*10)=-3.24345403686428 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: PDE4D [Title/Abstract] AND CRABP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PDE4D | GO:0006198 | cAMP catabolic process | 9371713|17404263 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-86-7713-01A | PDE4D | chr5 | 58334686 | - | CRABP1 | chr15 | 78640269 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000340635 | ENST00000299529 | PDE4D | chr5 | 58334686 | - | CRABP1 | chr15 | 78640269 | + |
| Frame-shift | ENST00000360047 | ENST00000299529 | PDE4D | chr5 | 58334686 | - | CRABP1 | chr15 | 78640269 | + |
| Frame-shift | ENST00000507116 | ENST00000299529 | PDE4D | chr5 | 58334686 | - | CRABP1 | chr15 | 78640269 | + |
| In-frame | ENST00000502484 | ENST00000299529 | PDE4D | chr5 | 58334686 | - | CRABP1 | chr15 | 78640269 | + |
| Frame-shift | ENST00000546160 | ENST00000299529 | PDE4D | chr5 | 58334686 | - | CRABP1 | chr15 | 78640269 | + |
| intron-3CDS | ENST00000502575 | ENST00000299529 | PDE4D | chr5 | 58334686 | - | CRABP1 | chr15 | 78640269 | + |
| Frame-shift | ENST00000358923 | ENST00000299529 | PDE4D | chr5 | 58334686 | - | CRABP1 | chr15 | 78640269 | + |
| Frame-shift | ENST00000503258 | ENST00000299529 | PDE4D | chr5 | 58334686 | - | CRABP1 | chr15 | 78640269 | + |
| Frame-shift | ENST00000405755 | ENST00000299529 | PDE4D | chr5 | 58334686 | - | CRABP1 | chr15 | 78640269 | + |
| intron-3CDS | ENST00000317118 | ENST00000299529 | PDE4D | chr5 | 58334686 | - | CRABP1 | chr15 | 78640269 | + |
| intron-3CDS | ENST00000503947 | ENST00000299529 | PDE4D | chr5 | 58334686 | - | CRABP1 | chr15 | 78640269 | + |
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FusionProtFeatures for PDE4D_CRABP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PDE4D | CRABP1 |
| Cytosolic CRABPs may regulate the access of retinoicacid to the nuclear retinoic acid receptors. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PDE4D_CRABP1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PDE4D_ENST00000502484_chr5_58334686_-_CRABP1_ENST00000299529_chr15_78640269_+_263aa MKRNTCDLLSRSKSASEETLHSSNEEEDPFRGMEPYLVRRLSCRNIQLPPLAFRQLEQADLKSESENIQRPTSLPLKILPLIAITSAESS GFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PDE4D_ENST00000502484_chr5_58334686_-_CRABP1_ENST00000299529_chr15_78640269_+_789nt ATGAAAAGAAATACCTGTGATTTGCTTTCTCGGAGCAAAAGTGCCTCTGAGGAAACACTACATTCCAGTAATGAAGAGGAAGACCCTTTC CGCGGAATGGAACCCTATCTTGTCCGGAGACTTTCATGTCGCAATATTCAGCTTCCCCCTCTCGCCTTCAGACAGTTGGAACAAGCTGAC TTGAAAAGTGAATCAGAGAACATTCAACGACCAACCAGCCTCCCCCTGAAGATTCTGCCGCTGATTGCTATCACTTCTGCAGAATCCAGT GGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAAT TTTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCC ATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCT GCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCATGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGAGGAG GCCTACCAGAAACTGGCCAGCGAGACCCTGGAGGAGCTGGACTGGTGTCTGGACCAGCTAGAGACCCTACAGACCAGGCACTCCGTCAGT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PDE4D_ENST00000502484_chr5_58334686_-_CRABP1_ENST00000299529_chr15_78640269_+_1266nt AAGCACGAGTCCTATAGTTGGCGTACCCTGAGGCCTGCCAGTTCCTGCCTTAATGCATATGTAGTCGTAATTGAGTTCTGACACGGCCTT GGATGTTTCTGTCCTAAATAGCTGACATTGCATCTTCAAGACTGTCATTCCAGTTGGCTTTTGAGTGGATACGTGCAGTGAGATCATTGA CACTGGAAACACTAGTTCCCATTTTAATTACTTAAAACACCACGATGAAAAGAAATACCTGTGATTTGCTTTCTCGGAGCAAAAGTGCCT CTGAGGAAACACTACATTCCAGTAATGAAGAGGAAGACCCTTTCCGCGGAATGGAACCCTATCTTGTCCGGAGACTTTCATGTCGCAATA TTCAGCTTCCCCCTCTCGCCTTCAGACAGTTGGAACAAGCTGACTTGAAAAGTGAATCAGAGAACATTCAACGACCAACCAGCCTCCCCC TGAAGATTCTGCCGCTGATTGCTATCACTTCTGCAGAATCCAGTGGTTTTGATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGG ATCCCATGACCAGCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCCACAGTCAACGACGGGAGTCCTTCCTGTATCGATCCGACA GCGATTATGACCTCTCTCCAAAGTCTATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGACTTGATTGTGACTCCATTTG CTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACTTTGCTGCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCA TGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGAGGAGGCCTACCAGAAACTGGCCAGCGAGACCCTGGAGGAGCTGGACTGGT GTCTGGACCAGCTAGAGACCCTACAGACCAGGCACTCCGTCAGTGAGATGGCCTCCAACAAGACGTTTGGCGCCGATGACGTGGTCTGCA CCAGAATTTATGTCCGAGAGTGAAGGCAGCTGGCTTGCTCCTACTTTCAGGAAGGGATGCAGGCTCCCCTGAGGAATATGTCATAGTTCT GAGCTGCCAGTGGACCGCCCTTTTCCCCTACCAATATTAGGTGATCCCGTTTTCCCCATGACAATGTTGTAGTGTCCCCCACCCCCACCC CCCAGGCCTTGGTGCCTCTTGTATCCCTAGTGCTCCATAGTTTGGCATTTGCACGGTTTCGAAGTCATTAAACTGGTTAGACGTGTCTCA |
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FusionGenePPI for PDE4D_CRABP1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PDE4D | PDE4DIP, PDE4D, AKAP6, GNB2L1, ARRB1, MDM2, ITSN1, ARRB2, PPP3CA, PPP3CB, PPP3R1, GSK3B, CSNK1A1, CDK2, PAFAH1B1, PRKACA, APP, LYN, SRC, FYN, ABL1, GRB2, PIAS4, MAPK1, BIN1, HDGFRP2, ZBTB1, MAGEA6, TRAF1, COIL, GOLGA8EP, GOLGA8F, ZDHHC17, SPTAN1, PIK3R1, TRIM23, ITPKB, PFKFB2, AKAP12, ATOH1, DUSP13, PDE4B, TRIM25 | CRABP1 | TRA2A, CDK2, TSPO, CETN1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PDE4D_CRABP1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | PDE4D | Q08499 | DB00651 | Dyphylline | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | small molecule | approved |
| Hgene | PDE4D | Q08499 | DB01656 | Roflumilast | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | small molecule | approved |
| Hgene | PDE4D | Q08499 | DB01088 | Iloprost | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | small molecule | approved|investigational |
| Hgene | PDE4D | Q08499 | DB05266 | Ibudilast | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | small molecule | approved|investigational |
| Hgene | PDE4D | Q08499 | DB05676 | Apremilast | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | small molecule | approved|investigational |
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RelatedDiseases for PDE4D_CRABP1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PDE4D | C3553250 | ACRODYSOSTOSIS 2 WITH OR WITHOUT HORMONE RESISTANCE | 4 | UNIPROT |
| Hgene | PDE4D | C0011581 | Depressive disorder | 3 | PSYGENET |
| Hgene | PDE4D | C0004096 | Asthma | 2 | CTD_human |
| Hgene | PDE4D | C0011570 | Mental Depression | 2 | PSYGENET |
| Hgene | PDE4D | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | PDE4D | C0036341 | Schizophrenia | 1 | PSYGENET |
| Hgene | PDE4D | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
| Tgene | CRABP1 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
| Tgene | CRABP1 | C0022548 | Keloid | 1 | CTD_human |
| Tgene | CRABP1 | C0023903 | Liver neoplasms | 1 | CTD_human |
| Tgene | CRABP1 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
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