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Fusion gene ID: 26397 |
FusionGeneSummary for PDE4D_AGPAT4 |
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Fusion gene information | Fusion gene name: PDE4D_AGPAT4 | Fusion gene ID: 26397 | Hgene | Tgene | Gene symbol | PDE4D | AGPAT4 | Gene ID | 5144 | 56895 |
Gene name | phosphodiesterase 4D | 1-acylglycerol-3-phosphate O-acyltransferase 4 | |
Synonyms | ACRDYS2|DPDE3|HSPDE4D|PDE43|PDE4DN2|STRK1 | 1-AGPAT4|LPAAT-delta|dJ473J16.2 | |
Cytomap | 5q11.2-q12.1 | 6q26 | |
Type of gene | protein-coding | protein-coding | |
Description | cAMP-specific 3',5'-cyclic phosphodiesterase 4DcAMP-specific phosphodiesterase PDE4D6phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)testicular tissue protein Li 136 | 1-acyl-sn-glycerol-3-phosphate acyltransferase delta1-AGP acyltransferase 41-AGPAT 41-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)lysophosphatidic acid acyltransferase deltalysophosphatidic acid acyltran | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q08499 | Q9NRZ5 | |
Ensembl transtripts involved in fusion gene | ENST00000340635, ENST00000360047, ENST00000507116, ENST00000502484, ENST00000546160, ENST00000502575, ENST00000358923, ENST00000503258, ENST00000405755, ENST00000317118, ENST00000503947, | ENST00000366911, ENST00000320285, ENST00000457520, ENST00000366908, ENST00000366906, ENST00000366905, | |
Fusion gene scores | * DoF score | 23 X 14 X 10=3220 | 2 X 3 X 1=6 |
# samples | 34 | 4 | |
** MAII score | log2(34/3220*10)=-3.24345403686428 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/6*10)=2.73696559416621 | |
Context | PubMed: PDE4D [Title/Abstract] AND AGPAT4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PDE4D | GO:0006198 | cAMP catabolic process | 9371713|17404263 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA282561 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000340635 | ENST00000366911 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000340635 | ENST00000320285 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000340635 | ENST00000457520 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000340635 | ENST00000366908 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000340635 | ENST00000366906 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000340635 | ENST00000366905 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000360047 | ENST00000366911 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000360047 | ENST00000320285 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000360047 | ENST00000457520 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000360047 | ENST00000366908 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000360047 | ENST00000366906 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000360047 | ENST00000366905 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000507116 | ENST00000366911 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000507116 | ENST00000320285 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000507116 | ENST00000457520 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000507116 | ENST00000366908 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000507116 | ENST00000366906 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000507116 | ENST00000366905 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000502484 | ENST00000366911 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000502484 | ENST00000320285 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000502484 | ENST00000457520 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000502484 | ENST00000366908 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000502484 | ENST00000366906 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000502484 | ENST00000366905 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000546160 | ENST00000366911 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000546160 | ENST00000320285 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000546160 | ENST00000457520 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000546160 | ENST00000366908 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000546160 | ENST00000366906 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000546160 | ENST00000366905 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000502575 | ENST00000366911 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000502575 | ENST00000320285 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000502575 | ENST00000457520 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000502575 | ENST00000366908 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000502575 | ENST00000366906 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000502575 | ENST00000366905 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000358923 | ENST00000366911 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000358923 | ENST00000320285 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000358923 | ENST00000457520 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000358923 | ENST00000366908 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000358923 | ENST00000366906 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000358923 | ENST00000366905 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000503258 | ENST00000366911 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000503258 | ENST00000320285 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000503258 | ENST00000457520 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000503258 | ENST00000366908 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000503258 | ENST00000366906 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000503258 | ENST00000366905 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000405755 | ENST00000366911 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000405755 | ENST00000320285 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000405755 | ENST00000457520 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000405755 | ENST00000366908 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000405755 | ENST00000366906 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000405755 | ENST00000366905 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000317118 | ENST00000366911 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000317118 | ENST00000320285 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000317118 | ENST00000457520 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000317118 | ENST00000366908 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000317118 | ENST00000366906 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000317118 | ENST00000366905 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000503947 | ENST00000366911 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000503947 | ENST00000320285 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000503947 | ENST00000457520 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000503947 | ENST00000366908 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000503947 | ENST00000366906 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
intron-5UTR | ENST00000503947 | ENST00000366905 | PDE4D | chr5 | 59129537 | - | AGPAT4 | chr6 | 161695030 | - |
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FusionProtFeatures for PDE4D_AGPAT4 |
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Hgene | Tgene |
PDE4D | AGPAT4 |
Converts lysophosphatidic acid (LPA) into phosphatidicacid by incorporating an acyl moiety at the sn-2 position of theglycerol backbone. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PDE4D_AGPAT4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PDE4D_AGPAT4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PDE4D_AGPAT4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | PDE4D | Q08499 | DB00651 | Dyphylline | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | small molecule | approved |
Hgene | PDE4D | Q08499 | DB01656 | Roflumilast | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | small molecule | approved |
Hgene | PDE4D | Q08499 | DB01088 | Iloprost | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | small molecule | approved|investigational |
Hgene | PDE4D | Q08499 | DB05266 | Ibudilast | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | small molecule | approved|investigational |
Hgene | PDE4D | Q08499 | DB05676 | Apremilast | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | small molecule | approved|investigational |
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RelatedDiseases for PDE4D_AGPAT4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PDE4D | C3553250 | ACRODYSOSTOSIS 2 WITH OR WITHOUT HORMONE RESISTANCE | 4 | UNIPROT |
Hgene | PDE4D | C0011581 | Depressive disorder | 3 | PSYGENET |
Hgene | PDE4D | C0004096 | Asthma | 2 | CTD_human |
Hgene | PDE4D | C0011570 | Mental Depression | 2 | PSYGENET |
Hgene | PDE4D | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | PDE4D | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | PDE4D | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |