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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26396

FusionGeneSummary for PDE4DIP_OSMR

check button Fusion gene summary
Fusion gene informationFusion gene name: PDE4DIP_OSMR
Fusion gene ID: 26396
HgeneTgene
Gene symbol

PDE4DIP

OSMR

Gene ID

9659

9180

Gene namephosphodiesterase 4D interacting proteinoncostatin M receptor
SynonymsCMYA2|MMGLIL-31R-beta|IL-31RB|OSMRB|PLCA1
Cytomap

1q21.2

5p13.1

Type of geneprotein-codingprotein-coding
Descriptionmyomegalincardiomyopathy-associated protein 2myomegalin/phosphodiesterase 4D interacting protein variant 8oncostatin-M-specific receptor subunit betaIL-31 receptor subunit betaIL-31R subunit betainterleukin-31 receptor subunit betaoncostatin-M specific receptor beta subunit
Modification date2018052320180523
UniProtAcc

Q5VU43

Q99650

Ensembl transtripts involved in fusion geneENST00000313382, ENST00000369354, 
ENST00000369356, ENST00000530740, 
ENST00000369359, ENST00000369351, 
ENST00000369349, ENST00000369347, 
ENST00000369348, ENST00000524974, 
ENST00000313431, ENST00000529945, 
ENST00000479408, ENST00000493130, 
ENST00000478649, ENST00000369345, 
ENST00000274276, ENST00000502536, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 2=18
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PDE4DIP [Title/Abstract] AND OSMR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePDE4DIP

GO:1903358

regulation of Golgi organization

27666745

TgeneOSMR

GO:0034097

response to cytokine

8999038


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-EB-A5SF-01APDE4DIPchr1

144866592

+OSMRchr5

38932565

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000313382ENST00000274276PDE4DIPchr1

144866592

+OSMRchr5

38932565

+
5CDS-intronENST00000313382ENST00000502536PDE4DIPchr1

144866592

+OSMRchr5

38932565

+
Frame-shiftENST00000369354ENST00000274276PDE4DIPchr1

144866592

+OSMRchr5

38932565

+
5CDS-intronENST00000369354ENST00000502536PDE4DIPchr1

144866592

+OSMRchr5

38932565

+
Frame-shiftENST00000369356ENST00000274276PDE4DIPchr1

144866592

+OSMRchr5

38932565

+
5CDS-intronENST00000369356ENST00000502536PDE4DIPchr1

144866592

+OSMRchr5

38932565

+
Frame-shiftENST00000530740ENST00000274276PDE4DIPchr1

144866592

+OSMRchr5

38932565

+
5CDS-intronENST00000530740ENST00000502536PDE4DIPchr1

144866592

+OSMRchr5

38932565

+
Frame-shiftENST00000369359ENST00000274276PDE4DIPchr1

144866592

+OSMRchr5

38932565

+
5CDS-intronENST00000369359ENST00000502536PDE4DIPchr1

144866592

+OSMRchr5

38932565

+
intron-3CDSENST00000369351ENST00000274276PDE4DIPchr1

144866592

+OSMRchr5

38932565

+
intron-intronENST00000369351ENST00000502536PDE4DIPchr1

144866592

+OSMRchr5

38932565

+
intron-3CDSENST00000369349ENST00000274276PDE4DIPchr1

144866592

+OSMRchr5

38932565

+
intron-intronENST00000369349ENST00000502536PDE4DIPchr1

144866592

+OSMRchr5

38932565

+
intron-3CDSENST00000369347ENST00000274276PDE4DIPchr1

144866592

+OSMRchr5

38932565

+
intron-intronENST00000369347ENST00000502536PDE4DIPchr1

144866592

+OSMRchr5

38932565

+
intron-3CDSENST00000369348ENST00000274276PDE4DIPchr1

144866592

+OSMRchr5

38932565

+
intron-intronENST00000369348ENST00000502536PDE4DIPchr1

144866592

+OSMRchr5

38932565

+
5UTR-3CDSENST00000524974ENST00000274276PDE4DIPchr1

144866592

+OSMRchr5

38932565

+
5UTR-intronENST00000524974ENST00000502536PDE4DIPchr1

144866592

+OSMRchr5

38932565

+
intron-3CDSENST00000313431ENST00000274276PDE4DIPchr1

144866592

+OSMRchr5

38932565

+
intron-intronENST00000313431ENST00000502536PDE4DIPchr1

144866592

+OSMRchr5

38932565

+
intron-3CDSENST00000529945ENST00000274276PDE4DIPchr1

144866592

+OSMRchr5

38932565

+
intron-intronENST00000529945ENST00000502536PDE4DIPchr1

144866592

+OSMRchr5

38932565

+
intron-3CDSENST00000479408ENST00000274276PDE4DIPchr1

144866592

+OSMRchr5

38932565

+
intron-intronENST00000479408ENST00000502536PDE4DIPchr1

144866592

+OSMRchr5

38932565

+
intron-3CDSENST00000493130ENST00000274276PDE4DIPchr1

144866592

+OSMRchr5

38932565

+
intron-intronENST00000493130ENST00000502536PDE4DIPchr1

144866592

+OSMRchr5

38932565

+
intron-3CDSENST00000478649ENST00000274276PDE4DIPchr1

144866592

+OSMRchr5

38932565

+
intron-intronENST00000478649ENST00000502536PDE4DIPchr1

144866592

+OSMRchr5

38932565

+
intron-3CDSENST00000369345ENST00000274276PDE4DIPchr1

144866592

+OSMRchr5

38932565

+
intron-intronENST00000369345ENST00000502536PDE4DIPchr1

144866592

+OSMRchr5

38932565

+

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FusionProtFeatures for PDE4DIP_OSMR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PDE4DIP

Q5VU43

OSMR

Q99650

Associates with IL31RA to form the IL31 receptor. BindsIL31 to activate STAT3 and possibly STAT1 and STAT5. Capable oftransducing OSM-specific signaling events.{ECO:0000269|PubMed:15184896, ECO:0000269|PubMed:8999038}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PDE4DIP_OSMR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PDE4DIP_OSMR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PDE4DIPPDE4D, CDC5L, TNIK, OSGEP, GADD45G, NEK2, SNCA, FES, TK1, FHL1, CDKN1A, LAMTOR3, KRAS, SMN1, IMMT, PFDN1, ITSN2, ELAVL1, TRAF4, PRNP, GFI1B, ZNF512B, USO1, KRT18, PIAS4, ADH1B, KDM1A, PRKACA, PRKACB, ANKRD11, ARNT2, BYSL, KRT31, NEFL, SDCBP, ZSCAN26, NAA10, LMO4, UTP14C, FCHSD2, MAPRE1, MTUS2, TFIP11, PRPF31, ZNF581, CHCHD3, C1orf109, C14orf105, C19orf66, VAC14, MIF4GD, CCDC146, SH2D4A, AEN, SCNM1, ZFYVE21, LENG1, ZNF408, FAM161A, KLC4, HAUS1, KLC3, PPP1R18, ZBTB38, RTP5, GOLGA8EP, FAM74A4, GOLGA8F, RNF2, MLF1, CEP170, PRKAR2B, SCCPDH, TEAD4, DYNLL1, PDE4DIP, PM20D1, A2ML1, AKAP9, FAM129B, CSNK1D, PRKACG, LCN2, CD207, CSNK1E, IVL, NDRG1, IGHG1, IGHG2, EVPL, ANXA8, C3, CRABP2, TYMP, DNAJC10, CCDC6, CDK5RAP2, ALDH1A3, ZNF785, RAB25, GATM, SERPINB4, S100A7, CALML3, MAPRE3, ACADVL, IGKC, PKP3, C1orf87, AKR1B10, PPL, S100A9, JUP, TGM1, LGALS7B, POF1B, SERPINB5, CST6, GM2A, ARF6, HMGCS2, GDPD3, NCCRP1, SERPINB3, CALML5, CYLDOSMRERBB2, IL6ST, GAPDH, CUL5, BAG3, EGFR, OSM, JAK1, ANKLE2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PDE4DIP_OSMR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PDE4DIP_OSMR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneOSMRC0268398Familial lichen amyloidosis2CTD_human;ORPHANET;UNIPROT
TgeneOSMRC0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneOSMRC0345967Malignant mesothelioma1CTD_human