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Fusion gene ID: 26392 |
FusionGeneSummary for PDE4B_MOB3C |
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Fusion gene information | Fusion gene name: PDE4B_MOB3C | Fusion gene ID: 26392 | Hgene | Tgene | Gene symbol | PDE4B | MOB3C | Gene ID | 5142 | 148932 |
Gene name | phosphodiesterase 4B | MOB kinase activator 3C | |
Synonyms | DPDE4|PDEIVB | MOB1E|MOBKL2C | |
Cytomap | 1p31.3 | 1p33 | |
Type of gene | protein-coding | protein-coding | |
Description | cAMP-specific 3',5'-cyclic phosphodiesterase 4Bdunce-like phosphodiesterase E4phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila) | MOB kinase activator 3CMOB1, Mps One Binder kinase activator-like 2Cmob1 homolog 2C | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q07343 | Q70IA8 | |
Ensembl transtripts involved in fusion gene | ENST00000329654, ENST00000371049, ENST00000423207, ENST00000371048, ENST00000371045, ENST00000480109, | ENST00000319928, ENST00000271139, ENST00000371940, ENST00000477318, | |
Fusion gene scores | * DoF score | 4 X 5 X 2=40 | 3 X 2 X 3=18 |
# samples | 5 | 3 | |
** MAII score | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PDE4B [Title/Abstract] AND MOB3C [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PDE4B | GO:0006198 | cAMP catabolic process | 17404263 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-AR-A24Z-01A | PDE4B | chr1 | 66731770 | + | MOB3C | chr1 | 47079043 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000329654 | ENST00000319928 | PDE4B | chr1 | 66731770 | + | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000329654 | ENST00000271139 | PDE4B | chr1 | 66731770 | + | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000329654 | ENST00000371940 | PDE4B | chr1 | 66731770 | + | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000329654 | ENST00000477318 | PDE4B | chr1 | 66731770 | + | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000371049 | ENST00000319928 | PDE4B | chr1 | 66731770 | + | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000371049 | ENST00000271139 | PDE4B | chr1 | 66731770 | + | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000371049 | ENST00000371940 | PDE4B | chr1 | 66731770 | + | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000371049 | ENST00000477318 | PDE4B | chr1 | 66731770 | + | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000423207 | ENST00000319928 | PDE4B | chr1 | 66731770 | + | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000423207 | ENST00000271139 | PDE4B | chr1 | 66731770 | + | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000423207 | ENST00000371940 | PDE4B | chr1 | 66731770 | + | MOB3C | chr1 | 47079043 | - |
5CDS-5UTR | ENST00000423207 | ENST00000477318 | PDE4B | chr1 | 66731770 | + | MOB3C | chr1 | 47079043 | - |
3UTR-5UTR | ENST00000371048 | ENST00000319928 | PDE4B | chr1 | 66731770 | + | MOB3C | chr1 | 47079043 | - |
3UTR-5UTR | ENST00000371048 | ENST00000271139 | PDE4B | chr1 | 66731770 | + | MOB3C | chr1 | 47079043 | - |
3UTR-5UTR | ENST00000371048 | ENST00000371940 | PDE4B | chr1 | 66731770 | + | MOB3C | chr1 | 47079043 | - |
3UTR-5UTR | ENST00000371048 | ENST00000477318 | PDE4B | chr1 | 66731770 | + | MOB3C | chr1 | 47079043 | - |
intron-5UTR | ENST00000371045 | ENST00000319928 | PDE4B | chr1 | 66731770 | + | MOB3C | chr1 | 47079043 | - |
intron-5UTR | ENST00000371045 | ENST00000271139 | PDE4B | chr1 | 66731770 | + | MOB3C | chr1 | 47079043 | - |
intron-5UTR | ENST00000371045 | ENST00000371940 | PDE4B | chr1 | 66731770 | + | MOB3C | chr1 | 47079043 | - |
intron-5UTR | ENST00000371045 | ENST00000477318 | PDE4B | chr1 | 66731770 | + | MOB3C | chr1 | 47079043 | - |
intron-5UTR | ENST00000480109 | ENST00000319928 | PDE4B | chr1 | 66731770 | + | MOB3C | chr1 | 47079043 | - |
intron-5UTR | ENST00000480109 | ENST00000271139 | PDE4B | chr1 | 66731770 | + | MOB3C | chr1 | 47079043 | - |
intron-5UTR | ENST00000480109 | ENST00000371940 | PDE4B | chr1 | 66731770 | + | MOB3C | chr1 | 47079043 | - |
intron-5UTR | ENST00000480109 | ENST00000477318 | PDE4B | chr1 | 66731770 | + | MOB3C | chr1 | 47079043 | - |
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FusionProtFeatures for PDE4B_MOB3C |
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Hgene | Tgene |
PDE4B | MOB3C |
Hydrolyzes the second messenger cAMP, which is a keyregulator of many important physiological processes. May beinvolved in mediating central nervous system effects oftherapeutic agents ranging from antidepressants to antiasthmaticand anti-inflammatory agents. {ECO:0000269|PubMed:10846163,ECO:0000269|PubMed:15003452}. | May regulate the activity of kinases. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PDE4B_MOB3C |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PDE4B_MOB3C |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PDE4B | DISC1, PAFAH1B1, APOA1, ALB, MAGEA11, RCBTB2, MOV10, NXF1, NTRK1, XPO1, PDE4D | MOB3C | LATS1, LATS2, APP, SIAH1, TDO2, TFCP2, TNIP1, NT5C2, FAM118A, ZBTB10, CMTM3, KRT40, C10orf107, MAU2, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PDE4B_MOB3C |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | PDE4B | Q07343 | DB00201 | Caffeine | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | small molecule | approved |
Hgene | PDE4B | Q07343 | DB00277 | Theophylline | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | small molecule | approved |
Hgene | PDE4B | Q07343 | DB00651 | Dyphylline | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | small molecule | approved |
Hgene | PDE4B | Q07343 | DB01427 | Amrinone | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | small molecule | approved |
Hgene | PDE4B | Q07343 | DB01656 | Roflumilast | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | small molecule | approved |
Hgene | PDE4B | Q07343 | DB00806 | Pentoxifylline | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | small molecule | approved|investigational |
Hgene | PDE4B | Q07343 | DB01088 | Iloprost | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | small molecule | approved|investigational |
Hgene | PDE4B | Q07343 | DB01113 | Papaverine | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | small molecule | approved|investigational |
Hgene | PDE4B | Q07343 | DB01412 | Theobromine | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | small molecule | approved|investigational |
Hgene | PDE4B | Q07343 | DB05266 | Ibudilast | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | small molecule | approved|investigational |
Hgene | PDE4B | Q07343 | DB05676 | Apremilast | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | small molecule | approved|investigational |
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RelatedDiseases for PDE4B_MOB3C |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PDE4B | C0011570 | Mental Depression | 5 | PSYGENET |
Hgene | PDE4B | C0011581 | Depressive disorder | 5 | PSYGENET |
Hgene | PDE4B | C0005586 | Bipolar Disorder | 4 | CTD_human;PSYGENET |
Hgene | PDE4B | C0036341 | Schizophrenia | 2 | CTD_human |
Hgene | PDE4B | C0001973 | Alcoholic Intoxication, Chronic | 1 | CTD_human |
Hgene | PDE4B | C0004096 | Asthma | 1 | CTD_human |
Hgene | PDE4B | C0004352 | Autistic Disorder | 1 | CTD_human |
Hgene | PDE4B | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
Hgene | PDE4B | C0037274 | Dermatologic disorders | 1 | CTD_human |
Hgene | PDE4B | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Hgene | PDE4B | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
Hgene | PDE4B | C0311375 | Arsenic Poisoning | 1 | CTD_human |