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Fusion gene ID: 26391 |
FusionGeneSummary for PDE4B_JAK1 |
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Fusion gene information | Fusion gene name: PDE4B_JAK1 | Fusion gene ID: 26391 | Hgene | Tgene | Gene symbol | PDE4B | JAK1 | Gene ID | 5142 | 3716 |
Gene name | phosphodiesterase 4B | Janus kinase 1 | |
Synonyms | DPDE4|PDEIVB | JAK1A|JAK1B|JTK3 | |
Cytomap | 1p31.3 | 1p31.3 | |
Type of gene | protein-coding | protein-coding | |
Description | cAMP-specific 3',5'-cyclic phosphodiesterase 4Bdunce-like phosphodiesterase E4phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila) | tyrosine-protein kinase JAK1 | |
Modification date | 20180519 | 20180527 | |
UniProtAcc | Q07343 | P23458 | |
Ensembl transtripts involved in fusion gene | ENST00000329654, ENST00000371049, ENST00000423207, ENST00000371048, ENST00000371045, ENST00000480109, | ENST00000342505, ENST00000465376, | |
Fusion gene scores | * DoF score | 4 X 5 X 2=40 | 9 X 8 X 4=288 |
# samples | 5 | 10 | |
** MAII score | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(10/288*10)=-1.52606881166759 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PDE4B [Title/Abstract] AND JAK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PDE4B | GO:0006198 | cAMP catabolic process | 17404263 |
Tgene | JAK1 | GO:0038110 | interleukin-2-mediated signaling pathway | 11909529 |
Tgene | JAK1 | GO:0046677 | response to antibiotic | 16280321 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-A8-A0A1-01A | PDE4B | chr1 | 66798303 | + | JAK1 | chr1 | 65352024 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000329654 | ENST00000342505 | PDE4B | chr1 | 66798303 | + | JAK1 | chr1 | 65352024 | - |
5CDS-intron | ENST00000329654 | ENST00000465376 | PDE4B | chr1 | 66798303 | + | JAK1 | chr1 | 65352024 | - |
5CDS-5UTR | ENST00000371049 | ENST00000342505 | PDE4B | chr1 | 66798303 | + | JAK1 | chr1 | 65352024 | - |
5CDS-intron | ENST00000371049 | ENST00000465376 | PDE4B | chr1 | 66798303 | + | JAK1 | chr1 | 65352024 | - |
5CDS-5UTR | ENST00000423207 | ENST00000342505 | PDE4B | chr1 | 66798303 | + | JAK1 | chr1 | 65352024 | - |
5CDS-intron | ENST00000423207 | ENST00000465376 | PDE4B | chr1 | 66798303 | + | JAK1 | chr1 | 65352024 | - |
intron-5UTR | ENST00000371048 | ENST00000342505 | PDE4B | chr1 | 66798303 | + | JAK1 | chr1 | 65352024 | - |
intron-intron | ENST00000371048 | ENST00000465376 | PDE4B | chr1 | 66798303 | + | JAK1 | chr1 | 65352024 | - |
5CDS-5UTR | ENST00000371045 | ENST00000342505 | PDE4B | chr1 | 66798303 | + | JAK1 | chr1 | 65352024 | - |
5CDS-intron | ENST00000371045 | ENST00000465376 | PDE4B | chr1 | 66798303 | + | JAK1 | chr1 | 65352024 | - |
intron-5UTR | ENST00000480109 | ENST00000342505 | PDE4B | chr1 | 66798303 | + | JAK1 | chr1 | 65352024 | - |
intron-intron | ENST00000480109 | ENST00000465376 | PDE4B | chr1 | 66798303 | + | JAK1 | chr1 | 65352024 | - |
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FusionProtFeatures for PDE4B_JAK1 |
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Hgene | Tgene |
PDE4B | JAK1 |
Hydrolyzes the second messenger cAMP, which is a keyregulator of many important physiological processes. May beinvolved in mediating central nervous system effects oftherapeutic agents ranging from antidepressants to antiasthmaticand anti-inflammatory agents. {ECO:0000269|PubMed:10846163,ECO:0000269|PubMed:15003452}. | Tyrosine kinase of the non-receptor type, involved inthe IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinasepartner for the interleukin (IL)-2 receptor (PubMed:11909529).{ECO:0000269|PubMed:11909529, ECO:0000269|PubMed:7615558}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PDE4B_JAK1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PDE4B_JAK1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PDE4B | DISC1, PAFAH1B1, APOA1, ALB, MAGEA11, RCBTB2, MOV10, NXF1, NTRK1, XPO1, PDE4D | JAK1 | ATIC, ARRB1, ELF3, STAT3, ABL1, ABL2, GNB2L1, IL27RA, PRMT5, SHB, IL10RA, PTK2B, TEC, BTK, IRS1, IGF1R, BRCA1, IL2RB, IL6ST, STAM2, PTPN11, TYK2, TNFRSF1A, STAT5B, STAT5A, IRS2, ELP2, IL21R, GRB2, CSF3R, IL5RA, IL9R, PTPN6, PLAUR, IFNAR2, IL4R, IFNGR1, TSHR, GHR, RAF1, AGO4, CSF2RB, TIRAP, HIST3H3, SIRT1, SOCS1, SOCS3, EGFR, TOP1, STAT6, EIF4A3, MAGOH, SMURF1, IL2RG, JAK1, EIF2AK2, HSP90AA1, ERBB2, INSR, STAT1, UBL4A, JAK3, PLCG1, NPM1, PLA2G4A, MDM2, NOC2L, PML, TAGLN, DTX3L, DSP, FLG2, RNF125, TGFBR2, LPAR6, NTRK1, KRAS, CTDSPL2, FAM46A, KIF24, EID1, CFTR, OSMR, LAMP2, LAMP3, IL13RA2, MANSC1, APLNR, MAS1, HAVCR2, SLC15A1, LRRIQ1, CYLD |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PDE4B_JAK1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | PDE4B | Q07343 | DB00201 | Caffeine | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | small molecule | approved |
Hgene | PDE4B | Q07343 | DB00277 | Theophylline | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | small molecule | approved |
Hgene | PDE4B | Q07343 | DB00651 | Dyphylline | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | small molecule | approved |
Hgene | PDE4B | Q07343 | DB01427 | Amrinone | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | small molecule | approved |
Hgene | PDE4B | Q07343 | DB01656 | Roflumilast | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | small molecule | approved |
Hgene | PDE4B | Q07343 | DB00806 | Pentoxifylline | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | small molecule | approved|investigational |
Hgene | PDE4B | Q07343 | DB01088 | Iloprost | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | small molecule | approved|investigational |
Hgene | PDE4B | Q07343 | DB01113 | Papaverine | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | small molecule | approved|investigational |
Hgene | PDE4B | Q07343 | DB01412 | Theobromine | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | small molecule | approved|investigational |
Hgene | PDE4B | Q07343 | DB05266 | Ibudilast | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | small molecule | approved|investigational |
Hgene | PDE4B | Q07343 | DB05676 | Apremilast | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | small molecule | approved|investigational |
Tgene | JAK1 | P23458 | DB08877 | Ruxolitinib | Tyrosine-protein kinase JAK1 | small molecule | approved |
Tgene | JAK1 | P23458 | DB08895 | Tofacitinib | Tyrosine-protein kinase JAK1 | small molecule | approved|investigational |
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RelatedDiseases for PDE4B_JAK1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PDE4B | C0011570 | Mental Depression | 5 | PSYGENET |
Hgene | PDE4B | C0011581 | Depressive disorder | 5 | PSYGENET |
Hgene | PDE4B | C0005586 | Bipolar Disorder | 4 | CTD_human;PSYGENET |
Hgene | PDE4B | C0036341 | Schizophrenia | 2 | CTD_human |
Hgene | PDE4B | C0001973 | Alcoholic Intoxication, Chronic | 1 | CTD_human |
Hgene | PDE4B | C0004096 | Asthma | 1 | CTD_human |
Hgene | PDE4B | C0004352 | Autistic Disorder | 1 | CTD_human |
Hgene | PDE4B | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
Hgene | PDE4B | C0037274 | Dermatologic disorders | 1 | CTD_human |
Hgene | PDE4B | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Hgene | PDE4B | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
Hgene | PDE4B | C0311375 | Arsenic Poisoning | 1 | CTD_human |