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Fusion gene ID: 26389 |
FusionGeneSummary for PDE4A_S1PR5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PDE4A_S1PR5 | Fusion gene ID: 26389 | Hgene | Tgene | Gene symbol | PDE4A | S1PR5 | Gene ID | 5141 | 53637 |
| Gene name | phosphodiesterase 4A | sphingosine-1-phosphate receptor 5 | |
| Synonyms | DPDE2|PDE4|PDE46 | EDG8|Edg-8|S1P5|SPPR-1|SPPR-2 | |
| Cytomap | 19p13.2 | 19p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cAMP-specific 3',5'-cyclic phosphodiesterase 4Aphosphodiesterase 4A, cAMP-specific (duncephosphodiesterase E2 dunce homolog, Drosophilaphosphodiesterase isozyme 4 | sphingosine 1-phosphate receptor 5S1P receptor 5S1P receptor Edg-8endothelial differentiation G-protein-coupled receptor 8endothelial differentiation, sphingolipid G-protein-coupled receptor, 8sphingosine 1-phosphate receptor EDG8sphingosine 1-phosp | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | P27815 | Q9H228 | |
| Ensembl transtripts involved in fusion gene | ENST00000592685, ENST00000380702, ENST00000352831, ENST00000293683, ENST00000440014, ENST00000344979, | ENST00000333430, ENST00000439028, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 3 X 2 X 3=18 |
| # samples | 3 | 3 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PDE4A [Title/Abstract] AND S1PR5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PDE4A | GO:0006198 | cAMP catabolic process | 17404263 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-22-4613-01A | PDE4A | chr19 | 10574651 | + | S1PR5 | chr19 | 10625705 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000592685 | ENST00000333430 | PDE4A | chr19 | 10574651 | + | S1PR5 | chr19 | 10625705 | - |
| 5CDS-5UTR | ENST00000592685 | ENST00000439028 | PDE4A | chr19 | 10574651 | + | S1PR5 | chr19 | 10625705 | - |
| 5CDS-5UTR | ENST00000380702 | ENST00000333430 | PDE4A | chr19 | 10574651 | + | S1PR5 | chr19 | 10625705 | - |
| 5CDS-5UTR | ENST00000380702 | ENST00000439028 | PDE4A | chr19 | 10574651 | + | S1PR5 | chr19 | 10625705 | - |
| 5CDS-5UTR | ENST00000352831 | ENST00000333430 | PDE4A | chr19 | 10574651 | + | S1PR5 | chr19 | 10625705 | - |
| 5CDS-5UTR | ENST00000352831 | ENST00000439028 | PDE4A | chr19 | 10574651 | + | S1PR5 | chr19 | 10625705 | - |
| 5CDS-5UTR | ENST00000293683 | ENST00000333430 | PDE4A | chr19 | 10574651 | + | S1PR5 | chr19 | 10625705 | - |
| 5CDS-5UTR | ENST00000293683 | ENST00000439028 | PDE4A | chr19 | 10574651 | + | S1PR5 | chr19 | 10625705 | - |
| 5CDS-5UTR | ENST00000440014 | ENST00000333430 | PDE4A | chr19 | 10574651 | + | S1PR5 | chr19 | 10625705 | - |
| 5CDS-5UTR | ENST00000440014 | ENST00000439028 | PDE4A | chr19 | 10574651 | + | S1PR5 | chr19 | 10625705 | - |
| 5CDS-5UTR | ENST00000344979 | ENST00000333430 | PDE4A | chr19 | 10574651 | + | S1PR5 | chr19 | 10625705 | - |
| 5CDS-5UTR | ENST00000344979 | ENST00000439028 | PDE4A | chr19 | 10574651 | + | S1PR5 | chr19 | 10625705 | - |
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FusionProtFeatures for PDE4A_S1PR5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PDE4A | S1PR5 |
| Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicitsdiverse physiological effect on most types of cells and tissues.Is coupled to both the G(i/0)alpha and G(12) subclass ofheteromeric G-proteins (By similarity). May play a regulatory rolein the transformation of radial glial cells into astrocytes andmay affect proliferative activity of these cells. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PDE4A_S1PR5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PDE4A_S1PR5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PDE4A | LYN, PRKAR2A, AKAP6, SQSTM1, PIAS4, ITPKB, FKBP6, TRIM25 | S1PR5 | TP63, SLC39A4, LYPD6, GPR21, VNN2, UPK1A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PDE4A_S1PR5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | PDE4A | P27815 | DB00277 | Theophylline | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | small molecule | approved |
| Hgene | PDE4A | P27815 | DB00651 | Dyphylline | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | small molecule | approved |
| Hgene | PDE4A | P27815 | DB00975 | Dipyridamole | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | small molecule | approved |
| Hgene | PDE4A | P27815 | DB01303 | Oxtriphylline | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | small molecule | approved |
| Hgene | PDE4A | P27815 | DB01656 | Roflumilast | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | small molecule | approved |
| Hgene | PDE4A | P27815 | DB08811 | Tofisopam | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | small molecule | approved |
| Hgene | PDE4A | P27815 | DB00806 | Pentoxifylline | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | small molecule | approved|investigational |
| Hgene | PDE4A | P27815 | DB01088 | Iloprost | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | small molecule | approved|investigational |
| Hgene | PDE4A | P27815 | DB05266 | Ibudilast | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | small molecule | approved|investigational |
| Hgene | PDE4A | P27815 | DB05676 | Apremilast | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | small molecule | approved|investigational |
| Hgene | PDE4A | P27815 | DB06751 | Drotaverine | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | small molecule | approved|investigational |
| Tgene | S1PR5 | Q9H228 | DB08868 | Fingolimod | Sphingosine 1-phosphate receptor 5 | small molecule | approved|investigational |
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RelatedDiseases for PDE4A_S1PR5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PDE4A | C0011570 | Mental Depression | 5 | PSYGENET |
| Hgene | PDE4A | C0011581 | Depressive disorder | 5 | PSYGENET |
| Hgene | PDE4A | C0036341 | Schizophrenia | 2 | PSYGENET |
| Hgene | PDE4A | C0004352 | Autistic Disorder | 1 | CTD_human |
| Hgene | PDE4A | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Hgene | PDE4A | C0085159 | Seasonal Affective Disorder | 1 | PSYGENET |
| Tgene | S1PR5 | C0011853 | Diabetes Mellitus, Experimental | 1 | CTD_human |
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