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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26373

FusionGeneSummary for PDE12_ROBO2

check button Fusion gene summary
Fusion gene informationFusion gene name: PDE12_ROBO2
Fusion gene ID: 26373
HgeneTgene
Gene symbol

PDE12

ROBO2

Gene ID

201626

6092

Gene namephosphodiesterase 12roundabout guidance receptor 2
Synonyms2'-PDE|2-PDESAX3
Cytomap

3p14.3

3p12.3

Type of geneprotein-codingprotein-coding
Description2',5'-phosphodiesterase 122'-phosphodiesterasemitochondrial deadenylaseroundabout homolog 2roundabout, axon guidance receptor, homolog 2
Modification date2018051920180519
UniProtAcc

Q6L8Q7

Q9HCK4

Ensembl transtripts involved in fusion geneENST00000487257, ENST00000311180, 
ENST00000487694, ENST00000461745, 
ENST00000332191, ENST00000469233, 
Fusion gene scores* DoF score3 X 2 X 3=188 X 8 X 6=384
# samples 38
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(8/384*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDE12 [Title/Abstract] AND ROBO2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePDE12

GO:0060548

negative regulation of cell death

15231837

HgenePDE12

GO:0071346

cellular response to interferon-gamma

15231837

HgenePDE12

GO:0071359

cellular response to dsRNA

15231837

HgenePDE12

GO:0090305

nucleic acid phosphodiester bond hydrolysis

22285541

TgeneROBO2

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

12504588

TgeneROBO2

GO:0050772

positive regulation of axonogenesis

12504588

TgeneROBO2

GO:0050925

negative regulation of negative chemotaxis

11748139


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-GF-A4EO-06APDE12chr3

57545115

+ROBO2chr3

77671378

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000487257ENST00000487694PDE12chr3

57545115

+ROBO2chr3

77671378

+
In-frameENST00000487257ENST00000461745PDE12chr3

57545115

+ROBO2chr3

77671378

+
In-frameENST00000487257ENST00000332191PDE12chr3

57545115

+ROBO2chr3

77671378

+
5CDS-intronENST00000487257ENST00000469233PDE12chr3

57545115

+ROBO2chr3

77671378

+
Frame-shiftENST00000311180ENST00000487694PDE12chr3

57545115

+ROBO2chr3

77671378

+
Frame-shiftENST00000311180ENST00000461745PDE12chr3

57545115

+ROBO2chr3

77671378

+
Frame-shiftENST00000311180ENST00000332191PDE12chr3

57545115

+ROBO2chr3

77671378

+
5CDS-intronENST00000311180ENST00000469233PDE12chr3

57545115

+ROBO2chr3

77671378

+

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FusionProtFeatures for PDE12_ROBO2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PDE12

Q6L8Q7

ROBO2

Q9HCK4

Enzyme that cleaves 2',5'-phosphodiester bond linkingadenosines of the 5'-triphosphorylated oligoadenylates,triphosphorylated oligoadenylates referred as 2-5A modulates the2-5A system. This enzyme degraded triphosphorylated 2-5A toproduce AMP and ATP. Also cleaves 3',5'-phosphodiester bond ofoligoadenylates. Plays a role as a negative regulator of the The2-5A system that is one of the major pathways for antiviral andantitumor functions induced by interferons (IFNs). Suppression ofthis enzyme induces reduction of viral replication in Hela cells,thus counteracting the antiviral pathway probably by inhibitingthe 2-5A system. {ECO:0000269|PubMed:15231837,ECO:0000269|PubMed:21245038, ECO:0000269|PubMed:21666256,ECO:0000269|PubMed:22285541}. Receptor for SLIT2, and probably SLIT1, which arethought to act as molecular guidance cue in cellular migration,including axonal navigation at the ventral midline of the neuraltube and projection of axons to different regions during neuronaldevelopment.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneROBO2chr3:57545115chr3:77671378ENST00000461745+2126133_22011841379DomainNote=Ig-like C2-type 2
TgeneROBO2chr3:57545115chr3:77671378ENST00000461745+2126225_30911841379DomainNote=Ig-like C2-type 3
TgeneROBO2chr3:57545115chr3:77671378ENST00000461745+2126314_40911841379DomainNote=Ig-like C2-type 4
TgeneROBO2chr3:57545115chr3:77671378ENST00000461745+212631_12711841379DomainNote=Ig-like C2-type 1
TgeneROBO2chr3:57545115chr3:77671378ENST00000461745+2126418_50411841379DomainNote=Ig-like C2-type 5
TgeneROBO2chr3:57545115chr3:77671378ENST00000461745+2126524_61811841379DomainFibronectin type-III 1
TgeneROBO2chr3:57545115chr3:77671378ENST00000461745+2126637_73511841379DomainFibronectin type-III 2
TgeneROBO2chr3:57545115chr3:77671378ENST00000461745+2126739_83611841379DomainFibronectin type-III 3
TgeneROBO2chr3:57545115chr3:77671378ENST00000487694+2227133_22012001395DomainNote=Ig-like C2-type 2
TgeneROBO2chr3:57545115chr3:77671378ENST00000487694+2227225_30912001395DomainNote=Ig-like C2-type 3
TgeneROBO2chr3:57545115chr3:77671378ENST00000487694+2227314_40912001395DomainNote=Ig-like C2-type 4
TgeneROBO2chr3:57545115chr3:77671378ENST00000487694+222731_12712001395DomainNote=Ig-like C2-type 1
TgeneROBO2chr3:57545115chr3:77671378ENST00000487694+2227418_50412001395DomainNote=Ig-like C2-type 5
TgeneROBO2chr3:57545115chr3:77671378ENST00000487694+2227524_61812001395DomainFibronectin type-III 1
TgeneROBO2chr3:57545115chr3:77671378ENST00000487694+2227637_73512001395DomainFibronectin type-III 2
TgeneROBO2chr3:57545115chr3:77671378ENST00000487694+2227739_83612001395DomainFibronectin type-III 3
TgeneROBO2chr3:57545115chr3:77671378ENST00000461745+212622_85911841379Topological domainExtracellular
TgeneROBO2chr3:57545115chr3:77671378ENST00000461745+2126881_137811841379Topological domainCytoplasmic
TgeneROBO2chr3:57545115chr3:77671378ENST00000487694+222722_85912001395Topological domainExtracellular
TgeneROBO2chr3:57545115chr3:77671378ENST00000487694+2227881_137812001395Topological domainCytoplasmic
TgeneROBO2chr3:57545115chr3:77671378ENST00000461745+2126860_88011841379TransmembraneHelical
TgeneROBO2chr3:57545115chr3:77671378ENST00000487694+2227860_88012001395TransmembraneHelical


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FusionGeneSequence for PDE12_ROBO2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PDE12_ENST00000487257_chr3_57545115_+_ROBO2_ENST00000487694_chr3_77671378_+_1173aa
MWRLPGARAALRVIRTAVEKLSRAEAGSQTAAGAMERAVVRCVPSEPKLSLSFALADGSHKNMQRDQSEPLGRVLSRIATNALKGHAKAA
AAKKSRKSRPNASGGAACSGPGPEPAVFCEPVVKLYYREEAVAEDVLNVDAWQDGAVLQIGDVKYKVERNPPAFTELQLPRYIMAGFPVC
PKLSLEFGDPASSLFRWYKEAKPGAAEPEVGVPSSLSPSSPSSSWTETDVEERVYTPSNADIGLRLKLHCTPGDGQRFGHSRELESVCVV
EAGPGTCTFDHRHLYTKKVTEDALIRTVSYNILADTYAQTEFSRTVLYPYCAPYALELDYRQNLIQKELTGYNADVICLQEVDRAVFSDS
LVPALEAFGLEGVFRIKQHEGLATFYRKSKFSLLSQHDISFYEALESDPLHKELLEKLVLYPSAQEKVLQRSSVLQVSVLQSTKDSSKRI
CVANTHLYWHPKGRFYLVSQVTXTRLKLFKVFYTNAYLERHPETVICVVFLFXLKDNFKKYLHXCFLYSXVGIFASFKWQXPWLTXDMFH
VICILAYQLYFVGTLIVHHQQECIILSSMAAFQRIMKTGLPMGRRKDAICLLHISSSXKVLVVNLLTQIMLVAFMDVXITFSLTXMLXRL
NRXFHYLVMKKLPPTRPYLVFPIPLITXHLYVIXNGNRCVFNGIEVXKGSSYFSRKFNMNQSLYVNFKEEWXNVQPSXLCSXCLRYETVD
VCIIHLLFPCFPLQLEEKQIYFLLAKXKIELFFSKLRLSEKEDXISVFFVCLFLFLFLFFXDGVSLLLPRLECNGTISAHCNLRPLGLSD
SPASASRVAGITGVRQHVWLIFVFLVEMGFRHVGQAGLELLTSGDPPTSASQSVGITGVSHRTRPLCTFLXENFFSXEFRIFKVPFEXSX
FFFHDNTFQNESCLCTKRENVFKLRVRDLSYRXPXRPKVRDLTHGRSNIRVYLYLNLVSDLLQFQSFNKRXKXIVTNCXHIQSNNQPPQP
PVPPLGYVSGALISDLETDVADDDADDEEEALEIPRPLRALDQTPGSSMDNLDSSVTGKAFTSSQRPRPTSPFSTDSNTSAALSQSQRPR
PTKKHKGGRMDQQPALPHRREGMTDEEALVPYSKPSFPSPGGHSSSGTASSKGSTGPRKTEVLRAGHQRNASDLLDIGYMGSNSQGQFTG

>In-frame_PDE12_ENST00000487257_chr3_57545115_+_ROBO2_ENST00000461745_chr3_77671378_+_1173aa
MWRLPGARAALRVIRTAVEKLSRAEAGSQTAAGAMERAVVRCVPSEPKLSLSFALADGSHKNMQRDQSEPLGRVLSRIATNALKGHAKAA
AAKKSRKSRPNASGGAACSGPGPEPAVFCEPVVKLYYREEAVAEDVLNVDAWQDGAVLQIGDVKYKVERNPPAFTELQLPRYIMAGFPVC
PKLSLEFGDPASSLFRWYKEAKPGAAEPEVGVPSSLSPSSPSSSWTETDVEERVYTPSNADIGLRLKLHCTPGDGQRFGHSRELESVCVV
EAGPGTCTFDHRHLYTKKVTEDALIRTVSYNILADTYAQTEFSRTVLYPYCAPYALELDYRQNLIQKELTGYNADVICLQEVDRAVFSDS
LVPALEAFGLEGVFRIKQHEGLATFYRKSKFSLLSQHDISFYEALESDPLHKELLEKLVLYPSAQEKVLQRSSVLQVSVLQSTKDSSKRI
CVANTHLYWHPKGRFYLVSQVTXTRLKLFKVFYTNAYLERHPETVICVVFLFXLKDNFKKYLHXCFLYSXVGIFASFKWQXPWLTXDMFH
VICILAYQLYFVGTLIVHHQQECIILSSMAAFQRIMKTGLPMGRRKDAICLLHISSSXKVLVVNLLTQIMLVAFMDVXITFSLTXMLXRL
NRXFHYLVMKKLPPTRPYLVFPIPLITXHLYVIXNGNRCVFNGIEVXKGSSYFSRKFNMNQSLYVNFKEEWXNVQPSXLCSXCLRYETVD
VCIIHLLFPCFPLQLEEKQIYFLLAKXKIELFFSKLRLSEKEDXISVFFVCLFLFLFLFFXDGVSLLLPRLECNGTISAHCNLRPLGLSD
SPASASRVAGITGVRQHVWLIFVFLVEMGFRHVGQAGLELLTSGDPPTSASQSVGITGVSHRTRPLCTFLXENFFSXEFRIFKVPFEXSX
FFFHDNTFQNESCLCTKRENVFKLRVRDLSYRXPXRPKVRDLTHGRSNIRVYLYLNLVSDLLQFQSFNKRXKXIVTNCXHIQSNNQPPQP
PVPPLGYVSGALISDLETDVADDDADDEEEALEIPRPLRALDQTPGSSMDNLDSSVTGKAFTSSQRPRPTSPFSTDSNTSAALSQSQRPR
PTKKHKGGRMDQQPALPHRREGMTDEEALVPYSKPSFPSPGGHSSSGTASSKGSTGPRKTEVLRAGHQRNASDLLDIGYMGSNSQGQFTG

>In-frame_PDE12_ENST00000487257_chr3_57545115_+_ROBO2_ENST00000332191_chr3_77671378_+_1234aa
MWRLPGARAALRVIRTAVEKLSRAEAGSQTAAGAMERAVVRCVPSEPKLSLSFALADGSHKNMQRDQSEPLGRVLSRIATNALKGHAKAA
AAKKSRKSRPNASGGAACSGPGPEPAVFCEPVVKLYYREEAVAEDVLNVDAWQDGAVLQIGDVKYKVERNPPAFTELQLPRYIMAGFPVC
PKLSLEFGDPASSLFRWYKEAKPGAAEPEVGVPSSLSPSSPSSSWTETDVEERVYTPSNADIGLRLKLHCTPGDGQRFGHSRELESVCVV
EAGPGTCTFDHRHLYTKKVTEDALIRTVSYNILADTYAQTEFSRTVLYPYCAPYALELDYRQNLIQKELTGYNADVICLQEVDRAVFSDS
LVPALEAFGLEGVFRIKQHEGLATFYRKSKFSLLSQHDISFYEALESDPLHKELLEKLVLYPSAQEKVLQRSSVLQVSVLQSTKDSSKRI
CVANTHLYWHPKGRFYLVSQVTXTRLKLFKVFYTNAYLERHPETVICVVFLFXLKDNFKKYLHXCFLYSXVGIFASFKWQXPWLTXDMFH
VICILAYQLYFVGTLIVHHQQECIILSSMAAFQRIMKTGLPMGRRKDAICLLHISSSXKVLVVNLLTQIMLVAFMDVXITFSLTXMLXRL
NRXFHYLVMKKLPPTRPYLVFPIPLITXHLYVIXNGNRCVFNGIEVXKGSSYFSRKFNMNQSLYVNFKEEWXNVQPSXLCSXCLRYETVD
VCIIHLLFPCFPLQLEEKQIYFLLAKXKIELFFSKLRLSEKEDXISVFFVCLFLFLFLFFXDGVSLLLPRLECNGTISAHCNLRPLGLSD
SPASASRVAGITGVRQHVWLIFVFLVEMGFRHVGQAGLELLTSGDPPTSASQSVGITGVSHRTRPLCTFLXENFFSXEFRIFKVPFEXSX
FFFHDNTFQNESCLCTKRENVFKLRVRDLSYRXPXRPKVRDLTHGRSNIRVYLYLNLVSDLLQFQSFNKRXKXIVTNCXHIQSNNQPPQP
PVPPLGYVSGALISDLETDVADDDADDEEEALEIPRPLRALDQTPGSSMDNLDSSVTGSMVNGWGSASDEDRNFSSHRSSVGSSSDGSIF
ASGSFAQALVAAADKAGFRLDGTSLTRTGKAFTSSQRPRPTSPFSTDSNTSAALSQSQRPRPTKKHKGGRMDQQPALPHRREGMTDEEAL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PDE12_ENST00000487257_chr3_57545115_+_ROBO2_ENST00000487694_chr3_77671378_+_3519nt
ATGTGGAGGCTCCCAGGCGCCCGCGCCGCGCTTCGGGTGATCCGGACGGCGGTGGAGAAGCTGAGCCGGGCTGAAGCGGGGAGCCAGACA
GCGGCGGGAGCGATGGAGCGCGCTGTAGTGCGCTGCGTACCTTCGGAACCCAAGCTGAGCCTGTCATTCGCTTTGGCTGATGGTAGCCAC
AAGAACATGCAGCGCGACCAGAGCGAGCCGCTGGGTCGAGTCCTCAGCCGCATCGCTACCAATGCCCTAAAGGGTCACGCTAAGGCGGCC
GCCGCCAAGAAGAGCAGGAAGAGCCGGCCGAATGCTAGCGGCGGTGCGGCCTGTTCAGGGCCGGGGCCTGAGCCGGCTGTGTTCTGCGAG
CCCGTGGTGAAGCTGTACTACCGGGAAGAGGCAGTGGCTGAGGACGTGCTCAACGTGGATGCCTGGCAAGACGGCGCGGTGCTGCAGATC
GGCGATGTTAAGTACAAGGTGGAGCGCAACCCGCCCGCCTTCACCGAACTGCAGTTGCCGCGCTACATCATGGCCGGGTTCCCTGTGTGC
CCCAAACTCAGCCTCGAATTTGGGGATCCCGCCAGCTCCCTTTTCCGCTGGTATAAGGAAGCCAAGCCCGGAGCGGCGGAGCCCGAGGTC
GGTGTCCCCTCGTCATTGTCTCCCTCCTCACCTTCTTCTTCTTGGACTGAGACTGATGTGGAGGAGCGTGTCTACACCCCGTCCAATGCC
GACATCGGGCTAAGGCTCAAGCTTCACTGCACCCCAGGCGATGGGCAGCGCTTTGGGCACAGCCGGGAGTTGGAAAGTGTGTGTGTGGTA
GAGGCTGGGCCTGGCACCTGCACTTTTGACCACCGGCATCTCTACACGAAGAAGGTGACTGAGGACGCTCTCATCCGCACTGTCTCTTAC
AACATCCTGGCAGACACGTACGCGCAGACTGAGTTCTCGCGAACGGTTCTGTACCCATACTGTGCCCCCTACGCCCTGGAGCTCGACTAC
CGCCAGAACCTTATCCAGAAGGAACTCACCGGCTACAACGCCGATGTCATCTGTTTGCAGGAGGTTGACCGCGCAGTGTTTTCTGACAGC
TTGGTACCCGCCCTAGAGGCCTTCGGGCTCGAGGGGGTGTTTCGAATCAAGCAGCACGAAGGCCTGGCCACTTTCTACCGAAAGTCTAAG
TTCAGCCTTCTTAGCCAGCATGACATTTCATTCTACGAAGCCCTCGAGTCCGACCCACTTCACAAAGAACTGCTGGAGAAACTAGTTTTG
TACCCATCAGCGCAGGAGAAGGTGCTCCAGAGATCTTCTGTTCTTCAGGTTTCAGTTCTTCAGTCTACAAAGGACTCTTCTAAAAGGATA
TGTGTTGCTAATACCCATCTTTACTGGCATCCTAAAGGTAGGTTTTATTTGGTATCACAAGTGACTTAAACACGCTTAAAGTTGTTTAAA
GTGTTTTACACAAATGCATATCTTGAACGTCACCCAGAGACTGTAATTTGTGTAGTTTTTCTTTTTTAACTTAAAGACAACTTTAAAAAA
TACTTACATTAATGTTTTTTATATTCATAGGTGGGTATATTCGCCTCATTCAAATGGCAGTAGCCTTGGCTCACATAAGACATGTTTCAT
GTGATCTGTATCCTGGCATACCAGTTATATTTTGTGGGGACTTTAATAGTACACCATCAACAGGAATGTATCATTTTGTCATCAATGGCA
GCATTCCAGAGGATCATGAAGACTGGGCTTCCAATGGGGAGGAGGAAAGATGCAATATGTCTCTTACACATTTCTTCAAGCTGAAAAGTG
CTTGTGGTGAACCTGCTTACACAAATTATGTTGGTGGCTTTCATGGATGTCTAGATTACATTTTCATTGACTTAAATGCTTTAGAGGTTG
AACAGGTGATTCCATTACCTAGTCATGAAGAAGTTACCACCCACCAGGCCTTACCTAGTGTTTCCCATCCCTCTGATCACATAGCACTTG
TATGTGATTTAAAATGGAAATAGATGTGTGTTTAATGGAATTGAAGTCTGAAAAGGAAGTAGTTATTTTAGCAGAAAATTTAATATGAAT
CAAAGCTTATATGTAAACTTCAAGGAGGAATGGTAAAATGTTCAGCCCTCCTAGTTATGTTCCTGATGTCTTCGTTATGAAACTGTTGAT
GTTTGCATCATACATCTTCTCTTTCCTTGTTTTCCTCTACAATTGGAGGAGAAACAAATATATTTCTTACTAGCAAAATAGAAAATTGAA
TTATTTTTCTCCAAATTGAGACTCTCAGAAAAGGAAGATTGAATTAGCGTGTTTTTTGTTTGTTTGTTTTTGTTTTTGTTTTTGTTTTTT
TGAGATGGAGTTTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGCACAATCTCGGCTCACTGCAACCTCCGCCCCCTGGGTTTAAGCGAT
TCTCCTGCCTCAGCTTCCCGAGTAGCTGGGATTACAGGCGTGCGCCAACATGTCTGGCTAATTTTTGTATTTTTAGTAGAAATGGGGTTT
CGCCACGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGTTGGGATTACAGGCGTGAGC
CACCGCACCCGGCCCTTGTGTACATTTTTATAAGAGAATTTTTTTAGCTAGGAGTTCAGAATTTTTAAAGTACCATTTGAATGATCTTAA
TTTTTCTTTCATGACAACACATTCCAAAATGAATCATGCTTATGTACTAAGAGGGAAAATGTATTTAAGTTAAGGGTGAGAGACTTAAGT
TATAGGTGACCTTAGAGACCTAAGGTGAGAGACTTGACACATGGAAGGAGTAACATTAGGGTCTACCTCTACCTCAATTTAGTTAGCGAT
TTACTACAATTTCAGAGCTTTAACAAAAGATAAAAATAAATCGTCACCAATTGTTAGCACATTCAAAGCAATAATCAACCTCCACAGCCT
CCAGTTCCACCGTTAGGTTATGTGTCTGGAGCCTTGATTTCTGATTTGGAAACGGATGTTGCAGATGATGATGCCGACGACGAAGAGGAA
GCTTTAGAAATCCCCAGGCCCCTGAGAGCACTGGACCAGACTCCTGGATCCAGCATGGACAATCTAGACAGCTCTGTGACAGGAAAAGCC
TTTACCTCCTCTCAAAGACCTCGACCTACCAGCCCATTTTCTACTGACAGTAACACCAGTGCAGCCCTGAGTCAAAGTCAGAGGCCTCGG
CCCACTAAAAAACACAAGGGAGGGCGGATGGACCAACAACCAGCATTGCCTCATCGAAGGGAAGGAATGACAGATGAGGAGGCCTTGGTG
CCCTATAGCAAGCCCAGTTTCCCATCTCCAGGTGGCCACAGCTCATCAGGAACAGCTTCTTCTAAGGGATCCACTGGACCTAGGAAAACC
GAGGTGTTGAGAGCAGGCCACCAGCGCAATGCCAGCGACCTTCTTGACATAGGATATATGGGCTCCAACAGTCAAGGACAGTTTACAGGT

>In-frame_PDE12_ENST00000487257_chr3_57545115_+_ROBO2_ENST00000461745_chr3_77671378_+_3519nt
ATGTGGAGGCTCCCAGGCGCCCGCGCCGCGCTTCGGGTGATCCGGACGGCGGTGGAGAAGCTGAGCCGGGCTGAAGCGGGGAGCCAGACA
GCGGCGGGAGCGATGGAGCGCGCTGTAGTGCGCTGCGTACCTTCGGAACCCAAGCTGAGCCTGTCATTCGCTTTGGCTGATGGTAGCCAC
AAGAACATGCAGCGCGACCAGAGCGAGCCGCTGGGTCGAGTCCTCAGCCGCATCGCTACCAATGCCCTAAAGGGTCACGCTAAGGCGGCC
GCCGCCAAGAAGAGCAGGAAGAGCCGGCCGAATGCTAGCGGCGGTGCGGCCTGTTCAGGGCCGGGGCCTGAGCCGGCTGTGTTCTGCGAG
CCCGTGGTGAAGCTGTACTACCGGGAAGAGGCAGTGGCTGAGGACGTGCTCAACGTGGATGCCTGGCAAGACGGCGCGGTGCTGCAGATC
GGCGATGTTAAGTACAAGGTGGAGCGCAACCCGCCCGCCTTCACCGAACTGCAGTTGCCGCGCTACATCATGGCCGGGTTCCCTGTGTGC
CCCAAACTCAGCCTCGAATTTGGGGATCCCGCCAGCTCCCTTTTCCGCTGGTATAAGGAAGCCAAGCCCGGAGCGGCGGAGCCCGAGGTC
GGTGTCCCCTCGTCATTGTCTCCCTCCTCACCTTCTTCTTCTTGGACTGAGACTGATGTGGAGGAGCGTGTCTACACCCCGTCCAATGCC
GACATCGGGCTAAGGCTCAAGCTTCACTGCACCCCAGGCGATGGGCAGCGCTTTGGGCACAGCCGGGAGTTGGAAAGTGTGTGTGTGGTA
GAGGCTGGGCCTGGCACCTGCACTTTTGACCACCGGCATCTCTACACGAAGAAGGTGACTGAGGACGCTCTCATCCGCACTGTCTCTTAC
AACATCCTGGCAGACACGTACGCGCAGACTGAGTTCTCGCGAACGGTTCTGTACCCATACTGTGCCCCCTACGCCCTGGAGCTCGACTAC
CGCCAGAACCTTATCCAGAAGGAACTCACCGGCTACAACGCCGATGTCATCTGTTTGCAGGAGGTTGACCGCGCAGTGTTTTCTGACAGC
TTGGTACCCGCCCTAGAGGCCTTCGGGCTCGAGGGGGTGTTTCGAATCAAGCAGCACGAAGGCCTGGCCACTTTCTACCGAAAGTCTAAG
TTCAGCCTTCTTAGCCAGCATGACATTTCATTCTACGAAGCCCTCGAGTCCGACCCACTTCACAAAGAACTGCTGGAGAAACTAGTTTTG
TACCCATCAGCGCAGGAGAAGGTGCTCCAGAGATCTTCTGTTCTTCAGGTTTCAGTTCTTCAGTCTACAAAGGACTCTTCTAAAAGGATA
TGTGTTGCTAATACCCATCTTTACTGGCATCCTAAAGGTAGGTTTTATTTGGTATCACAAGTGACTTAAACACGCTTAAAGTTGTTTAAA
GTGTTTTACACAAATGCATATCTTGAACGTCACCCAGAGACTGTAATTTGTGTAGTTTTTCTTTTTTAACTTAAAGACAACTTTAAAAAA
TACTTACATTAATGTTTTTTATATTCATAGGTGGGTATATTCGCCTCATTCAAATGGCAGTAGCCTTGGCTCACATAAGACATGTTTCAT
GTGATCTGTATCCTGGCATACCAGTTATATTTTGTGGGGACTTTAATAGTACACCATCAACAGGAATGTATCATTTTGTCATCAATGGCA
GCATTCCAGAGGATCATGAAGACTGGGCTTCCAATGGGGAGGAGGAAAGATGCAATATGTCTCTTACACATTTCTTCAAGCTGAAAAGTG
CTTGTGGTGAACCTGCTTACACAAATTATGTTGGTGGCTTTCATGGATGTCTAGATTACATTTTCATTGACTTAAATGCTTTAGAGGTTG
AACAGGTGATTCCATTACCTAGTCATGAAGAAGTTACCACCCACCAGGCCTTACCTAGTGTTTCCCATCCCTCTGATCACATAGCACTTG
TATGTGATTTAAAATGGAAATAGATGTGTGTTTAATGGAATTGAAGTCTGAAAAGGAAGTAGTTATTTTAGCAGAAAATTTAATATGAAT
CAAAGCTTATATGTAAACTTCAAGGAGGAATGGTAAAATGTTCAGCCCTCCTAGTTATGTTCCTGATGTCTTCGTTATGAAACTGTTGAT
GTTTGCATCATACATCTTCTCTTTCCTTGTTTTCCTCTACAATTGGAGGAGAAACAAATATATTTCTTACTAGCAAAATAGAAAATTGAA
TTATTTTTCTCCAAATTGAGACTCTCAGAAAAGGAAGATTGAATTAGCGTGTTTTTTGTTTGTTTGTTTTTGTTTTTGTTTTTGTTTTTT
TGAGATGGAGTTTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGCACAATCTCGGCTCACTGCAACCTCCGCCCCCTGGGTTTAAGCGAT
TCTCCTGCCTCAGCTTCCCGAGTAGCTGGGATTACAGGCGTGCGCCAACATGTCTGGCTAATTTTTGTATTTTTAGTAGAAATGGGGTTT
CGCCACGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGTTGGGATTACAGGCGTGAGC
CACCGCACCCGGCCCTTGTGTACATTTTTATAAGAGAATTTTTTTAGCTAGGAGTTCAGAATTTTTAAAGTACCATTTGAATGATCTTAA
TTTTTCTTTCATGACAACACATTCCAAAATGAATCATGCTTATGTACTAAGAGGGAAAATGTATTTAAGTTAAGGGTGAGAGACTTAAGT
TATAGGTGACCTTAGAGACCTAAGGTGAGAGACTTGACACATGGAAGGAGTAACATTAGGGTCTACCTCTACCTCAATTTAGTTAGCGAT
TTACTACAATTTCAGAGCTTTAACAAAAGATAAAAATAAATCGTCACCAATTGTTAGCACATTCAAAGCAATAATCAACCTCCACAGCCT
CCAGTTCCACCGTTAGGTTATGTGTCTGGAGCCTTGATTTCTGATTTGGAAACGGATGTTGCAGATGATGATGCCGACGACGAAGAGGAA
GCTTTAGAAATCCCCAGGCCCCTGAGAGCACTGGACCAGACTCCTGGATCCAGCATGGACAATCTAGACAGCTCTGTGACAGGAAAAGCC
TTTACCTCCTCTCAAAGACCTCGACCTACCAGCCCATTTTCTACTGACAGTAACACCAGTGCAGCCCTGAGTCAAAGTCAGAGGCCTCGG
CCCACTAAAAAACACAAGGGAGGGCGGATGGACCAACAACCAGCATTGCCTCATCGAAGGGAAGGAATGACAGATGAGGAGGCCTTGGTG
CCCTATAGCAAGCCCAGTTTCCCATCTCCAGGTGGCCACAGCTCATCAGGAACAGCTTCTTCTAAGGGATCCACTGGACCTAGGAAAACC
GAGGTGTTGAGAGCAGGCCACCAGCGCAATGCCAGCGACCTTCTTGACATAGGATATATGGGCTCCAACAGTCAAGGACAGTTTACAGGT

>In-frame_PDE12_ENST00000487257_chr3_57545115_+_ROBO2_ENST00000332191_chr3_77671378_+_3702nt
ATGTGGAGGCTCCCAGGCGCCCGCGCCGCGCTTCGGGTGATCCGGACGGCGGTGGAGAAGCTGAGCCGGGCTGAAGCGGGGAGCCAGACA
GCGGCGGGAGCGATGGAGCGCGCTGTAGTGCGCTGCGTACCTTCGGAACCCAAGCTGAGCCTGTCATTCGCTTTGGCTGATGGTAGCCAC
AAGAACATGCAGCGCGACCAGAGCGAGCCGCTGGGTCGAGTCCTCAGCCGCATCGCTACCAATGCCCTAAAGGGTCACGCTAAGGCGGCC
GCCGCCAAGAAGAGCAGGAAGAGCCGGCCGAATGCTAGCGGCGGTGCGGCCTGTTCAGGGCCGGGGCCTGAGCCGGCTGTGTTCTGCGAG
CCCGTGGTGAAGCTGTACTACCGGGAAGAGGCAGTGGCTGAGGACGTGCTCAACGTGGATGCCTGGCAAGACGGCGCGGTGCTGCAGATC
GGCGATGTTAAGTACAAGGTGGAGCGCAACCCGCCCGCCTTCACCGAACTGCAGTTGCCGCGCTACATCATGGCCGGGTTCCCTGTGTGC
CCCAAACTCAGCCTCGAATTTGGGGATCCCGCCAGCTCCCTTTTCCGCTGGTATAAGGAAGCCAAGCCCGGAGCGGCGGAGCCCGAGGTC
GGTGTCCCCTCGTCATTGTCTCCCTCCTCACCTTCTTCTTCTTGGACTGAGACTGATGTGGAGGAGCGTGTCTACACCCCGTCCAATGCC
GACATCGGGCTAAGGCTCAAGCTTCACTGCACCCCAGGCGATGGGCAGCGCTTTGGGCACAGCCGGGAGTTGGAAAGTGTGTGTGTGGTA
GAGGCTGGGCCTGGCACCTGCACTTTTGACCACCGGCATCTCTACACGAAGAAGGTGACTGAGGACGCTCTCATCCGCACTGTCTCTTAC
AACATCCTGGCAGACACGTACGCGCAGACTGAGTTCTCGCGAACGGTTCTGTACCCATACTGTGCCCCCTACGCCCTGGAGCTCGACTAC
CGCCAGAACCTTATCCAGAAGGAACTCACCGGCTACAACGCCGATGTCATCTGTTTGCAGGAGGTTGACCGCGCAGTGTTTTCTGACAGC
TTGGTACCCGCCCTAGAGGCCTTCGGGCTCGAGGGGGTGTTTCGAATCAAGCAGCACGAAGGCCTGGCCACTTTCTACCGAAAGTCTAAG
TTCAGCCTTCTTAGCCAGCATGACATTTCATTCTACGAAGCCCTCGAGTCCGACCCACTTCACAAAGAACTGCTGGAGAAACTAGTTTTG
TACCCATCAGCGCAGGAGAAGGTGCTCCAGAGATCTTCTGTTCTTCAGGTTTCAGTTCTTCAGTCTACAAAGGACTCTTCTAAAAGGATA
TGTGTTGCTAATACCCATCTTTACTGGCATCCTAAAGGTAGGTTTTATTTGGTATCACAAGTGACTTAAACACGCTTAAAGTTGTTTAAA
GTGTTTTACACAAATGCATATCTTGAACGTCACCCAGAGACTGTAATTTGTGTAGTTTTTCTTTTTTAACTTAAAGACAACTTTAAAAAA
TACTTACATTAATGTTTTTTATATTCATAGGTGGGTATATTCGCCTCATTCAAATGGCAGTAGCCTTGGCTCACATAAGACATGTTTCAT
GTGATCTGTATCCTGGCATACCAGTTATATTTTGTGGGGACTTTAATAGTACACCATCAACAGGAATGTATCATTTTGTCATCAATGGCA
GCATTCCAGAGGATCATGAAGACTGGGCTTCCAATGGGGAGGAGGAAAGATGCAATATGTCTCTTACACATTTCTTCAAGCTGAAAAGTG
CTTGTGGTGAACCTGCTTACACAAATTATGTTGGTGGCTTTCATGGATGTCTAGATTACATTTTCATTGACTTAAATGCTTTAGAGGTTG
AACAGGTGATTCCATTACCTAGTCATGAAGAAGTTACCACCCACCAGGCCTTACCTAGTGTTTCCCATCCCTCTGATCACATAGCACTTG
TATGTGATTTAAAATGGAAATAGATGTGTGTTTAATGGAATTGAAGTCTGAAAAGGAAGTAGTTATTTTAGCAGAAAATTTAATATGAAT
CAAAGCTTATATGTAAACTTCAAGGAGGAATGGTAAAATGTTCAGCCCTCCTAGTTATGTTCCTGATGTCTTCGTTATGAAACTGTTGAT
GTTTGCATCATACATCTTCTCTTTCCTTGTTTTCCTCTACAATTGGAGGAGAAACAAATATATTTCTTACTAGCAAAATAGAAAATTGAA
TTATTTTTCTCCAAATTGAGACTCTCAGAAAAGGAAGATTGAATTAGCGTGTTTTTTGTTTGTTTGTTTTTGTTTTTGTTTTTGTTTTTT
TGAGATGGAGTTTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGCACAATCTCGGCTCACTGCAACCTCCGCCCCCTGGGTTTAAGCGAT
TCTCCTGCCTCAGCTTCCCGAGTAGCTGGGATTACAGGCGTGCGCCAACATGTCTGGCTAATTTTTGTATTTTTAGTAGAAATGGGGTTT
CGCCACGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGTTGGGATTACAGGCGTGAGC
CACCGCACCCGGCCCTTGTGTACATTTTTATAAGAGAATTTTTTTAGCTAGGAGTTCAGAATTTTTAAAGTACCATTTGAATGATCTTAA
TTTTTCTTTCATGACAACACATTCCAAAATGAATCATGCTTATGTACTAAGAGGGAAAATGTATTTAAGTTAAGGGTGAGAGACTTAAGT
TATAGGTGACCTTAGAGACCTAAGGTGAGAGACTTGACACATGGAAGGAGTAACATTAGGGTCTACCTCTACCTCAATTTAGTTAGCGAT
TTACTACAATTTCAGAGCTTTAACAAAAGATAAAAATAAATCGTCACCAATTGTTAGCACATTCAAAGCAATAATCAACCTCCACAGCCT
CCAGTTCCACCGTTAGGTTATGTGTCTGGAGCCTTGATTTCTGATTTGGAAACGGATGTTGCAGATGATGATGCCGACGACGAAGAGGAA
GCTTTAGAAATCCCCAGGCCCCTGAGAGCACTGGACCAGACTCCTGGATCCAGCATGGACAATCTAGACAGCTCTGTGACAGGTTCAATG
GTAAATGGATGGGGCTCTGCATCTGATGAGGATCGTAACTTTTCTAGTCATAGATCTAGTGTAGGTAGCTCCTCAGATGGCTCTATCTTT
GCCAGCGGCAGTTTTGCACAAGCACTGGTGGCAGCAGCAGATAAAGCTGGTTTTAGGCTGGATGGAACCAGCCTTACAAGAACAGGAAAA
GCCTTTACCTCCTCTCAAAGACCTCGACCTACCAGCCCATTTTCTACTGACAGTAACACCAGTGCAGCCCTGAGTCAAAGTCAGAGGCCT
CGGCCCACTAAAAAACACAAGGGAGGGCGGATGGACCAACAACCAGCATTGCCTCATCGAAGGGAAGGAATGACAGATGAGGAGGCCTTG
GTGCCCTATAGCAAGCCCAGTTTCCCATCTCCAGGTGGCCACAGCTCATCAGGAACAGCTTCTTCTAAGGGATCCACTGGACCTAGGAAA
ACCGAGGTGTTGAGAGCAGGCCACCAGCGCAATGCCAGCGACCTTCTTGACATAGGATATATGGGCTCCAACAGTCAAGGACAGTTTACA


* Fusion transcript sequences (Full-length transcript).
>In-frame_PDE12_ENST00000487257_chr3_57545115_+_ROBO2_ENST00000487694_chr3_77671378_+_3720nt
ACTGGCGGCCGAGGTAGAGGCAGTGGCGCTTGAGTTGGTCGGGGGCAGCGGCAGGTTTCAGTTCTTCAGTCTACAAAGGACTCTTCTAAA
AGGATATGTGTTGCTAATACCCATCTTTACTGGCATCCTAAAGGTAGGTTTTATTTGGTATCACAAGTGACTTAAACACGCTTAAAGTTG
TTTAAAGTGTTTTACACAAATGCATATCTTGAACGTCACCCAGAGACTGTAATTTGTGTAGTTTTTCTTTTTTAACTTAAAGACAACTTT
AAAAAATACTTACATTAATGTTTTTTATATTCATAGGTGGGTATATTCGCCTCATTCAAATGGCAGTAGCCTTGGCTCACATAAGACATG
TTTCATGTGATCTGTATCCTGGCATACCAGTTATATTTTGTGGGGACTTTAATAGTACACCATCAACAGGAATGTATCATTTTGTCATCA
ATGGCAGCATTCCAGAGGATCATGAAGACTGGGCTTCCAATGGGGAGGAGGAAAGATGCAATATGTCTCTTACACATTTCTTCAAGCTGA
AAAGTGCTTGTGGTGAACCTGCTTACACAAATTATGTTGGTGGCTTTCATGGATGTCTAGATTACATTTTCATTGACTTAAATGCTTTAG
AGGTTGAACAGGTGATTCCATTACCTAGTCATGAAGAAGTTACCACCCACCAGGCCTTACCTAGTGTTTCCCATCCCTCTGATCACATAG
CACTTGTATGTGATTTAAAATGGAAATAGATGTGTGTTTAATGGAATTGAAGTCTGAAAAGGAAGTAGTTATTTTAGCAGAAAATTTAAT
ATGAATCAAAGCTTATATGTAAACTTCAAGGAGGAATGGTAAAATGTTCAGCCCTCCTAGTTATGTTCCTGATGTCTTCGTTATGAAACT
GTTGATGTTTGCATCATACATCTTCTCTTTCCTTGTTTTCCTCTACAATTGGAGGAGAAACAAATATATTTCTTACTAGCAAAATAGAAA
ATTGAATTATTTTTCTCCAAATTGAGACTCTCAGAAAAGGAAGATTGAATTAGCGTGTTTTTTGTTTGTTTGTTTTTGTTTTTGTTTTTG
TTTTTTTGAGATGGAGTTTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGCACAATCTCGGCTCACTGCAACCTCCGCCCCCTGGGTTTA
AGCGATTCTCCTGCCTCAGCTTCCCGAGTAGCTGGGATTACAGGCGTGCGCCAACATGTCTGGCTAATTTTTGTATTTTTAGTAGAAATG
GGGTTTCGCCACGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGTTGGGATTACAGGC
GTGAGCCACCGCACCCGGCCCTTGTGTACATTTTTATAAGAGAATTTTTTTAGCTAGGAGTTCAGAATTTTTAAAGTACCATTTGAATGA
TCTTAATTTTTCTTTCATGACAACACATTCCAAAATGAATCATGCTTATGTACTAAGAGGGAAAATGTATTTAAGTTAAGGGTGAGAGAC
TTAAGTTATAGGTGACCTTAGAGACCTAAGGTGAGAGACTTGACACATGGAAGGAGTAACATTAGGGTCTACCTCTACCTCAATTTAGTT
AGCGATTTACTACAATTTCAGAGCTTTAACAAAAGATAAAAATAAATCGTCACCAATTGTTAGCACATTCAAAGCAATAATCAACCTCCA
CAGCCTCCAGTTCCACCGTTAGGTTATGTGTCTGGAGCCTTGATTTCTGATTTGGAAACGGATGTTGCAGATGATGATGCCGACGACGAA
GAGGAAGCTTTAGAAATCCCCAGGCCCCTGAGAGCACTGGACCAGACTCCTGGATCCAGCATGGACAATCTAGACAGCTCTGTGACAGGA
AAAGCCTTTACCTCCTCTCAAAGACCTCGACCTACCAGCCCATTTTCTACTGACAGTAACACCAGTGCAGCCCTGAGTCAAAGTCAGAGG
CCTCGGCCCACTAAAAAACACAAGGGAGGGCGGATGGACCAACAACCAGCATTGCCTCATCGAAGGGAAGGAATGACAGATGAGGAGGCC
TTGGTGCCCTATAGCAAGCCCAGTTTCCCATCTCCAGGTGGCCACAGCTCATCAGGAACAGCTTCTTCTAAGGGATCCACTGGACCTAGG
AAAACCGAGGTGTTGAGAGCAGGCCACCAGCGCAATGCCAGCGACCTTCTTGACATAGGATATATGGGCTCCAACAGTCAAGGACAGTTT
ACAGGTGAATTATAGTAAATGAGAGGAGACATACAAAGCTGCTCTGAAGGACCATCAGGTCCGGACTCATGGAAGTGATGACTCTAAACA
GTGCAATGAACAATTTATTTATGTACTATTAAAAGAACTGTAAATGCAATGTAAAGACACACAGCCACACATATCCCACAGATATTTTCA
TTGTGTTCTTCTCTTAAGTACACCACCCACCTTAACTCTTTCTTGTCAGGAGTATATAAAAAAGAAAGAAAACAAAACTCGCCCTACAGG
AAGAAAAGGATTCTCCTCTGTATATAATTTCTTTTGTGCATTGCTATGCAAGCTCACTCTTTTTAGCTCTGCTCATATTATTGTCTGTTC
TTATTGGTCTGTTGTACTATATGTGAATTAATAGGCTGTGGTGCCATATATTAACTTTTAATTGTGTAACTTTTATGTTTAAATTTTGCA
CTGCAATTTTATTTGGTGATAAGCACAAATCTCTACTCCTCATGACATGAAGAAAAAGACTGAATGTGAAGGGAGTTTCTGTACTGTAAG
CTAGATTGGATAATGATGGCTGTAACAAATCATGTTAGATGGTTTTCAGTTGGGGTGTAGAAATAGGAAGATGCAAAGGAACAATGGTGT
TGGCAAAGTCTTCTTTGAATATCAGGGACTGAGTCAATAAAAAAAATAGTAGAAAGGTGGCTTTTACTATTGACAAAAGCCGGGGTCAAA
AAAAGTAGTTTAAGTCTTAAGACTGAATATGCATTAAAGTATGCAGGTAGCAAAGATGTAATAAATTTGCTTAAAAAAAGAAATTAAAGT
TTTATTTAGAATCAATTTTACCTGTCATTGTAATTGACCCATCTGAGAATTACAATAAGCAAGAGGAAATTAAGGTGTTTTGCAAGAGCT
GTATTTATATTACAGTTTTTTAAAAACATTTTCTGAATTATCGTAATTAAGCTCTCCAACTCGTTAAGTCAGAATATAATATGAAGTTCC
CCAAGGAAACGAACAAAATGAACTCTAGAATATCTAGCAAATAGTTAAAGAAGCAATTTATTATTAGGGCATACTCGGGCTGTTTCCAAA
TATAAACTCTATTGCAATATCTTATTTCATCTTTCTAATACATGTACAGTGCACACTAGAGGATAGAGCTGCATCACTTAAATTCATGAC
TTAAAAAATAATACAGTTTATATACAACTTGTTTTTTATTTGATTAAGAAGTGAAGTTTACGCCACCCAATGTATAGCCAAATTGTACGT
GCTTAAAAAACAGTGCCGAGAGTATGTTCAGTTCGCAGTAAGTAGATTTATTGGAATAAATATTCTATGGTACATTCTCAGAAATTGGCT
TCCAACTAAAATACGTTTGACCCATTTTGAATAAGGAAATTGAAAAGAAAAATTTAAAAGGAGAAAAAAATGCATGTTTATAAACTTTTT

>In-frame_PDE12_ENST00000487257_chr3_57545115_+_ROBO2_ENST00000461745_chr3_77671378_+_6174nt
ACTGGCGGCCGAGGTAGAGGCAGTGGCGCTTGAGTTGGTCGGGGGCAGCGGCAGGTTTCAGTTCTTCAGTCTACAAAGGACTCTTCTAAA
AGGATATGTGTTGCTAATACCCATCTTTACTGGCATCCTAAAGGTAGGTTTTATTTGGTATCACAAGTGACTTAAACACGCTTAAAGTTG
TTTAAAGTGTTTTACACAAATGCATATCTTGAACGTCACCCAGAGACTGTAATTTGTGTAGTTTTTCTTTTTTAACTTAAAGACAACTTT
AAAAAATACTTACATTAATGTTTTTTATATTCATAGGTGGGTATATTCGCCTCATTCAAATGGCAGTAGCCTTGGCTCACATAAGACATG
TTTCATGTGATCTGTATCCTGGCATACCAGTTATATTTTGTGGGGACTTTAATAGTACACCATCAACAGGAATGTATCATTTTGTCATCA
ATGGCAGCATTCCAGAGGATCATGAAGACTGGGCTTCCAATGGGGAGGAGGAAAGATGCAATATGTCTCTTACACATTTCTTCAAGCTGA
AAAGTGCTTGTGGTGAACCTGCTTACACAAATTATGTTGGTGGCTTTCATGGATGTCTAGATTACATTTTCATTGACTTAAATGCTTTAG
AGGTTGAACAGGTGATTCCATTACCTAGTCATGAAGAAGTTACCACCCACCAGGCCTTACCTAGTGTTTCCCATCCCTCTGATCACATAG
CACTTGTATGTGATTTAAAATGGAAATAGATGTGTGTTTAATGGAATTGAAGTCTGAAAAGGAAGTAGTTATTTTAGCAGAAAATTTAAT
ATGAATCAAAGCTTATATGTAAACTTCAAGGAGGAATGGTAAAATGTTCAGCCCTCCTAGTTATGTTCCTGATGTCTTCGTTATGAAACT
GTTGATGTTTGCATCATACATCTTCTCTTTCCTTGTTTTCCTCTACAATTGGAGGAGAAACAAATATATTTCTTACTAGCAAAATAGAAA
ATTGAATTATTTTTCTCCAAATTGAGACTCTCAGAAAAGGAAGATTGAATTAGCGTGTTTTTTGTTTGTTTGTTTTTGTTTTTGTTTTTG
TTTTTTTGAGATGGAGTTTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGCACAATCTCGGCTCACTGCAACCTCCGCCCCCTGGGTTTA
AGCGATTCTCCTGCCTCAGCTTCCCGAGTAGCTGGGATTACAGGCGTGCGCCAACATGTCTGGCTAATTTTTGTATTTTTAGTAGAAATG
GGGTTTCGCCACGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGTTGGGATTACAGGC
GTGAGCCACCGCACCCGGCCCTTGTGTACATTTTTATAAGAGAATTTTTTTAGCTAGGAGTTCAGAATTTTTAAAGTACCATTTGAATGA
TCTTAATTTTTCTTTCATGACAACACATTCCAAAATGAATCATGCTTATGTACTAAGAGGGAAAATGTATTTAAGTTAAGGGTGAGAGAC
TTAAGTTATAGGTGACCTTAGAGACCTAAGGTGAGAGACTTGACACATGGAAGGAGTAACATTAGGGTCTACCTCTACCTCAATTTAGTT
AGCGATTTACTACAATTTCAGAGCTTTAACAAAAGATAAAAATAAATCGTCACCAATTGTTAGCACATTCAAAGCAATAATCAACCTCCA
CAGCCTCCAGTTCCACCGTTAGGTTATGTGTCTGGAGCCTTGATTTCTGATTTGGAAACGGATGTTGCAGATGATGATGCCGACGACGAA
GAGGAAGCTTTAGAAATCCCCAGGCCCCTGAGAGCACTGGACCAGACTCCTGGATCCAGCATGGACAATCTAGACAGCTCTGTGACAGGA
AAAGCCTTTACCTCCTCTCAAAGACCTCGACCTACCAGCCCATTTTCTACTGACAGTAACACCAGTGCAGCCCTGAGTCAAAGTCAGAGG
CCTCGGCCCACTAAAAAACACAAGGGAGGGCGGATGGACCAACAACCAGCATTGCCTCATCGAAGGGAAGGAATGACAGATGAGGAGGCC
TTGGTGCCCTATAGCAAGCCCAGTTTCCCATCTCCAGGTGGCCACAGCTCATCAGGAACAGCTTCTTCTAAGGGATCCACTGGACCTAGG
AAAACCGAGGTGTTGAGAGCAGGCCACCAGCGCAATGCCAGCGACCTTCTTGACATAGGATATATGGGCTCCAACAGTCAAGGACAGTTT
ACAGGTGAATTATAGTAAATGAGAGGAGACATACAAAGCTGCTCTGAAGGACCATCAGGTCCGGACTCATGGAAGTGATGACTCTAAACA
GTGCAATGAACAATTTATTTATGTACTATTAAAAGAACTGTAAATGCAATGTAAAGACACACAGCCACACATATCCCACAGATATTTTCA
TTGTGTTCTTCTCTTAAGTACACCACCCACCTTAACTCTTTCTTGTCAGGAGTATATAAAAAAGAAAGAAAACAAAACTCGCCCTACAGG
AAGAAAAGGATTCTCCTCTGTATATAATTTCTTTTGTGCATTGCTATGCAAGCTCACTCTTTTTAGCTCTGCTCATATTATTGTCTGTTC
TTATTGGTCTGTTGTACTATATGTGAATTAATAGGCTGTGGTGCCATATATTAACTTTTAATTGTGTAACTTTTATGTTTAAATTTTGCA
CTGCAATTTTATTTGGTGATAAGCACAAATCTCTACTCCTCATGACATGAAGAAAAAGACTGAATGTGAAGGGAGTTTCTGTACTGTAAG
CTAGATTGGATAATGATGGCTGTAACAAATCATGTTAGATGGTTTTCAGTTGGGGTGTAGAAATAGGAAGATGCAAAGGAACAATGGTGT
TGGCAAAGTCTTCTTTGAATATCAGGGACTGAGTCAATAAAAAAAATAGTAGAAAGGTGGCTTTTACTATTGACAAAAGCCGGGGTCAAA
AAAAGTAGTTTAAGTCTTAAGACTGAATATGCATTAAAGTATGCAGGTAGCAAAGATGTAATAAATTTGCTTAAAAAAAGAAATTAAAGT
TTTATTTAGAATCAATTTTACCTGTCATTGTAATTGACCCATCTGAGAATTACAATAAGCAAGAGGAAATTAAGGTGTTTTGCAAGAGCT
GTATTTATATTACAGTTTTTTAAAAACATTTTCTGAATTATCGTAATTAAGCTCTCCAACTCGTTAAGTCAGAATATAATATGAAGTTCC
CCAAGGAAACGAACAAAATGAACTCTAGAATATCTAGCAAATAGTTAAAGAAGCAATTTATTATTAGGGCATACTCGGGCTGTTTCCAAA
TATAAACTCTATTGCAATATCTTATTTCATCTTTCTAATACATGTACAGTGCACACTAGAGGATAGAGCTGCATCACTTAAATTCATGAC
TTAAAAAATAATACAGTTTATATACAACTTGTTTTTTATTTGATTAAGAAGTGAAGTTTACGCCACCCAATGTATAGCCAAATTGTACGT
GCTTAAAAAACAGTGCCGAGAGTATGTTCAGTTCGCAGTAAGTAGATTTATTGGAATAAATATTCTATGGTACATTCTCAGAAATTGGCT
TCCAACTAAAATACGTTTGACCCATTTTGAATAAGGAAATTGAAAAGAAAAATTTAAAAGGAGAAAAAAATGCATGTTTATAAACTTTTT
AAATAAAACCAGACCTTGTAAGTGGACATTAATAATTGTCCTGCCTCATTTGTTTTCACGACTTTGACAACAAGAAGTTCCTGAACATTA
GTCATGTATGCTCAGAATAAATGTGACTTTGAAATATATGTTAGCTACTGTACATGTATAGTCAGTCAAGTAGAAGAGGACCTTCCTGAA
ATTCCCACTTGTGACATTTTCCCATGGGTTTCCTACACAATCTTAAATTTTATTTCTGTCTATACTTTCTCAAATTTTTCCTATGATAAG
TTCAGTTGTTGGTACTCTTCTAAAAATATTCAACGTGATTAGGATCAGTTCTAAAATACGGGACCCCTTTGAGTGACAATTCGCACTCCA
TGCATTATTGGCTCAGTAGCCAATTTTTGTCACGTCGTTATAACAAGGAGATGACATAATTAAACATTTCCATCCTTTCTATTCCCTGAG
ACTGCATCAGCACAGGCAAGTATAGAATGTAATGTTCTTCATGGGCCCCACCAGCTTTTTGGTGCCATGTAATTTATTTCTTCGCTGAAG
AGAAAAAGAATTCTGAGACACAGTTATTAAACCCTTTATCAACTTTCTACCATCAGTGCCTGAATTCTAATGCAGTGTGATTTCTCTGGG
ACAAAGAGACTGAGGAAGATGAAAAGTTTCTTCAAAGAGTGAATACATACTTATTCACAACTCTAGGATGTGAGGACTTTAAATATCTCT
TTATGAAGTTCCCTGCCTAACCTCTTTCTATTTAAAGGCAAACAAATTTCGAAGAGGTTTTGTGTTCCCTCTTTATGTTTCTCTATGACC
CAGTTTAGTCTAAAACCTTAGTTCATTACATATACAACACATAGCCTTTGATCCCTGGTAACTGGCAGGTGTTGGTGATTAATAAACCAA
GGCTTCAAAGTGAAGTATGTGTGTGCAGATGACTTTTGGAATAACGTGGGCATAGCATCATACCTTCCTGATTGTCTTCAGCATATAAAA
ATTAACTGTTGTAGTTAAAATTATGTCAGTGCAGAGCTTGTGGTTACTTGGAATGTTCTTTCAGAATAGTCCATGTTGCCTATTAAACCT
AGTTTTAAACACATTGGGCAGTCAATTTATGCACCCAAAATATCACCCTCAGGTAGATTGAGGGCAAGATAAAATGCTGTATGTAGCTAT
ACAAAGGAATTCAGAAACATTACTGGAAAGCAAAGCCTTTGTCAGCTTGCTACTGACAAAGTAGTAAAAAGCTACTAATCAGTGTTGAGT
CAGATGTCAACAGAAAAATACAAATACCTATGAGAGCCACAGCAGTTTCTCGTTTCATAGCCGATTCAATGAATATGATTAGAAATTCAC
TGAGCTCACTCTTGCAGGTTTAAATGGAGGCCTGCATAAGGACTGCAAGAGGAAATCTGGGTGGGAGAGAATGTAATCTGATCTTGCACT
CATAGGCAATGCTGCAATGCAATCATGTCCAATACAAGCACAGCTTCATTCATAACAGGAAACGTCTTCTTTGGGAAAATAGCTCTATTG
GTGCCCAAACTCAGGTATGCCAGTGTATGCAGGTGGAGTCGCCCTACCCCTCTTCCAAACATGTCCTGTGAGATTTTTAAAATAAGATGG
GATAGTACAGGGGCATGAAAAGAATTGATTCCTTCACAGGATTTGAATCCAGTTCAAGGGAGAATGTAGAAAATTCAAAACCAACATATA
AGGTATCACACAACCAAGAAAAGTAAAACCATTGCAAGTTTACTTGCGTTGAGTACAAAACAGATTTAATGGTGTTCTATGTCATAGTTT
AATGCTCTGGGTATTTAAATATGTTTTCAACAGGATTTGAGTTGAAAGTTTGTAATGTGCTTTGATGGAACACCTCTCAATTTCTATTCA
ATAAACTTATGTAATTGTCCATTGACAATATAATGATAACAGTACCATTGAACTCTAAACTGTGGTTTATCTTCACTACTGGGAAGCAAC
TGTGCATCAGTATTAAAGATATGCAGAAACATAATATTCACTAATTTGTTCATCTGCTTCTGTATATTGTTTATGGAATTACATGGCAAG
AACTGTTCTAAAGCAACATGTCTTTCCACATTATTTTAGAGGTGAAATTACTTTTGTTTTGCTTCTCTATAATGTGTACTTCAAATGAAA
CACCATACTTTTTTCTAAAAAAAGATGTTCAATTTACTAATTTTTTTAAATCTCATAATTTAAAAAGCATTTGTTGTGATTTTAAAGTGT
TGCAAGAAAAGGGATTTTGTGGCCGTGGGTAGACTTTTTATACTTTGTTTTATAGATGGATTTTTTTTAACTGTAGTTTGTTTAAGTCAC
CAAGCAGCATCCAAAATCTTAATGTGTTTCATTTGATGTTGTTAGATCAGAGAAGAAATTGGCATAAAATCGGTTAATAGTATTGTCAAA

>In-frame_PDE12_ENST00000487257_chr3_57545115_+_ROBO2_ENST00000332191_chr3_77671378_+_3509nt
ACTGGCGGCCGAGGTAGAGGCAGTGGCGCTTGAGTTGGTCGGGGGCAGCGGCAGGTTTCAGTTCTTCAGTCTACAAAGGACTCTTCTAAA
AGGATATGTGTTGCTAATACCCATCTTTACTGGCATCCTAAAGGTAGGTTTTATTTGGTATCACAAGTGACTTAAACACGCTTAAAGTTG
TTTAAAGTGTTTTACACAAATGCATATCTTGAACGTCACCCAGAGACTGTAATTTGTGTAGTTTTTCTTTTTTAACTTAAAGACAACTTT
AAAAAATACTTACATTAATGTTTTTTATATTCATAGGTGGGTATATTCGCCTCATTCAAATGGCAGTAGCCTTGGCTCACATAAGACATG
TTTCATGTGATCTGTATCCTGGCATACCAGTTATATTTTGTGGGGACTTTAATAGTACACCATCAACAGGAATGTATCATTTTGTCATCA
ATGGCAGCATTCCAGAGGATCATGAAGACTGGGCTTCCAATGGGGAGGAGGAAAGATGCAATATGTCTCTTACACATTTCTTCAAGCTGA
AAAGTGCTTGTGGTGAACCTGCTTACACAAATTATGTTGGTGGCTTTCATGGATGTCTAGATTACATTTTCATTGACTTAAATGCTTTAG
AGGTTGAACAGGTGATTCCATTACCTAGTCATGAAGAAGTTACCACCCACCAGGCCTTACCTAGTGTTTCCCATCCCTCTGATCACATAG
CACTTGTATGTGATTTAAAATGGAAATAGATGTGTGTTTAATGGAATTGAAGTCTGAAAAGGAAGTAGTTATTTTAGCAGAAAATTTAAT
ATGAATCAAAGCTTATATGTAAACTTCAAGGAGGAATGGTAAAATGTTCAGCCCTCCTAGTTATGTTCCTGATGTCTTCGTTATGAAACT
GTTGATGTTTGCATCATACATCTTCTCTTTCCTTGTTTTCCTCTACAATTGGAGGAGAAACAAATATATTTCTTACTAGCAAAATAGAAA
ATTGAATTATTTTTCTCCAAATTGAGACTCTCAGAAAAGGAAGATTGAATTAGCGTGTTTTTTGTTTGTTTGTTTTTGTTTTTGTTTTTG
TTTTTTTGAGATGGAGTTTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGCACAATCTCGGCTCACTGCAACCTCCGCCCCCTGGGTTTA
AGCGATTCTCCTGCCTCAGCTTCCCGAGTAGCTGGGATTACAGGCGTGCGCCAACATGTCTGGCTAATTTTTGTATTTTTAGTAGAAATG
GGGTTTCGCCACGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGTTGGGATTACAGGC
GTGAGCCACCGCACCCGGCCCTTGTGTACATTTTTATAAGAGAATTTTTTTAGCTAGGAGTTCAGAATTTTTAAAGTACCATTTGAATGA
TCTTAATTTTTCTTTCATGACAACACATTCCAAAATGAATCATGCTTATGTACTAAGAGGGAAAATGTATTTAAGTTAAGGGTGAGAGAC
TTAAGTTATAGGTGACCTTAGAGACCTAAGGTGAGAGACTTGACACATGGAAGGAGTAACATTAGGGTCTACCTCTACCTCAATTTAGTT
AGCGATTTACTACAATTTCAGAGCTTTAACAAAAGATAAAAATAAATCGTCACCAATTGTTAGCACATTCAAAGCAATAATCAACCTCCA
CAGCCTCCAGTTCCACCGTTAGGTTATGTGTCTGGAGCCTTGATTTCTGATTTGGAAACGGATGTTGCAGATGATGATGCCGACGACGAA
GAGGAAGCTTTAGAAATCCCCAGGCCCCTGAGAGCACTGGACCAGACTCCTGGATCCAGCATGGACAATCTAGACAGCTCTGTGACAGGT
TCAATGGTAAATGGATGGGGCTCTGCATCTGATGAGGATCGTAACTTTTCTAGTCATAGATCTAGTGTAGGTAGCTCCTCAGATGGCTCT
ATCTTTGCCAGCGGCAGTTTTGCACAAGCACTGGTGGCAGCAGCAGATAAAGCTGGTTTTAGGCTGGATGGAACCAGCCTTACAAGAACA
GGAAAAGCCTTTACCTCCTCTCAAAGACCTCGACCTACCAGCCCATTTTCTACTGACAGTAACACCAGTGCAGCCCTGAGTCAAAGTCAG
AGGCCTCGGCCCACTAAAAAACACAAGGGAGGGCGGATGGACCAACAACCAGCATTGCCTCATCGAAGGGAAGGAATGACAGATGAGGAG
GCCTTGGTGCCCTATAGCAAGCCCAGTTTCCCATCTCCAGGTGGCCACAGCTCATCAGGAACAGCTTCTTCTAAGGGATCCACTGGACCT
AGGAAAACCGAGGTGTTGAGAGCAGGCCACCAGCGCAATGCCAGCGACCTTCTTGACATAGGATATATGGGCTCCAACAGTCAAGGACAG
TTTACAGGTGAATTATAGTAAATGAGAGGAGACATACAAAGCTGCTCTGAAGGACCATCAGGTCCGGACTCATGGAAGTGATGACTCTAA
ACAGTGCAATGAACAATTTATTTATGTACTATTAAAAGAACTGTAAATGCAATGTAAAGACACACAGCCACACATATCCCACAGATATTT
TCATTGTGTTCTTCTCTTAAGTACACCACCCACCTTAACTCTTTCTTGTCAGGAGTATATAAAAAAGAAAGAAAACAAAACTCGCCCTAC
AGGAAGAAAAGGATTCTCCTCTGTATATAATTTCTTTTGTGCATTGCTATGCAAGCTCACTCTTTTTAGCTCTGCTCATATTATTGTCTG
TTCTTATTGGTCTGTTGTACTATATGTGAATTAATAGGCTGTGGTGCCATATATTAACTTTTAATTGTGTAACTTTTATGTTTAAATTTT
GCACTGCAATTTTATTTGGTGATAAGCACAAATCTCTACTCCTCATGACATGAAGAAAAAGACTGAATGTGAAGGGAGTTTCTGTACTGT
AAGCTAGATTGGATAATGATGGCTGTAACAAATCATGTTAGATGGTTTTCAGTTGGGGTGTAGAAATAGGAAGATGCAAAGGAACAATGG
TGTTGGCAAAGTCTTCTTTGAATATCAGGGACTGAGTCAATAAAAAAAATAGTAGAAAGGTGGCTTTTACTATTGACAAAAGCCGGGGTC
AAAAAAAGTAGTTTAAGTCTTAAGACTGAATATGCATTAAAGTATGCAGGTAGCAAAGATGTAATAAATTTGCTTAAAAAAAGAAATTAA
AGTTTTATTTAGAATCAATTTTACCTGTCATTGTAATTGACCCATCTGAGAATTACAATAAGCAAGAGGAAATTAAGGTGTTTTGCAAGA
GCTGTATTTATATTACAGTTTTTTAAAAACATTTTCTGAATTATCGTAATTAAGCTCTCCAACTCGTTAAGTCAGAATATAATATGAAGT


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FusionGenePPI for PDE12_ROBO2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PDE12UBL4A, UBC, CUL3, COPS5, APEX2, ADSL, CUL5, DCTPP1, DNAJB1, EHD1, NPLOC4, PDLIM5, RAD23B, SAE1, STAT6, UBA2, UBQLN2, XPNPEP1, PGGT1B, WDR4, APEX1, CUL1, NTRK1, SORT1, SGTB, VWA9, BAG6, CHCHD2, BRCA1ROBO2CPE, BNIP3L, RDH11, CENPU, RPS6KA5, HLA-DPB1, TRIM13, NR1H2, NR4A1, UBQLN4, MYC, MYCBP2, KIF2A, VAPA, KIF1C, TMEM248, METTL3, PARD6B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PDE12_ROBO2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PDE12_ROBO2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePDE12C0035235Respiratory Syncytial Virus Infections1CTD_human
HgenePDE12C0206617Cardiovirus Infections1CTD_human
TgeneROBO2C0004352Autistic Disorder1CTD_human
TgeneROBO2C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneROBO2C0023897Liver Diseases, Parasitic1CTD_human
TgeneROBO2C0206698Cholangiocarcinoma1CTD_human
TgeneROBO2C1970483Vesicoureteral Reflux 21CTD_human;UNIPROT