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Fusion gene ID: 26363 |
FusionGeneSummary for PDCL_ADH5 |
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Fusion gene information | Fusion gene name: PDCL_ADH5 | Fusion gene ID: 26363 | Hgene | Tgene | Gene symbol | PDCL | ADH5 | Gene ID | 5082 | 128 |
Gene name | phosducin like | alcohol dehydrogenase 5 (class III), chi polypeptide | |
Synonyms | PhLP | ADH-3|ADHX|FALDH|FDH|GSH-FDH|GSNOR|HEL-S-60p | |
Cytomap | 9q33.2 | 4q23 | |
Type of gene | protein-coding | protein-coding | |
Description | phosducin-like protein | alcohol dehydrogenase class-3S-(hydroxymethyl)glutathione dehydrogenaseS-nitrosoglutathione reductasealcohol dehydrogenase (class III), chi polypeptidealcohol dehydrogenase class chi chainalcohol dehydrogenase class-IIIepididymis secretory sperm bin | |
Modification date | 20180522 | 20180527 | |
UniProtAcc | Q13371 | P11766 | |
Ensembl transtripts involved in fusion gene | ENST00000259467, | ENST00000296412, ENST00000512991, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 2 X 1=4 |
# samples | 2 | 2 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: PDCL [Title/Abstract] AND ADH5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ADH5 | GO:0051775 | response to redox state | 8460164 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CN258364 | PDCL | chr9 | 125588991 | - | ADH5 | chr4 | 99993775 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000259467 | ENST00000296412 | PDCL | chr9 | 125588991 | - | ADH5 | chr4 | 99993775 | - |
intron-intron | ENST00000259467 | ENST00000512991 | PDCL | chr9 | 125588991 | - | ADH5 | chr4 | 99993775 | - |
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FusionProtFeatures for PDCL_ADH5 |
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Hgene | Tgene |
PDCL | ADH5 |
Acts as a positive regulator of hedgehog signaling andregulates ciliary function. {ECO:0000250|UniProtKB:Q9DBX2}. Isoform 1: Functions as a co-chaperone for CCT in theassembly of heterotrimeric G protein complexes, facilitates theassembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers. Isoform 2: Acts as a negative regulator ofheterotrimeric G proteins assembly by trapping the preloaded Gbeta subunits inside the CCT chaperonin. | Class-III ADH is remarkably ineffective in oxidizingethanol, but it readily catalyzes the oxidation of long-chainprimary alcohols and the oxidation of S-(hydroxymethyl)glutathione. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PDCL_ADH5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PDCL_ADH5 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PDCL_ADH5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PDCL_ADH5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ADH5 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |