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Fusion gene ID: 26352 |
FusionGeneSummary for PDCD6IP_GADL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PDCD6IP_GADL1 | Fusion gene ID: 26352 | Hgene | Tgene | Gene symbol | PDCD6IP | GADL1 | Gene ID | 10015 | 339896 |
| Gene name | programmed cell death 6 interacting protein | glutamate decarboxylase like 1 | |
| Synonyms | AIP1|ALIX|DRIP4|HP95 | ADC|CSADC|HuADC|HuCSADC | |
| Cytomap | 3p22.3 | 3p24.1-p23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | programmed cell death 6-interacting proteinALG-2 interacting protein 1ALG-2-interacting protein XPDCD6-interacting proteinapoptosis-linked gene 2-interacting protein Xdopamine receptor interacting protein 4 | acidic amino acid decarboxylase GADL1aspartate 1-decarboxylasecysteine sulfinic acid decarboxylaseglutamate decarboxylase-like protein 1 | |
| Modification date | 20180527 | 20180329 | |
| UniProtAcc | Q8WUM4 | Q6ZQY3 | |
| Ensembl transtripts involved in fusion gene | ENST00000307296, ENST00000457054, ENST00000498147, | ENST00000282538, ENST00000498387, ENST00000454381, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 5 X 5 X 5=125 |
| # samples | 4 | 5 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/125*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PDCD6IP [Title/Abstract] AND GADL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PDCD6IP | GO:0000281 | mitotic cytokinesis | 18641129 |
| Hgene | PDCD6IP | GO:0046755 | viral budding | 18641129 |
| Hgene | PDCD6IP | GO:0051260 | protein homooligomerization | 18641129 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | STAD | TCGA-D7-6527-01A | PDCD6IP | chr3 | 33870461 | + | GADL1 | chr3 | 30769907 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000307296 | ENST00000282538 | PDCD6IP | chr3 | 33870461 | + | GADL1 | chr3 | 30769907 | - |
| 5CDS-5UTR | ENST00000307296 | ENST00000498387 | PDCD6IP | chr3 | 33870461 | + | GADL1 | chr3 | 30769907 | - |
| 5CDS-intron | ENST00000307296 | ENST00000454381 | PDCD6IP | chr3 | 33870461 | + | GADL1 | chr3 | 30769907 | - |
| In-frame | ENST00000457054 | ENST00000282538 | PDCD6IP | chr3 | 33870461 | + | GADL1 | chr3 | 30769907 | - |
| 5CDS-5UTR | ENST00000457054 | ENST00000498387 | PDCD6IP | chr3 | 33870461 | + | GADL1 | chr3 | 30769907 | - |
| 5CDS-intron | ENST00000457054 | ENST00000454381 | PDCD6IP | chr3 | 33870461 | + | GADL1 | chr3 | 30769907 | - |
| intron-3CDS | ENST00000498147 | ENST00000282538 | PDCD6IP | chr3 | 33870461 | + | GADL1 | chr3 | 30769907 | - |
| intron-5UTR | ENST00000498147 | ENST00000498387 | PDCD6IP | chr3 | 33870461 | + | GADL1 | chr3 | 30769907 | - |
| intron-intron | ENST00000498147 | ENST00000454381 | PDCD6IP | chr3 | 33870461 | + | GADL1 | chr3 | 30769907 | - |
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FusionProtFeatures for PDCD6IP_GADL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PDCD6IP | GADL1 |
| Multifunctional protein involved in endocytosis,multivesicular body biogenesis, membrane repair, cytokinesis,apoptosis and maintenance of tight junction integrity. Class E VPSprotein involved in concentration and sorting of cargo proteins ofthe multivesicular body (MVB) for incorporation into intralumenalvesicles (ILVs) that are generated by invagination and scissionfrom the limiting membrane of the endosome. Binds to thephospholipid lysobisphosphatidic acid (LBPA) which is abundant inMVBs internal membranes. The MVB pathway requires the sequentialfunction of ESCRT-O, -I,-II and -III complexes (PubMed:14739459).The ESCRT machinery also functions in topologically equivalentmembrane fission events, such as the terminal stages ofcytokinesis (PubMed:17853893, PubMed:17556548). Adapter for asubset of ESCRT-III proteins, such as CHMP4, to function atdistinct membranes. Required for completion of cytokinesis(PubMed:17853893, PubMed:17556548, PubMed:18641129). May play arole in the regulation of both apoptosis and cell proliferation.Regulates exosome biogenesis in concert with SDC1/4 and SDCBP(PubMed:22660413). By interacting with F-actin, PARD3 and TJP1secures the proper assembly and positioning of actomyosin-tightjunction complex at the apical sides of adjacent epithelial cellsthat defines a spatial membrane domain essential for themaintenance of epithelial cell polarity and barrier (Bysimilarity). {ECO:0000250|UniProtKB:Q9WU78,ECO:0000269|PubMed:14739459, ECO:0000269|PubMed:17556548,ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:18641129,ECO:0000269|PubMed:22660413}. (Microbial infection) Involved in HIV-1 virus budding.Can replace TSG101 it its role of supporting HIV-1 release; thisfunction requires the interaction with CHMP4B. The ESCRT machineryalso functions in topologically equivalent membrane fissionevents, such as enveloped virus budding (HIV-1 and otherlentiviruses). {ECO:0000269|PubMed:14505569,ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844,ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:18641129}. | May catalyze the decarboxylation of aspartate, cysteinesulfinic acid, and cysteic acid to beta-alanine, hypotaurine andtaurine, respectively. Does not exhibit any decarboxylationactivity toward glutamate. {ECO:0000269|PubMed:23038267}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PDCD6IP | chr3:33870461 | chr3:30769907 | ENST00000307296 | + | 7 | 18 | 717_860 | 278 | 869 | Compositional bias | Note=Pro-rich |
| Hgene | >PDCD6IP | chr3:33870461 | chr3:30769907 | ENST00000457054 | + | 7 | 18 | 717_860 | 283 | 874 | Compositional bias | Note=Pro-rich |
| Hgene | >PDCD6IP | chr3:33870461 | chr3:30769907 | ENST00000307296 | + | 7 | 18 | 3_392 | 278 | 869 | Domain | BRO1 |
| Hgene | >PDCD6IP | chr3:33870461 | chr3:30769907 | ENST00000457054 | + | 7 | 18 | 3_392 | 283 | 874 | Domain | BRO1 |
| Hgene | >PDCD6IP | chr3:33870461 | chr3:30769907 | ENST00000307296 | + | 7 | 18 | 503_868 | 278 | 869 | Region | Note=Self-association |
| Hgene | >PDCD6IP | chr3:33870461 | chr3:30769907 | ENST00000307296 | + | 7 | 18 | 864_868 | 278 | 869 | Region | Note=Essential to promote virus budding |
| Hgene | >PDCD6IP | chr3:33870461 | chr3:30769907 | ENST00000457054 | + | 7 | 18 | 503_868 | 283 | 874 | Region | Note=Self-association |
| Hgene | >PDCD6IP | chr3:33870461 | chr3:30769907 | ENST00000457054 | + | 7 | 18 | 864_868 | 283 | 874 | Region | Note=Essential to promote virus budding |
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FusionGeneSequence for PDCD6IP_GADL1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PDCD6IP_ENST00000307296_chr3_33870461_+_GADL1_ENST00000282538_chr3_30769907_-_336aa MATFISVQLKKTSEVDLAKPLVKFIQQTYPSGGEEQAQYCRAAEELSKLRRAAVGRPLDKHEGALETLLRYYDQICSIEPKFPFSENQIC LTFTWKDAFDKGSLFGGSVKLALASLGYEKSCVLFNCAALASQIAAEQNLDNDEGLKIAAKHYQFASGAFLHIKETVLSALSREPTVDIS PDTVGTLSLIMLAQAQEVFFLKATRDKMKDAIIAKLANQAADYFGDAFKQCQYKDTLPKEVFPVLAAKHCIMQANAEYHQSILAKQQKKF >In-frame_PDCD6IP_ENST00000457054_chr3_33870461_+_GADL1_ENST00000282538_chr3_30769907_-_341aa MATFISVQLKKTSEVDLAKPLVKFIQQTYPSGGEEQAQYCRAAEELSKLRRAAVGRPLDKHEGALETLLRYYDQICSIEPKFPFSENQIC LTFTWKDAFDKGSLFGGSVKLALASLGYEKSCVLFNCAALASQIAAEQNLDNDEGLKIAAKHYQFASGAFLHIKETVLSALSREPTVDIS PDTVGTLSLIMLAQAQEVFFLKATRDKMKDAIIAKLANQAADYFGDAFKQCQYKDTLPKYFYFQEVFPVLAAKHCIMQANAEYHQSILAK |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PDCD6IP_ENST00000307296_chr3_33870461_+_GADL1_ENST00000282538_chr3_30769907_-_1008nt ATGGCGACATTCATCTCGGTGCAGCTGAAAAAGACCTCAGAGGTGGACCTGGCCAAGCCGCTGGTGAAGTTCATCCAGCAGACTTACCCA AGCGGCGGGGAAGAGCAGGCCCAGTACTGCCGCGCGGCGGAGGAGCTCAGCAAGCTGCGCCGCGCCGCAGTCGGTCGTCCGCTGGACAAG CACGAGGGCGCGCTCGAGACGCTCCTGAGATATTATGATCAGATTTGTTCTATTGAACCCAAATTCCCATTTTCTGAAAATCAGATCTGC TTGACATTTACCTGGAAGGATGCTTTCGATAAAGGTTCACTTTTTGGAGGCTCTGTAAAACTGGCTCTTGCAAGCTTAGGATATGAAAAG AGCTGTGTGTTGTTCAATTGTGCAGCCTTAGCTAGCCAAATTGCAGCAGAACAGAACCTGGATAATGATGAAGGATTGAAAATCGCTGCT AAACATTACCAGTTTGCTAGTGGTGCCTTTTTACATATTAAAGAGACGGTTTTATCTGCCTTAAGTCGAGAGCCGACCGTGGACATATCT CCAGATACTGTTGGGACCCTCAGTCTTATTATGCTGGCACAGGCTCAAGAAGTATTTTTTTTAAAAGCCACAAGAGATAAAATGAAAGAT GCCATCATAGCTAAATTGGCTAATCAGGCTGCAGATTATTTTGGTGATGCTTTCAAACAGTGTCAATACAAAGATACTCTCCCCAAGGAG GTGTTCCCTGTCTTGGCTGCAAAGCACTGTATCATGCAGGCCAATGCTGAGTACCATCAGTCTATCCTGGCAAAACAGCAGAAGAAATTT GGAGAAGAAATTGCAAGGTTACAGGTGGCCCCAGCCATTAAGGAGAGGATGATGAAGAAGGGAAGCTTGATGCTGGGCTACCAGCCGCAC CGGGGAAAGGTCAACTTCTTCCGCCAGGTGGTGATCAGCCCTCAAGTGAGCCGGGAGGACATGGACTTCCTCCTGGATGAGATAGACTTA >In-frame_PDCD6IP_ENST00000457054_chr3_33870461_+_GADL1_ENST00000282538_chr3_30769907_-_1023nt ATGGCGACATTCATCTCGGTGCAGCTGAAAAAGACCTCAGAGGTGGACCTGGCCAAGCCGCTGGTGAAGTTCATCCAGCAGACTTACCCA AGCGGCGGGGAAGAGCAGGCCCAGTACTGCCGCGCGGCGGAGGAGCTCAGCAAGCTGCGCCGCGCCGCAGTCGGTCGTCCGCTGGACAAG CACGAGGGCGCGCTCGAGACGCTCCTGAGATATTATGATCAGATTTGTTCTATTGAACCCAAATTCCCATTTTCTGAAAATCAGATCTGC TTGACATTTACCTGGAAGGATGCTTTCGATAAAGGTTCACTTTTTGGAGGCTCTGTAAAACTGGCTCTTGCAAGCTTAGGATATGAAAAG AGCTGTGTGTTGTTCAATTGTGCAGCCTTAGCTAGCCAAATTGCAGCAGAACAGAACCTGGATAATGATGAAGGATTGAAAATCGCTGCT AAACATTACCAGTTTGCTAGTGGTGCCTTTTTACATATTAAAGAGACGGTTTTATCTGCCTTAAGTCGAGAGCCGACCGTGGACATATCT CCAGATACTGTTGGGACCCTCAGTCTTATTATGCTGGCACAGGCTCAAGAAGTATTTTTTTTAAAAGCCACAAGAGATAAAATGAAAGAT GCCATCATAGCTAAATTGGCTAATCAGGCTGCAGATTATTTTGGTGATGCTTTCAAACAGTGTCAATACAAAGATACTCTCCCCAAGTAT TTTTATTTCCAGGAGGTGTTCCCTGTCTTGGCTGCAAAGCACTGTATCATGCAGGCCAATGCTGAGTACCATCAGTCTATCCTGGCAAAA CAGCAGAAGAAATTTGGAGAAGAAATTGCAAGGTTACAGGTGGCCCCAGCCATTAAGGAGAGGATGATGAAGAAGGGAAGCTTGATGCTG GGCTACCAGCCGCACCGGGGAAAGGTCAACTTCTTCCGCCAGGTGGTGATCAGCCCTCAAGTGAGCCGGGAGGACATGGACTTCCTCCTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PDCD6IP_ENST00000307296_chr3_33870461_+_GADL1_ENST00000282538_chr3_30769907_-_3427nt AGTACTTCTCCGGGGGGTTGTTCGAGTGGAGGAATACTCTTACGTGAAAGTGCTCAGTACACCACTGCGGCAGGAAGGAGGAAGGGAAGA ATTCCAGATGGGGAGAAAGTAATATTTTGCAGCACAGTACAGGGTAAACTGGGTCCAGGTGGGCGTAGCCGCCGCGACACCTTCACGTGA CCGCGGACAGCTTAAGGACCCCGCATCCAGTGCGCCTGCGCTGGAGCTCCCGGAAGTTGCCGGACCCGGAACGCAGGCGGAGCGCAAGTC TGTCAGCCAGTCAGTCCGCCAGTCCGCCAGCCCAGTACCTCTCTCTCCTCGGCCCTCGTAAGCTGTCCGCGGTCTGTTTGGCCCGAACGG CGGCGGAGGCGCTGATCATGGCGACATTCATCTCGGTGCAGCTGAAAAAGACCTCAGAGGTGGACCTGGCCAAGCCGCTGGTGAAGTTCA TCCAGCAGACTTACCCAAGCGGCGGGGAAGAGCAGGCCCAGTACTGCCGCGCGGCGGAGGAGCTCAGCAAGCTGCGCCGCGCCGCAGTCG GTCGTCCGCTGGACAAGCACGAGGGCGCGCTCGAGACGCTCCTGAGATATTATGATCAGATTTGTTCTATTGAACCCAAATTCCCATTTT CTGAAAATCAGATCTGCTTGACATTTACCTGGAAGGATGCTTTCGATAAAGGTTCACTTTTTGGAGGCTCTGTAAAACTGGCTCTTGCAA GCTTAGGATATGAAAAGAGCTGTGTGTTGTTCAATTGTGCAGCCTTAGCTAGCCAAATTGCAGCAGAACAGAACCTGGATAATGATGAAG GATTGAAAATCGCTGCTAAACATTACCAGTTTGCTAGTGGTGCCTTTTTACATATTAAAGAGACGGTTTTATCTGCCTTAAGTCGAGAGC CGACCGTGGACATATCTCCAGATACTGTTGGGACCCTCAGTCTTATTATGCTGGCACAGGCTCAAGAAGTATTTTTTTTAAAAGCCACAA GAGATAAAATGAAAGATGCCATCATAGCTAAATTGGCTAATCAGGCTGCAGATTATTTTGGTGATGCTTTCAAACAGTGTCAATACAAAG ATACTCTCCCCAAGGAGGTGTTCCCTGTCTTGGCTGCAAAGCACTGTATCATGCAGGCCAATGCTGAGTACCATCAGTCTATCCTGGCAA AACAGCAGAAGAAATTTGGAGAAGAAATTGCAAGGTTACAGGTGGCCCCAGCCATTAAGGAGAGGATGATGAAGAAGGGAAGCTTGATGC TGGGCTACCAGCCGCACCGGGGAAAGGTCAACTTCTTCCGCCAGGTGGTGATCAGCCCTCAAGTGAGCCGGGAGGACATGGACTTCCTCC TGGATGAGATAGACTTACTGGGTAAAGACATGTAGCTGTGGCTTTGGTCCCCCAGAGGCATAGATCCTATCCTGGGAGAGTTTAGATCCA GAACATCTTGGAGATACACAGTAGATTGCAGCCCTTCTGATGAGAAATAGGGAATACTCCCAGTCCAGGCCCAGCAAAACCAAAATGCTA AGCAATGAATATTAAGGACTCTCTAGCTGCCTGGGCATTACTGTTGCTAAAAGAAGAAAGTTTAAAAAAAAAAATGATTTTCTCAAGGAA TGCCCCTGGAACACAGCTCTGAAGAGAGTTTAGTAAGTACCATGTAGGTTCTGGATTCTAAGCTTACATTGCTCTTTAAAGAACTTATAA ACTAACGGTTTAAAGCAGTGGTTCTCAAAGTGTGGTCCCTGGACTATCAGCATCAAAGCATCACCTGGGAACTTGCTAAAAATGCAGATT CTCAGGCTTTCTCTAGACCAACTGGATCAGAAGCTCTGGGGGTGAGGCCCAGTATTCTGTGTTTTAACAAGCCCGTCAGGGAATTCTGAT GCACAGTAAAATCCGAGAAACACTGGTTTAAGAAAAACCTTGTAATGATCGAATACCCACTCTGATGTTTTGCCAGCAAAGGGATATCTA ATATTTCAGAAGCCTCTGAGCCAGTCTTTGAAAAAATACAACTATGGCATCTGCAGCACAAATATTTAAGGACATCAGAAGCATGTCAAA GCTATTTTTAAAGAGAGAAACTGTATAAGATGTTTACTTCATAGAGATTTATGTTTTATGCAGGCTGAATGTTTATCTCAAAAGTTAAAA TTATCCATTCTCAAAAGTTAAAATTATATATATATATATATATACACACACACACATATATATATATATATAATTCAAAGCACAATAATT GAAAGCACAATAATTGACAGAAAAATACAGGTTCTATTAATAAATTAATAAACTGTTGGTCTTCAAAATAGAAATGCATGTAATATCCAT ATTAGTTTTTTCTTGGTAGACAACTGGAAGGTTTTCTTTTTTTTCGTCTATGACTAATTTTCTTTATTCAAGATACCTGAACTGGGGTGC TTTTTAAGAAAAATTTGGGAAATATATATGTTTCTGTGATATACATATATACATATATATGTATATATATACACACACATACATATGTGT GTGTATAGTATATATATATATACACACATATATGTTTCTGTGTTCCTCTTTTAGCTTGAGGGGCTTGTTTATTATCTTGCTCTGTGCCTC ATAGGGAATAAACACAATGAAGTCCAGGGTTGTACAACATTCCCTTTCCTAAGCTTTGAAATGTCAGTATAGATTATTAAGTGGTTTATA TTACAGAATCTGGGATTCAGCAGACTTTCAGTGTAAATGCTTCCTCCATTTCTCCTGAGAGTGGGTGATTTTAATTCTATCTCTGACCCT GGTCCTAGGTTTCTAGGAGAGTTTTGTTTAACTAAGAAATTGACAGAATTCATAGGTGTGGGTGTAGAGTTCACCAAGATAAGATTATGA ATATAATTAAAGGTCTGCATTAAAAGGTGAATGATTGAAGAGTGTTAAAGCATTAGACTTAGCACATTCAATAACCTTTTCGTACTCCAT TGTTAACCAATGTCATTTAAATTTTGAGTACTATTTGCTTTTATTGCTTATTTTCATTTTAGTGTGCACAGTTTCTCGGTATCTCTATTG GTCAAAGAATATTAAATCTGTCTCTGAATTACTTCAAATTCTCAGGTGAAACCTATTGGTGTGTGTGTGTGTGTGTGTGTGTTTATTTTG CATTTCTTGTTGCCTTTTTGTTTTAATGTCTACATAAAATATTTCTAAAATTGATGTTTGTAACAATTTGGGTTTCATGAAACAAAAAGG AACATTACTATACTTAGTGTTGTTGACTTTTCTTTTCCTGTCATCTCCTCTTTACTGGATTGTACCAATACATTTTAGAAGTGAACTGGA CTTGGTTGGCATTTTAGTTTAATGACTGAAAAAGTAGGTTGAAAGCTCTCTGTATTTTAGTTAACACCTTGAATAAAATGGAAAAAGCAG >In-frame_PDCD6IP_ENST00000457054_chr3_33870461_+_GADL1_ENST00000282538_chr3_30769907_-_3220nt GGAGCTCCCGGAAGTTGCCGGACCCGGAACGCAGGCGGAGCGCAAGTCTGTCAGCCAGTCAGTCCGCCAGTCCGCCAGCCCAGTACCTCT CTCTCCTCGGCCCTCGTAAGCTGTCCGCGGTCTGTTTGGCCCGAACGGCGGCGGAGGCGCTGATCATGGCGACATTCATCTCGGTGCAGC TGAAAAAGACCTCAGAGGTGGACCTGGCCAAGCCGCTGGTGAAGTTCATCCAGCAGACTTACCCAAGCGGCGGGGAAGAGCAGGCCCAGT ACTGCCGCGCGGCGGAGGAGCTCAGCAAGCTGCGCCGCGCCGCAGTCGGTCGTCCGCTGGACAAGCACGAGGGCGCGCTCGAGACGCTCC TGAGATATTATGATCAGATTTGTTCTATTGAACCCAAATTCCCATTTTCTGAAAATCAGATCTGCTTGACATTTACCTGGAAGGATGCTT TCGATAAAGGTTCACTTTTTGGAGGCTCTGTAAAACTGGCTCTTGCAAGCTTAGGATATGAAAAGAGCTGTGTGTTGTTCAATTGTGCAG CCTTAGCTAGCCAAATTGCAGCAGAACAGAACCTGGATAATGATGAAGGATTGAAAATCGCTGCTAAACATTACCAGTTTGCTAGTGGTG CCTTTTTACATATTAAAGAGACGGTTTTATCTGCCTTAAGTCGAGAGCCGACCGTGGACATATCTCCAGATACTGTTGGGACCCTCAGTC TTATTATGCTGGCACAGGCTCAAGAAGTATTTTTTTTAAAAGCCACAAGAGATAAAATGAAAGATGCCATCATAGCTAAATTGGCTAATC AGGCTGCAGATTATTTTGGTGATGCTTTCAAACAGTGTCAATACAAAGATACTCTCCCCAAGTATTTTTATTTCCAGGAGGTGTTCCCTG TCTTGGCTGCAAAGCACTGTATCATGCAGGCCAATGCTGAGTACCATCAGTCTATCCTGGCAAAACAGCAGAAGAAATTTGGAGAAGAAA TTGCAAGGTTACAGGTGGCCCCAGCCATTAAGGAGAGGATGATGAAGAAGGGAAGCTTGATGCTGGGCTACCAGCCGCACCGGGGAAAGG TCAACTTCTTCCGCCAGGTGGTGATCAGCCCTCAAGTGAGCCGGGAGGACATGGACTTCCTCCTGGATGAGATAGACTTACTGGGTAAAG ACATGTAGCTGTGGCTTTGGTCCCCCAGAGGCATAGATCCTATCCTGGGAGAGTTTAGATCCAGAACATCTTGGAGATACACAGTAGATT GCAGCCCTTCTGATGAGAAATAGGGAATACTCCCAGTCCAGGCCCAGCAAAACCAAAATGCTAAGCAATGAATATTAAGGACTCTCTAGC TGCCTGGGCATTACTGTTGCTAAAAGAAGAAAGTTTAAAAAAAAAAATGATTTTCTCAAGGAATGCCCCTGGAACACAGCTCTGAAGAGA GTTTAGTAAGTACCATGTAGGTTCTGGATTCTAAGCTTACATTGCTCTTTAAAGAACTTATAAACTAACGGTTTAAAGCAGTGGTTCTCA AAGTGTGGTCCCTGGACTATCAGCATCAAAGCATCACCTGGGAACTTGCTAAAAATGCAGATTCTCAGGCTTTCTCTAGACCAACTGGAT CAGAAGCTCTGGGGGTGAGGCCCAGTATTCTGTGTTTTAACAAGCCCGTCAGGGAATTCTGATGCACAGTAAAATCCGAGAAACACTGGT TTAAGAAAAACCTTGTAATGATCGAATACCCACTCTGATGTTTTGCCAGCAAAGGGATATCTAATATTTCAGAAGCCTCTGAGCCAGTCT TTGAAAAAATACAACTATGGCATCTGCAGCACAAATATTTAAGGACATCAGAAGCATGTCAAAGCTATTTTTAAAGAGAGAAACTGTATA AGATGTTTACTTCATAGAGATTTATGTTTTATGCAGGCTGAATGTTTATCTCAAAAGTTAAAATTATCCATTCTCAAAAGTTAAAATTAT ATATATATATATATATACACACACACACATATATATATATATATAATTCAAAGCACAATAATTGAAAGCACAATAATTGACAGAAAAATA CAGGTTCTATTAATAAATTAATAAACTGTTGGTCTTCAAAATAGAAATGCATGTAATATCCATATTAGTTTTTTCTTGGTAGACAACTGG AAGGTTTTCTTTTTTTTCGTCTATGACTAATTTTCTTTATTCAAGATACCTGAACTGGGGTGCTTTTTAAGAAAAATTTGGGAAATATAT ATGTTTCTGTGATATACATATATACATATATATGTATATATATACACACACATACATATGTGTGTGTATAGTATATATATATATACACAC ATATATGTTTCTGTGTTCCTCTTTTAGCTTGAGGGGCTTGTTTATTATCTTGCTCTGTGCCTCATAGGGAATAAACACAATGAAGTCCAG GGTTGTACAACATTCCCTTTCCTAAGCTTTGAAATGTCAGTATAGATTATTAAGTGGTTTATATTACAGAATCTGGGATTCAGCAGACTT TCAGTGTAAATGCTTCCTCCATTTCTCCTGAGAGTGGGTGATTTTAATTCTATCTCTGACCCTGGTCCTAGGTTTCTAGGAGAGTTTTGT TTAACTAAGAAATTGACAGAATTCATAGGTGTGGGTGTAGAGTTCACCAAGATAAGATTATGAATATAATTAAAGGTCTGCATTAAAAGG TGAATGATTGAAGAGTGTTAAAGCATTAGACTTAGCACATTCAATAACCTTTTCGTACTCCATTGTTAACCAATGTCATTTAAATTTTGA GTACTATTTGCTTTTATTGCTTATTTTCATTTTAGTGTGCACAGTTTCTCGGTATCTCTATTGGTCAAAGAATATTAAATCTGTCTCTGA ATTACTTCAAATTCTCAGGTGAAACCTATTGGTGTGTGTGTGTGTGTGTGTGTGTTTATTTTGCATTTCTTGTTGCCTTTTTGTTTTAAT GTCTACATAAAATATTTCTAAAATTGATGTTTGTAACAATTTGGGTTTCATGAAACAAAAAGGAACATTACTATACTTAGTGTTGTTGAC TTTTCTTTTCCTGTCATCTCCTCTTTACTGGATTGTACCAATACATTTTAGAAGTGAACTGGACTTGGTTGGCATTTTAGTTTAATGACT 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FusionGenePPI for PDCD6IP_GADL1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PDCD6IP | TTF2, VPS37C, GSTK1, PHLDA3, STK24, PDCD6, USP7, PDGFRB, NEDD4, MAP1LC3A, UBA5, GRB2, EGFR, SH3GL2, SH3KBP1, SH3RF1, TSG101, MAPK6, TAB1, ARRDC1, ARRDC3, CHMP4A, F2R, ITSN1, ITSN2, ELAVL1, SIRT7, SH3GL1, CD2AP, SGSM3, CHMP4B, ALG2, PTPN23, SRC, YES1, PTK2, PTK2B, TUBA1A, TUBB, TUBG1, MASP1, GFAP, ACTC1, VPS4B, PDCD6IP, CHMP4C, CEP55, EEA1, CUL3, PEF1, ABCC1, GPI, VCAM1, RNF11, ITGA4, BAG3, TNIP2, CXCR1, KEAP1, MAPK1, EZR, IPO9, MCTS1, AHCYL1, UBA1, UBA6, SDCBP, CCDC8, EZH2, ENO1, ESD, GOT1, MIF, ABAT, ALDH1B1, ALDH2, ASS1, BROX, GLOD4, HTRA2, LACTB2, PIR, PRDX2, SOD1, SPR, SRI, TKT, UQCRQ, TPI1, NTRK1, IFI16, TFG, GOLT1B, CNTROB, WDR5, NF2, SNW1, WWP2, SENP3, ITCH, UBC, DLD, DLST, HSD17B10, PDHA1, SOAT1, G3BP1, UBE2A, BRCA1, TES | GADL1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | PDCD6IP | chr3:33870461 | chr3:30769907 | ENST00000307296 | + | 7 | 18 | 801_806 | 278 | 869 | CEP55 |
| Hgene | PDCD6IP | chr3:33870461 | chr3:30769907 | ENST00000457054 | + | 7 | 18 | 801_806 | 283 | 874 | CEP55 |
| Hgene | PDCD6IP | chr3:33870461 | chr3:30769907 | ENST00000307296 | + | 7 | 18 | 176_503 | 278 | 869 | CHMP4A%2C CHMP4B and CHMP4C |
| Hgene | PDCD6IP | chr3:33870461 | chr3:30769907 | ENST00000457054 | + | 7 | 18 | 176_503 | 283 | 874 | CHMP4A%2C CHMP4B and CHMP4C |
| Hgene | PDCD6IP | chr3:33870461 | chr3:30769907 | ENST00000307296 | + | 7 | 18 | 176_868 | 278 | 869 | EIAV p9 |
| Hgene | PDCD6IP | chr3:33870461 | chr3:30769907 | ENST00000457054 | + | 7 | 18 | 176_868 | 283 | 874 | EIAV p9 |
| Hgene | PDCD6IP | chr3:33870461 | chr3:30769907 | ENST00000307296 | + | 7 | 18 | 418_868 | 278 | 869 | SDCBP |
| Hgene | PDCD6IP | chr3:33870461 | chr3:30769907 | ENST00000457054 | + | 7 | 18 | 418_868 | 283 | 874 | SDCBP |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PDCD6IP_GADL1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | GADL1 | Q6ZQY3 | DB00114 | Pyridoxal Phosphate | Acidic amino acid decarboxylase GADL1 | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for PDCD6IP_GADL1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PDCD6IP | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
| Tgene | GADL1 | C0023903 | Liver neoplasms | 1 | CTD_human |
| Tgene | GADL1 | C0853193 | Bipolar I disorder | 1 | PSYGENET |
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