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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 26346

FusionGeneSummary for PDCD4_CHD1L

check button Fusion gene summary
Fusion gene informationFusion gene name: PDCD4_CHD1L
Fusion gene ID: 26346
HgeneTgene
Gene symbol

PDCD4

CHD1L

Gene ID

27250

9557

Gene nameprogrammed cell death 4chromodomain helicase DNA binding protein 1 like
SynonymsH731ALC1|CHDL
Cytomap

10q25.2

1q21.1

Type of geneprotein-codingprotein-coding
Descriptionprogrammed cell death protein 4neoplastic transformation inhibitor proteinnuclear antigen H731programmed cell death 4 (neoplastic transformation inhibitor)protein 197/15achromodomain-helicase-DNA-binding protein 1-likeamplified in liver cancer 1amplified in liver cancer protein 1
Modification date2018052720180522
UniProtAcc

Q53EL6

Q86WJ1

Ensembl transtripts involved in fusion geneENST00000280154, ENST00000393104, 
ENST00000481353, 		ENST00000431239, 
ENST00000369259, ENST00000369258, 
ENST00000467213, ENST00000361293, 
Fusion gene scores* DoF score5 X 5 X 1=255 X 4 X 4=80
# samples 55
** MAII scorelog2(5/25*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDCD4 [Title/Abstract] AND CHD1L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePDCD4

GO:0007569

cell aging

12054647

HgenePDCD4

GO:0030509

BMP signaling pathway

18548003

HgenePDCD4

GO:0045892

negative regulation of transcription, DNA-templated

16357133

HgenePDCD4

GO:1905064

negative regulation of vascular smooth muscle cell differentiation

18548003

TgeneCHD1L

GO:0006338

chromatin remodeling

19661379

TgeneCHD1L

GO:0006974

cellular response to DNA damage stimulus

19661379


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA689020PDCD4chr10

112635830

+CHD1Lchr1

146747014

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000280154ENST00000431239PDCD4chr10

112635830

+CHD1Lchr1

146747014

+
In-frameENST00000280154ENST00000369259PDCD4chr10

112635830

+CHD1Lchr1

146747014

+
In-frameENST00000280154ENST00000369258PDCD4chr10

112635830

+CHD1Lchr1

146747014

+
5CDS-3UTRENST00000280154ENST00000467213PDCD4chr10

112635830

+CHD1Lchr1

146747014

+
5CDS-3UTRENST00000280154ENST00000361293PDCD4chr10

112635830

+CHD1Lchr1

146747014

+
5UTR-3CDSENST00000393104ENST00000431239PDCD4chr10

112635830

+CHD1Lchr1

146747014

+
5UTR-3CDSENST00000393104ENST00000369259PDCD4chr10

112635830

+CHD1Lchr1

146747014

+
5UTR-3CDSENST00000393104ENST00000369258PDCD4chr10

112635830

+CHD1Lchr1

146747014

+
5UTR-3UTRENST00000393104ENST00000467213PDCD4chr10

112635830

+CHD1Lchr1

146747014

+
5UTR-3UTRENST00000393104ENST00000361293PDCD4chr10

112635830

+CHD1Lchr1

146747014

+
intron-3CDSENST00000481353ENST00000431239PDCD4chr10

112635830

+CHD1Lchr1

146747014

+
intron-3CDSENST00000481353ENST00000369259PDCD4chr10

112635830

+CHD1Lchr1

146747014

+
intron-3CDSENST00000481353ENST00000369258PDCD4chr10

112635830

+CHD1Lchr1

146747014

+
intron-3UTRENST00000481353ENST00000467213PDCD4chr10

112635830

+CHD1Lchr1

146747014

+
intron-3UTRENST00000481353ENST00000361293PDCD4chr10

112635830

+CHD1Lchr1

146747014

+

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FusionProtFeatures for PDCD4_CHD1L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PDCD4

Q53EL6

CHD1L

Q86WJ1

Inhibits translation initiation and cap-dependenttranslation. May excert its function by hindering the interactionbetween EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A.Modulates the activation of JUN kinase. Down-regulates theexpression of MAP4K1, thus inhibiting events important in drivinginvasion, namely, MAPK85 activation and consequent JUN-dependenttranscription. May play a role in apoptosis. Tumor suppressor.Inhibits tumor promoter-induced neoplastic transformation. BindsRNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:16357133,ECO:0000269|PubMed:16449643, ECO:0000269|PubMed:17053147,ECO:0000269|PubMed:18296639, ECO:0000269|PubMed:19153607,ECO:0000269|PubMed:19204291}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCHD1Lchr10:112635830chr1:146747014ENST00000369258+1123638_675423898Coiled coilOntology_term=ECO:0000255
TgeneCHD1Lchr10:112635830chr1:146747014ENST00000369259+517638_675219694Coiled coilOntology_term=ECO:0000255
TgeneCHD1Lchr10:112635830chr1:146747014ENST00000431239+820638_675329804Coiled coilOntology_term=ECO:0000255
TgeneCHD1Lchr10:112635830chr1:146747014ENST00000369258+1123704_897423898DomainMacro
TgeneCHD1Lchr10:112635830chr1:146747014ENST00000369259+517351_513219694DomainHelicase C-terminal
TgeneCHD1Lchr10:112635830chr1:146747014ENST00000369259+517704_897219694DomainMacro
TgeneCHD1Lchr10:112635830chr1:146747014ENST00000431239+820351_513329804DomainHelicase C-terminal
TgeneCHD1Lchr10:112635830chr1:146747014ENST00000431239+820704_897329804DomainMacro

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDCD4chr10:112635830chr1:146747014ENST00000280154+212163_28414470DomainMI 1
HgenePDCD4chr10:112635830chr1:146747014ENST00000280154+212326_44914470DomainMI 2
HgenePDCD4chr10:112635830chr1:146747014ENST00000393104+213163_284-25459DomainMI 1
HgenePDCD4chr10:112635830chr1:146747014ENST00000393104+213326_449-25459DomainMI 2
HgenePDCD4chr10:112635830chr1:146747014ENST00000280154+212241_25014470MotifNuclear localization signal
HgenePDCD4chr10:112635830chr1:146747014ENST00000280154+21258_6414470MotifNuclear localization signal
HgenePDCD4chr10:112635830chr1:146747014ENST00000280154+21270_7614470MotifNote=Phosphodegron
HgenePDCD4chr10:112635830chr1:146747014ENST00000393104+213241_250-25459MotifNuclear localization signal
HgenePDCD4chr10:112635830chr1:146747014ENST00000393104+21358_64-25459MotifNuclear localization signal
HgenePDCD4chr10:112635830chr1:146747014ENST00000393104+21370_76-25459MotifNote=Phosphodegron
TgeneCHD1Lchr10:112635830chr1:146747014ENST00000369258+1123351_513423898DomainHelicase C-terminal
TgeneCHD1Lchr10:112635830chr1:146747014ENST00000369258+112358_223423898DomainHelicase ATP-binding
TgeneCHD1Lchr10:112635830chr1:146747014ENST00000369259+51758_223219694DomainHelicase ATP-binding
TgeneCHD1Lchr10:112635830chr1:146747014ENST00000431239+82058_223329804DomainHelicase ATP-binding
TgeneCHD1Lchr10:112635830chr1:146747014ENST00000369258+1123174_177423898MotifNote=DEAH box
TgeneCHD1Lchr10:112635830chr1:146747014ENST00000369259+517174_177219694MotifNote=DEAH box
TgeneCHD1Lchr10:112635830chr1:146747014ENST00000431239+820174_177329804MotifNote=DEAH box
TgeneCHD1Lchr10:112635830chr1:146747014ENST00000369258+112371_78423898Nucleotide bindingATP
TgeneCHD1Lchr10:112635830chr1:146747014ENST00000369259+51771_78219694Nucleotide bindingATP
TgeneCHD1Lchr10:112635830chr1:146747014ENST00000431239+82071_78329804Nucleotide bindingATP


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FusionGeneSequence for PDCD4_CHD1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PDCD4_ENST00000280154_chr10_112635830_+_CHD1L_ENST00000431239_chr1_146747014_+_489aa
MDVENEQILNVNPAGGVGMNLTAADTVIFVDSDFNPQNDLQAAARAHRIGQNKSVKVIRLIGRDTVEEIVYRKAASKLQLTNMIIEGGHF
TLGAQKPAADADLQLSEILKFGLDKLLASEGSTMDEIDLESILGETKDGQWVSDALPAAEGGSRDQEEGKNHMYLFEGKDYSKEPSKEDR
KSFEQLVNLQKTLLEKASQEGRSLRNKGSVLIPGLVEGSTKRKRVLSPEELEDRQKKRQEAAAKRRRLIEEKKRQKEEAEHKKKMAWWES
NNYQSFCLPSEESEPEDLENGEESSAELDYQDPDATSLKYVSGDVTHPQAGAEDALIVHCVDDSGHWGRGGLFTALEKRSAEPRKIYELA
GKMKDLSLGGVLLFPVDDKESRNKGQDLLALIVAQHRDRSNVLSGIKMAALEEGLKKIFLAAKKKKASVHLPRIGHATKGFNWYGTERLI

>In-frame_PDCD4_ENST00000280154_chr10_112635830_+_CHD1L_ENST00000369259_chr1_146747014_+_489aa
MDVENEQILNVNPAGGVGMNLTAADTVIFVDSDFNPQNDLQAAARAHRIGQNKSVKVIRLIGRDTVEEIVYRKAASKLQLTNMIIEGGHF
TLGAQKPAADADLQLSEILKFGLDKLLASEGSTMDEIDLESILGETKDGQWVSDALPAAEGGSRDQEEGKNHMYLFEGKDYSKEPSKEDR
KSFEQLVNLQKTLLEKASQEGRSLRNKGSVLIPGLVEGSTKRKRVLSPEELEDRQKKRQEAAAKRRRLIEEKKRQKEEAEHKKKMAWWES
NNYQSFCLPSEESEPEDLENGEESSAELDYQDPDATSLKYVSGDVTHPQAGAEDALIVHCVDDSGHWGRGGLFTALEKRSAEPRKIYELA
GKMKDLSLGGVLLFPVDDKESRNKGQDLLALIVAQHRDRSNVLSGIKMAALEEGLKKIFLAAKKKKASVHLPRIGHATKGFNWYGTERLI

>In-frame_PDCD4_ENST00000280154_chr10_112635830_+_CHD1L_ENST00000369258_chr1_146747014_+_489aa
MDVENEQILNVNPAGGVGMNLTAADTVIFVDSDFNPQNDLQAAARAHRIGQNKSVKVIRLIGRDTVEEIVYRKAASKLQLTNMIIEGGHF
TLGAQKPAADADLQLSEILKFGLDKLLASEGSTMDEIDLESILGETKDGQWVSDALPAAEGGSRDQEEGKNHMYLFEGKDYSKEPSKEDR
KSFEQLVNLQKTLLEKASQEGRSLRNKGSVLIPGLVEGSTKRKRVLSPEELEDRQKKRQEAAAKRRRLIEEKKRQKEEAEHKKKMAWWES
NNYQSFCLPSEESEPEDLENGEESSAELDYQDPDATSLKYVSGDVTHPQAGAEDALIVHCVDDSGHWGRGGLFTALEKRSAEPRKIYELA
GKMKDLSLGGVLLFPVDDKESRNKGQDLLALIVAQHRDRSNVLSGIKMAALEEGLKKIFLAAKKKKASVHLPRIGHATKGFNWYGTERLI


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PDCD4_ENST00000280154_chr10_112635830_+_CHD1L_ENST00000431239_chr1_146747014_+_1467nt
ATGGATGTAGAAAATGAGCAGATACTGAATGTAAACCCTGCAGGTGGAGTTGGCATGAACTTAACAGCAGCAGATACTGTGATTTTTGTT
GACAGTGACTTTAATCCTCAGAATGACTTGCAAGCAGCTGCCAGGGCTCATCGCATTGGCCAAAACAAGTCTGTTAAAGTTATTCGGCTG
ATTGGTCGAGACACTGTGGAAGAAATAGTCTATAGGAAAGCAGCCTCCAAACTGCAGCTCACCAACATGATCATAGAAGGAGGCCATTTT
ACTCTGGGAGCCCAGAAACCCGCTGCCGATGCTGACCTCCAGTTGAGTGAGATACTCAAATTTGGTTTGGATAAACTGCTGGCCTCTGAG
GGGAGCACCATGGATGAAATAGACCTGGAGTCCATACTGGGAGAAACAAAAGATGGCCAGTGGGTCTCTGATGCCTTGCCTGCAGCAGAA
GGAGGGAGCAGAGATCAAGAGGAAGGAAAAAATCATATGTACTTATTTGAAGGTAAAGATTATTCTAAAGAGCCCAGTAAGGAAGACAGA
AAATCATTTGAACAACTGGTAAACCTTCAGAAAACCCTTTTGGAGAAAGCTAGTCAAGAGGGCCGATCACTCCGAAATAAAGGCAGTGTT
CTCATCCCAGGCCTTGTGGAGGGATCTACCAAAAGGAAGCGGGTTCTGAGTCCAGAAGAGCTGGAGGACAGACAGAAGAAAAGACAAGAA
GCAGCTGCCAAGAGAAGGAGACTCATAGAGGAGAAGAAGAGGCAAAAGGAAGAGGCTGAACATAAGAAAAAGATGGCCTGGTGGGAATCC
AACAATTACCAGTCCTTCTGCCTGCCCTCTGAGGAGAGCGAGCCAGAGGACCTTGAGAATGGGGAAGAGAGCTCTGCTGAGCTGGATTAC
CAAGACCCAGATGCTACTTCCCTCAAGTACGTTAGTGGTGATGTCACCCACCCTCAGGCTGGGGCCGAGGATGCTCTCATTGTGCACTGC
GTAGATGACTCTGGCCACTGGGGCAGAGGTGGTTTATTTACAGCTCTGGAAAAGCGATCCGCTGAGCCAAGAAAAATATATGAGCTGGCT
GGGAAAATGAAAGACCTGAGTTTGGGAGGTGTCCTTTTATTTCCTGTTGATGATAAAGAATCAAGAAACAAAGGGCAAGATTTGTTGGCC
TTGATTGTGGCTCAGCATCGTGATCGTTCCAATGTCCTGTCTGGCATTAAGATGGCAGCCCTAGAAGAGGGCCTGAAGAAGATATTTTTA
GCAGCAAAAAAGAAGAAAGCAAGTGTTCATCTTCCACGTATTGGACATGCCACGAAAGGTTTTAACTGGTATGGTACTGAGCGACTTATT
CGGAAACATCTGGCTGCAAGAGGCATCCCAACTTACATATATTATTTTCCTAGAAGCAAGTCTGCTGTCCTTCATGCACAGTCTTCATCT

>In-frame_PDCD4_ENST00000280154_chr10_112635830_+_CHD1L_ENST00000369259_chr1_146747014_+_1467nt
ATGGATGTAGAAAATGAGCAGATACTGAATGTAAACCCTGCAGGTGGAGTTGGCATGAACTTAACAGCAGCAGATACTGTGATTTTTGTT
GACAGTGACTTTAATCCTCAGAATGACTTGCAAGCAGCTGCCAGGGCTCATCGCATTGGCCAAAACAAGTCTGTTAAAGTTATTCGGCTG
ATTGGTCGAGACACTGTGGAAGAAATAGTCTATAGGAAAGCAGCCTCCAAACTGCAGCTCACCAACATGATCATAGAAGGAGGCCATTTT
ACTCTGGGAGCCCAGAAACCCGCTGCCGATGCTGACCTCCAGTTGAGTGAGATACTCAAATTTGGTTTGGATAAACTGCTGGCCTCTGAG
GGGAGCACCATGGATGAAATAGACCTGGAGTCCATACTGGGAGAAACAAAAGATGGCCAGTGGGTCTCTGATGCCTTGCCTGCAGCAGAA
GGAGGGAGCAGAGATCAAGAGGAAGGAAAAAATCATATGTACTTATTTGAAGGTAAAGATTATTCTAAAGAGCCCAGTAAGGAAGACAGA
AAATCATTTGAACAACTGGTAAACCTTCAGAAAACCCTTTTGGAGAAAGCTAGTCAAGAGGGCCGATCACTCCGAAATAAAGGCAGTGTT
CTCATCCCAGGCCTTGTGGAGGGATCTACCAAAAGGAAGCGGGTTCTGAGTCCAGAAGAGCTGGAGGACAGACAGAAGAAAAGACAAGAA
GCAGCTGCCAAGAGAAGGAGACTCATAGAGGAGAAGAAGAGGCAAAAGGAAGAGGCTGAACATAAGAAAAAGATGGCCTGGTGGGAATCC
AACAATTACCAGTCCTTCTGCCTGCCCTCTGAGGAGAGCGAGCCAGAGGACCTTGAGAATGGGGAAGAGAGCTCTGCTGAGCTGGATTAC
CAAGACCCAGATGCTACTTCCCTCAAGTACGTTAGTGGTGATGTCACCCACCCTCAGGCTGGGGCCGAGGATGCTCTCATTGTGCACTGC
GTAGATGACTCTGGCCACTGGGGCAGAGGTGGTTTATTTACAGCTCTGGAAAAGCGATCCGCTGAGCCAAGAAAAATATATGAGCTGGCT
GGGAAAATGAAAGACCTGAGTTTGGGAGGTGTCCTTTTATTTCCTGTTGATGATAAAGAATCAAGAAACAAAGGGCAAGATTTGTTGGCC
TTGATTGTGGCTCAGCATCGTGATCGTTCCAATGTCCTGTCTGGCATTAAGATGGCAGCCCTAGAAGAGGGCCTGAAGAAGATATTTTTA
GCAGCAAAAAAGAAGAAAGCAAGTGTTCATCTTCCACGTATTGGACATGCCACGAAAGGTTTTAACTGGTATGGTACTGAGCGACTTATT
CGGAAACATCTGGCTGCAAGAGGCATCCCAACTTACATATATTATTTTCCTAGAAGCAAGTCTGCTGTCCTTCATGCACAGTCTTCATCT

>In-frame_PDCD4_ENST00000280154_chr10_112635830_+_CHD1L_ENST00000369258_chr1_146747014_+_1467nt
ATGGATGTAGAAAATGAGCAGATACTGAATGTAAACCCTGCAGGTGGAGTTGGCATGAACTTAACAGCAGCAGATACTGTGATTTTTGTT
GACAGTGACTTTAATCCTCAGAATGACTTGCAAGCAGCTGCCAGGGCTCATCGCATTGGCCAAAACAAGTCTGTTAAAGTTATTCGGCTG
ATTGGTCGAGACACTGTGGAAGAAATAGTCTATAGGAAAGCAGCCTCCAAACTGCAGCTCACCAACATGATCATAGAAGGAGGCCATTTT
ACTCTGGGAGCCCAGAAACCCGCTGCCGATGCTGACCTCCAGTTGAGTGAGATACTCAAATTTGGTTTGGATAAACTGCTGGCCTCTGAG
GGGAGCACCATGGATGAAATAGACCTGGAGTCCATACTGGGAGAAACAAAAGATGGCCAGTGGGTCTCTGATGCCTTGCCTGCAGCAGAA
GGAGGGAGCAGAGATCAAGAGGAAGGAAAAAATCATATGTACTTATTTGAAGGTAAAGATTATTCTAAAGAGCCCAGTAAGGAAGACAGA
AAATCATTTGAACAACTGGTAAACCTTCAGAAAACCCTTTTGGAGAAAGCTAGTCAAGAGGGCCGATCACTCCGAAATAAAGGCAGTGTT
CTCATCCCAGGCCTTGTGGAGGGATCTACCAAAAGGAAGCGGGTTCTGAGTCCAGAAGAGCTGGAGGACAGACAGAAGAAAAGACAAGAA
GCAGCTGCCAAGAGAAGGAGACTCATAGAGGAGAAGAAGAGGCAAAAGGAAGAGGCTGAACATAAGAAAAAGATGGCCTGGTGGGAATCC
AACAATTACCAGTCCTTCTGCCTGCCCTCTGAGGAGAGCGAGCCAGAGGACCTTGAGAATGGGGAAGAGAGCTCTGCTGAGCTGGATTAC
CAAGACCCAGATGCTACTTCCCTCAAGTACGTTAGTGGTGATGTCACCCACCCTCAGGCTGGGGCCGAGGATGCTCTCATTGTGCACTGC
GTAGATGACTCTGGCCACTGGGGCAGAGGTGGTTTATTTACAGCTCTGGAAAAGCGATCCGCTGAGCCAAGAAAAATATATGAGCTGGCT
GGGAAAATGAAAGACCTGAGTTTGGGAGGTGTCCTTTTATTTCCTGTTGATGATAAAGAATCAAGAAACAAAGGGCAAGATTTGTTGGCC
TTGATTGTGGCTCAGCATCGTGATCGTTCCAATGTCCTGTCTGGCATTAAGATGGCAGCCCTAGAAGAGGGCCTGAAGAAGATATTTTTA
GCAGCAAAAAAGAAGAAAGCAAGTGTTCATCTTCCACGTATTGGACATGCCACGAAAGGTTTTAACTGGTATGGTACTGAGCGACTTATT
CGGAAACATCTGGCTGCAAGAGGCATCCCAACTTACATATATTATTTTCCTAGAAGCAAGTCTGCTGTCCTTCATGCACAGTCTTCATCT


* Fusion transcript sequences (Full-length transcript).
>In-frame_PDCD4_ENST00000280154_chr10_112635830_+_CHD1L_ENST00000431239_chr1_146747014_+_1992nt
AGCTCCGGCTCCGCCGCCACGATTGGCCAGCCGACCACCCGGCCTCGGCCAATAAGCGCCGCCCTCTCGCCCCCGTGTTACTGGGTAGAA
GAAAACAAAAACAAACAGAGCGAGAAGGGCCAGAGACTCTCCGAGGCGGCGGCAGAGACAGAAGAGCGGGGTCGGGGCCGGCTGACCAGG
AACCTGGGCGAGCAGCGGCGGGGGCCCGAGGGATTCTGAAGGAAGATTTCCATTAGGTAATTTGTTTAATCAGTGCAAGCGAAATTAAGG
GAAAATGGATGTAGAAAATGAGCAGATACTGAATGTAAACCCTGCAGGTGGAGTTGGCATGAACTTAACAGCAGCAGATACTGTGATTTT
TGTTGACAGTGACTTTAATCCTCAGAATGACTTGCAAGCAGCTGCCAGGGCTCATCGCATTGGCCAAAACAAGTCTGTTAAAGTTATTCG
GCTGATTGGTCGAGACACTGTGGAAGAAATAGTCTATAGGAAAGCAGCCTCCAAACTGCAGCTCACCAACATGATCATAGAAGGAGGCCA
TTTTACTCTGGGAGCCCAGAAACCCGCTGCCGATGCTGACCTCCAGTTGAGTGAGATACTCAAATTTGGTTTGGATAAACTGCTGGCCTC
TGAGGGGAGCACCATGGATGAAATAGACCTGGAGTCCATACTGGGAGAAACAAAAGATGGCCAGTGGGTCTCTGATGCCTTGCCTGCAGC
AGAAGGAGGGAGCAGAGATCAAGAGGAAGGAAAAAATCATATGTACTTATTTGAAGGTAAAGATTATTCTAAAGAGCCCAGTAAGGAAGA
CAGAAAATCATTTGAACAACTGGTAAACCTTCAGAAAACCCTTTTGGAGAAAGCTAGTCAAGAGGGCCGATCACTCCGAAATAAAGGCAG
TGTTCTCATCCCAGGCCTTGTGGAGGGATCTACCAAAAGGAAGCGGGTTCTGAGTCCAGAAGAGCTGGAGGACAGACAGAAGAAAAGACA
AGAAGCAGCTGCCAAGAGAAGGAGACTCATAGAGGAGAAGAAGAGGCAAAAGGAAGAGGCTGAACATAAGAAAAAGATGGCCTGGTGGGA
ATCCAACAATTACCAGTCCTTCTGCCTGCCCTCTGAGGAGAGCGAGCCAGAGGACCTTGAGAATGGGGAAGAGAGCTCTGCTGAGCTGGA
TTACCAAGACCCAGATGCTACTTCCCTCAAGTACGTTAGTGGTGATGTCACCCACCCTCAGGCTGGGGCCGAGGATGCTCTCATTGTGCA
CTGCGTAGATGACTCTGGCCACTGGGGCAGAGGTGGTTTATTTACAGCTCTGGAAAAGCGATCCGCTGAGCCAAGAAAAATATATGAGCT
GGCTGGGAAAATGAAAGACCTGAGTTTGGGAGGTGTCCTTTTATTTCCTGTTGATGATAAAGAATCAAGAAACAAAGGGCAAGATTTGTT
GGCCTTGATTGTGGCTCAGCATCGTGATCGTTCCAATGTCCTGTCTGGCATTAAGATGGCAGCCCTAGAAGAGGGCCTGAAGAAGATATT
TTTAGCAGCAAAAAAGAAGAAAGCAAGTGTTCATCTTCCACGTATTGGACATGCCACGAAAGGTTTTAACTGGTATGGTACTGAGCGACT
TATTCGGAAACATCTGGCTGCAAGAGGCATCCCAACTTACATATATTATTTTCCTAGAAGCAAGTCTGCTGTCCTTCATGCACAGTCTTC
ATCTTCCTCCTCAAGACAGCTGGTGCCTTAAGAATTGGCCCAGCCTCAGATCCTGTCTTTAGCAACCAGCTAATATTTACCCAGAGGTAC
TGCAATAGAGTATTTCAAAATGGAATCAGGATCTGGTGGGCCTCAGAAATTGTCTCTTTTCTGAGTTTCAATTTGGTTCTCCTGGATGTT
TTGCTCTGTTTTGGTACCTGTAATATAGGGAAACACAACTTTTTTTGGGAAAGCCCTTTGACCCCAGCTTGCTAGTTGCATAATAATAAA

>In-frame_PDCD4_ENST00000280154_chr10_112635830_+_CHD1L_ENST00000369259_chr1_146747014_+_1992nt
AGCTCCGGCTCCGCCGCCACGATTGGCCAGCCGACCACCCGGCCTCGGCCAATAAGCGCCGCCCTCTCGCCCCCGTGTTACTGGGTAGAA
GAAAACAAAAACAAACAGAGCGAGAAGGGCCAGAGACTCTCCGAGGCGGCGGCAGAGACAGAAGAGCGGGGTCGGGGCCGGCTGACCAGG
AACCTGGGCGAGCAGCGGCGGGGGCCCGAGGGATTCTGAAGGAAGATTTCCATTAGGTAATTTGTTTAATCAGTGCAAGCGAAATTAAGG
GAAAATGGATGTAGAAAATGAGCAGATACTGAATGTAAACCCTGCAGGTGGAGTTGGCATGAACTTAACAGCAGCAGATACTGTGATTTT
TGTTGACAGTGACTTTAATCCTCAGAATGACTTGCAAGCAGCTGCCAGGGCTCATCGCATTGGCCAAAACAAGTCTGTTAAAGTTATTCG
GCTGATTGGTCGAGACACTGTGGAAGAAATAGTCTATAGGAAAGCAGCCTCCAAACTGCAGCTCACCAACATGATCATAGAAGGAGGCCA
TTTTACTCTGGGAGCCCAGAAACCCGCTGCCGATGCTGACCTCCAGTTGAGTGAGATACTCAAATTTGGTTTGGATAAACTGCTGGCCTC
TGAGGGGAGCACCATGGATGAAATAGACCTGGAGTCCATACTGGGAGAAACAAAAGATGGCCAGTGGGTCTCTGATGCCTTGCCTGCAGC
AGAAGGAGGGAGCAGAGATCAAGAGGAAGGAAAAAATCATATGTACTTATTTGAAGGTAAAGATTATTCTAAAGAGCCCAGTAAGGAAGA
CAGAAAATCATTTGAACAACTGGTAAACCTTCAGAAAACCCTTTTGGAGAAAGCTAGTCAAGAGGGCCGATCACTCCGAAATAAAGGCAG
TGTTCTCATCCCAGGCCTTGTGGAGGGATCTACCAAAAGGAAGCGGGTTCTGAGTCCAGAAGAGCTGGAGGACAGACAGAAGAAAAGACA
AGAAGCAGCTGCCAAGAGAAGGAGACTCATAGAGGAGAAGAAGAGGCAAAAGGAAGAGGCTGAACATAAGAAAAAGATGGCCTGGTGGGA
ATCCAACAATTACCAGTCCTTCTGCCTGCCCTCTGAGGAGAGCGAGCCAGAGGACCTTGAGAATGGGGAAGAGAGCTCTGCTGAGCTGGA
TTACCAAGACCCAGATGCTACTTCCCTCAAGTACGTTAGTGGTGATGTCACCCACCCTCAGGCTGGGGCCGAGGATGCTCTCATTGTGCA
CTGCGTAGATGACTCTGGCCACTGGGGCAGAGGTGGTTTATTTACAGCTCTGGAAAAGCGATCCGCTGAGCCAAGAAAAATATATGAGCT
GGCTGGGAAAATGAAAGACCTGAGTTTGGGAGGTGTCCTTTTATTTCCTGTTGATGATAAAGAATCAAGAAACAAAGGGCAAGATTTGTT
GGCCTTGATTGTGGCTCAGCATCGTGATCGTTCCAATGTCCTGTCTGGCATTAAGATGGCAGCCCTAGAAGAGGGCCTGAAGAAGATATT
TTTAGCAGCAAAAAAGAAGAAAGCAAGTGTTCATCTTCCACGTATTGGACATGCCACGAAAGGTTTTAACTGGTATGGTACTGAGCGACT
TATTCGGAAACATCTGGCTGCAAGAGGCATCCCAACTTACATATATTATTTTCCTAGAAGCAAGTCTGCTGTCCTTCATGCACAGTCTTC
ATCTTCCTCCTCAAGACAGCTGGTGCCTTAAGAATTGGCCCAGCCTCAGATCCTGTCTTTAGCAACCAGCTAATATTTACCCAGAGGTAC
TGCAATAGAGTATTTCAAAATGGAATCAGGATCTGGTGGGCCTCAGAAATTGTCTCTTTTCTGAGTTTCAATTTGGTTCTCCTGGATGTT
TTGCTCTGTTTTGGTACCTGTAATATAGGGAAACACAACTTTTTTTGGGAAAGCCCTTTGACCCCAGCTTGCTAGTTGCATAATAATAAA

>In-frame_PDCD4_ENST00000280154_chr10_112635830_+_CHD1L_ENST00000369258_chr1_146747014_+_1994nt
AGCTCCGGCTCCGCCGCCACGATTGGCCAGCCGACCACCCGGCCTCGGCCAATAAGCGCCGCCCTCTCGCCCCCGTGTTACTGGGTAGAA
GAAAACAAAAACAAACAGAGCGAGAAGGGCCAGAGACTCTCCGAGGCGGCGGCAGAGACAGAAGAGCGGGGTCGGGGCCGGCTGACCAGG
AACCTGGGCGAGCAGCGGCGGGGGCCCGAGGGATTCTGAAGGAAGATTTCCATTAGGTAATTTGTTTAATCAGTGCAAGCGAAATTAAGG
GAAAATGGATGTAGAAAATGAGCAGATACTGAATGTAAACCCTGCAGGTGGAGTTGGCATGAACTTAACAGCAGCAGATACTGTGATTTT
TGTTGACAGTGACTTTAATCCTCAGAATGACTTGCAAGCAGCTGCCAGGGCTCATCGCATTGGCCAAAACAAGTCTGTTAAAGTTATTCG
GCTGATTGGTCGAGACACTGTGGAAGAAATAGTCTATAGGAAAGCAGCCTCCAAACTGCAGCTCACCAACATGATCATAGAAGGAGGCCA
TTTTACTCTGGGAGCCCAGAAACCCGCTGCCGATGCTGACCTCCAGTTGAGTGAGATACTCAAATTTGGTTTGGATAAACTGCTGGCCTC
TGAGGGGAGCACCATGGATGAAATAGACCTGGAGTCCATACTGGGAGAAACAAAAGATGGCCAGTGGGTCTCTGATGCCTTGCCTGCAGC
AGAAGGAGGGAGCAGAGATCAAGAGGAAGGAAAAAATCATATGTACTTATTTGAAGGTAAAGATTATTCTAAAGAGCCCAGTAAGGAAGA
CAGAAAATCATTTGAACAACTGGTAAACCTTCAGAAAACCCTTTTGGAGAAAGCTAGTCAAGAGGGCCGATCACTCCGAAATAAAGGCAG
TGTTCTCATCCCAGGCCTTGTGGAGGGATCTACCAAAAGGAAGCGGGTTCTGAGTCCAGAAGAGCTGGAGGACAGACAGAAGAAAAGACA
AGAAGCAGCTGCCAAGAGAAGGAGACTCATAGAGGAGAAGAAGAGGCAAAAGGAAGAGGCTGAACATAAGAAAAAGATGGCCTGGTGGGA
ATCCAACAATTACCAGTCCTTCTGCCTGCCCTCTGAGGAGAGCGAGCCAGAGGACCTTGAGAATGGGGAAGAGAGCTCTGCTGAGCTGGA
TTACCAAGACCCAGATGCTACTTCCCTCAAGTACGTTAGTGGTGATGTCACCCACCCTCAGGCTGGGGCCGAGGATGCTCTCATTGTGCA
CTGCGTAGATGACTCTGGCCACTGGGGCAGAGGTGGTTTATTTACAGCTCTGGAAAAGCGATCCGCTGAGCCAAGAAAAATATATGAGCT
GGCTGGGAAAATGAAAGACCTGAGTTTGGGAGGTGTCCTTTTATTTCCTGTTGATGATAAAGAATCAAGAAACAAAGGGCAAGATTTGTT
GGCCTTGATTGTGGCTCAGCATCGTGATCGTTCCAATGTCCTGTCTGGCATTAAGATGGCAGCCCTAGAAGAGGGCCTGAAGAAGATATT
TTTAGCAGCAAAAAAGAAGAAAGCAAGTGTTCATCTTCCACGTATTGGACATGCCACGAAAGGTTTTAACTGGTATGGTACTGAGCGACT
TATTCGGAAACATCTGGCTGCAAGAGGCATCCCAACTTACATATATTATTTTCCTAGAAGCAAGTCTGCTGTCCTTCATGCACAGTCTTC
ATCTTCCTCCTCAAGACAGCTGGTGCCTTAAGAATTGGCCCAGCCTCAGATCCTGTCTTTAGCAACCAGCTAATATTTACCCAGAGGTAC
TGCAATAGAGTATTTCAAAATGGAATCAGGATCTGGTGGGCCTCAGAAATTGTCTCTTTTCTGAGTTTCAATTTGGTTCTCCTGGATGTT
TTGCTCTGTTTTGGTACCTGTAATATAGGGAAACACAACTTTTTTTGGGAAAGCCCTTTGACCCCAGCTTGCTAGTTGCATAATAATAAA


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FusionGenePPI for PDCD4_CHD1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PDCD4EIF4A2, EIF4A1, RPL5, RPS13, EIF4G1, BTRC, FBXW11, EMD, ELAVL1, RPS6KA1, APOE, PSEN2, PSEN1, NAP1L1, NR1H2, VCP, CSNK2A1, DAXX, CD81, IGSF8, ARPC1B, BTF3, PAIP1, AAMP, TPD52, UFD1L, EIF4A3, TMEM51, COMTD1, RPS6KB2, HNRNPA1, UNK, EIF6, ETF1, NCAPD3, PCF11, EIF3H, EIF3I, PPP2R1B, PRMT5, PSMB6, THOC2, PSMC1, SNRPD1, NTRK1, UBE2S, HIST1H2BG, IBTK, CEP19, XPO1, TGIF2LYCHD1LXRCC6, PARP1, HIST2H2AA4, HIST3H2A, XRCC5, H2AFX, RPA3, SUPT16H, H3F3AP6, H2AFZ, RPA2, PRKDC, PARP2, HIST1H2BK, HIST1H2BB, RPA1, API5, EIF4A1, RFC2, CBX1, CBX3, CBX5, XRCC1, APLF, SCYL1, NR4A1, HIST2H2BE, TRIM33, CIAO1, KLK11, KLK5, FAS, KIR2DS2, RNF146, NT5E, ART3, TGOLN2, RNF166, HIST1H2BA, NTRK1, HIST1H2BG, SRPK2, ID1, PLK1, FAM134A, LRRK2, SGOL1, TEAD2, FOXB1, FOXL1, FOXP1, SNW1, CDC5L, XPC, LAMP2, TNKS2, HLTF, CCL22, HSPA8, TNKS, FAM196A, SSRP1, C1orf85, BAALC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PDCD4_CHD1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PDCD4_CHD1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePDCD4C0027626Neoplasm Invasiveness1CTD_human
TgeneCHD1LC0236969Substance-Related Disorders1CTD_human