FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 26339

FusionGeneSummary for PDCD10_HNRNPD

check button Fusion gene summary
Fusion gene informationFusion gene name: PDCD10_HNRNPD
Fusion gene ID: 26339
HgeneTgene
Gene symbol

PDCD10

HNRNPD

Gene ID

11235

3184

Gene nameprogrammed cell death 10heterogeneous nuclear ribonucleoprotein D
SynonymsCCM3|TFAR15AUF1|AUF1A|HNRPD|P37|hnRNPD0
Cytomap

3q26.1

4q21.22

Type of geneprotein-codingprotein-coding
Descriptionprogrammed cell death protein 10TF-1 cell apoptosis-related protein 15apoptosis-related protein 15cerebral cavernous malformations 3 proteinheterogeneous nuclear ribonucleoprotein D0ARE-binding protein AUFI, type AAU-rich element RNA binding protein 1, 37kDahnRNP D0
Modification date2018052220180523
UniProtAcc

Q9BUL8

Q14103

Ensembl transtripts involved in fusion geneENST00000392750, ENST00000473645, 
ENST00000497056, ENST00000492396, 
ENST00000461494, ENST00000470131, 
ENST00000487947, ENST00000471885, 
ENST00000487678, 
ENST00000313899, 
ENST00000353341, ENST00000543098, 
ENST00000352301, ENST00000508119, 
ENST00000541060, 
Fusion gene scores* DoF score4 X 3 X 3=3610 X 10 X 3=300
# samples 512
** MAII scorelog2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(12/300*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PDCD10 [Title/Abstract] AND HNRNPD [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePDCD10

GO:0008284

positive regulation of cell proliferation

17360971|23541896

HgenePDCD10

GO:0030335

positive regulation of cell migration

23541896

HgenePDCD10

GO:0032874

positive regulation of stress-activated MAPK cascade

22652780

HgenePDCD10

GO:0042542

response to hydrogen peroxide

22291017

HgenePDCD10

GO:0043066

negative regulation of apoptotic process

17360971

HgenePDCD10

GO:0043406

positive regulation of MAP kinase activity

17360971


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF096260PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
ChiTaRS3.1BF096098PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000392750ENST00000313899PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000392750ENST00000353341PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000392750ENST00000543098PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000392750ENST00000352301PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-5UTRENST00000392750ENST00000508119PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-5UTRENST00000392750ENST00000541060PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000473645ENST00000313899PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000473645ENST00000353341PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000473645ENST00000543098PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000473645ENST00000352301PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-5UTRENST00000473645ENST00000508119PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-5UTRENST00000473645ENST00000541060PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000497056ENST00000313899PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000497056ENST00000353341PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000497056ENST00000543098PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000497056ENST00000352301PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-5UTRENST00000497056ENST00000508119PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-5UTRENST00000497056ENST00000541060PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000492396ENST00000313899PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000492396ENST00000353341PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000492396ENST00000543098PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000492396ENST00000352301PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-5UTRENST00000492396ENST00000508119PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-5UTRENST00000492396ENST00000541060PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000461494ENST00000313899PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000461494ENST00000353341PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000461494ENST00000543098PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000461494ENST00000352301PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-5UTRENST00000461494ENST00000508119PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-5UTRENST00000461494ENST00000541060PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000470131ENST00000313899PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000470131ENST00000353341PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000470131ENST00000543098PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000470131ENST00000352301PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-5UTRENST00000470131ENST00000508119PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-5UTRENST00000470131ENST00000541060PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000487947ENST00000313899PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000487947ENST00000353341PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000487947ENST00000543098PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000487947ENST00000352301PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-5UTRENST00000487947ENST00000508119PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-5UTRENST00000487947ENST00000541060PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000471885ENST00000313899PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000471885ENST00000353341PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000471885ENST00000543098PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000471885ENST00000352301PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-5UTRENST00000471885ENST00000508119PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-5UTRENST00000471885ENST00000541060PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000487678ENST00000313899PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000487678ENST00000353341PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000487678ENST00000543098PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-3CDSENST00000487678ENST00000352301PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-5UTRENST00000487678ENST00000508119PDCD10chr3

167446632

+HNRNPDchr4

83277976

-
intron-5UTRENST00000487678ENST00000541060PDCD10chr3

167446632

+HNRNPDchr4

83277976

-

Top

FusionProtFeatures for PDCD10_HNRNPD


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PDCD10

Q9BUL8

HNRNPD

Q14103

Promotes cell proliferation. Modulates apoptoticpathways. Increases mitogen-activated protein kinase activity andSTK26 activity (PubMed:27807006). Important for cell migration,and for normal structure and assembly of the Golgi complex(PubMed:27807006). Important for KDR/VEGFR2 signaling. Increasesthe stability of KDR/VEGFR2 and prevents its breakdown. Requiredfor normal cardiovascular development. Required for normalangiogenesis, vasculogenesis and hematopoiesis during embryonicdevelopment (By similarity). {ECO:0000250|UniProtKB:Q8VE70,ECO:0000269|PubMed:15543491, ECO:0000269|PubMed:17360971,ECO:0000269|PubMed:20332113, ECO:0000269|PubMed:27807006}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PDCD10_HNRNPD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PDCD10_HNRNPD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PDCD10_HNRNPD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneHNRNPDQ14103DB11638ArtenimolHeterogeneous nuclear ribonucleoprotein D0small moleculeapproved|investigational

Top

RelatedDiseases for PDCD10_HNRNPD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource