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Fusion gene ID: 26339 |
FusionGeneSummary for PDCD10_HNRNPD |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PDCD10_HNRNPD | Fusion gene ID: 26339 | Hgene | Tgene | Gene symbol | PDCD10 | HNRNPD | Gene ID | 11235 | 3184 |
| Gene name | programmed cell death 10 | heterogeneous nuclear ribonucleoprotein D | |
| Synonyms | CCM3|TFAR15 | AUF1|AUF1A|HNRPD|P37|hnRNPD0 | |
| Cytomap | 3q26.1 | 4q21.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | programmed cell death protein 10TF-1 cell apoptosis-related protein 15apoptosis-related protein 15cerebral cavernous malformations 3 protein | heterogeneous nuclear ribonucleoprotein D0ARE-binding protein AUFI, type AAU-rich element RNA binding protein 1, 37kDahnRNP D0 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q9BUL8 | Q14103 | |
| Ensembl transtripts involved in fusion gene | ENST00000392750, ENST00000473645, ENST00000497056, ENST00000492396, ENST00000461494, ENST00000470131, ENST00000487947, ENST00000471885, ENST00000487678, | ENST00000313899, ENST00000353341, ENST00000543098, ENST00000352301, ENST00000508119, ENST00000541060, | |
| Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 10 X 10 X 3=300 |
| # samples | 5 | 12 | |
| ** MAII score | log2(5/36*10)=0.473931188332412 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(12/300*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PDCD10 [Title/Abstract] AND HNRNPD [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PDCD10 | GO:0008284 | positive regulation of cell proliferation | 17360971|23541896 |
| Hgene | PDCD10 | GO:0030335 | positive regulation of cell migration | 23541896 |
| Hgene | PDCD10 | GO:0032874 | positive regulation of stress-activated MAPK cascade | 22652780 |
| Hgene | PDCD10 | GO:0042542 | response to hydrogen peroxide | 22291017 |
| Hgene | PDCD10 | GO:0043066 | negative regulation of apoptotic process | 17360971 |
| Hgene | PDCD10 | GO:0043406 | positive regulation of MAP kinase activity | 17360971 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF096260 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - | ||
| ChiTaRS3.1 | BF096098 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000392750 | ENST00000313899 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000392750 | ENST00000353341 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000392750 | ENST00000543098 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000392750 | ENST00000352301 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-5UTR | ENST00000392750 | ENST00000508119 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-5UTR | ENST00000392750 | ENST00000541060 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000473645 | ENST00000313899 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000473645 | ENST00000353341 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000473645 | ENST00000543098 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000473645 | ENST00000352301 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-5UTR | ENST00000473645 | ENST00000508119 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-5UTR | ENST00000473645 | ENST00000541060 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000497056 | ENST00000313899 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000497056 | ENST00000353341 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000497056 | ENST00000543098 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000497056 | ENST00000352301 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-5UTR | ENST00000497056 | ENST00000508119 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-5UTR | ENST00000497056 | ENST00000541060 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000492396 | ENST00000313899 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000492396 | ENST00000353341 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000492396 | ENST00000543098 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000492396 | ENST00000352301 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-5UTR | ENST00000492396 | ENST00000508119 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-5UTR | ENST00000492396 | ENST00000541060 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000461494 | ENST00000313899 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000461494 | ENST00000353341 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000461494 | ENST00000543098 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000461494 | ENST00000352301 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-5UTR | ENST00000461494 | ENST00000508119 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-5UTR | ENST00000461494 | ENST00000541060 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000470131 | ENST00000313899 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000470131 | ENST00000353341 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000470131 | ENST00000543098 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000470131 | ENST00000352301 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-5UTR | ENST00000470131 | ENST00000508119 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-5UTR | ENST00000470131 | ENST00000541060 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000487947 | ENST00000313899 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000487947 | ENST00000353341 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000487947 | ENST00000543098 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000487947 | ENST00000352301 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-5UTR | ENST00000487947 | ENST00000508119 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-5UTR | ENST00000487947 | ENST00000541060 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000471885 | ENST00000313899 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000471885 | ENST00000353341 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000471885 | ENST00000543098 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000471885 | ENST00000352301 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-5UTR | ENST00000471885 | ENST00000508119 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-5UTR | ENST00000471885 | ENST00000541060 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000487678 | ENST00000313899 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000487678 | ENST00000353341 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000487678 | ENST00000543098 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-3CDS | ENST00000487678 | ENST00000352301 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-5UTR | ENST00000487678 | ENST00000508119 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
| intron-5UTR | ENST00000487678 | ENST00000541060 | PDCD10 | chr3 | 167446632 | + | HNRNPD | chr4 | 83277976 | - |
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FusionProtFeatures for PDCD10_HNRNPD |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PDCD10 | HNRNPD |
| Promotes cell proliferation. Modulates apoptoticpathways. Increases mitogen-activated protein kinase activity andSTK26 activity (PubMed:27807006). Important for cell migration,and for normal structure and assembly of the Golgi complex(PubMed:27807006). Important for KDR/VEGFR2 signaling. Increasesthe stability of KDR/VEGFR2 and prevents its breakdown. Requiredfor normal cardiovascular development. Required for normalangiogenesis, vasculogenesis and hematopoiesis during embryonicdevelopment (By similarity). {ECO:0000250|UniProtKB:Q8VE70,ECO:0000269|PubMed:15543491, ECO:0000269|PubMed:17360971,ECO:0000269|PubMed:20332113, ECO:0000269|PubMed:27807006}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PDCD10_HNRNPD |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PDCD10_HNRNPD |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PDCD10_HNRNPD |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | HNRNPD | Q14103 | DB11638 | Artenimol | Heterogeneous nuclear ribonucleoprotein D0 | small molecule | approved|investigational |
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RelatedDiseases for PDCD10_HNRNPD |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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