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Fusion gene ID: 26332 |
FusionGeneSummary for PC_PPP6R3 |
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Fusion gene information | Fusion gene name: PC_PPP6R3 | Fusion gene ID: 26332 | Hgene | Tgene | Gene symbol | PC | PPP6R3 | Gene ID | 5420 | 55291 |
Gene name | podocalyxin like | protein phosphatase 6 regulatory subunit 3 | |
Synonyms | Gp200|PC|PCLP|PCLP-1 | C11orf23|PP6R3|SAP190|SAPL|SAPLa|SAPS3 | |
Cytomap | 7q32.3 | 11q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | podocalyxinGCTM-2 antigenpodocalyxin-like protein 1 | serine/threonine-protein phosphatase 6 regulatory subunit 3SAPS domain family, member 3sporulation-induced transcript 4-associated protein SAPL | |
Modification date | 20180527 | 20180520 | |
UniProtAcc | P11498 | Q5H9R7 | |
Ensembl transtripts involved in fusion gene | ENST00000393958, ENST00000393960, ENST00000355677, ENST00000524491, ENST00000529047, ENST00000393955, ENST00000528224, | ENST00000393799, ENST00000530427, ENST00000393800, ENST00000534534, ENST00000524845, ENST00000265637, ENST00000524904, ENST00000393801, ENST00000265636, ENST00000529710, ENST00000527403, | |
Fusion gene scores | * DoF score | 15 X 6 X 7=630 | 15 X 15 X 6=1350 |
# samples | 15 | 19 | |
** MAII score | log2(15/630*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(19/1350*10)=-2.82888808360725 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PC [Title/Abstract] AND PPP6R3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PC | GO:0030335 | positive regulation of cell migration | 18456258 |
Hgene | PC | GO:0033634 | positive regulation of cell-cell adhesion mediated by integrin | 18456258 |
Tgene | PPP6R3 | GO:0043666 | regulation of phosphoprotein phosphatase activity | 16716191 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-S3-A6ZH-01A | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000393958 | ENST00000393799 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000393958 | ENST00000530427 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000393958 | ENST00000393800 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000393958 | ENST00000534534 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000393958 | ENST00000524845 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000393958 | ENST00000265637 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000393958 | ENST00000524904 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000393958 | ENST00000393801 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000393958 | ENST00000265636 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000393958 | ENST00000529710 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000393958 | ENST00000527403 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-3CDS | ENST00000393960 | ENST00000393799 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000393960 | ENST00000530427 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000393960 | ENST00000393800 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000393960 | ENST00000534534 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000393960 | ENST00000524845 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000393960 | ENST00000265637 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000393960 | ENST00000524904 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000393960 | ENST00000393801 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000393960 | ENST00000265636 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000393960 | ENST00000529710 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000393960 | ENST00000527403 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-3CDS | ENST00000355677 | ENST00000393799 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000355677 | ENST00000530427 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000355677 | ENST00000393800 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000355677 | ENST00000534534 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000355677 | ENST00000524845 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000355677 | ENST00000265637 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000355677 | ENST00000524904 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000355677 | ENST00000393801 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000355677 | ENST00000265636 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000355677 | ENST00000529710 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000355677 | ENST00000527403 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-3CDS | ENST00000524491 | ENST00000393799 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000524491 | ENST00000530427 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000524491 | ENST00000393800 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000524491 | ENST00000534534 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000524491 | ENST00000524845 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000524491 | ENST00000265637 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000524491 | ENST00000524904 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000524491 | ENST00000393801 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000524491 | ENST00000265636 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000524491 | ENST00000529710 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
5UTR-intron | ENST00000524491 | ENST00000527403 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
intron-3CDS | ENST00000529047 | ENST00000393799 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
intron-intron | ENST00000529047 | ENST00000530427 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
intron-intron | ENST00000529047 | ENST00000393800 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
intron-intron | ENST00000529047 | ENST00000534534 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
intron-intron | ENST00000529047 | ENST00000524845 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
intron-intron | ENST00000529047 | ENST00000265637 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
intron-intron | ENST00000529047 | ENST00000524904 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
intron-intron | ENST00000529047 | ENST00000393801 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
intron-intron | ENST00000529047 | ENST00000265636 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
intron-intron | ENST00000529047 | ENST00000529710 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
intron-intron | ENST00000529047 | ENST00000527403 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
intron-3CDS | ENST00000393955 | ENST00000393799 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
intron-intron | ENST00000393955 | ENST00000530427 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
intron-intron | ENST00000393955 | ENST00000393800 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
intron-intron | ENST00000393955 | ENST00000534534 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
intron-intron | ENST00000393955 | ENST00000524845 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
intron-intron | ENST00000393955 | ENST00000265637 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
intron-intron | ENST00000393955 | ENST00000524904 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
intron-intron | ENST00000393955 | ENST00000393801 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
intron-intron | ENST00000393955 | ENST00000265636 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
intron-intron | ENST00000393955 | ENST00000529710 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
intron-intron | ENST00000393955 | ENST00000527403 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
intron-3CDS | ENST00000528224 | ENST00000393799 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
intron-intron | ENST00000528224 | ENST00000530427 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
intron-intron | ENST00000528224 | ENST00000393800 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
intron-intron | ENST00000528224 | ENST00000534534 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
intron-intron | ENST00000528224 | ENST00000524845 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
intron-intron | ENST00000528224 | ENST00000265637 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
intron-intron | ENST00000528224 | ENST00000524904 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
intron-intron | ENST00000528224 | ENST00000393801 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
intron-intron | ENST00000528224 | ENST00000265636 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
intron-intron | ENST00000528224 | ENST00000529710 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
intron-intron | ENST00000528224 | ENST00000527403 | PC | chr11 | 66719901 | - | PPP6R3 | chr11 | 68370810 | + |
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FusionProtFeatures for PC_PPP6R3 |
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Hgene | Tgene |
PC | PPP6R3 |
Pyruvate carboxylase catalyzes a 2-step reaction,involving the ATP-dependent carboxylation of the covalentlyattached biotin in the first step and the transfer of the carboxylgroup to pyruvate in the second. Catalyzes in a tissue specificmanner, the initial reactions of glucose (liver, kidney) and lipid(adipose tissue, liver, brain) synthesis from pyruvate. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PC_PPP6R3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PC_PPP6R3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PC | MDH2, GOT1, NPM1, UBE2N, ILF2, ILF3, MTHFD1, CDH2, RPS3A, NACA, PPT2, PRKCDBP, TUFM, IFIT1, ADRB2, HECW2, HUWE1, EGFR, TSHR, KLK5, DTWD2, ANTXR1, DNASE2B, CBWD1, PSG1, THBS3, CAD, CCT6A, COPB1, CYP27A1, FASN, KPNA4, ATP1A1, CANX, CCT3, GNB2, PPP2R1A, RPN1, RPN2, SLC25A3, PFAS, UQCRC2, NTRK1, PTEN, ERBB2, XRCC3, RAB7A, DYNLL1, WWP2, ZNF746, PTPN9, STRAP, DEFA5, ASS1, HSD3B2, BPNT1, SLAMF1, LRP1, TPSB2, YBEY, EPHA7, TES | PPP6R3 | KDM6A, TNFAIP3, USP21, USP36, USP49, PPP6C, PRKDC, HDAC1, HDAC2, ELAVL1, SIRT7, TERF2IP, TINF2, TFAP4, GRK5, PFAS, BRCA1, ECT2, NOTCH1, LATS1, GPSM1, HDAC11, USP10, ANKRD28, MOB1A, MOB1B, ACAD11, ANKRD44, ANKRD52, AP1B1, AP2A1, AP2A2, AURKA, DNAJC11, ECH1, ERLIN2, PPP6R1, PPP6R2, CDC37, ENAH, ETFA, HSP90AA1, HSP90AB1, RUVBL2, SRRT, TPM1, USP7, CSNK1E, SNAI2, RNF2, GPHA2, RPS6KB2, UNK, DIEXF, NSUN5, EIF4A3, TIPRL, NTRK1, CEP44, CEP19, XPO1, ZNRF2, ZNF746, TRMT2A, TRIM25, TES |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PC_PPP6R3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | PC | P11498 | DB00121 | Biotin | Pyruvate carboxylase, mitochondrial | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for PC_PPP6R3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PC | C0006413 | Burkitt Lymphoma | 1 | CTD_human |
Hgene | PC | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | PC | C0034341 | Pyruvate Carboxylase Deficiency Disease | 1 | CTD_human;UNIPROT |