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Fusion gene ID: 26328 |
FusionGeneSummary for PC_MIEN1 |
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Fusion gene information | Fusion gene name: PC_MIEN1 | Fusion gene ID: 26328 | Hgene | Tgene | Gene symbol | PC | MIEN1 | Gene ID | 5420 | 84299 |
Gene name | podocalyxin like | migration and invasion enhancer 1 | |
Synonyms | Gp200|PC|PCLP|PCLP-1 | C17orf37|C35|ORB3|RDX12|XTP4 | |
Cytomap | 7q32.3 | 17q12 | |
Type of gene | protein-coding | protein-coding | |
Description | podocalyxinGCTM-2 antigenpodocalyxin-like protein 1 | migration and invasion enhancer 1HBV X-transactivated gene 4 proteinHBV XAg-transactivated protein 4protein C17orf37 | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | P11498 | Q9BRT3 | |
Ensembl transtripts involved in fusion gene | ENST00000393958, ENST00000393960, ENST00000355677, ENST00000524491, ENST00000529047, ENST00000393955, ENST00000528224, | ENST00000474210, ENST00000394231, ENST00000577810, | |
Fusion gene scores | * DoF score | 15 X 6 X 7=630 | 13 X 8 X 9=936 |
# samples | 15 | 14 | |
** MAII score | log2(15/630*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(14/936*10)=-2.74108170263844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PC [Title/Abstract] AND MIEN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PC | GO:0030335 | positive regulation of cell migration | 18456258 |
Hgene | PC | GO:0033634 | positive regulation of cell-cell adhesion mediated by integrin | 18456258 |
Tgene | MIEN1 | GO:0030335 | positive regulation of cell migration | 21628459 |
Tgene | MIEN1 | GO:0043066 | negative regulation of apoptotic process | 21068479 |
Tgene | MIEN1 | GO:0051491 | positive regulation of filopodium assembly | 21628459 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF894585 | PC | chr11 | 66633761 | - | MIEN1 | chr17 | 37886518 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000393958 | ENST00000474210 | PC | chr11 | 66633761 | - | MIEN1 | chr17 | 37886518 | - |
intron-intron | ENST00000393958 | ENST00000394231 | PC | chr11 | 66633761 | - | MIEN1 | chr17 | 37886518 | - |
intron-intron | ENST00000393958 | ENST00000577810 | PC | chr11 | 66633761 | - | MIEN1 | chr17 | 37886518 | - |
intron-intron | ENST00000393960 | ENST00000474210 | PC | chr11 | 66633761 | - | MIEN1 | chr17 | 37886518 | - |
intron-intron | ENST00000393960 | ENST00000394231 | PC | chr11 | 66633761 | - | MIEN1 | chr17 | 37886518 | - |
intron-intron | ENST00000393960 | ENST00000577810 | PC | chr11 | 66633761 | - | MIEN1 | chr17 | 37886518 | - |
intron-intron | ENST00000355677 | ENST00000474210 | PC | chr11 | 66633761 | - | MIEN1 | chr17 | 37886518 | - |
intron-intron | ENST00000355677 | ENST00000394231 | PC | chr11 | 66633761 | - | MIEN1 | chr17 | 37886518 | - |
intron-intron | ENST00000355677 | ENST00000577810 | PC | chr11 | 66633761 | - | MIEN1 | chr17 | 37886518 | - |
intron-intron | ENST00000524491 | ENST00000474210 | PC | chr11 | 66633761 | - | MIEN1 | chr17 | 37886518 | - |
intron-intron | ENST00000524491 | ENST00000394231 | PC | chr11 | 66633761 | - | MIEN1 | chr17 | 37886518 | - |
intron-intron | ENST00000524491 | ENST00000577810 | PC | chr11 | 66633761 | - | MIEN1 | chr17 | 37886518 | - |
intron-intron | ENST00000529047 | ENST00000474210 | PC | chr11 | 66633761 | - | MIEN1 | chr17 | 37886518 | - |
intron-intron | ENST00000529047 | ENST00000394231 | PC | chr11 | 66633761 | - | MIEN1 | chr17 | 37886518 | - |
intron-intron | ENST00000529047 | ENST00000577810 | PC | chr11 | 66633761 | - | MIEN1 | chr17 | 37886518 | - |
intron-intron | ENST00000393955 | ENST00000474210 | PC | chr11 | 66633761 | - | MIEN1 | chr17 | 37886518 | - |
intron-intron | ENST00000393955 | ENST00000394231 | PC | chr11 | 66633761 | - | MIEN1 | chr17 | 37886518 | - |
intron-intron | ENST00000393955 | ENST00000577810 | PC | chr11 | 66633761 | - | MIEN1 | chr17 | 37886518 | - |
intron-intron | ENST00000528224 | ENST00000474210 | PC | chr11 | 66633761 | - | MIEN1 | chr17 | 37886518 | - |
intron-intron | ENST00000528224 | ENST00000394231 | PC | chr11 | 66633761 | - | MIEN1 | chr17 | 37886518 | - |
intron-intron | ENST00000528224 | ENST00000577810 | PC | chr11 | 66633761 | - | MIEN1 | chr17 | 37886518 | - |
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FusionProtFeatures for PC_MIEN1 |
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Hgene | Tgene |
PC | MIEN1 |
Pyruvate carboxylase catalyzes a 2-step reaction,involving the ATP-dependent carboxylation of the covalentlyattached biotin in the first step and the transfer of the carboxylgroup to pyruvate in the second. Catalyzes in a tissue specificmanner, the initial reactions of glucose (liver, kidney) and lipid(adipose tissue, liver, brain) synthesis from pyruvate. | Increases cell migration by inducing filopodia formationat the leading edge of migrating cells. Plays a role in regulationof apoptosis, possibly through control of CASP3. May be involvedin a redox-related process. {ECO:0000269|PubMed:19503095,ECO:0000269|PubMed:21628459}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PC_MIEN1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PC_MIEN1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PC_MIEN1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | PC | P11498 | DB00121 | Biotin | Pyruvate carboxylase, mitochondrial | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for PC_MIEN1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PC | C0006413 | Burkitt Lymphoma | 1 | CTD_human |
Hgene | PC | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | PC | C0034341 | Pyruvate Carboxylase Deficiency Disease | 1 | CTD_human;UNIPROT |