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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 26281

FusionGeneSummary for PCNT_DIP2A

check button Fusion gene summary
Fusion gene informationFusion gene name: PCNT_DIP2A
Fusion gene ID: 26281
HgeneTgene
Gene symbol

PCNT

DIP2A

Gene ID

5116

23181

Gene namepericentrindisco interacting protein 2 homolog A
SynonymsKEN|MOPD2|PCN|PCNT2|PCNTB|PCTN2|SCKL4C21orf106|DIP2
Cytomap

21q22.3

21q22.3

Type of geneprotein-codingprotein-coding
Descriptionpericentrinkendrinpericentrin-2pericentrin-380pericentrin-Bdisco-interacting protein 2 homolog ADIP2 disco-interacting protein 2 homolog ADIP2 homolog Adisco-interacting protein 2A
Modification date2018052220180523
UniProtAcc

O95613

Q14689

Ensembl transtripts involved in fusion geneENST00000359568, ENST00000480896, 
ENST00000400274, ENST00000427143, 
ENST00000318711, ENST00000417564, 
ENST00000457905, ENST00000466639, 
ENST00000435722, ENST00000479654, 
Fusion gene scores* DoF score5 X 4 X 5=1005 X 5 X 3=75
# samples 55
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PCNT [Title/Abstract] AND DIP2A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePCNT

GO:0060271

cilium assembly

15337773

TgeneDIP2A

GO:0010629

negative regulation of gene expression

20860622


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLGGTCGA-DB-5277-01APCNTchr21

47787054

+DIP2Achr21

47980635

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000359568ENST00000400274PCNTchr21

47787054

+DIP2Achr21

47980635

+
5CDS-intronENST00000359568ENST00000427143PCNTchr21

47787054

+DIP2Achr21

47980635

+
5CDS-intronENST00000359568ENST00000318711PCNTchr21

47787054

+DIP2Achr21

47980635

+
5CDS-intronENST00000359568ENST00000417564PCNTchr21

47787054

+DIP2Achr21

47980635

+
5CDS-intronENST00000359568ENST00000457905PCNTchr21

47787054

+DIP2Achr21

47980635

+
5CDS-intronENST00000359568ENST00000466639PCNTchr21

47787054

+DIP2Achr21

47980635

+
5CDS-intronENST00000359568ENST00000435722PCNTchr21

47787054

+DIP2Achr21

47980635

+
5CDS-intronENST00000359568ENST00000479654PCNTchr21

47787054

+DIP2Achr21

47980635

+
3UTR-3CDSENST00000480896ENST00000400274PCNTchr21

47787054

+DIP2Achr21

47980635

+
3UTR-intronENST00000480896ENST00000427143PCNTchr21

47787054

+DIP2Achr21

47980635

+
3UTR-intronENST00000480896ENST00000318711PCNTchr21

47787054

+DIP2Achr21

47980635

+
3UTR-intronENST00000480896ENST00000417564PCNTchr21

47787054

+DIP2Achr21

47980635

+
3UTR-intronENST00000480896ENST00000457905PCNTchr21

47787054

+DIP2Achr21

47980635

+
3UTR-intronENST00000480896ENST00000466639PCNTchr21

47787054

+DIP2Achr21

47980635

+
3UTR-intronENST00000480896ENST00000435722PCNTchr21

47787054

+DIP2Achr21

47980635

+
3UTR-intronENST00000480896ENST00000479654PCNTchr21

47787054

+DIP2Achr21

47980635

+

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FusionProtFeatures for PCNT_DIP2A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PCNT

O95613

DIP2A

Q14689

Integral component of the filamentous matrix of thecentrosome involved in the initial establishment of organizedmicrotubule arrays in both mitosis and meiosis. Plays a role,together with DISC1, in the microtubule network formation. Is anintegral component of the pericentriolar material (PCM). May playan important role in preventing premature centrosome splittingduring interphase by inhibiting NEK2 kinase activity at thecentrosome. {ECO:0000269|PubMed:10823944,ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030,ECO:0000269|PubMed:20599736}. May provide positional cues for axon pathfinding andpatterning in the central nervous system.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePCNTchr21:47787054chr21:47980635ENST00000359568+1547258_55310553337Coiled coilOntology_term=ECO:0000255
HgenePCNTchr21:47787054chr21:47980635ENST00000359568+1547675_83510553337Coiled coilOntology_term=ECO:0000255
HgenePCNTchr21:47787054chr21:47980635ENST00000359568+1547214_79510553337Compositional biasNote=Glu-rich
TgeneDIP2Achr21:47787054chr21:47980635ENST00000400274+31381498_150113191568Compositional biasNote=Poly-Val
TgeneDIP2Achr21:47787054chr21:47980635ENST00000417564+31381498_150113231572Compositional biasNote=Poly-Val
TgeneDIP2Achr21:47787054chr21:47980635ENST00000427143+0281114_1117-641111Compositional biasNote=Poly-Ala
TgeneDIP2Achr21:47787054chr21:47980635ENST00000427143+0281498_1501-641111Compositional biasNote=Poly-Val
TgeneDIP2Achr21:47787054chr21:47980635ENST00000435722+0211114_1117-25842Compositional biasNote=Poly-Ala
TgeneDIP2Achr21:47787054chr21:47980635ENST00000435722+0211498_1501-25842Compositional biasNote=Poly-Val
TgeneDIP2Achr21:47787054chr21:47980635ENST00000457905+0221114_1117-61890Compositional biasNote=Poly-Ala
TgeneDIP2Achr21:47787054chr21:47980635ENST00000457905+0221498_1501-61890Compositional biasNote=Poly-Val
TgeneDIP2Achr21:47787054chr21:47980635ENST00000466639+0201114_1117-52799Compositional biasNote=Poly-Ala
TgeneDIP2Achr21:47787054chr21:47980635ENST00000466639+0201498_1501-52799Compositional biasNote=Poly-Val

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePCNTchr21:47787054chr21:47980635ENST00000359568+15471010_114610553337Coiled coilOntology_term=ECO:0000255
HgenePCNTchr21:47787054chr21:47980635ENST00000359568+15471299_194910553337Coiled coilOntology_term=ECO:0000255
HgenePCNTchr21:47787054chr21:47980635ENST00000359568+15472064_208210553337Coiled coilOntology_term=ECO:0000255
HgenePCNTchr21:47787054chr21:47980635ENST00000359568+15472536_308610553337Coiled coilOntology_term=ECO:0000255
HgenePCNTchr21:47787054chr21:47980635ENST00000359568+15473195_320810553337RegionNote=Calmodulin-binding
TgeneDIP2Achr21:47787054chr21:47980635ENST00000400274+31381114_111713191568Compositional biasNote=Poly-Ala
TgeneDIP2Achr21:47787054chr21:47980635ENST00000417564+31381114_111713231572Compositional biasNote=Poly-Ala


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FusionGeneSequence for PCNT_DIP2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PCNT_ENST00000359568_chr21_47787054_+_DIP2A_ENST00000400274_chr21_47980635_+_1304aa
MEVEQEQRRRKVEAGRTKLAHFRQRKTKGDSSHSEKKTAKRKGSAVDASVQEESPVTKEDSALCGGGDICKSTSCDDTPDGAGGAFAAQP
EDCDGEKREDLEQLQQKQVNDHPPEQCGMFTVSDHPPEQHGMFTVGDHPPEQRGMFTVSDHPPEQHGMFTVSDHPPEQRGMFTISDHQPE
QRGMFTVSDHTPEQRGIFTISDHPAEQRGMFTKECEQECELAITDLESGREDEAGLHQSQAVHGLELEALRLSLSNMHTAQLELTQANLQ
KEKETALTELREMLNSRRAQELALLQSRQQHELELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLEN
LRKELSAKHQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGRCLEDLEFKFKESEKEKQLELE
NLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTL
LQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEALESPLCIQHEGHVSDRCCVETSA
LGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKVK
HNLIEDHQKELNNAKQKTELMKQEFQRKETDWKVMKEELQREAEEKLTLMLLELREKAESEKQTIINKFELREAEMRQLQDQQAAQILDL
ERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARE
LQLLQERHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQAL
ELLRADFEEQLWKKDSLHQTILTQELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGTAGPDPTTVYVDMRALRHDRVRLV
ERGSPHSLPLMESGKILPGVKVIIAHTETKGPLGDSHLGEIWVSSPHNATGYYTVYGEEALHADHFSARLSFGDTQTIWARTGYLGFLRR
TELTDASGGRHDALYVVGSLDETLELRGMRYHPIDIETSVIRAHRSIAECAVFTWTNLLVVVVELDGLEQDALDLVALVTNVVLEEHYLV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PCNT_ENST00000359568_chr21_47787054_+_DIP2A_ENST00000400274_chr21_47980635_+_3912nt
ATGGAAGTTGAGCAAGAGCAGCGGCGCAGAAAGGTGGAGGCCGGGAGGACGAAGCTTGCTCACTTCCGACAGAGAAAAACAAAAGGTGAC
AGTTCGCATTCGGAGAAAAAGACGGCGAAGAGGAAGGGCTCGGCTGTCGATGCGTCTGTCCAGGAGGAGAGTCCGGTAACCAAGGAGGAC
AGCGCACTCTGTGGAGGAGGGGACATTTGCAAAAGCACATCATGTGACGACACCCCTGATGGGGCAGGAGGGGCCTTTGCAGCTCAGCCG
GAGGACTGTGATGGAGAGAAGAGAGAGGACTTGGAACAGCTGCAGCAGAAGCAAGTCAATGACCATCCTCCAGAGCAGTGTGGGATGTTC
ACAGTCAGTGACCACCCACCAGAACAGCATGGGATGTTCACAGTCGGTGACCACCCACCAGAACAGCGTGGGATGTTCACAGTCAGTGAC
CACCCACCAGAACAGCATGGGATGTTCACAGTCAGTGACCACCCACCAGAACAGCGTGGGATGTTCACAATCAGTGACCACCAACCGGAA
CAGCGTGGGATGTTCACAGTCAGTGACCACACACCAGAACAGCGTGGGATCTTCACAATCAGTGACCACCCAGCAGAACAGCGTGGGATG
TTCACAAAGGAGTGTGAACAAGAATGTGAACTTGCCATTACTGACCTGGAGAGCGGCCGTGAAGATGAGGCTGGCCTGCATCAGAGTCAG
GCCGTGCATGGCCTTGAGCTGGAGGCGCTGCGCCTGAGTCTGAGCAACATGCACACGGCGCAGCTGGAGCTGACACAGGCCAACCTCCAG
AAGGAGAAGGAGACGGCATTGACGGAGCTGCGGGAGATGCTCAACAGCCGGCGTGCCCAGGAGCTGGCCCTGCTACAGAGCAGGCAGCAG
CACGAGCTGGAGCTCCTCAGGGAGCAGCACGCACGGGAGAAGGAGGAGGTGGTGCTCAGGTGTGGACAGGAAGCAGCTGAGCTGAAGGAG
AAGTTACAATCAGAAATGGAGAAAAACGCCCAGATAGTAAAGACCCTGAAGGAAGATTGGGAATCTGAAAAAGATTTATGTTTAGAAAAT
CTACGCAAAGAACTGTCTGCAAAGCATCAATCAGAAATGGAGGATTTACAAAACCAGTTTCAGAAAGAATTGGCAGAACAGAGAGCTGAG
TTGGAGAAGATTTTTCAAGACAAAAACCAGGCTGAACGGGCCCTTAGGAACCTGGAGAGTCATCATCAAGCAGCCATTGAGAAGTTACGT
GAAGACCTGCAGTCCGAGCACGGCCGGTGTTTAGAAGACTTGGAGTTCAAGTTCAAAGAGAGCGAGAAAGAAAAACAGCTGGAGTTAGAG
AATCTTCAAGCATCATATGAAGACCTGAAGGCACAATCACAAGAAGAGATCAGGCGCTTGTGGTCCCAGCTTGATTCTGCCAGGACCAGT
AGACAGGAATTGAGTGAGCTACATGAGCAACTCCTGGCGCGCACCTCTCGTGTGGAAGATTTAGAACAGCTGAAGCAGCGAGAAAAAACC
CAGCATGAGTCCGAACTGGAGCAACTGAGGATTTATTTTGAAAAGAAGTTAAGGGATGCTGAGAAAACTTACCAAGAAGACCTAACCCTG
TTACAGCAGAGGCTGCAGGGGGCGAGGGAAGATGCTCTTCTGGACTCTGTGGAAGTTGGGTTGTCCTGTGTGGGTTTAGAAGAGAAACCT
GAGAAAGGAAGAAAAGATCACGTTGATGAACTCGAGCCTGAGCGACATAAGGAGAGCCTGCCACGCTTCCAGGCGGAGTTAGAAGAAAGC
CACAGGCACCAGCTGGAAGCGCTGGAGTCTCCCCTCTGCATCCAGCACGAGGGGCATGTCTCAGACAGATGCTGCGTAGAGACTTCAGCA
TTGGGACACGAGTGGCGTCTGGAACCCTCTGAAGGGCACAGCCAAGAGCTTCCCTGGGTGCATCTCCAGGGTGTGCAGGACGGGGACTTG
GAGGCCGACACAGAGCGGGCAGCCAGAGTCTTGGGTCTGGAAACTGAGCACAAGGTGCAACTTTCGCTTCTTCAGACTGAGCTCAAAGAA
GAAATTGAACTCCTAAAAATAGAAAATAGAAATTTGTATGGGAAGTTGCAGCATGAAACTCGTCTGAAGGACGATTTGGAGAAGGTAAAA
CACAATCTAATTGAAGACCACCAGAAGGAACTAAATAATGCTAAGCAAAAGACTGAGCTGATGAAACAGGAATTCCAAAGAAAAGAAACG
GACTGGAAAGTTATGAAGGAGGAGCTACAGCGGGAAGCTGAGGAGAAGTTAACATTGATGCTACTTGAACTGAGAGAAAAGGCTGAATCC
GAGAAACAGACCATCATAAACAAGTTTGAGCTTCGAGAAGCTGAAATGAGGCAGCTTCAGGACCAACAGGCAGCCCAGATCCTGGATCTG
GAGAGGTCCTTGACGGAGCAGCAGGGCCGCCTGCAGCAGCTGGAACAGGACCTCACTTCAGACGACGCCCTGCATTGCAGCCAGTGTGGG
CGGGAGCCGCCCACAGCCCAGGACGGGGAGCTTGCTGCGCTCCACGTGAAGGAAGACTGCGCCCTGCAGCTGATGCTGGCCCGGAGCAGG
TTTTTAGAGGAACGTAAAGAGATCACCGAGAAATTCAGTGCGGAACAAGATGCCTTCCTGCAGGAGGCCCAGGAGCAGCATGCCCGTGAG
CTGCAGCTCCTCCAGGAGAGACACCAGCAGCAGCTCCTGTCAGTGACGGCGGAGCTCGAGGCCAGACACCAGGCCGCGTTGGGCGAGCTG
ACAGCCTCCTTAGAGAGCAAGCAGGGGGCTCTGCTGGCTGCACGTGTGGCCGAACTGCAGACAAAACACGCTGCCGACCTCGGCGCTCTG
GAGACCAGACATCTGTCCAGCCTTGATTCTTTGGAATCCTGTTACCTCTCTGAATTTCAGACCATCCGTGAGGAGCACAGGCAGGCCCTA
GAGCTCTTACGAGCAGACTTTGAGGAACAACTGTGGAAAAAGGACTCTCTTCACCAAACGATTTTGACTCAAGAGTTGGAGAAACTGAAG
CGGAAACACGAAGGGGAGCTACAGTCTGTGCGGGACCACCTGCGAACCGAAGTGAGCACAGAGCTCGCCGGAACCGTGGCTCACGAGCTG
CAGGGAGTGCACCAGGGCACAGCTGGCCCGGACCCCACAACCGTCTACGTGGACATGCGGGCACTGCGCCATGACAGGGTTCGTTTGGTA
GAACGGGGTTCTCCGCACAGCCTGCCATTGATGGAGTCTGGAAAGATCCTCCCCGGCGTGAAGGTCATCATCGCACACACCGAGACCAAA
GGACCCTTGGGAGACTCACACCTGGGAGAGATCTGGGTAAGCAGCCCCCACAATGCCACCGGGTACTACACCGTTTACGGGGAGGAGGCG
CTTCATGCCGACCACTTCAGTGCCCGGCTGAGTTTTGGAGACACACAGACCATCTGGGCAAGGACCGGCTACCTTGGCTTCCTTCGGCGA
ACAGAGCTCACTGATGCCAGTGGAGGGCGGCACGATGCACTGTATGTGGTTGGGTCTCTGGATGAAACTCTGGAGCTCAGAGGCATGCGG
TACCACCCCATCGACATTGAGACCTCTGTCATCCGAGCACACAGGAGCATCGCTGAGTGTGCCGTATTCACCTGGACCAACCTGCTGGTG
GTGGTGGTGGAGCTGGATGGGCTAGAGCAGGATGCCCTGGACCTGGTGGCCCTGGTGACCAACGTGGTGCTGGAGGAGCACTACCTGGTC
GTGGGAGTGGTGGTCATCGTGGACCCAGGGGTGATCCCTATCAACTCTCGGGGTGAGAAGCAGCGCATGCACCTGCGGGACGGCTTCCTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_PCNT_ENST00000359568_chr21_47787054_+_DIP2A_ENST00000400274_chr21_47980635_+_6105nt
GCGGGGGGAGGGCGAGCCCAAGCGCGGGGGAGGGAGTGTAAATAGAGCGAAGGCTGCTCTGTGTCAGCCCCGTCACCGCCGGGCGGCCCG
CGCGGAGTCTGAGGGAGATGGAAGTTGAGCAAGAGCAGCGGCGCAGAAAGGTGGAGGCCGGGAGGACGAAGCTTGCTCACTTCCGACAGA
GAAAAACAAAAGGTGACAGTTCGCATTCGGAGAAAAAGACGGCGAAGAGGAAGGGCTCGGCTGTCGATGCGTCTGTCCAGGAGGAGAGTC
CGGTAACCAAGGAGGACAGCGCACTCTGTGGAGGAGGGGACATTTGCAAAAGCACATCATGTGACGACACCCCTGATGGGGCAGGAGGGG
CCTTTGCAGCTCAGCCGGAGGACTGTGATGGAGAGAAGAGAGAGGACTTGGAACAGCTGCAGCAGAAGCAAGTCAATGACCATCCTCCAG
AGCAGTGTGGGATGTTCACAGTCAGTGACCACCCACCAGAACAGCATGGGATGTTCACAGTCGGTGACCACCCACCAGAACAGCGTGGGA
TGTTCACAGTCAGTGACCACCCACCAGAACAGCATGGGATGTTCACAGTCAGTGACCACCCACCAGAACAGCGTGGGATGTTCACAATCA
GTGACCACCAACCGGAACAGCGTGGGATGTTCACAGTCAGTGACCACACACCAGAACAGCGTGGGATCTTCACAATCAGTGACCACCCAG
CAGAACAGCGTGGGATGTTCACAAAGGAGTGTGAACAAGAATGTGAACTTGCCATTACTGACCTGGAGAGCGGCCGTGAAGATGAGGCTG
GCCTGCATCAGAGTCAGGCCGTGCATGGCCTTGAGCTGGAGGCGCTGCGCCTGAGTCTGAGCAACATGCACACGGCGCAGCTGGAGCTGA
CACAGGCCAACCTCCAGAAGGAGAAGGAGACGGCATTGACGGAGCTGCGGGAGATGCTCAACAGCCGGCGTGCCCAGGAGCTGGCCCTGC
TACAGAGCAGGCAGCAGCACGAGCTGGAGCTCCTCAGGGAGCAGCACGCACGGGAGAAGGAGGAGGTGGTGCTCAGGTGTGGACAGGAAG
CAGCTGAGCTGAAGGAGAAGTTACAATCAGAAATGGAGAAAAACGCCCAGATAGTAAAGACCCTGAAGGAAGATTGGGAATCTGAAAAAG
ATTTATGTTTAGAAAATCTACGCAAAGAACTGTCTGCAAAGCATCAATCAGAAATGGAGGATTTACAAAACCAGTTTCAGAAAGAATTGG
CAGAACAGAGAGCTGAGTTGGAGAAGATTTTTCAAGACAAAAACCAGGCTGAACGGGCCCTTAGGAACCTGGAGAGTCATCATCAAGCAG
CCATTGAGAAGTTACGTGAAGACCTGCAGTCCGAGCACGGCCGGTGTTTAGAAGACTTGGAGTTCAAGTTCAAAGAGAGCGAGAAAGAAA
AACAGCTGGAGTTAGAGAATCTTCAAGCATCATATGAAGACCTGAAGGCACAATCACAAGAAGAGATCAGGCGCTTGTGGTCCCAGCTTG
ATTCTGCCAGGACCAGTAGACAGGAATTGAGTGAGCTACATGAGCAACTCCTGGCGCGCACCTCTCGTGTGGAAGATTTAGAACAGCTGA
AGCAGCGAGAAAAAACCCAGCATGAGTCCGAACTGGAGCAACTGAGGATTTATTTTGAAAAGAAGTTAAGGGATGCTGAGAAAACTTACC
AAGAAGACCTAACCCTGTTACAGCAGAGGCTGCAGGGGGCGAGGGAAGATGCTCTTCTGGACTCTGTGGAAGTTGGGTTGTCCTGTGTGG
GTTTAGAAGAGAAACCTGAGAAAGGAAGAAAAGATCACGTTGATGAACTCGAGCCTGAGCGACATAAGGAGAGCCTGCCACGCTTCCAGG
CGGAGTTAGAAGAAAGCCACAGGCACCAGCTGGAAGCGCTGGAGTCTCCCCTCTGCATCCAGCACGAGGGGCATGTCTCAGACAGATGCT
GCGTAGAGACTTCAGCATTGGGACACGAGTGGCGTCTGGAACCCTCTGAAGGGCACAGCCAAGAGCTTCCCTGGGTGCATCTCCAGGGTG
TGCAGGACGGGGACTTGGAGGCCGACACAGAGCGGGCAGCCAGAGTCTTGGGTCTGGAAACTGAGCACAAGGTGCAACTTTCGCTTCTTC
AGACTGAGCTCAAAGAAGAAATTGAACTCCTAAAAATAGAAAATAGAAATTTGTATGGGAAGTTGCAGCATGAAACTCGTCTGAAGGACG
ATTTGGAGAAGGTAAAACACAATCTAATTGAAGACCACCAGAAGGAACTAAATAATGCTAAGCAAAAGACTGAGCTGATGAAACAGGAAT
TCCAAAGAAAAGAAACGGACTGGAAAGTTATGAAGGAGGAGCTACAGCGGGAAGCTGAGGAGAAGTTAACATTGATGCTACTTGAACTGA
GAGAAAAGGCTGAATCCGAGAAACAGACCATCATAAACAAGTTTGAGCTTCGAGAAGCTGAAATGAGGCAGCTTCAGGACCAACAGGCAG
CCCAGATCCTGGATCTGGAGAGGTCCTTGACGGAGCAGCAGGGCCGCCTGCAGCAGCTGGAACAGGACCTCACTTCAGACGACGCCCTGC
ATTGCAGCCAGTGTGGGCGGGAGCCGCCCACAGCCCAGGACGGGGAGCTTGCTGCGCTCCACGTGAAGGAAGACTGCGCCCTGCAGCTGA
TGCTGGCCCGGAGCAGGTTTTTAGAGGAACGTAAAGAGATCACCGAGAAATTCAGTGCGGAACAAGATGCCTTCCTGCAGGAGGCCCAGG
AGCAGCATGCCCGTGAGCTGCAGCTCCTCCAGGAGAGACACCAGCAGCAGCTCCTGTCAGTGACGGCGGAGCTCGAGGCCAGACACCAGG
CCGCGTTGGGCGAGCTGACAGCCTCCTTAGAGAGCAAGCAGGGGGCTCTGCTGGCTGCACGTGTGGCCGAACTGCAGACAAAACACGCTG
CCGACCTCGGCGCTCTGGAGACCAGACATCTGTCCAGCCTTGATTCTTTGGAATCCTGTTACCTCTCTGAATTTCAGACCATCCGTGAGG
AGCACAGGCAGGCCCTAGAGCTCTTACGAGCAGACTTTGAGGAACAACTGTGGAAAAAGGACTCTCTTCACCAAACGATTTTGACTCAAG
AGTTGGAGAAACTGAAGCGGAAACACGAAGGGGAGCTACAGTCTGTGCGGGACCACCTGCGAACCGAAGTGAGCACAGAGCTCGCCGGAA
CCGTGGCTCACGAGCTGCAGGGAGTGCACCAGGGCACAGCTGGCCCGGACCCCACAACCGTCTACGTGGACATGCGGGCACTGCGCCATG
ACAGGGTTCGTTTGGTAGAACGGGGTTCTCCGCACAGCCTGCCATTGATGGAGTCTGGAAAGATCCTCCCCGGCGTGAAGGTCATCATCG
CACACACCGAGACCAAAGGACCCTTGGGAGACTCACACCTGGGAGAGATCTGGGTAAGCAGCCCCCACAATGCCACCGGGTACTACACCG
TTTACGGGGAGGAGGCGCTTCATGCCGACCACTTCAGTGCCCGGCTGAGTTTTGGAGACACACAGACCATCTGGGCAAGGACCGGCTACC
TTGGCTTCCTTCGGCGAACAGAGCTCACTGATGCCAGTGGAGGGCGGCACGATGCACTGTATGTGGTTGGGTCTCTGGATGAAACTCTGG
AGCTCAGAGGCATGCGGTACCACCCCATCGACATTGAGACCTCTGTCATCCGAGCACACAGGAGCATCGCTGAGTGTGCCGTATTCACCT
GGACCAACCTGCTGGTGGTGGTGGTGGAGCTGGATGGGCTAGAGCAGGATGCCCTGGACCTGGTGGCCCTGGTGACCAACGTGGTGCTGG
AGGAGCACTACCTGGTCGTGGGAGTGGTGGTCATCGTGGACCCAGGGGTGATCCCTATCAACTCTCGGGGTGAGAAGCAGCGCATGCACC
TGCGGGACGGCTTCCTGGCTGACCAGCTGGACCCCATCTATGTCGCCTACAACATGTGAGCGCAGCACACCGGCCCAGGTGCCGGAGATG
AATGAGCCCCAGCAGTCCAAGGTGTGATGTGGGAAGACACCGCAGAGCTCACTCACCGGGACTCGCCCTTCCTGTGCTCTTACAGATCCC
TCTCAACAATCCCCGCATCTCCTTTTAGAAAGCACTTCCTGAATTATTTAAAGAAATATTTTGAATCTGCCAAGTACATTTACAAAAACA
CGGATGCTGGTATTTTAACAGATGGAGAGACAAGGAAAGGAAAGGAAAGGCCTGGCATGGGCATTGTGAGGAATCACAGGCACCGAGGTT
GTTCTCTGCTGTACTGCAAGTTTGCACTTTCTTTAGGCTAAAAATATAGTTCCTGATTTTTAAAATTCAGTTATTTATTCCCACTTCAAA
TGACAAGTTCATATATAGAATTTACGGGAGAAACTTGAGACCATTTACGGGGAGAAACTTGATTCTGGGAAGATAGCAGAGTACAAACCA
GCTGCCTCACTTCTGTTTCACAGGGAGGCTGATGGAAAAAGGAAGCAAGCTGGACCCATCCTCCCTGCTCACAGAGGGCACTGTGGTCAC
ACACAGTGCCTCCTCTGCCAGTTCCTTTATTGAAAGAGGTGTGCTGGCTGGCCACGGTGGCTTACACCTGTAATCCCAGCACTTTGGGAG
GCCGAGGCGAGCAGATCACGAGGTCAGGAGACCGAGACCATCCTGGCTAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAAATTA
GCCGGGTGTGGTGGTGGGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGTATGAACCAGGGAGGCGGAGCTTGCAGT
GAGCCGAGATCACGCTACTGCACTCCAGCCTGGGTGACAGCACGAGATGCCGTCTTAAAAAAACAAAAAAGAGGTGTGCTGCTTGTCAGC
ATGTATTGTCACGGACACTCAATAAGTGCCATTTTGGACTGTCAAATTTAGATGCTTTGTTTCAGAAAGATAAGCCAGCATTTAGTTTTA
AATCACTTTCCTGGTTTGTAACTTGATGCTGTTTAGTTAAATTGCTAGTTTTCCTAACACTACAATATTAATTCTTCTCGTGGAAGTGTA
CTGATTTATTATTTTTATTCCAAGTCAGCAGATTTGGAAGCATTGTGGTAAAGTCTAAGGTTTTCATATCCATAGTGCTGTTTGGTGAGT
ACCGGCAGTACAGTTGAGGGGAGCAGGGAACAGCATTGCCCCGTATTGAAGGTGGAGATGGTTACATTCTTCACTGCTTTTTGCATTTTG
AGTTGTGTGCCTATAAAATTTGGCCAAACCATTTTATTATTTTGTTCAAACTTGACTAAGCTGAGTGATCTAAAATTATACAGAACCTAA
ATCAAAGAAGAGAATGTAAAGTCCTTTAGTTACTTCTAAGAATTTGAAGTCAAGCACGAATCTAAGACATAGATTATTTTTATATAGCTA
ATGAAGAGTATGTTACGAAATTGTTGGGTTTTTGGGGTATTGAGGGTGGCAAATTTTGTGAATCATGCATGCTTCACAGAAACAACCAGG
TTTTTCCAGAATTAGTCTGGATCAGTGCCTAACAAAGCTGTTATTAATTCTCCACACATGAGTCTGGCTAACTGGGCCAGCTCTCATGTT
TTACTCCTGTCTGGCTACAAATAGCACTGTGCATAGTAGCCCTGTTTCCCCATGGTGTTGGACTGTGGTAAAGTATGTTGTGACATACTG
GAATTCTAATAATCCTGTTGTAAGTATGTACAGAATCTATGTAACTTATTGTTGACATACAGAGGTTTGGGAAGTAGTCTAATGGACATT
CCTTACAATAGAATGGCTGGGAAGGGAAAGAAAAAAAAAAAAAAACTACCTAACTCCAATCTTAATGTTGTAGTTTTATAGCAAACAAAA
ATTGTCAGCTTTTTGTATTGAAAGGTCAGTGGTGGTAAGACAAGGTGTCTTGTAAATTAAGATTTTAAGAAGTGCATTAAAATGTTTTAG


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FusionGenePPI for PCNT_DIP2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PCNTCALM1, PCM1, TUBGCP3, TUBGCP2, DYNC1LI1, CHD3, CHD4, MBD3, MTA2, RBBP7, SIRT7, TP53BP1, CDK5RAP2, AKAP9, OBSL1, CCDC8, SUZ12, CCDC183, TSNAX, TXNDC11, DTNBP1, BIRC7, FGL2, CEP68, PLK4, CEP192, CEP63, CCDC67, CENPJ, CEP152, MED4, CEP290, CEP162, RPGRIP1L, CNTRL, SLC25A4, PAX6, YWHAZ, MAPRE1, RACGAP1, PON2, PRKAR2A, OFD1, PIBF1, CEP131, CEP72, MIB1, WDR35, C7orf50, MPV17L2, IMP4, GAN, CDC5L, EID1, TPTE2, LPXN, IKBIP, FAM81B, MZT1, MIS18A, C1orf87, TCP10L, EXOC1DIP2AMRGBP, JMJD6, AES, PTPN3, TRIP13, TMCC2, SORBS3, PSME3, ZBTB43, MBIP, ADAMTSL4, GPATCH2L, TRIM39, CCDC33, FAM214B, CEP44, STAC3, NXF1, SPINT2, EFNB2, TEX264, TGFBR2, BTN2A1, DLK1, LPCAT1, PTGER3, THBS3, C1orf186, EGFR, HAVCR2, MANSC1, SELE, TPCN2, SSSCA1, IL20RA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePCNTchr21:47787054chr21:47980635ENST00000359568+15472983_324610553337NEK2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PCNT_DIP2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PCNT_DIP2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePCNTC0005586Bipolar Disorder3PSYGENET
HgenePCNTC0036341Schizophrenia2PSYGENET
HgenePCNTC0041696Unipolar Depression2PSYGENET
HgenePCNTC1269683Major Depressive Disorder2PSYGENET
HgenePCNTC0033975Psychotic Disorders1PSYGENET
HgenePCNTC0265202Seckel syndrome1CTD_human;ORPHANET
HgenePCNTC0349204Nonorganic psychosis1PSYGENET
HgenePCNTC1847572SECKEL SYNDROME 21CTD_human