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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26280

FusionGeneSummary for PCNP_PCCA

check button Fusion gene summary
Fusion gene informationFusion gene name: PCNP_PCCA
Fusion gene ID: 26280
HgeneTgene
Gene symbol

PCNP

PCCA

Gene ID

57092

5095

Gene namePEST proteolytic signal containing nuclear proteinpropionyl-CoA carboxylase subunit alpha
Synonyms--
Cytomap

3q12.3

13q32.3

Type of geneprotein-codingprotein-coding
DescriptionPEST proteolytic signal-containing nuclear proteinPEST-containing nuclear proteinpropionyl-CoA carboxylase alpha chain, mitochondrialPCCase alpha subunitpccA complementation grouppropanoyl-CoA:carbon dioxide ligase alpha subunitpropionyl CoA carboxylase, alpha polypeptidepropionyl Coenzyme A carboxylase, alpha polypeptidepropion
Modification date2018051920180522
UniProtAcc

Q8WW12

P05165

Ensembl transtripts involved in fusion geneENST00000265260, ENST00000469941, 
ENST00000296024, ENST00000486406, 
ENST00000376279, ENST00000376286, 
ENST00000376285, ENST00000485946, 
Fusion gene scores* DoF score5 X 5 X 2=505 X 5 X 2=50
# samples 56
** MAII scorelog2(5/50*10)=0log2(6/50*10)=0.263034405833794
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PCNP [Title/Abstract] AND PCCA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePCNP

GO:0016567

protein ubiquitination

14741369

HgenePCNP

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

14741369


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI951320PCNPchr3

101313224

-PCCAchr13

100921006

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000265260ENST00000376279PCNPchr3

101313224

-PCCAchr13

100921006

-
3UTR-3CDSENST00000265260ENST00000376286PCNPchr3

101313224

-PCCAchr13

100921006

-
3UTR-3CDSENST00000265260ENST00000376285PCNPchr3

101313224

-PCCAchr13

100921006

-
3UTR-intronENST00000265260ENST00000485946PCNPchr3

101313224

-PCCAchr13

100921006

-
3UTR-3CDSENST00000469941ENST00000376279PCNPchr3

101313224

-PCCAchr13

100921006

-
3UTR-3CDSENST00000469941ENST00000376286PCNPchr3

101313224

-PCCAchr13

100921006

-
3UTR-3CDSENST00000469941ENST00000376285PCNPchr3

101313224

-PCCAchr13

100921006

-
3UTR-intronENST00000469941ENST00000485946PCNPchr3

101313224

-PCCAchr13

100921006

-
3UTR-3CDSENST00000296024ENST00000376279PCNPchr3

101313224

-PCCAchr13

100921006

-
3UTR-3CDSENST00000296024ENST00000376286PCNPchr3

101313224

-PCCAchr13

100921006

-
3UTR-3CDSENST00000296024ENST00000376285PCNPchr3

101313224

-PCCAchr13

100921006

-
3UTR-intronENST00000296024ENST00000485946PCNPchr3

101313224

-PCCAchr13

100921006

-
intron-3CDSENST00000486406ENST00000376279PCNPchr3

101313224

-PCCAchr13

100921006

-
intron-3CDSENST00000486406ENST00000376286PCNPchr3

101313224

-PCCAchr13

100921006

-
intron-3CDSENST00000486406ENST00000376285PCNPchr3

101313224

-PCCAchr13

100921006

-
intron-intronENST00000486406ENST00000485946PCNPchr3

101313224

-PCCAchr13

100921006

-

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FusionProtFeatures for PCNP_PCCA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PCNP

Q8WW12

PCCA

P05165

May be involved in cell cycle regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PCNP_PCCA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PCNP_PCCA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PCNP_PCCA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePCCAP05165DB00121BiotinPropionyl-CoA carboxylase alpha chain, mitochondrialsmall moleculeapproved|investigational|nutraceutical

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RelatedDiseases for PCNP_PCCA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePCCAC0268579Propionic acidemia3CTD_human;HPO;ORPHANET;UNIPROT