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Fusion gene ID: 26280 |
FusionGeneSummary for PCNP_PCCA |
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Fusion gene information | Fusion gene name: PCNP_PCCA | Fusion gene ID: 26280 | Hgene | Tgene | Gene symbol | PCNP | PCCA | Gene ID | 57092 | 5095 |
Gene name | PEST proteolytic signal containing nuclear protein | propionyl-CoA carboxylase subunit alpha | |
Synonyms | - | - | |
Cytomap | 3q12.3 | 13q32.3 | |
Type of gene | protein-coding | protein-coding | |
Description | PEST proteolytic signal-containing nuclear proteinPEST-containing nuclear protein | propionyl-CoA carboxylase alpha chain, mitochondrialPCCase alpha subunitpccA complementation grouppropanoyl-CoA:carbon dioxide ligase alpha subunitpropionyl CoA carboxylase, alpha polypeptidepropionyl Coenzyme A carboxylase, alpha polypeptidepropion | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | Q8WW12 | P05165 | |
Ensembl transtripts involved in fusion gene | ENST00000265260, ENST00000469941, ENST00000296024, ENST00000486406, | ENST00000376279, ENST00000376286, ENST00000376285, ENST00000485946, | |
Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 5 X 5 X 2=50 |
# samples | 5 | 6 | |
** MAII score | log2(5/50*10)=0 | log2(6/50*10)=0.263034405833794 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PCNP [Title/Abstract] AND PCCA [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PCNP | GO:0016567 | protein ubiquitination | 14741369 |
Hgene | PCNP | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 14741369 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI951320 | PCNP | chr3 | 101313224 | - | PCCA | chr13 | 100921006 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000265260 | ENST00000376279 | PCNP | chr3 | 101313224 | - | PCCA | chr13 | 100921006 | - |
3UTR-3CDS | ENST00000265260 | ENST00000376286 | PCNP | chr3 | 101313224 | - | PCCA | chr13 | 100921006 | - |
3UTR-3CDS | ENST00000265260 | ENST00000376285 | PCNP | chr3 | 101313224 | - | PCCA | chr13 | 100921006 | - |
3UTR-intron | ENST00000265260 | ENST00000485946 | PCNP | chr3 | 101313224 | - | PCCA | chr13 | 100921006 | - |
3UTR-3CDS | ENST00000469941 | ENST00000376279 | PCNP | chr3 | 101313224 | - | PCCA | chr13 | 100921006 | - |
3UTR-3CDS | ENST00000469941 | ENST00000376286 | PCNP | chr3 | 101313224 | - | PCCA | chr13 | 100921006 | - |
3UTR-3CDS | ENST00000469941 | ENST00000376285 | PCNP | chr3 | 101313224 | - | PCCA | chr13 | 100921006 | - |
3UTR-intron | ENST00000469941 | ENST00000485946 | PCNP | chr3 | 101313224 | - | PCCA | chr13 | 100921006 | - |
3UTR-3CDS | ENST00000296024 | ENST00000376279 | PCNP | chr3 | 101313224 | - | PCCA | chr13 | 100921006 | - |
3UTR-3CDS | ENST00000296024 | ENST00000376286 | PCNP | chr3 | 101313224 | - | PCCA | chr13 | 100921006 | - |
3UTR-3CDS | ENST00000296024 | ENST00000376285 | PCNP | chr3 | 101313224 | - | PCCA | chr13 | 100921006 | - |
3UTR-intron | ENST00000296024 | ENST00000485946 | PCNP | chr3 | 101313224 | - | PCCA | chr13 | 100921006 | - |
intron-3CDS | ENST00000486406 | ENST00000376279 | PCNP | chr3 | 101313224 | - | PCCA | chr13 | 100921006 | - |
intron-3CDS | ENST00000486406 | ENST00000376286 | PCNP | chr3 | 101313224 | - | PCCA | chr13 | 100921006 | - |
intron-3CDS | ENST00000486406 | ENST00000376285 | PCNP | chr3 | 101313224 | - | PCCA | chr13 | 100921006 | - |
intron-intron | ENST00000486406 | ENST00000485946 | PCNP | chr3 | 101313224 | - | PCCA | chr13 | 100921006 | - |
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FusionProtFeatures for PCNP_PCCA |
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Hgene | Tgene |
PCNP | PCCA |
May be involved in cell cycle regulation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PCNP_PCCA |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PCNP_PCCA |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PCNP_PCCA |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | PCCA | P05165 | DB00121 | Biotin | Propionyl-CoA carboxylase alpha chain, mitochondrial | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for PCNP_PCCA |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PCCA | C0268579 | Propionic acidemia | 3 | CTD_human;HPO;ORPHANET;UNIPROT |