FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 26279

FusionGeneSummary for PCNP_OIP5

check button Fusion gene summary
Fusion gene informationFusion gene name: PCNP_OIP5
Fusion gene ID: 26279
HgeneTgene
Gene symbol

PCNP

OIP5

Gene ID

57092

11339

Gene namePEST proteolytic signal containing nuclear proteinOpa interacting protein 5
Synonyms-5730547N13Rik|CT86|LINT-25|MIS18B|MIS18beta|hMIS18beta
Cytomap

3q12.3

15q15.1

Type of geneprotein-codingprotein-coding
DescriptionPEST proteolytic signal-containing nuclear proteinPEST-containing nuclear proteinprotein Mis18-betaLAP2alpha interactor-25MIS18 kinetochore protein homolog Bcancer/testis antigen 86opa-interacting protein 5
Modification date2018051920180523
UniProtAcc

Q8WW12

O43482

Ensembl transtripts involved in fusion geneENST00000265260, ENST00000469941, 
ENST00000296024, ENST00000486406, 
ENST00000220514, 
Fusion gene scores* DoF score5 X 5 X 2=502 X 2 X 2=8
# samples 52
** MAII scorelog2(5/50*10)=0log2(2/8*10)=1.32192809488736
Context

PubMed: PCNP [Title/Abstract] AND OIP5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePCNP

GO:0016567

protein ubiquitination

14741369

HgenePCNP

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

14741369


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE080901PCNPchr3

101307347

-OIP5chr15

41614146

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000265260ENST00000220514PCNPchr3

101307347

-OIP5chr15

41614146

+
intron-intronENST00000469941ENST00000220514PCNPchr3

101307347

-OIP5chr15

41614146

+
intron-intronENST00000296024ENST00000220514PCNPchr3

101307347

-OIP5chr15

41614146

+
intron-intronENST00000486406ENST00000220514PCNPchr3

101307347

-OIP5chr15

41614146

+

Top

FusionProtFeatures for PCNP_OIP5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PCNP

Q8WW12

OIP5

O43482

May be involved in cell cycle regulation. Required for recruitment of CENPA to centromeres andnormal chromosome segregation during mitosis.{ECO:0000269|PubMed:17199038}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PCNP_OIP5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PCNP_OIP5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PCNP_OIP5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for PCNP_OIP5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource