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Fusion gene ID: 26279 |
FusionGeneSummary for PCNP_OIP5 |
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Fusion gene information | Fusion gene name: PCNP_OIP5 | Fusion gene ID: 26279 | Hgene | Tgene | Gene symbol | PCNP | OIP5 | Gene ID | 57092 | 11339 |
Gene name | PEST proteolytic signal containing nuclear protein | Opa interacting protein 5 | |
Synonyms | - | 5730547N13Rik|CT86|LINT-25|MIS18B|MIS18beta|hMIS18beta | |
Cytomap | 3q12.3 | 15q15.1 | |
Type of gene | protein-coding | protein-coding | |
Description | PEST proteolytic signal-containing nuclear proteinPEST-containing nuclear protein | protein Mis18-betaLAP2alpha interactor-25MIS18 kinetochore protein homolog Bcancer/testis antigen 86opa-interacting protein 5 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q8WW12 | O43482 | |
Ensembl transtripts involved in fusion gene | ENST00000265260, ENST00000469941, ENST00000296024, ENST00000486406, | ENST00000220514, | |
Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 2 X 2 X 2=8 |
# samples | 5 | 2 | |
** MAII score | log2(5/50*10)=0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: PCNP [Title/Abstract] AND OIP5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PCNP | GO:0016567 | protein ubiquitination | 14741369 |
Hgene | PCNP | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 14741369 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE080901 | PCNP | chr3 | 101307347 | - | OIP5 | chr15 | 41614146 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000265260 | ENST00000220514 | PCNP | chr3 | 101307347 | - | OIP5 | chr15 | 41614146 | + |
intron-intron | ENST00000469941 | ENST00000220514 | PCNP | chr3 | 101307347 | - | OIP5 | chr15 | 41614146 | + |
intron-intron | ENST00000296024 | ENST00000220514 | PCNP | chr3 | 101307347 | - | OIP5 | chr15 | 41614146 | + |
intron-intron | ENST00000486406 | ENST00000220514 | PCNP | chr3 | 101307347 | - | OIP5 | chr15 | 41614146 | + |
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FusionProtFeatures for PCNP_OIP5 |
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Hgene | Tgene |
PCNP | OIP5 |
May be involved in cell cycle regulation. | Required for recruitment of CENPA to centromeres andnormal chromosome segregation during mitosis.{ECO:0000269|PubMed:17199038}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PCNP_OIP5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PCNP_OIP5 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PCNP_OIP5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PCNP_OIP5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |