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Fusion gene ID: 26276 |
FusionGeneSummary for PCNP_ATR |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PCNP_ATR | Fusion gene ID: 26276 | Hgene | Tgene | Gene symbol | PCNP | ATR | Gene ID | 57092 | 84168 |
| Gene name | PEST proteolytic signal containing nuclear protein | ANTXR cell adhesion molecule 1 | |
| Synonyms | - | ATR|GAPO|TEM8 | |
| Cytomap | 3q12.3 | 2p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | PEST proteolytic signal-containing nuclear proteinPEST-containing nuclear protein | anthrax toxin receptor 12310008J16Rik2810405N18Riktumor endothelial marker 8 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8WW12 | Q13535 | |
| Ensembl transtripts involved in fusion gene | ENST00000265260, ENST00000469941, ENST00000296024, ENST00000486406, | ENST00000350721, ENST00000383101, | |
| Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 5 X 4 X 4=80 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/50*10)=0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PCNP [Title/Abstract] AND ATR [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PCNP | GO:0016567 | protein ubiquitination | 14741369 |
| Hgene | PCNP | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 14741369 |
| Tgene | ATR | GO:0031532 | actin cytoskeleton reorganization | 16762926 |
| Tgene | ATR | GO:0034446 | substrate adhesion-dependent cell spreading | 16762926 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-YL-A9WK-01A | PCNP | chr3 | 101298848 | + | ATR | chr3 | 142185375 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000265260 | ENST00000350721 | PCNP | chr3 | 101298848 | + | ATR | chr3 | 142185375 | - |
| In-frame | ENST00000265260 | ENST00000383101 | PCNP | chr3 | 101298848 | + | ATR | chr3 | 142185375 | - |
| intron-3CDS | ENST00000469941 | ENST00000350721 | PCNP | chr3 | 101298848 | + | ATR | chr3 | 142185375 | - |
| intron-3CDS | ENST00000469941 | ENST00000383101 | PCNP | chr3 | 101298848 | + | ATR | chr3 | 142185375 | - |
| In-frame | ENST00000296024 | ENST00000350721 | PCNP | chr3 | 101298848 | + | ATR | chr3 | 142185375 | - |
| In-frame | ENST00000296024 | ENST00000383101 | PCNP | chr3 | 101298848 | + | ATR | chr3 | 142185375 | - |
| intron-3CDS | ENST00000486406 | ENST00000350721 | PCNP | chr3 | 101298848 | + | ATR | chr3 | 142185375 | - |
| intron-3CDS | ENST00000486406 | ENST00000383101 | PCNP | chr3 | 101298848 | + | ATR | chr3 | 142185375 | - |
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FusionProtFeatures for PCNP_ATR |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PCNP | ATR |
| May be involved in cell cycle regulation. | Serine/threonine protein kinase which activatescheckpoint signaling upon genotoxic stresses such as ionizingradiation (IR), ultraviolet light (UV), or DNA replicationstalling, thereby acting as a DNA damage sensor. Recognizes thesubstrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1,MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibitDNA replication and mitosis and promote DNA repair, recombinationand apoptosis. Phosphorylates 'Ser-139' of histone variantH2AX/H2AFX at sites of DNA damage, thereby regulating DNA damageresponse mechanism. Required for FANCD2 ubiquitination. Criticalfor maintenance of fragile site stability and efficient regulationof centrosome duplication. {ECO:0000269|PubMed:10597277,ECO:0000269|PubMed:10608806, ECO:0000269|PubMed:10859164,ECO:0000269|PubMed:11114888, ECO:0000269|PubMed:11418864,ECO:0000269|PubMed:11673449, ECO:0000269|PubMed:11721054,ECO:0000269|PubMed:11865061, ECO:0000269|PubMed:12526805,ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:12814551,ECO:0000269|PubMed:14657349, ECO:0000269|PubMed:14729973,ECO:0000269|PubMed:14742437, ECO:0000269|PubMed:15210935,ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15496423,ECO:0000269|PubMed:16260606, ECO:0000269|PubMed:21144835,ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720,ECO:0000269|PubMed:9427750, ECO:0000269|PubMed:9636169,ECO:0000269|PubMed:9925639}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >ATR | chr3:101298848 | chr3:142185375 | ENST00000350721 | - | 38 | 47 | 2322_2567 | 2229 | 2645 | Domain | PI3K/PI4K |
| Tgene | >ATR | chr3:101298848 | chr3:142185375 | ENST00000350721 | - | 38 | 47 | 2612_2644 | 2229 | 2645 | Domain | FATC |
| Tgene | >ATR | chr3:101298848 | chr3:142185375 | ENST00000383101 | - | 37 | 46 | 2322_2567 | 2165 | 2581 | Domain | PI3K/PI4K |
| Tgene | >ATR | chr3:101298848 | chr3:142185375 | ENST00000383101 | - | 37 | 46 | 2612_2644 | 2165 | 2581 | Domain | FATC |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | ATR | chr3:101298848 | chr3:142185375 | ENST00000350721 | - | 38 | 47 | 1640_2185 | 2229 | 2645 | Domain | FAT |
| Tgene | ATR | chr3:101298848 | chr3:142185375 | ENST00000383101 | - | 37 | 46 | 1640_2185 | 2165 | 2581 | Domain | FAT |
| Tgene | ATR | chr3:101298848 | chr3:142185375 | ENST00000350721 | - | 38 | 47 | 1329_1365 | 2229 | 2645 | Repeat | Note=HEAT 2 |
| Tgene | ATR | chr3:101298848 | chr3:142185375 | ENST00000350721 | - | 38 | 47 | 799_835 | 2229 | 2645 | Repeat | Note=HEAT 1 |
| Tgene | ATR | chr3:101298848 | chr3:142185375 | ENST00000383101 | - | 37 | 46 | 1329_1365 | 2165 | 2581 | Repeat | Note=HEAT 2 |
| Tgene | ATR | chr3:101298848 | chr3:142185375 | ENST00000383101 | - | 37 | 46 | 799_835 | 2165 | 2581 | Repeat | Note=HEAT 1 |
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FusionGeneSequence for PCNP_ATR |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PCNP_ENST00000265260_chr3_101298848_+_ATR_ENST00000350721_chr3_142185375_-_509aa MADGKAGDEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADLPTKPTKISKFGFAIGSQTTKKASAISIKL GSSVDGSSSTLSMSTHFKMLKKLVEEATFSEILIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKG SDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKEL RQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFN CLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNETGEVVNE >In-frame_PCNP_ENST00000265260_chr3_101298848_+_ATR_ENST00000383101_chr3_142185375_-_509aa MADGKAGDEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADLPTKPTKISKFGFAIGSQTTKKASAISIKL GSSVDGSSSTLSMSTHFKMLKKLVEEATFSEILIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKG SDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKEL RQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFN CLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNETGEVVNE >In-frame_PCNP_ENST00000296024_chr3_101298848_+_ATR_ENST00000350721_chr3_142185375_-_509aa MADGKAGDEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADLPTKPTKISKFGFAIGSQTTKKASAISIKL GSSVDGSSSTLSMSTHFKMLKKLVEEATFSEILIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKG SDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKEL RQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFN CLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNETGEVVNE >In-frame_PCNP_ENST00000296024_chr3_101298848_+_ATR_ENST00000383101_chr3_142185375_-_509aa MADGKAGDEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADLPTKPTKISKFGFAIGSQTTKKASAISIKL GSSVDGSSSTLSMSTHFKMLKKLVEEATFSEILIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKG SDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKEL RQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFN CLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNETGEVVNE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PCNP_ENST00000265260_chr3_101298848_+_ATR_ENST00000350721_chr3_142185375_-_1527nt ATGGCGGACGGGAAGGCGGGAGACGAGAAGCCTGAAAAGTCGCAGCGAGCTGGAGCCGCCGGAGGACCTGAAGAAGAAGCAGAAAAACCT GTGAAAACTAAGACTGTTTCTTCCAGTAATGGAGGGGAAAGTTCCAGTCGCAGCGCTGAGAAGCGATCAGCTGAAGAAGAAGCTGCCGAC CTCCCAACAAAGCCTACAAAGATCTCCAAGTTTGGATTTGCCATAGGTAGTCAGACGACAAAGAAAGCATCAGCCATATCCATCAAACTT GGATCAAGTGTTGATGGAAGTAGTTCCACATTAAGCATGAGCACTCATTTTAAAATGCTTAAAAAGCTGGTAGAAGAAGCAACATTTAGT GAAATCCTCATTCCTCTACAATCAGTCATGATACCTACACTTCCATCAATTCTGGGTACCCATGCTAACCATGCTAGCCATGAACCATTT CCTGGACATTGGGCCTATATTGCAGGGTTTGATGATATGGTGGAAATTCTTGCTTCTCTTCAGAAACCAAAGAAGATTTCTTTAAAAGGC TCAGATGGAAAGTTCTACATCATGATGTGTAAGCCAAAAGATGACCTGAGAAAGGATTGTAGACTAATGGAATTCAATTCCTTGATTAAT AAGTGCTTAAGAAAAGATGCAGAGTCTCGTAGAAGAGAACTTCATATTCGAACATATGCAGTTATTCCACTAAATGATGAATGTGGGATT ATTGAATGGGTGAACAACACTGCTGGTTTGAGACCTATTCTGACCAAACTATATAAAGAAAAGGGAGTGTATATGACAGGAAAAGAACTT CGCCAGTGTATGCTACCAAAGTCAGCAGCTTTATCTGAAAAACTCAAAGTATTCCGAGAATTTCTCCTGCCCAGGCATCCTCCTATTTTT CATGAGTGGTTTCTGAGAACATTCCCTGATCCTACATCATGGTACAGTAGTAGATCAGCTTACTGCCGTTCCACTGCAGTAATGTCAATG GTTGGTTATATTCTGGGGCTTGGAGACCGTCATGGTGAAAATATTCTCTTTGATTCTTTGACTGGTGAATGCGTACATGTAGATTTCAAT TGTCTTTTCAATAAGGGAGAAACCTTTGAAGTTCCAGAAATTGTGCCATTTCGCCTGACTCATAATATGGTTAATGGAATGGGTCCTATG GGAACAGAGGGTCTTTTTCGAAGAGCATGTGAAGTTACAATGAGGCTGATGCGTGATCAGCGAGAGCCTTTAATGAGTGTCTTAAAGACT TTTCTACATGATCCTCTTGTGGAATGGAGTAAACCAGTGAAAGGGCATTCCAAAGCGCCACTGAATGAAACTGGAGAAGTTGTCAATGAA AAGGCCAAGACCCATGTTCTTGACATTGAGCAGCGACTACAAGGTGTAATCAAGACTCGAAATAGAGTGACAGGACTGCCGTTATCTATT >In-frame_PCNP_ENST00000265260_chr3_101298848_+_ATR_ENST00000383101_chr3_142185375_-_1527nt ATGGCGGACGGGAAGGCGGGAGACGAGAAGCCTGAAAAGTCGCAGCGAGCTGGAGCCGCCGGAGGACCTGAAGAAGAAGCAGAAAAACCT GTGAAAACTAAGACTGTTTCTTCCAGTAATGGAGGGGAAAGTTCCAGTCGCAGCGCTGAGAAGCGATCAGCTGAAGAAGAAGCTGCCGAC CTCCCAACAAAGCCTACAAAGATCTCCAAGTTTGGATTTGCCATAGGTAGTCAGACGACAAAGAAAGCATCAGCCATATCCATCAAACTT GGATCAAGTGTTGATGGAAGTAGTTCCACATTAAGCATGAGCACTCATTTTAAAATGCTTAAAAAGCTGGTAGAAGAAGCAACATTTAGT GAAATCCTCATTCCTCTACAATCAGTCATGATACCTACACTTCCATCAATTCTGGGTACCCATGCTAACCATGCTAGCCATGAACCATTT CCTGGACATTGGGCCTATATTGCAGGGTTTGATGATATGGTGGAAATTCTTGCTTCTCTTCAGAAACCAAAGAAGATTTCTTTAAAAGGC TCAGATGGAAAGTTCTACATCATGATGTGTAAGCCAAAAGATGACCTGAGAAAGGATTGTAGACTAATGGAATTCAATTCCTTGATTAAT AAGTGCTTAAGAAAAGATGCAGAGTCTCGTAGAAGAGAACTTCATATTCGAACATATGCAGTTATTCCACTAAATGATGAATGTGGGATT ATTGAATGGGTGAACAACACTGCTGGTTTGAGACCTATTCTGACCAAACTATATAAAGAAAAGGGAGTGTATATGACAGGAAAAGAACTT CGCCAGTGTATGCTACCAAAGTCAGCAGCTTTATCTGAAAAACTCAAAGTATTCCGAGAATTTCTCCTGCCCAGGCATCCTCCTATTTTT CATGAGTGGTTTCTGAGAACATTCCCTGATCCTACATCATGGTACAGTAGTAGATCAGCTTACTGCCGTTCCACTGCAGTAATGTCAATG GTTGGTTATATTCTGGGGCTTGGAGACCGTCATGGTGAAAATATTCTCTTTGATTCTTTGACTGGTGAATGCGTACATGTAGATTTCAAT TGTCTTTTCAATAAGGGAGAAACCTTTGAAGTTCCAGAAATTGTGCCATTTCGCCTGACTCATAATATGGTTAATGGAATGGGTCCTATG GGAACAGAGGGTCTTTTTCGAAGAGCATGTGAAGTTACAATGAGGCTGATGCGTGATCAGCGAGAGCCTTTAATGAGTGTCTTAAAGACT TTTCTACATGATCCTCTTGTGGAATGGAGTAAACCAGTGAAAGGGCATTCCAAAGCGCCACTGAATGAAACTGGAGAAGTTGTCAATGAA AAGGCCAAGACCCATGTTCTTGACATTGAGCAGCGACTACAAGGTGTAATCAAGACTCGAAATAGAGTGACAGGACTGCCGTTATCTATT >In-frame_PCNP_ENST00000296024_chr3_101298848_+_ATR_ENST00000350721_chr3_142185375_-_1527nt ATGGCGGACGGGAAGGCGGGAGACGAGAAGCCTGAAAAGTCGCAGCGAGCTGGAGCCGCCGGAGGACCTGAAGAAGAAGCAGAAAAACCT GTGAAAACTAAGACTGTTTCTTCCAGTAATGGAGGGGAAAGTTCCAGTCGCAGCGCTGAGAAGCGATCAGCTGAAGAAGAAGCTGCCGAC CTCCCAACAAAGCCTACAAAGATCTCCAAGTTTGGATTTGCCATAGGTAGTCAGACGACAAAGAAAGCATCAGCCATATCCATCAAACTT GGATCAAGTGTTGATGGAAGTAGTTCCACATTAAGCATGAGCACTCATTTTAAAATGCTTAAAAAGCTGGTAGAAGAAGCAACATTTAGT GAAATCCTCATTCCTCTACAATCAGTCATGATACCTACACTTCCATCAATTCTGGGTACCCATGCTAACCATGCTAGCCATGAACCATTT CCTGGACATTGGGCCTATATTGCAGGGTTTGATGATATGGTGGAAATTCTTGCTTCTCTTCAGAAACCAAAGAAGATTTCTTTAAAAGGC TCAGATGGAAAGTTCTACATCATGATGTGTAAGCCAAAAGATGACCTGAGAAAGGATTGTAGACTAATGGAATTCAATTCCTTGATTAAT AAGTGCTTAAGAAAAGATGCAGAGTCTCGTAGAAGAGAACTTCATATTCGAACATATGCAGTTATTCCACTAAATGATGAATGTGGGATT ATTGAATGGGTGAACAACACTGCTGGTTTGAGACCTATTCTGACCAAACTATATAAAGAAAAGGGAGTGTATATGACAGGAAAAGAACTT CGCCAGTGTATGCTACCAAAGTCAGCAGCTTTATCTGAAAAACTCAAAGTATTCCGAGAATTTCTCCTGCCCAGGCATCCTCCTATTTTT CATGAGTGGTTTCTGAGAACATTCCCTGATCCTACATCATGGTACAGTAGTAGATCAGCTTACTGCCGTTCCACTGCAGTAATGTCAATG GTTGGTTATATTCTGGGGCTTGGAGACCGTCATGGTGAAAATATTCTCTTTGATTCTTTGACTGGTGAATGCGTACATGTAGATTTCAAT TGTCTTTTCAATAAGGGAGAAACCTTTGAAGTTCCAGAAATTGTGCCATTTCGCCTGACTCATAATATGGTTAATGGAATGGGTCCTATG GGAACAGAGGGTCTTTTTCGAAGAGCATGTGAAGTTACAATGAGGCTGATGCGTGATCAGCGAGAGCCTTTAATGAGTGTCTTAAAGACT TTTCTACATGATCCTCTTGTGGAATGGAGTAAACCAGTGAAAGGGCATTCCAAAGCGCCACTGAATGAAACTGGAGAAGTTGTCAATGAA AAGGCCAAGACCCATGTTCTTGACATTGAGCAGCGACTACAAGGTGTAATCAAGACTCGAAATAGAGTGACAGGACTGCCGTTATCTATT >In-frame_PCNP_ENST00000296024_chr3_101298848_+_ATR_ENST00000383101_chr3_142185375_-_1527nt ATGGCGGACGGGAAGGCGGGAGACGAGAAGCCTGAAAAGTCGCAGCGAGCTGGAGCCGCCGGAGGACCTGAAGAAGAAGCAGAAAAACCT GTGAAAACTAAGACTGTTTCTTCCAGTAATGGAGGGGAAAGTTCCAGTCGCAGCGCTGAGAAGCGATCAGCTGAAGAAGAAGCTGCCGAC CTCCCAACAAAGCCTACAAAGATCTCCAAGTTTGGATTTGCCATAGGTAGTCAGACGACAAAGAAAGCATCAGCCATATCCATCAAACTT GGATCAAGTGTTGATGGAAGTAGTTCCACATTAAGCATGAGCACTCATTTTAAAATGCTTAAAAAGCTGGTAGAAGAAGCAACATTTAGT GAAATCCTCATTCCTCTACAATCAGTCATGATACCTACACTTCCATCAATTCTGGGTACCCATGCTAACCATGCTAGCCATGAACCATTT CCTGGACATTGGGCCTATATTGCAGGGTTTGATGATATGGTGGAAATTCTTGCTTCTCTTCAGAAACCAAAGAAGATTTCTTTAAAAGGC TCAGATGGAAAGTTCTACATCATGATGTGTAAGCCAAAAGATGACCTGAGAAAGGATTGTAGACTAATGGAATTCAATTCCTTGATTAAT AAGTGCTTAAGAAAAGATGCAGAGTCTCGTAGAAGAGAACTTCATATTCGAACATATGCAGTTATTCCACTAAATGATGAATGTGGGATT ATTGAATGGGTGAACAACACTGCTGGTTTGAGACCTATTCTGACCAAACTATATAAAGAAAAGGGAGTGTATATGACAGGAAAAGAACTT CGCCAGTGTATGCTACCAAAGTCAGCAGCTTTATCTGAAAAACTCAAAGTATTCCGAGAATTTCTCCTGCCCAGGCATCCTCCTATTTTT CATGAGTGGTTTCTGAGAACATTCCCTGATCCTACATCATGGTACAGTAGTAGATCAGCTTACTGCCGTTCCACTGCAGTAATGTCAATG GTTGGTTATATTCTGGGGCTTGGAGACCGTCATGGTGAAAATATTCTCTTTGATTCTTTGACTGGTGAATGCGTACATGTAGATTTCAAT TGTCTTTTCAATAAGGGAGAAACCTTTGAAGTTCCAGAAATTGTGCCATTTCGCCTGACTCATAATATGGTTAATGGAATGGGTCCTATG GGAACAGAGGGTCTTTTTCGAAGAGCATGTGAAGTTACAATGAGGCTGATGCGTGATCAGCGAGAGCCTTTAATGAGTGTCTTAAAGACT TTTCTACATGATCCTCTTGTGGAATGGAGTAAACCAGTGAAAGGGCATTCCAAAGCGCCACTGAATGAAACTGGAGAAGTTGTCAATGAA AAGGCCAAGACCCATGTTCTTGACATTGAGCAGCGACTACAAGGTGTAATCAAGACTCGAAATAGAGTGACAGGACTGCCGTTATCTATT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PCNP_ENST00000265260_chr3_101298848_+_ATR_ENST00000350721_chr3_142185375_-_1840nt TTTTCATTCCTCGGGACCGCTCTAGGCTGCCACCACGCCGGCTGGCCCCAAAAACTCGATGGTTGTTGGGCGGGGTCGTGACGTCCTTGG CGTGGCTGCAGGGGAGGCCGCGGCGGGGAAAATGGCGGACGGGAAGGCGGGAGACGAGAAGCCTGAAAAGTCGCAGCGAGCTGGAGCCGC CGGAGGACCTGAAGAAGAAGCAGAAAAACCTGTGAAAACTAAGACTGTTTCTTCCAGTAATGGAGGGGAAAGTTCCAGTCGCAGCGCTGA GAAGCGATCAGCTGAAGAAGAAGCTGCCGACCTCCCAACAAAGCCTACAAAGATCTCCAAGTTTGGATTTGCCATAGGTAGTCAGACGAC AAAGAAAGCATCAGCCATATCCATCAAACTTGGATCAAGTGTTGATGGAAGTAGTTCCACATTAAGCATGAGCACTCATTTTAAAATGCT TAAAAAGCTGGTAGAAGAAGCAACATTTAGTGAAATCCTCATTCCTCTACAATCAGTCATGATACCTACACTTCCATCAATTCTGGGTAC CCATGCTAACCATGCTAGCCATGAACCATTTCCTGGACATTGGGCCTATATTGCAGGGTTTGATGATATGGTGGAAATTCTTGCTTCTCT TCAGAAACCAAAGAAGATTTCTTTAAAAGGCTCAGATGGAAAGTTCTACATCATGATGTGTAAGCCAAAAGATGACCTGAGAAAGGATTG TAGACTAATGGAATTCAATTCCTTGATTAATAAGTGCTTAAGAAAAGATGCAGAGTCTCGTAGAAGAGAACTTCATATTCGAACATATGC AGTTATTCCACTAAATGATGAATGTGGGATTATTGAATGGGTGAACAACACTGCTGGTTTGAGACCTATTCTGACCAAACTATATAAAGA AAAGGGAGTGTATATGACAGGAAAAGAACTTCGCCAGTGTATGCTACCAAAGTCAGCAGCTTTATCTGAAAAACTCAAAGTATTCCGAGA ATTTCTCCTGCCCAGGCATCCTCCTATTTTTCATGAGTGGTTTCTGAGAACATTCCCTGATCCTACATCATGGTACAGTAGTAGATCAGC TTACTGCCGTTCCACTGCAGTAATGTCAATGGTTGGTTATATTCTGGGGCTTGGAGACCGTCATGGTGAAAATATTCTCTTTGATTCTTT GACTGGTGAATGCGTACATGTAGATTTCAATTGTCTTTTCAATAAGGGAGAAACCTTTGAAGTTCCAGAAATTGTGCCATTTCGCCTGAC TCATAATATGGTTAATGGAATGGGTCCTATGGGAACAGAGGGTCTTTTTCGAAGAGCATGTGAAGTTACAATGAGGCTGATGCGTGATCA GCGAGAGCCTTTAATGAGTGTCTTAAAGACTTTTCTACATGATCCTCTTGTGGAATGGAGTAAACCAGTGAAAGGGCATTCCAAAGCGCC ACTGAATGAAACTGGAGAAGTTGTCAATGAAAAGGCCAAGACCCATGTTCTTGACATTGAGCAGCGACTACAAGGTGTAATCAAGACTCG AAATAGAGTGACAGGACTGCCGTTATCTATTGAAGGACATGTGCATTACCTTATACAGGAAGCTACTGATGAAAACTTACTATGCCAGAT GTATCTTGGTTGGACTCCATATATGTGAAATGAAATTATGTAAAAGAATATGTTAATAATCTAAAAGTAATGCATTTGGTATGAATCTGT GGTTGTATCTGTTCAATTCTAAAGTACAACATAAATTTACGTTCTCAGCAACTGTTATTTCTCTCTGATCATTAATTATATGTAAAATAA >In-frame_PCNP_ENST00000265260_chr3_101298848_+_ATR_ENST00000383101_chr3_142185375_-_1839nt TTTTCATTCCTCGGGACCGCTCTAGGCTGCCACCACGCCGGCTGGCCCCAAAAACTCGATGGTTGTTGGGCGGGGTCGTGACGTCCTTGG CGTGGCTGCAGGGGAGGCCGCGGCGGGGAAAATGGCGGACGGGAAGGCGGGAGACGAGAAGCCTGAAAAGTCGCAGCGAGCTGGAGCCGC CGGAGGACCTGAAGAAGAAGCAGAAAAACCTGTGAAAACTAAGACTGTTTCTTCCAGTAATGGAGGGGAAAGTTCCAGTCGCAGCGCTGA GAAGCGATCAGCTGAAGAAGAAGCTGCCGACCTCCCAACAAAGCCTACAAAGATCTCCAAGTTTGGATTTGCCATAGGTAGTCAGACGAC AAAGAAAGCATCAGCCATATCCATCAAACTTGGATCAAGTGTTGATGGAAGTAGTTCCACATTAAGCATGAGCACTCATTTTAAAATGCT TAAAAAGCTGGTAGAAGAAGCAACATTTAGTGAAATCCTCATTCCTCTACAATCAGTCATGATACCTACACTTCCATCAATTCTGGGTAC CCATGCTAACCATGCTAGCCATGAACCATTTCCTGGACATTGGGCCTATATTGCAGGGTTTGATGATATGGTGGAAATTCTTGCTTCTCT TCAGAAACCAAAGAAGATTTCTTTAAAAGGCTCAGATGGAAAGTTCTACATCATGATGTGTAAGCCAAAAGATGACCTGAGAAAGGATTG TAGACTAATGGAATTCAATTCCTTGATTAATAAGTGCTTAAGAAAAGATGCAGAGTCTCGTAGAAGAGAACTTCATATTCGAACATATGC AGTTATTCCACTAAATGATGAATGTGGGATTATTGAATGGGTGAACAACACTGCTGGTTTGAGACCTATTCTGACCAAACTATATAAAGA AAAGGGAGTGTATATGACAGGAAAAGAACTTCGCCAGTGTATGCTACCAAAGTCAGCAGCTTTATCTGAAAAACTCAAAGTATTCCGAGA ATTTCTCCTGCCCAGGCATCCTCCTATTTTTCATGAGTGGTTTCTGAGAACATTCCCTGATCCTACATCATGGTACAGTAGTAGATCAGC TTACTGCCGTTCCACTGCAGTAATGTCAATGGTTGGTTATATTCTGGGGCTTGGAGACCGTCATGGTGAAAATATTCTCTTTGATTCTTT GACTGGTGAATGCGTACATGTAGATTTCAATTGTCTTTTCAATAAGGGAGAAACCTTTGAAGTTCCAGAAATTGTGCCATTTCGCCTGAC TCATAATATGGTTAATGGAATGGGTCCTATGGGAACAGAGGGTCTTTTTCGAAGAGCATGTGAAGTTACAATGAGGCTGATGCGTGATCA GCGAGAGCCTTTAATGAGTGTCTTAAAGACTTTTCTACATGATCCTCTTGTGGAATGGAGTAAACCAGTGAAAGGGCATTCCAAAGCGCC ACTGAATGAAACTGGAGAAGTTGTCAATGAAAAGGCCAAGACCCATGTTCTTGACATTGAGCAGCGACTACAAGGTGTAATCAAGACTCG AAATAGAGTGACAGGACTGCCGTTATCTATTGAAGGACATGTGCATTACCTTATACAGGAAGCTACTGATGAAAACTTACTATGCCAGAT GTATCTTGGTTGGACTCCATATATGTGAAATGAAATTATGTAAAAGAATATGTTAATAATCTAAAAGTAATGCATTTGGTATGAATCTGT GGTTGTATCTGTTCAATTCTAAAGTACAACATAAATTTACGTTCTCAGCAACTGTTATTTCTCTCTGATCATTAATTATATGTAAAATAA >In-frame_PCNP_ENST00000296024_chr3_101298848_+_ATR_ENST00000350721_chr3_142185375_-_1739nt GGGAGGCCGCGGCGGGGAAAATGGCGGACGGGAAGGCGGGAGACGAGAAGCCTGAAAAGTCGCAGCGAGCTGGAGCCGCCGGAGGACCTG AAGAAGAAGCAGAAAAACCTGTGAAAACTAAGACTGTTTCTTCCAGTAATGGAGGGGAAAGTTCCAGTCGCAGCGCTGAGAAGCGATCAG CTGAAGAAGAAGCTGCCGACCTCCCAACAAAGCCTACAAAGATCTCCAAGTTTGGATTTGCCATAGGTAGTCAGACGACAAAGAAAGCAT CAGCCATATCCATCAAACTTGGATCAAGTGTTGATGGAAGTAGTTCCACATTAAGCATGAGCACTCATTTTAAAATGCTTAAAAAGCTGG TAGAAGAAGCAACATTTAGTGAAATCCTCATTCCTCTACAATCAGTCATGATACCTACACTTCCATCAATTCTGGGTACCCATGCTAACC ATGCTAGCCATGAACCATTTCCTGGACATTGGGCCTATATTGCAGGGTTTGATGATATGGTGGAAATTCTTGCTTCTCTTCAGAAACCAA AGAAGATTTCTTTAAAAGGCTCAGATGGAAAGTTCTACATCATGATGTGTAAGCCAAAAGATGACCTGAGAAAGGATTGTAGACTAATGG AATTCAATTCCTTGATTAATAAGTGCTTAAGAAAAGATGCAGAGTCTCGTAGAAGAGAACTTCATATTCGAACATATGCAGTTATTCCAC TAAATGATGAATGTGGGATTATTGAATGGGTGAACAACACTGCTGGTTTGAGACCTATTCTGACCAAACTATATAAAGAAAAGGGAGTGT ATATGACAGGAAAAGAACTTCGCCAGTGTATGCTACCAAAGTCAGCAGCTTTATCTGAAAAACTCAAAGTATTCCGAGAATTTCTCCTGC CCAGGCATCCTCCTATTTTTCATGAGTGGTTTCTGAGAACATTCCCTGATCCTACATCATGGTACAGTAGTAGATCAGCTTACTGCCGTT CCACTGCAGTAATGTCAATGGTTGGTTATATTCTGGGGCTTGGAGACCGTCATGGTGAAAATATTCTCTTTGATTCTTTGACTGGTGAAT GCGTACATGTAGATTTCAATTGTCTTTTCAATAAGGGAGAAACCTTTGAAGTTCCAGAAATTGTGCCATTTCGCCTGACTCATAATATGG TTAATGGAATGGGTCCTATGGGAACAGAGGGTCTTTTTCGAAGAGCATGTGAAGTTACAATGAGGCTGATGCGTGATCAGCGAGAGCCTT TAATGAGTGTCTTAAAGACTTTTCTACATGATCCTCTTGTGGAATGGAGTAAACCAGTGAAAGGGCATTCCAAAGCGCCACTGAATGAAA CTGGAGAAGTTGTCAATGAAAAGGCCAAGACCCATGTTCTTGACATTGAGCAGCGACTACAAGGTGTAATCAAGACTCGAAATAGAGTGA CAGGACTGCCGTTATCTATTGAAGGACATGTGCATTACCTTATACAGGAAGCTACTGATGAAAACTTACTATGCCAGATGTATCTTGGTT GGACTCCATATATGTGAAATGAAATTATGTAAAAGAATATGTTAATAATCTAAAAGTAATGCATTTGGTATGAATCTGTGGTTGTATCTG TTCAATTCTAAAGTACAACATAAATTTACGTTCTCAGCAACTGTTATTTCTCTCTGATCATTAATTATATGTAAAATAATATACATTCAG >In-frame_PCNP_ENST00000296024_chr3_101298848_+_ATR_ENST00000383101_chr3_142185375_-_1738nt GGGAGGCCGCGGCGGGGAAAATGGCGGACGGGAAGGCGGGAGACGAGAAGCCTGAAAAGTCGCAGCGAGCTGGAGCCGCCGGAGGACCTG AAGAAGAAGCAGAAAAACCTGTGAAAACTAAGACTGTTTCTTCCAGTAATGGAGGGGAAAGTTCCAGTCGCAGCGCTGAGAAGCGATCAG CTGAAGAAGAAGCTGCCGACCTCCCAACAAAGCCTACAAAGATCTCCAAGTTTGGATTTGCCATAGGTAGTCAGACGACAAAGAAAGCAT CAGCCATATCCATCAAACTTGGATCAAGTGTTGATGGAAGTAGTTCCACATTAAGCATGAGCACTCATTTTAAAATGCTTAAAAAGCTGG TAGAAGAAGCAACATTTAGTGAAATCCTCATTCCTCTACAATCAGTCATGATACCTACACTTCCATCAATTCTGGGTACCCATGCTAACC ATGCTAGCCATGAACCATTTCCTGGACATTGGGCCTATATTGCAGGGTTTGATGATATGGTGGAAATTCTTGCTTCTCTTCAGAAACCAA AGAAGATTTCTTTAAAAGGCTCAGATGGAAAGTTCTACATCATGATGTGTAAGCCAAAAGATGACCTGAGAAAGGATTGTAGACTAATGG AATTCAATTCCTTGATTAATAAGTGCTTAAGAAAAGATGCAGAGTCTCGTAGAAGAGAACTTCATATTCGAACATATGCAGTTATTCCAC TAAATGATGAATGTGGGATTATTGAATGGGTGAACAACACTGCTGGTTTGAGACCTATTCTGACCAAACTATATAAAGAAAAGGGAGTGT ATATGACAGGAAAAGAACTTCGCCAGTGTATGCTACCAAAGTCAGCAGCTTTATCTGAAAAACTCAAAGTATTCCGAGAATTTCTCCTGC CCAGGCATCCTCCTATTTTTCATGAGTGGTTTCTGAGAACATTCCCTGATCCTACATCATGGTACAGTAGTAGATCAGCTTACTGCCGTT CCACTGCAGTAATGTCAATGGTTGGTTATATTCTGGGGCTTGGAGACCGTCATGGTGAAAATATTCTCTTTGATTCTTTGACTGGTGAAT GCGTACATGTAGATTTCAATTGTCTTTTCAATAAGGGAGAAACCTTTGAAGTTCCAGAAATTGTGCCATTTCGCCTGACTCATAATATGG TTAATGGAATGGGTCCTATGGGAACAGAGGGTCTTTTTCGAAGAGCATGTGAAGTTACAATGAGGCTGATGCGTGATCAGCGAGAGCCTT TAATGAGTGTCTTAAAGACTTTTCTACATGATCCTCTTGTGGAATGGAGTAAACCAGTGAAAGGGCATTCCAAAGCGCCACTGAATGAAA CTGGAGAAGTTGTCAATGAAAAGGCCAAGACCCATGTTCTTGACATTGAGCAGCGACTACAAGGTGTAATCAAGACTCGAAATAGAGTGA CAGGACTGCCGTTATCTATTGAAGGACATGTGCATTACCTTATACAGGAAGCTACTGATGAAAACTTACTATGCCAGATGTATCTTGGTT GGACTCCATATATGTGAAATGAAATTATGTAAAAGAATATGTTAATAATCTAAAAGTAATGCATTTGGTATGAATCTGTGGTTGTATCTG TTCAATTCTAAAGTACAACATAAATTTACGTTCTCAGCAACTGTTATTTCTCTCTGATCATTAATTATATGTAAAATAATATACATTCAG |
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FusionGenePPI for PCNP_ATR |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PCNP | UHRF2, ELAVL1, TERF2IP, CAND1, LMNA, HUWE1, MOV10, NXF1, BMI1, HIST1H3E, MYO1C, PTPN1, XRCC3, USP11, EMC2, MMGT1 | ATR | BRCA1, TP53, ABL1, AP1B1, ARHGEF1, ATM, ATR, BRCA2, CHEK1, E4F1, LIG4, MRE11A, NBN, PA2G4, PIK3CA, POLD1, RAD17, RPA1, WRN, MCM7, MCM2, MSH2, CLSPN, CHD4, HDAC2, HDAC1, MTA1, MTA2, ATRIP, RHEB, H2AFX, XPC, PMS1, CDC6, TTI1, TELO2, MSH6, FANCA, TOPBP1, C19orf40, RPA2, CHEK2, MCPH1, UPF1, SMC1A, CEP164, RAD1, HUS1, RAD9A, POLN, BLM, EP300, SNIP1, FANCD2, E2F1, NCOA2, CDK9, HSP90AA1, HSPA4, XRCC5, ARRB1, CDC5L, VPRBP, DCLRE1C, DTL, SOCS1, XPA, CCNB2, CDKN2A, CDKN2C, CREB1, IKBKG, CINP, EGFR, RPA3, CLTC, YBX3, FAM133B, PABPN1, BSG, CD274, CEACAM21, VSIG2, CA14, NT5E, LYPD3, SCN2B, SCARA3, ALDH3A2, HTR6, NOSIP, PPP2R3A, RASSF1, AP3B1, TERT, ETV1, SNW1, POU5F1, USP20, AIRE, MTMR4, PDGFRB, GYPA, TNFRSF1A, TNFSF8, SCN3B, PVR, NCR3LG1, GYPB, VSIG1, VASN, OPRM1, HELQ, FANCI, UHRF2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PCNP_ATR |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PCNP_ATR |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | ATR | C0032273 | Pneumoconiosis | 1 | CTD_human |
| Tgene | ATR | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | ATR | C0042076 | Urologic Neoplasms | 1 | CTD_human |
| Tgene | ATR | C3281203 | CUTANEOUS TELANGIECTASIA AND CANCER SYNDROME, FAMILIAL | 1 | ORPHANET;UNIPROT |
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