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Fusion gene ID: 26266 |
FusionGeneSummary for PCMTD1_MSN |
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Fusion gene information | Fusion gene name: PCMTD1_MSN | Fusion gene ID: 26266 | Hgene | Tgene | Gene symbol | PCMTD1 | MSN | Gene ID | 115294 | 4478 |
Gene name | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | moesin | |
Synonyms | - | HEL70|IMD50 | |
Cytomap | 8q11.23 | Xq12 | |
Type of gene | protein-coding | protein-coding | |
Description | protein-L-isoaspartate O-methyltransferase domain-containing protein 1 | moesinepididymis luminal protein 70membrane-organizing extension spike protein | |
Modification date | 20180523 | 20180527 | |
UniProtAcc | Q96MG8 | P26038 | |
Ensembl transtripts involved in fusion gene | ENST00000360540, ENST00000544451, ENST00000519559, ENST00000522514, ENST00000521344, | ENST00000609205, ENST00000360270, | |
Fusion gene scores | * DoF score | 12 X 6 X 10=720 | 6 X 6 X 2=72 |
# samples | 19 | 7 | |
** MAII score | log2(19/720*10)=-1.92199748799873 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/72*10)=-0.0406419844973459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PCMTD1 [Title/Abstract] AND MSN [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | MSN | GO:0001771 | immunological synapse formation | 27405666 |
Tgene | MSN | GO:0042098 | T cell proliferation | 27405666 |
Tgene | MSN | GO:0070489 | T cell aggregation | 27405666 |
Tgene | MSN | GO:0071394 | cellular response to testosterone stimulus | 24065547 |
Tgene | MSN | GO:0072678 | T cell migration | 27405666 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BQ331576 | PCMTD1 | chr8 | 52762170 | - | MSN | chrX | 64887536 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000360540 | ENST00000609205 | PCMTD1 | chr8 | 52762170 | - | MSN | chrX | 64887536 | + |
intron-intron | ENST00000360540 | ENST00000360270 | PCMTD1 | chr8 | 52762170 | - | MSN | chrX | 64887536 | + |
intron-intron | ENST00000544451 | ENST00000609205 | PCMTD1 | chr8 | 52762170 | - | MSN | chrX | 64887536 | + |
intron-intron | ENST00000544451 | ENST00000360270 | PCMTD1 | chr8 | 52762170 | - | MSN | chrX | 64887536 | + |
intron-intron | ENST00000519559 | ENST00000609205 | PCMTD1 | chr8 | 52762170 | - | MSN | chrX | 64887536 | + |
intron-intron | ENST00000519559 | ENST00000360270 | PCMTD1 | chr8 | 52762170 | - | MSN | chrX | 64887536 | + |
intron-intron | ENST00000522514 | ENST00000609205 | PCMTD1 | chr8 | 52762170 | - | MSN | chrX | 64887536 | + |
intron-intron | ENST00000522514 | ENST00000360270 | PCMTD1 | chr8 | 52762170 | - | MSN | chrX | 64887536 | + |
intron-intron | ENST00000521344 | ENST00000609205 | PCMTD1 | chr8 | 52762170 | - | MSN | chrX | 64887536 | + |
intron-intron | ENST00000521344 | ENST00000360270 | PCMTD1 | chr8 | 52762170 | - | MSN | chrX | 64887536 | + |
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FusionProtFeatures for PCMTD1_MSN |
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Hgene | Tgene |
PCMTD1 | MSN |
Probably involved in connections of major cytoskeletalstructures to the plasma membrane. May inhibit herpes simplexvirus 1 infection at an early stage. Plays a role in regulatingthe proliferation, migration, and adhesion of human lymphoid cellsand participates in immunologic synapse formation(PubMed:27405666). {ECO:0000269|PubMed:21549406,ECO:0000269|PubMed:27405666}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PCMTD1_MSN |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PCMTD1_MSN |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PCMTD1_MSN |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PCMTD1_MSN |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | MSN | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | MSN | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Tgene | MSN | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Tgene | MSN | C3495559 | Juvenile arthritis | 1 | CTD_human |