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Fusion gene ID: 26253 |
FusionGeneSummary for PCM1_SLC6A2 |
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Fusion gene information | Fusion gene name: PCM1_SLC6A2 | Fusion gene ID: 26253 | Hgene | Tgene | Gene symbol | PCM1 | SLC6A2 | Gene ID | 5108 | 6530 |
Gene name | pericentriolar material 1 | solute carrier family 6 member 2 | |
Synonyms | PTC4|RET/PCM-1 | NAT1|NET|NET1|SLC6A5 | |
Cytomap | 8p22 | 16q12.2 | |
Type of gene | protein-coding | protein-coding | |
Description | pericentriolar material 1 proteinPCM-1hPCM-1pericentriolar material 1, PCM1 | sodium-dependent noradrenaline transporterneurotransmitter transporternorepinephrine transportersolute carrier family 6 (neurotransmitter transporter), member 2solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2solute carri | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q15154 | P23975 | |
Ensembl transtripts involved in fusion gene | ENST00000325083, ENST00000519253, ENST00000524226, ENST00000518537, ENST00000518936, ENST00000327578, | ENST00000568943, ENST00000414754, ENST00000379906, ENST00000561820, ENST00000219833, ENST00000566163, ENST00000567238, | |
Fusion gene scores | * DoF score | 8 X 7 X 5=280 | 3 X 3 X 2=18 |
# samples | 8 | 3 | |
** MAII score | log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PCM1 [Title/Abstract] AND SLC6A2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | SLC6A2 | GO:0015844 | monoamine transport | 16024787 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-A1-A0SD-01A | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000325083 | ENST00000568943 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
5CDS-intron | ENST00000325083 | ENST00000414754 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
5CDS-intron | ENST00000325083 | ENST00000379906 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
5CDS-intron | ENST00000325083 | ENST00000561820 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
5CDS-intron | ENST00000325083 | ENST00000219833 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
5CDS-intron | ENST00000325083 | ENST00000566163 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
5CDS-intron | ENST00000325083 | ENST00000567238 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
5CDS-intron | ENST00000519253 | ENST00000568943 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
5CDS-intron | ENST00000519253 | ENST00000414754 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
5CDS-intron | ENST00000519253 | ENST00000379906 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
5CDS-intron | ENST00000519253 | ENST00000561820 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
5CDS-intron | ENST00000519253 | ENST00000219833 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
5CDS-intron | ENST00000519253 | ENST00000566163 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
5CDS-intron | ENST00000519253 | ENST00000567238 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
5CDS-intron | ENST00000524226 | ENST00000568943 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
5CDS-intron | ENST00000524226 | ENST00000414754 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
5CDS-intron | ENST00000524226 | ENST00000379906 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
5CDS-intron | ENST00000524226 | ENST00000561820 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
5CDS-intron | ENST00000524226 | ENST00000219833 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
5CDS-intron | ENST00000524226 | ENST00000566163 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
5CDS-intron | ENST00000524226 | ENST00000567238 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
intron-intron | ENST00000518537 | ENST00000568943 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
intron-intron | ENST00000518537 | ENST00000414754 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
intron-intron | ENST00000518537 | ENST00000379906 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
intron-intron | ENST00000518537 | ENST00000561820 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
intron-intron | ENST00000518537 | ENST00000219833 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
intron-intron | ENST00000518537 | ENST00000566163 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
intron-intron | ENST00000518537 | ENST00000567238 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
intron-intron | ENST00000518936 | ENST00000568943 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
intron-intron | ENST00000518936 | ENST00000414754 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
intron-intron | ENST00000518936 | ENST00000379906 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
intron-intron | ENST00000518936 | ENST00000561820 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
intron-intron | ENST00000518936 | ENST00000219833 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
intron-intron | ENST00000518936 | ENST00000566163 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
intron-intron | ENST00000518936 | ENST00000567238 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
5CDS-intron | ENST00000327578 | ENST00000568943 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
5CDS-intron | ENST00000327578 | ENST00000414754 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
5CDS-intron | ENST00000327578 | ENST00000379906 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
5CDS-intron | ENST00000327578 | ENST00000561820 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
5CDS-intron | ENST00000327578 | ENST00000219833 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
5CDS-intron | ENST00000327578 | ENST00000566163 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
5CDS-intron | ENST00000327578 | ENST00000567238 | PCM1 | chr8 | 17843596 | + | SLC6A2 | chr8 | 18028188 | + |
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FusionProtFeatures for PCM1_SLC6A2 |
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Hgene | Tgene |
PCM1 | SLC6A2 |
Amine transporter. Terminates the action ofnoradrenaline by its high affinity sodium-dependent reuptake intopresynaptic terminals. {ECO:0000269|PubMed:2008212}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PCM1_SLC6A2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PCM1_SLC6A2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PCM1 | BBS4, KRT15, ING5, KIAA0368, KRT19, CCDC53, ABI2, EXOC8, EPS8, CEP72, PCNT, HAP1, EWSR1, HNRNPUL1, CLTC, MIB1, FUS, CEP131, PPIB, SIRT7, NEURL4, PAN2, CASK, E2F4, YWHAQ, LATS2, SAV1, CEP250, HAUS2, OBSL1, CCDC8, CSPP1, CCDC183, SLC25A41, SSFA2, RASSF8, RASSF7, IFT81, NTRK1, BTRC, MED4, HERC2, AHI1, CEP162, RPGRIP1L, CC2D2A, CEP128, LCA5, OFD1, CCDC138, CEP170, PIBF1, SSX2IP, WRAP73, HAUS1, HAUS4, KIAA0753, CCDC77, CCNB2, CEP350, CEP95, CSNK1A1, DSP, KIF20A, LUZP1, MCM10, MCRS1, MPRIP, NDC80, SMARCD2, TPGS1, SUPT5H, SSBP1, KIF7, SKA1, TSPYL1, SREK1IP1, CSNK1D, IFT172, CEP55, IFT20, CCDC14, HMMR, CFAP97, IPO5, KCTD12, SNRPE, SPICE1, ABCD3, ACOT9, ATP5L, CAMSAP1, CC2D1A, CCDC66, CEP120, CKAP2, FGFR1OP, HAUS3, HAUS5, HAUS6, HAUS7, HAUS8, IDH3B, IFT57, IFT74, NCKAP5L, RAE1, STAU1, TP53BP2, TTK, TXLNA, TXLNG, TBC1D31, WDR83, XRN1, ZNF280C, ACTR2, ANKRD26, BAIAP2, BICD1, BICD2, BTF3, C11orf49, KNSTRN, C2CD3, CAMSAP2, CCDC112, CCDC18, CCDC22, CCDC85C, CCDC92, CCNB1, CCP110, CDC123, CEP164, CEP192, CEP57L1, CEP63, CEP85, CEP89, CEP97, CKAP2L, CNOT10, COMMD2, COMMD4, CSNK1E, DAPK3, DIAPH3, ERC1, EXOC4, FOPNL, GNAO1, GPATCH1, IBTK, IQCB1, KIAA1328, KIF14, LRRC49, LRRCC1, MAGED1, MAP7D3, MED29, MIS18A, MIS18BP1, MOB4, MPHOSPH9, MYO9A, NAV1, NEDD1, NME7, NOL11, NUF2, ODF2L, ODF2, PCBP3, PKN2, PLK1, KIZ, PPP1R9B, IFT22, RRM2, SCLT1, SDCCAG3, SECISBP2, SMG5, SMG7, SPATA24, SPATS2, SPC24, SRGAP2, STRN4, TANC1, TCHP, TEX9, TNIP1, TRAF3IP1, TTC12, TTF2, TTLL4, TTLL5, CEP104, CEP290, CEP152, CEP135, CNTRL, FBF1, NINL, NIN, POC5, SASS6, RPGRIP1, STIL, CENPJ, CENPE, PPP2CA, PRKAR2B, DYNLL1, MAPRE1, SLAIN2, CEP170P1, PPP2R3C, YWHAE, YWHAZ, MTMR7, C6orf118, BIN3, CCDC172, LPXN, FAM81B, COG5, ING2, CCDC65, LCA5L, CCDC40, DKK3, NECAB2, ATG14, TSC1, RNF168 | SLC6A2 | STX1A, SNCA, ACTB |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PCM1_SLC6A2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | SLC6A2 | P23975 | DB00285 | Venlafaxine | Sodium-dependent noradrenaline transporter | small molecule | approved |
Tgene | SLC6A2 | P23975 | DB00289 | Atomoxetine | Sodium-dependent noradrenaline transporter | small molecule | approved |
Tgene | SLC6A2 | P23975 | DB00321 | Amitriptyline | Sodium-dependent noradrenaline transporter | small molecule | approved |
Tgene | SLC6A2 | P23975 | DB00344 | Protriptyline | Sodium-dependent noradrenaline transporter | small molecule | approved |
Tgene | SLC6A2 | P23975 | DB00370 | Mirtazapine | Sodium-dependent noradrenaline transporter | small molecule | approved |
Tgene | SLC6A2 | P23975 | DB00408 | Loxapine | Sodium-dependent noradrenaline transporter | small molecule | approved |
Tgene | SLC6A2 | P23975 | DB00454 | Pethidine | Sodium-dependent noradrenaline transporter | small molecule | approved |
Tgene | SLC6A2 | P23975 | DB00458 | Imipramine | Sodium-dependent noradrenaline transporter | small molecule | approved |
Tgene | SLC6A2 | P23975 | DB00476 | Duloxetine | Sodium-dependent noradrenaline transporter | small molecule | approved |
Tgene | SLC6A2 | P23975 | DB00514 | Dextromethorphan | Sodium-dependent noradrenaline transporter | small molecule | approved |
Tgene | SLC6A2 | P23975 | DB00540 | Nortriptyline | Sodium-dependent noradrenaline transporter | small molecule | approved |
Tgene | SLC6A2 | P23975 | DB00543 | Amoxapine | Sodium-dependent noradrenaline transporter | small molecule | approved |
Tgene | SLC6A2 | P23975 | DB00696 | Ergotamine | Sodium-dependent noradrenaline transporter | small molecule | approved |
Tgene | SLC6A2 | P23975 | DB00726 | Trimipramine | Sodium-dependent noradrenaline transporter | small molecule | approved |
Tgene | SLC6A2 | P23975 | DB00852 | Pseudoephedrine | Sodium-dependent noradrenaline transporter | small molecule | approved |
Tgene | SLC6A2 | P23975 | DB00988 | Dopamine | Sodium-dependent noradrenaline transporter | small molecule | approved |
Tgene | SLC6A2 | P23975 | DB01114 | Chlorphenamine | Sodium-dependent noradrenaline transporter | small molecule | approved |
Tgene | SLC6A2 | P23975 | DB01156 | Bupropion | Sodium-dependent noradrenaline transporter | small molecule | approved |
Tgene | SLC6A2 | P23975 | DB01170 | Guanethidine | Sodium-dependent noradrenaline transporter | small molecule | approved |
Tgene | SLC6A2 | P23975 | DB01173 | Orphenadrine | Sodium-dependent noradrenaline transporter | small molecule | approved |
Tgene | SLC6A2 | P23975 | DB01364 | Ephedrine | Sodium-dependent noradrenaline transporter | small molecule | approved |
Tgene | SLC6A2 | P23975 | DB06204 | Tapentadol | Sodium-dependent noradrenaline transporter | small molecule | approved |
Tgene | SLC6A2 | P23975 | DB09167 | Dosulepin | Sodium-dependent noradrenaline transporter | small molecule | approved |
Tgene | SLC6A2 | P23975 | DB00191 | Phentermine | Sodium-dependent noradrenaline transporter | small molecule | approved|illicit |
Tgene | SLC6A2 | P23975 | DB00907 | Cocaine | Sodium-dependent noradrenaline transporter | small molecule | approved|illicit |
Tgene | SLC6A2 | P23975 | DB00937 | Diethylpropion | Sodium-dependent noradrenaline transporter | small molecule | approved|illicit |
Tgene | SLC6A2 | P23975 | DB01576 | Dextroamphetamine | Sodium-dependent noradrenaline transporter | small molecule | approved|illicit |
Tgene | SLC6A2 | P23975 | DB01577 | Methamphetamine | Sodium-dependent noradrenaline transporter | small molecule | approved|illicit |
Tgene | SLC6A2 | P23975 | DB00182 | Amphetamine | Sodium-dependent noradrenaline transporter | small molecule | approved|illicit|investigational |
Tgene | SLC6A2 | P23975 | DB01105 | Sibutramine | Sodium-dependent noradrenaline transporter | small molecule | approved|illicit|investigational|withdrawn |
Tgene | SLC6A2 | P23975 | DB00193 | Tramadol | Sodium-dependent noradrenaline transporter | small molecule | approved|investigational |
Tgene | SLC6A2 | P23975 | DB00234 | Reboxetine | Sodium-dependent noradrenaline transporter | small molecule | approved|investigational |
Tgene | SLC6A2 | P23975 | DB00422 | Methylphenidate | Sodium-dependent noradrenaline transporter | small molecule | approved|investigational |
Tgene | SLC6A2 | P23975 | DB00579 | Mazindol | Sodium-dependent noradrenaline transporter | small molecule | approved|investigational |
Tgene | SLC6A2 | P23975 | DB00715 | Paroxetine | Sodium-dependent noradrenaline transporter | small molecule | approved|investigational |
Tgene | SLC6A2 | P23975 | DB00934 | Maprotiline | Sodium-dependent noradrenaline transporter | small molecule | approved|investigational |
Tgene | SLC6A2 | P23975 | DB01142 | Doxepin | Sodium-dependent noradrenaline transporter | small molecule | approved|investigational |
Tgene | SLC6A2 | P23975 | DB01151 | Desipramine | Sodium-dependent noradrenaline transporter | small molecule | approved|investigational |
Tgene | SLC6A2 | P23975 | DB01175 | Escitalopram | Sodium-dependent noradrenaline transporter | small molecule | approved|investigational |
Tgene | SLC6A2 | P23975 | DB04840 | Debrisoquin | Sodium-dependent noradrenaline transporter | small molecule | approved|investigational |
Tgene | SLC6A2 | P23975 | DB04896 | Milnacipran | Sodium-dependent noradrenaline transporter | small molecule | approved|investigational |
Tgene | SLC6A2 | P23975 | DB06148 | Mianserin | Sodium-dependent noradrenaline transporter | small molecule | approved|investigational |
Tgene | SLC6A2 | P23975 | DB06700 | Desvenlafaxine | Sodium-dependent noradrenaline transporter | small molecule | approved|investigational |
Tgene | SLC6A2 | P23975 | DB06701 | Dexmethylphenidate | Sodium-dependent noradrenaline transporter | small molecule | approved|investigational |
Tgene | SLC6A2 | P23975 | DB01381 | Ginkgo biloba | Sodium-dependent noradrenaline transporter | small molecule | approved|investigational|nutraceutical |
Tgene | SLC6A2 | P23975 | DB01242 | Clomipramine | Sodium-dependent noradrenaline transporter | small molecule | approved|investigational|vet_approved |
Tgene | SLC6A2 | P23975 | DB09185 | Viloxazine | Sodium-dependent noradrenaline transporter | small molecule | approved|investigational|withdrawn |
Tgene | SLC6A2 | P23975 | DB09225 | Zotepine | Sodium-dependent noradrenaline transporter | small molecule | approved|investigational|withdrawn |
Tgene | SLC6A2 | P23975 | DB01221 | Ketamine | Sodium-dependent noradrenaline transporter | small molecule | approved|vet_approved |
Tgene | SLC6A2 | P23975 | DB01149 | Nefazodone | Sodium-dependent noradrenaline transporter | small molecule | approved|withdrawn |
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RelatedDiseases for PCM1_SLC6A2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PCM1 | C0036341 | Schizophrenia | 1 | CTD_human |
Tgene | SLC6A2 | C0001973 | Alcoholic Intoxication, Chronic | 5 | PSYGENET |
Tgene | SLC6A2 | C0011570 | Mental Depression | 5 | PSYGENET |
Tgene | SLC6A2 | C0011581 | Depressive disorder | 5 | PSYGENET |
Tgene | SLC6A2 | C0041696 | Unipolar Depression | 5 | PSYGENET |
Tgene | SLC6A2 | C1269683 | Major Depressive Disorder | 5 | PSYGENET |
Tgene | SLC6A2 | C0005586 | Bipolar Disorder | 3 | PSYGENET |
Tgene | SLC6A2 | C0525045 | Mood Disorders | 3 | PSYGENET |
Tgene | SLC6A2 | C0036341 | Schizophrenia | 2 | PSYGENET |
Tgene | SLC6A2 | C0221480 | Recurrent depression | 2 | PSYGENET |
Tgene | SLC6A2 | C1535893 | Orthostatic intolerance | 2 | CTD_human;ORPHANET;UNIPROT |
Tgene | SLC6A2 | C2063866 | Depressive Disorder, Treatment-Resistant | 2 | PSYGENET |
Tgene | SLC6A2 | C0020538 | Hypertensive disease | 1 | CTD_human |
Tgene | SLC6A2 | C0036572 | Seizures | 1 | CTD_human |