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Fusion gene ID: 26252 |
FusionGeneSummary for PCM1_RET |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PCM1_RET | Fusion gene ID: 26252 | Hgene | Tgene | Gene symbol | PCM1 | RET | Gene ID | 5108 | 5979 |
| Gene name | pericentriolar material 1 | ret proto-oncogene | |
| Synonyms | PTC4|RET/PCM-1 | CDHF12|CDHR16|HSCR1|MEN2A|MEN2B|MTC1|PTC|RET-ELE1 | |
| Cytomap | 8p22 | 10q11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pericentriolar material 1 proteinPCM-1hPCM-1pericentriolar material 1, PCM1 | proto-oncogene tyrosine-protein kinase receptor RetRET receptor tyrosine kinasecadherin family member 12cadherin-related family member 16proto-oncogene c-Retrearranged during transfectionret proto-oncogene (multiple endocrine neoplasia and medullary | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q15154 | P07949 | |
| Ensembl transtripts involved in fusion gene | ENST00000325083, ENST00000519253, ENST00000524226, ENST00000518537, ENST00000518936, ENST00000327578, | ENST00000355710, ENST00000340058, | |
| Fusion gene scores | * DoF score | 8 X 7 X 5=280 | 18 X 10 X 7=1260 |
| # samples | 8 | 65 | |
| ** MAII score | log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(65/1260*10)=-0.954912110471462 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PCM1 [Title/Abstract] AND RET [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | RET | GO:0030155 | regulation of cell adhesion | 21357690 |
| Tgene | RET | GO:0030335 | positive regulation of cell migration | 20702524 |
| Tgene | RET | GO:0033619 | membrane protein proteolysis | 21357690 |
| Tgene | RET | GO:0033630 | positive regulation of cell adhesion mediated by integrin | 20702524 |
| Tgene | RET | GO:0035860 | glial cell-derived neurotrophic factor receptor signaling pathway | 28953886 |
| Tgene | RET | GO:0043410 | positive regulation of MAPK cascade | 28846099 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AJ297349 | PCM1 | chr8 | 17851129 | + | RET | chr10 | 43612030 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000325083 | ENST00000355710 | PCM1 | chr8 | 17851129 | + | RET | chr10 | 43612030 | + |
| In-frame | ENST00000325083 | ENST00000340058 | PCM1 | chr8 | 17851129 | + | RET | chr10 | 43612030 | + |
| In-frame | ENST00000519253 | ENST00000355710 | PCM1 | chr8 | 17851129 | + | RET | chr10 | 43612030 | + |
| In-frame | ENST00000519253 | ENST00000340058 | PCM1 | chr8 | 17851129 | + | RET | chr10 | 43612030 | + |
| In-frame | ENST00000524226 | ENST00000355710 | PCM1 | chr8 | 17851129 | + | RET | chr10 | 43612030 | + |
| In-frame | ENST00000524226 | ENST00000340058 | PCM1 | chr8 | 17851129 | + | RET | chr10 | 43612030 | + |
| intron-3CDS | ENST00000518537 | ENST00000355710 | PCM1 | chr8 | 17851129 | + | RET | chr10 | 43612030 | + |
| intron-3CDS | ENST00000518537 | ENST00000340058 | PCM1 | chr8 | 17851129 | + | RET | chr10 | 43612030 | + |
| intron-3CDS | ENST00000518936 | ENST00000355710 | PCM1 | chr8 | 17851129 | + | RET | chr10 | 43612030 | + |
| intron-3CDS | ENST00000518936 | ENST00000340058 | PCM1 | chr8 | 17851129 | + | RET | chr10 | 43612030 | + |
| In-frame | ENST00000327578 | ENST00000355710 | PCM1 | chr8 | 17851129 | + | RET | chr10 | 43612030 | + |
| In-frame | ENST00000327578 | ENST00000340058 | PCM1 | chr8 | 17851129 | + | RET | chr10 | 43612030 | + |
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FusionProtFeatures for PCM1_RET |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PCM1 | RET |
| Receptor tyrosine-protein kinase involved in numerouscellular mechanisms including cell proliferation, neuronalnavigation, cell migration, and cell differentiation upon bindingwith glial cell derived neurotrophic factor family ligands.Phosphorylates PTK2/FAK1. Regulates both cell death/survivalbalance and positional information. Required for the molecularmechanisms orchestration during intestine organogenesis; involvedin the development of enteric nervous system and renalorganogenesis during embryonic life, and promotes the formation ofPeyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via itscleavage by caspase in sympathetic neurons and mediates cellmigration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner.Involved in the development of the neural crest. Active in theabsence of ligand, triggering apoptosis through a mechanism thatrequires receptor intracellular caspase cleavage. Acts as adependence receptor; in the presence of the ligand GDNF insomatotrophs (within pituitary), promotes survival and downregulates growth hormone (GH) production, but triggers apoptosisin absence of GDNF. Regulates nociceptor survival and size.Triggers the differentiation of rapidly adapting (RA)mechanoreceptors. Mediator of several diseases such asneuroendocrine cancers; these diseases are characterized byaberrant integrins-regulated cell migration. Mediates, throughinteraction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which induces inhibition of food-intake. Activates MAPK- and AKT-signaling pathways(PubMed:28846097, PubMed:28953886, PubMed:28846099). Isoform 1 incomplex with GFRAL induces higher activation of MAPK-signalingpathway than isoform 2 in complex with GFRAL (PubMed:28846099).{ECO:0000269|PubMed:20064382, ECO:0000269|PubMed:20616503,ECO:0000269|PubMed:20702524, ECO:0000269|PubMed:21357690,ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:28846097,ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PCM1 | chr8:17851129 | chr10:43612030 | ENST00000325083 | + | 29 | 39 | 1063_1089 | 1609 | 2025 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | PCM1 | chr8:17851129 | chr10:43612030 | ENST00000325083 | + | 29 | 39 | 1515_1539 | 1609 | 2025 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | PCM1 | chr8:17851129 | chr10:43612030 | ENST00000325083 | + | 29 | 39 | 218_301 | 1609 | 2025 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | PCM1 | chr8:17851129 | chr10:43612030 | ENST00000325083 | + | 29 | 39 | 400_424 | 1609 | 2025 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | PCM1 | chr8:17851129 | chr10:43612030 | ENST00000325083 | + | 29 | 39 | 487_543 | 1609 | 2025 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | PCM1 | chr8:17851129 | chr10:43612030 | ENST00000325083 | + | 29 | 39 | 651_682 | 1609 | 2025 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | PCM1 | chr8:17851129 | chr10:43612030 | ENST00000325083 | + | 29 | 39 | 726_769 | 1609 | 2025 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | PCM1 | chr8:17851129 | chr10:43612030 | ENST00000325083 | + | 29 | 39 | 824_858 | 1609 | 2025 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >RET | chr8:17851129 | chr10:43612030 | ENST00000340058 | + | 10 | 19 | 724_1016 | 712 | 1073 | Domain | Protein kinase |
| Tgene | >RET | chr8:17851129 | chr10:43612030 | ENST00000355710 | + | 10 | 20 | 724_1016 | 712 | 1115 | Domain | Protein kinase |
| Tgene | >RET | chr8:17851129 | chr10:43612030 | ENST00000340058 | + | 10 | 19 | 730_738 | 712 | 1073 | Nucleotide binding | ATP |
| Tgene | >RET | chr8:17851129 | chr10:43612030 | ENST00000355710 | + | 10 | 20 | 730_738 | 712 | 1115 | Nucleotide binding | ATP |
| Tgene | >RET | chr8:17851129 | chr10:43612030 | ENST00000340058 | + | 10 | 19 | 805_807 | 712 | 1073 | Region | Note=Inhibitors binding |
| Tgene | >RET | chr8:17851129 | chr10:43612030 | ENST00000355710 | + | 10 | 20 | 805_807 | 712 | 1115 | Region | Note=Inhibitors binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | RET | chr8:17851129 | chr10:43612030 | ENST00000340058 | + | 10 | 19 | 168_272 | 712 | 1073 | Domain | Cadherin |
| Tgene | RET | chr8:17851129 | chr10:43612030 | ENST00000355710 | + | 10 | 20 | 168_272 | 712 | 1115 | Domain | Cadherin |
| Tgene | RET | chr8:17851129 | chr10:43612030 | ENST00000340058 | + | 10 | 19 | 29_635 | 712 | 1073 | Topological domain | Extracellular |
| Tgene | RET | chr8:17851129 | chr10:43612030 | ENST00000340058 | + | 10 | 19 | 658_1114 | 712 | 1073 | Topological domain | Cytoplasmic |
| Tgene | RET | chr8:17851129 | chr10:43612030 | ENST00000355710 | + | 10 | 20 | 29_635 | 712 | 1115 | Topological domain | Extracellular |
| Tgene | RET | chr8:17851129 | chr10:43612030 | ENST00000355710 | + | 10 | 20 | 658_1114 | 712 | 1115 | Topological domain | Cytoplasmic |
| Tgene | RET | chr8:17851129 | chr10:43612030 | ENST00000340058 | + | 10 | 19 | 636_657 | 712 | 1073 | Transmembrane | Helical |
| Tgene | RET | chr8:17851129 | chr10:43612030 | ENST00000355710 | + | 10 | 20 | 636_657 | 712 | 1115 | Transmembrane | Helical |
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FusionGeneSequence for PCM1_RET |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PCM1_ENST00000327578_chr8_17851129_+_RET_ENST00000355710_chr10_43612030_+_711aa MSSTCEPCKSRNRHSAQTEEPVQAKVFSRKNHEQLEKIIKCNRSTEISSAHARRILQQSNRNACNEAPETGSDFSMFEALRDTIYSEVAT LISQNESRPHFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERET HKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHLDQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENR SSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPFLKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENA SPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISF AWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEI VTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLS >In-frame_PCM1_ENST00000327578_chr8_17851129_+_RET_ENST00000340058_chr10_43612030_+_669aa MSSTCEPCKSRNRHSAQTEEPVQAKVFSRKNHEQLEKIIKCNRSTEISSAHARRILQQSNRNACNEAPETGSDFSMFEALRDTIYSEVAT LISQNESRPHFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERET HKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHLDQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENR SSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPFLKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENA SPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISF AWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEI VTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PCM1_ENST00000327578_chr8_17851129_+_RET_ENST00000355710_chr10_43612030_+_2133nt ATGTCTAGCACATGTGAACCTTGCAAAAGTAGGAACAGACATTCAGCCCAGACTGAAGAGCCTGTTCAAGCAAAAGTATTCAGCAGAAAG AATCATGAGCAACTGGAAAAAATAATAAAATGTAATAGGTCTACAGAAATATCTTCAGCACATGCTAGGAGAATACTACAGCAGTCTAAC AGAAATGCATGCAATGAAGCGCCAGAAACTGGGAGTGATTTTTCCATGTTTGAAGCTTTGCGAGATACTATTTATTCTGAAGTAGCTACA TTAATTTCTCAAAATGAATCTCGTCCACATTTTCTTATTGAACTCTTCCATGAGCTGCAGCTACTAAACACAGACTACTTGAGACAGAGG GCTTTATATGCATTGCAGGACATAGTATCCAGACATATTTCTGAGAGCCATGAAAAAGGAGAAAATGTAAAGTCAGTAAACTCTGGTACT TGGATAGCATCAAACTCAGAACTTACTCCTAGTGAGAGCCTTGCTACTACTGATGATGAAACTTTTGAGAAGAACTTTGAAAGAGAAACC CATAAAATAAGTGAGCAAAATGATGCTGATAATGCTAGTGTCCTGTCTGTATCATCAAATTTTGAGCCTTTTGCAACAGATGATCTAGGT AACACCGTGATTCACTTAGATCAAGCATTAGCCAGAATGAGAGAATATGAGCGTATGAAGACTGAGGCTGAAAGTAACTCAAATATGAGA TGCACCTGCAGGATTATTGAGGATGGAGATGGTGCTGGTGCAGGTACTACAGTTAATAATTTAGAAGAAACTCCCGTTATTGAAAATCGT AGTTCACAACAACCTGTAAGTGAAGTTTCTACCATCCCATGTCCTAGAATTGATACTCAGCAGCTGGACCGGCAAATTAAAGCAATTATG AAAGAAGTCATTCCTTTTTTGAAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAA TTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCC TCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGC AGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCT GGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTT GCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAG GGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCA GTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATC GTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGAC AACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGAC CTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCA GAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGCATG TCAGACCCGAACTGGCCTGGAGAGAGTCCTGTACCACTCACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATATCCAAATGATAGT >In-frame_PCM1_ENST00000327578_chr8_17851129_+_RET_ENST00000340058_chr10_43612030_+_2007nt ATGTCTAGCACATGTGAACCTTGCAAAAGTAGGAACAGACATTCAGCCCAGACTGAAGAGCCTGTTCAAGCAAAAGTATTCAGCAGAAAG AATCATGAGCAACTGGAAAAAATAATAAAATGTAATAGGTCTACAGAAATATCTTCAGCACATGCTAGGAGAATACTACAGCAGTCTAAC AGAAATGCATGCAATGAAGCGCCAGAAACTGGGAGTGATTTTTCCATGTTTGAAGCTTTGCGAGATACTATTTATTCTGAAGTAGCTACA TTAATTTCTCAAAATGAATCTCGTCCACATTTTCTTATTGAACTCTTCCATGAGCTGCAGCTACTAAACACAGACTACTTGAGACAGAGG GCTTTATATGCATTGCAGGACATAGTATCCAGACATATTTCTGAGAGCCATGAAAAAGGAGAAAATGTAAAGTCAGTAAACTCTGGTACT TGGATAGCATCAAACTCAGAACTTACTCCTAGTGAGAGCCTTGCTACTACTGATGATGAAACTTTTGAGAAGAACTTTGAAAGAGAAACC CATAAAATAAGTGAGCAAAATGATGCTGATAATGCTAGTGTCCTGTCTGTATCATCAAATTTTGAGCCTTTTGCAACAGATGATCTAGGT AACACCGTGATTCACTTAGATCAAGCATTAGCCAGAATGAGAGAATATGAGCGTATGAAGACTGAGGCTGAAAGTAACTCAAATATGAGA TGCACCTGCAGGATTATTGAGGATGGAGATGGTGCTGGTGCAGGTACTACAGTTAATAATTTAGAAGAAACTCCCGTTATTGAAAATCGT AGTTCACAACAACCTGTAAGTGAAGTTTCTACCATCCCATGTCCTAGAATTGATACTCAGCAGCTGGACCGGCAAATTAAAGCAATTATG AAAGAAGTCATTCCTTTTTTGAAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAA TTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCC TCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGC AGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCT GGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTT GCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAG GGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCA GTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATC GTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGAC AACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGAC CTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCA GAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGTAGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PCM1_ENST00000325083_chr8_17851129_+_RET_ENST00000355710_chr10_43612030_+_8557nt TCCGGCGGGTCACATGACTCCAGTCTAGCTCGCATTGCGGCTCCCGCCCGGGCGAGTTCTCGCCCCCGCGCGGCCGTTGCCGAGGAGACG GCGCATGTCCCGCCGCGCGTTGCCCCCTCTGCAGTACCCCCGCCCCTCTTCTCCCACCACAATGAGATCCTAAGATGGCGGTGGCTGCGG CGGTTGGCGCTGCGTAGCTGAGGTCGAAAAGGCGGCCACTGGGGCCGAGGCAGCCAGGAAACGTGTGGGCCTCTCTGCTGCGGTCTCCGA GGGCCGACCGCTGCCGGCGGCGGGTCGTGGGGGCTGACTGTCGCTCTGCCTTTGACAGGAGAGGCTGCTTCTTGTAGAGGAAACAGCTTT GAAGTGTGGAGCGGGAAAGGAGCAGTTTCTGAGCTGCAAAAACTAGTTTCTAAACAGAGAGTTAATTGTTAAATCCAGTATGGCCACAGG AGGAGGTCCCTTTGAAGATGGCATGAATGATCAGGATTTACCAAACTGGAGTAATGAGAATGTTGATGACAGGCTCAACAATATGGATTG GGGTGCCCAACAGAAGAAAGCAAATAGATCATCAGAAAAGAATAAGAAAAAGTTTGGTGTAGAAAGTGATAAAAGAGTAACCAATGATAT TTCTCCGGAGTCGTCACCAGGAGTTGGAAGGCGAAGAACAAAGACTCCACATACGTTCCCACACAGTAGATACATGAGTCAGATGTCTGT CCCAGAGCAGGCAGAATTAGAGAAACTGAAACAGCGGATAAACTTCAGTGATTTAGATCAGAGAAGCATTGGAAGTGATTCCCAAGGTAG AGCAACAGCTGCTAACAACAAACGTCAGCTTAGTGAAAACCGAAAGCCCTTCAACTTTTTGCCTATGCAGATTAATACTAACAAGAGCAA AGATGCATCTACAAACCCCCCAAACAGAGAAACGATTGGATCAGCACAGTGTAAAGAGTTGTTTGCTTCTGCTTTAAGTAATGACCTCTT GCAAAACTGTCAGGTGTCTGAAGAAGATGGGAGGGGAGAACCTGCAATGGAGAGCAGCCAGATTGTAAGCAGGCTTGTTCAAATTCGCGA TTATATTACTAAAGCTAGTTCCATGCGGGAAGATCTTGTAGAGAAAAATGAGAGATCTGCTAATGTTGAGCGCCTTACTCATCTAATAGA TCACCTTAAAGAACAAGAGAAGTCATATATGAAATTTCTTAAAAAAATCCTTGCCAGAGATCCTCAGCAGGAGCCTATGGAAGAGATAGA AAATTTGAAGAAACAACATGATTTATTAAAAAGAATGTTACAACAGCAGGAGCAACTAAGAGCTCTACAGGGACGGCAGGCTGCACTTCT AGCTCTGCAACATAAAGCAGAGCAAGCTATTGCAGTGATGGATGATTCTGTTGTTGCAGAAACTGCAGGTAGCTTATCTGGCGTCAGTAT CACATCTGAACTAAATGAAGAATTGAATGACTTAATTCAGCGTTTTCATAATCAGCTTCGTGATTCTCAGCCTCCAGCTGTTCCAGACAA TAGAAGACAGGCAGAAAGTCTTTCATTAACTAGGGAGGTTTCCCAGAGCAGGAAACCATCAGCTTCAGAACGTTTACCTGATGAGAAAGT CGAACTTTTTAGCAAAATGAGAGTGCTACAGGAAAAGAAACAAAAAATGGACAAATTGCTTGGAGAACTTCATACACTTCGAGATCAGCA TCTTAACAATTCATCATCCTCTCCACAAAGGAGTGTCGATCAGAGAAGTACTTCAGCTCCCTCTGCTTCTGTAGGCTTGGCACCGGTTGT CAATGGAGAATCCAATAGCCTCACATCATCTGTTCCTTATCCTACTGCTTCTCTAGTATCTCAGAATGAGAGTGAAAACGAAGGCCACCT CAATCCATCTGAAAAACTCCAGAAGTTAAATGAAGTTCGAAAGAGATTGAATGAGCTAAGAGAATTAGTTCATTATTATGAACAAACGTC AGACATGATGACAGATGCTGTGAATGAAAACAGGAAAGATGAAGAAACTGAAGAGTCAGAATATGATTCTGAGCATGAAAATTCCGAGCC TGTTACTAACATTCGAAATCCACAAGTAGCTTCCACTTGGAATGAAGTAAATAGTCATAGTAATGCACAGTGTGTTTCTAATAATAGAGA TGGGCGAACAGTTAATTCTAATTGTGAAATTAACAACAGATCTGCTGCCAACATAAGGGCTCTAAACATGCCTCCTTCTTTAGATTGTCG ATATAATAGAGAAGGGGAACAGGAGATTCATGTTGCACAAGGTGAAGATGATGAGGAGGAGGAGGAAGAAGCAGAAGAGGAGGGAGTCAG TGGAGCTTCATTATCTAGTCACAGGAGCAGTCTGGTTGATGAGCATCCAGAAGATGCTGAATTTGAACAGAAGATCAACCGACTTATGGC TGCAAAACAGAAACTTAGACAGTTACAAGATCTTGTTGCTATGGTACAGGATGATGATGCAGCTCAAGGAGTTATCTCTGCCAGTGCATC AAATTTGGATGATTTCTACCCAGCAGAAGAAGACACCAAGCAAAATTCAAATAACACTAGAGGAAATGCCAATAAAACACAGAAAGATAC TGGAGTAAATGAAAAGGCAAGAGAGAAATTTTATGAGGCTAAACTACAGCAGCAACAGAGAGAGCTAAAACAATTGCAGGAAGAAAGAAA GAAACTGATTGACATTCAGGAGAAAATTCAAGCATTGCAAACGGCATGCCCTGACTTACAGCTGTCAGCTGCTAGTGTGGGTAACTGTCC CACCAAAAAATATATGCCAGCTGTTACTTCAACCCCAACTGTTAATCAACACGAGACCAGTACAAGCAAATCTGTTTTTGAGCCTGAAGA TTCTTCAATAGTAGATAATGAGTTGTGGTCAGAAATGAGAAGACATGAAATGTTGAGGGAGGAGCTGCGACAGAGAAGAAAGCAGCTTGA AGCTCTGATGGCTGAACATCAGAGGAGGCAAGGTCTAGCTGAAACTGCATCTCCAGTGGCTGTGTCATTGAGAAGTGATGGATCTGAGAA CCTATGTACTCCTCAGCAAAGTAGAACAGAAAAAACGATGGCAACTTGGGGAGGGTCTACCCAGTGTGCACTAGATGAAGAAGGAGATGA AGACGGTTACCTTTCTGAAGGAATTGTTCGGACAGATGAAGAGGAGGAAGAAGAGCAAGATGCCAGTTCCAATGATAACTTTTCTGTGTG TCCTTCTAACAGTGTGAATCATAACTCCTACAATGGAAAGGAAACTAAAAATAGGTGGAAGAACAATTGCCCTTTTTCGGCAGATGAAAA TTATCGTCCTTTAGCCAAGACAAGGCAACAGAATATCAGCATGCAACGGCAAGAAAACCTTCGTTGGGTGTCAGAGCTCTCTTACGTAGA AGAGAAAGAACAATGGCAAGAACAAATCAATCAGCTAAAGAAACAGCTTGATTTTAGTGTCAGTATTTGTCAGACTTTGATGCAAGACCA GCAGACTCTATCTTGTCTGCTACAAACTCTTCTCACGGGTCCTTACAGTGTTATGCCCAGCAATGTTGCATCTCCTCAAGTACACTTCAT AATGCACCAGTTGAACCAGTGCTATACTCAGCTAACATGGCAACAGAATAATGTTCAGAGGTTGAAACAAATGCTAAATGAACTTATGCG CCAGCAAAATCAGCATCCAGAAAAACCTGGAGGCAAGGAAAGAGGCAGTAGTGCATCGCACCCTCCTTCTCCCAGTTTATTTTGTCCTTT CAGCTTTCCAACACAGCCTGTAAATCTCTTCAATATACCTGGATTTACTAACTTTTCATCATTTGCACCAGGTATGAATTTCAGCCCTTT ATTTCCTTCTAATTTTGGAGATTTTTCTCAGAATATCTCTACACCCAGTGAACAGCAGCAACCCTTAGCCCAGAATTCTTCAGGAAAAAC AGAATATATGGCTTTTCCAAAACCTTTTGAAAGCAGTTCCTCTATTGGAGCAGAGAAACCAAGGAATAAAAAACTGCCTGAAGAGGAGGT GGAAAGCAGTAGGACACCATGGTTATATGAACAAGAAGGTGAAGTAGAGAAACCATTTATCAAGACTGGATTTTCAGTGTCTGTAGAAAA ATCTACAAGTAGTAACCGCAAAAATCAATTAGATACAAACGGAAGAAGACGCCAGTTTGATGAAGAATCACTGGAAAGCTTTAGCAGTAT GCCTGATCCAGTAGATCCAACAACAGTGACTAAAACATTCAAGACAAGAAAAGCGTCTGCACAGGCCAGCCTGGCATCTAAAGATAAAAC TCCCAAGTCAAAAAGTAAGAAGAGGAATTCTACTCAGCTGAAAAGCAGAGTTAAAAACATCAGGTATGAAAGTGCCAGTATGTCTAGCAC ATGTGAACCTTGCAAAAGTAGGAACAGACATTCAGCCCAGACTGAAGAGCCTGTTCAAGCAAAAGTATTCAGCAGAAAGAATCATGAGCA ACTGGAAAAAATAATAAAATGTAATAGGTCTACAGAAATATCTTCAGAAACTGGGAGTGATTTTTCCATGTTTGAAGCTTTGCGAGATAC TATTTATTCTGAAGTAGCTACATTAATTTCTCAAAATGAATCTCGTCCACATTTTCTTATTGAACTCTTCCATGAGCTGCAGCTACTAAA CACAGACTACTTGAGACAGAGGGCTTTATATGCATTGCAGGACATAGTATCCAGACATATTTCTGAGAGCCATGAAAAAGGAGAAAATGT AAAGTCAGTAAACTCTGGTACTTGGATAGCATCAAACTCAGAACTTACTCCTAGTGAGAGCCTTGCTACTACTGATGATGAAACTTTTGA GAAGAACTTTGAAAGAGAAACCCATAAAATAAGTGAGCAAAATGATGCTGATAATGCTAGTGTCCTGTCTGTATCATCAAATTTTGAGCC TTTTGCAACAGATGATCTAGGTAACACCGTGATTCACTTAGATCAAGCATTAGCCAGAATGAGAGAATATGAGCGTATGAAGACTGAGGC TGAAAGTAACTCAAATATGAGATGCACCTGCAGGATTATTGAGGATGGAGATGGTGCTGGTGCAGGTACTACAGTTAATAATTTAGAAGA AACTCCCGTTATTGAAAATCGTAGTTCACAACAACCTGTAAGTGAAGTTTCTACCATCCCATGTCCTAGAATTGATACTCAGCAGCTGGA CCGGCAAATTAAAGCAATTATGAAAGAAGTCATTCCTTTTTTGAAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGG AAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGT GAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGT CATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCG CGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCAC CATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGC CAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAA GAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTT TGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGG CCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGT GTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCT GATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGAT TGAAAACAAACTCTATGGCATGTCAGACCCGAACTGGCCTGGAGAGAGTCCTGTACCACTCACGAGAGCTGATGGCACTAACACTGGGTT TCCAAGATATCCAAATGATAGTGTATATGCTAACTGGATGCTTTCACCCTCAGCGGCAAAATTAATGGACACGTTTGATAGTTAACATTT CTTTGTGAAAGGTAATGGACTCACAAGGGGAAGAAACATGCTGAGAATGGAAAGTCTACCGGCCCTTTCTTTGTGAACGTCACATTGGCC GAGCCGTGTTCAGTTCCCAGGTGGCAGACTCGTTTTTGGTAGTTTGTTTTAACTTCCAAGGTGGTTTTACTTCTGATAGCCGGTGATTTT CCCTCCTAGCAGACATGCCACACCGGGTAAGAGCTCTGAGTCTTAGTGGTTAAGCATTCCTTTCTCTTCAGTGCCCAGCAGCACCCAGTG TTGGTCTGTGTCCATCAGTGACCACCAACATTCTGTGTTCACATGTGTGGGTCCAACACTTACTACCTGGTGTATGAAATTGGACCTGAA CTGTTGGATTTTTCTAGTTGCCGCCAAACAAGGCAAAAAAATTTAAACATGAAGCACACACACAAAAAAGGCAGTAGGAAAAATGCTGGC CCTGATGACCTGTCCTTATTCAGAATGAGAGACTGCGGGGGGGGCCTGGGGGTAGTGTCAATGCCCCTCCAGGGCTGGAGGGGAAGAGGG GCCCCGAGGATGGGCCTGGGCTCAGCATTCGAGATCTTGAGAATGATTTTTTTTAAATCATGCAACCTTTCCTTAGGAAGACATTTGGTT TTCATCATGATTAAGATGATTCCTAGATTTAGCACAATGGAGAGATTCCATGCCATCTTTACTATGTGGATGGTGGTATCAGGGAAGAGG GCTCACAAGACACATTTGTCCCCCGGGCCCACCACATCATCCTCACGTGTTCGGTACTGAGCAGCCACTACCCCTGATGAGAACAGTATG AAGAAAGGGGGCTGTTGGAGTCCCAGAATTGCTGACAGCAGAGGCTTTGCTGCTGTGAATCCCACCTGCCACCAGCCTGCAGCACACCCC ACAGCCAAGTAGAGGCGAAAGCAGTGGCTCATCCTACCTGTTAGGAGCAGGTAGGGCTTGTACTCACTTTAATTTGAATCTTATCAACTT ACTCATAAAGGGACAGGCTAGCTAGCTGTGTTAGAAGTAGCAATGACAATGACCAAGGACTGCTACACCTCTGATTACAATTCTGATGTG AAAAAGATGGTGTTTGGCTCTTATAGAGCCTGTGTGAAAGGCCCATGGATCAGCTCTTCCTGTGTTTGTAATTTAATGCTGCTACAAGAT GTTTCTGTTTCTTAGATTCTGACCATGACTCATAAGCTTCTTGTCATTCTTCATTGCTTGTTTGTGGTCACAGATGCACAACACTCCTCC AGTCTTGTGGGGGCAGCTTTTGGGAAGTCTCAGCAGCTCTTCTGGCTGTGTTGTCAGCACTGTAACTTCGCAGAAAAGAGTCGGATTACC AAAACACTGCCTGCTCTTCAGACTTAAAGCACTGATAGGACTTAAAATAGTCTCATTCAAATACTGTATTTTATATAGGCATTTCACAAA AACAGCAAAATTGTGGCATTTTGTGAGGCCAAGGCTTGGATGCGTGTGTAATAGAGCCTTGTGGTGTGTGCGCACACACCCAGAGGGAGA GTTTGAAAAATGCTTATTGGACACGTAACCTGGCTCTAATTTGGGCTGTTTTTCAGATACACTGTGATAAGTTCTTTTACAAATATCTAT AGACATGGTAAACTTTTGGTTTTCAGATATGCTTAATGATAGTCTTACTAAATGCAGAAATAAGAATAAACTTTCTCAAATTATTAAAAA TGCCTACACAGTAAGTGTGAATTGCTGCAACAGGTTTGTTCTCAGGAGGGTAAGAACTCCAGGTCTAAACAGCTGACCCAGTGATGGGGA ATTTATCCTTGACCAATTTATCCTTGACCAATAACCTAATTGTCTATTCCTGAGTTATAAAAGTCCCCATCCTTATTAGCTCTACTGGAA TTTTCATACACGTAAATGCAGAAGTTACTAAGTATTAAGTATTACTGAGTATTAAGTAGTAATCTGTCAGTTATTAAAATTTGTAAAATC TATTTATGAAAGGTCATTAAACCAGATCATGTTCCTTTTTTTGTAATCAAGGTGACTAAGAAAATCAGTTGTGTAAATAAAATCATGTAT >In-frame_PCM1_ENST00000325083_chr8_17851129_+_RET_ENST00000340058_chr10_43612030_+_7099nt TCCGGCGGGTCACATGACTCCAGTCTAGCTCGCATTGCGGCTCCCGCCCGGGCGAGTTCTCGCCCCCGCGCGGCCGTTGCCGAGGAGACG GCGCATGTCCCGCCGCGCGTTGCCCCCTCTGCAGTACCCCCGCCCCTCTTCTCCCACCACAATGAGATCCTAAGATGGCGGTGGCTGCGG CGGTTGGCGCTGCGTAGCTGAGGTCGAAAAGGCGGCCACTGGGGCCGAGGCAGCCAGGAAACGTGTGGGCCTCTCTGCTGCGGTCTCCGA GGGCCGACCGCTGCCGGCGGCGGGTCGTGGGGGCTGACTGTCGCTCTGCCTTTGACAGGAGAGGCTGCTTCTTGTAGAGGAAACAGCTTT GAAGTGTGGAGCGGGAAAGGAGCAGTTTCTGAGCTGCAAAAACTAGTTTCTAAACAGAGAGTTAATTGTTAAATCCAGTATGGCCACAGG AGGAGGTCCCTTTGAAGATGGCATGAATGATCAGGATTTACCAAACTGGAGTAATGAGAATGTTGATGACAGGCTCAACAATATGGATTG GGGTGCCCAACAGAAGAAAGCAAATAGATCATCAGAAAAGAATAAGAAAAAGTTTGGTGTAGAAAGTGATAAAAGAGTAACCAATGATAT TTCTCCGGAGTCGTCACCAGGAGTTGGAAGGCGAAGAACAAAGACTCCACATACGTTCCCACACAGTAGATACATGAGTCAGATGTCTGT CCCAGAGCAGGCAGAATTAGAGAAACTGAAACAGCGGATAAACTTCAGTGATTTAGATCAGAGAAGCATTGGAAGTGATTCCCAAGGTAG AGCAACAGCTGCTAACAACAAACGTCAGCTTAGTGAAAACCGAAAGCCCTTCAACTTTTTGCCTATGCAGATTAATACTAACAAGAGCAA AGATGCATCTACAAACCCCCCAAACAGAGAAACGATTGGATCAGCACAGTGTAAAGAGTTGTTTGCTTCTGCTTTAAGTAATGACCTCTT GCAAAACTGTCAGGTGTCTGAAGAAGATGGGAGGGGAGAACCTGCAATGGAGAGCAGCCAGATTGTAAGCAGGCTTGTTCAAATTCGCGA TTATATTACTAAAGCTAGTTCCATGCGGGAAGATCTTGTAGAGAAAAATGAGAGATCTGCTAATGTTGAGCGCCTTACTCATCTAATAGA TCACCTTAAAGAACAAGAGAAGTCATATATGAAATTTCTTAAAAAAATCCTTGCCAGAGATCCTCAGCAGGAGCCTATGGAAGAGATAGA AAATTTGAAGAAACAACATGATTTATTAAAAAGAATGTTACAACAGCAGGAGCAACTAAGAGCTCTACAGGGACGGCAGGCTGCACTTCT AGCTCTGCAACATAAAGCAGAGCAAGCTATTGCAGTGATGGATGATTCTGTTGTTGCAGAAACTGCAGGTAGCTTATCTGGCGTCAGTAT CACATCTGAACTAAATGAAGAATTGAATGACTTAATTCAGCGTTTTCATAATCAGCTTCGTGATTCTCAGCCTCCAGCTGTTCCAGACAA TAGAAGACAGGCAGAAAGTCTTTCATTAACTAGGGAGGTTTCCCAGAGCAGGAAACCATCAGCTTCAGAACGTTTACCTGATGAGAAAGT CGAACTTTTTAGCAAAATGAGAGTGCTACAGGAAAAGAAACAAAAAATGGACAAATTGCTTGGAGAACTTCATACACTTCGAGATCAGCA TCTTAACAATTCATCATCCTCTCCACAAAGGAGTGTCGATCAGAGAAGTACTTCAGCTCCCTCTGCTTCTGTAGGCTTGGCACCGGTTGT CAATGGAGAATCCAATAGCCTCACATCATCTGTTCCTTATCCTACTGCTTCTCTAGTATCTCAGAATGAGAGTGAAAACGAAGGCCACCT CAATCCATCTGAAAAACTCCAGAAGTTAAATGAAGTTCGAAAGAGATTGAATGAGCTAAGAGAATTAGTTCATTATTATGAACAAACGTC AGACATGATGACAGATGCTGTGAATGAAAACAGGAAAGATGAAGAAACTGAAGAGTCAGAATATGATTCTGAGCATGAAAATTCCGAGCC TGTTACTAACATTCGAAATCCACAAGTAGCTTCCACTTGGAATGAAGTAAATAGTCATAGTAATGCACAGTGTGTTTCTAATAATAGAGA TGGGCGAACAGTTAATTCTAATTGTGAAATTAACAACAGATCTGCTGCCAACATAAGGGCTCTAAACATGCCTCCTTCTTTAGATTGTCG ATATAATAGAGAAGGGGAACAGGAGATTCATGTTGCACAAGGTGAAGATGATGAGGAGGAGGAGGAAGAAGCAGAAGAGGAGGGAGTCAG TGGAGCTTCATTATCTAGTCACAGGAGCAGTCTGGTTGATGAGCATCCAGAAGATGCTGAATTTGAACAGAAGATCAACCGACTTATGGC TGCAAAACAGAAACTTAGACAGTTACAAGATCTTGTTGCTATGGTACAGGATGATGATGCAGCTCAAGGAGTTATCTCTGCCAGTGCATC AAATTTGGATGATTTCTACCCAGCAGAAGAAGACACCAAGCAAAATTCAAATAACACTAGAGGAAATGCCAATAAAACACAGAAAGATAC TGGAGTAAATGAAAAGGCAAGAGAGAAATTTTATGAGGCTAAACTACAGCAGCAACAGAGAGAGCTAAAACAATTGCAGGAAGAAAGAAA GAAACTGATTGACATTCAGGAGAAAATTCAAGCATTGCAAACGGCATGCCCTGACTTACAGCTGTCAGCTGCTAGTGTGGGTAACTGTCC CACCAAAAAATATATGCCAGCTGTTACTTCAACCCCAACTGTTAATCAACACGAGACCAGTACAAGCAAATCTGTTTTTGAGCCTGAAGA TTCTTCAATAGTAGATAATGAGTTGTGGTCAGAAATGAGAAGACATGAAATGTTGAGGGAGGAGCTGCGACAGAGAAGAAAGCAGCTTGA AGCTCTGATGGCTGAACATCAGAGGAGGCAAGGTCTAGCTGAAACTGCATCTCCAGTGGCTGTGTCATTGAGAAGTGATGGATCTGAGAA CCTATGTACTCCTCAGCAAAGTAGAACAGAAAAAACGATGGCAACTTGGGGAGGGTCTACCCAGTGTGCACTAGATGAAGAAGGAGATGA AGACGGTTACCTTTCTGAAGGAATTGTTCGGACAGATGAAGAGGAGGAAGAAGAGCAAGATGCCAGTTCCAATGATAACTTTTCTGTGTG TCCTTCTAACAGTGTGAATCATAACTCCTACAATGGAAAGGAAACTAAAAATAGGTGGAAGAACAATTGCCCTTTTTCGGCAGATGAAAA TTATCGTCCTTTAGCCAAGACAAGGCAACAGAATATCAGCATGCAACGGCAAGAAAACCTTCGTTGGGTGTCAGAGCTCTCTTACGTAGA AGAGAAAGAACAATGGCAAGAACAAATCAATCAGCTAAAGAAACAGCTTGATTTTAGTGTCAGTATTTGTCAGACTTTGATGCAAGACCA GCAGACTCTATCTTGTCTGCTACAAACTCTTCTCACGGGTCCTTACAGTGTTATGCCCAGCAATGTTGCATCTCCTCAAGTACACTTCAT AATGCACCAGTTGAACCAGTGCTATACTCAGCTAACATGGCAACAGAATAATGTTCAGAGGTTGAAACAAATGCTAAATGAACTTATGCG CCAGCAAAATCAGCATCCAGAAAAACCTGGAGGCAAGGAAAGAGGCAGTAGTGCATCGCACCCTCCTTCTCCCAGTTTATTTTGTCCTTT CAGCTTTCCAACACAGCCTGTAAATCTCTTCAATATACCTGGATTTACTAACTTTTCATCATTTGCACCAGGTATGAATTTCAGCCCTTT ATTTCCTTCTAATTTTGGAGATTTTTCTCAGAATATCTCTACACCCAGTGAACAGCAGCAACCCTTAGCCCAGAATTCTTCAGGAAAAAC AGAATATATGGCTTTTCCAAAACCTTTTGAAAGCAGTTCCTCTATTGGAGCAGAGAAACCAAGGAATAAAAAACTGCCTGAAGAGGAGGT GGAAAGCAGTAGGACACCATGGTTATATGAACAAGAAGGTGAAGTAGAGAAACCATTTATCAAGACTGGATTTTCAGTGTCTGTAGAAAA ATCTACAAGTAGTAACCGCAAAAATCAATTAGATACAAACGGAAGAAGACGCCAGTTTGATGAAGAATCACTGGAAAGCTTTAGCAGTAT GCCTGATCCAGTAGATCCAACAACAGTGACTAAAACATTCAAGACAAGAAAAGCGTCTGCACAGGCCAGCCTGGCATCTAAAGATAAAAC TCCCAAGTCAAAAAGTAAGAAGAGGAATTCTACTCAGCTGAAAAGCAGAGTTAAAAACATCAGGTATGAAAGTGCCAGTATGTCTAGCAC ATGTGAACCTTGCAAAAGTAGGAACAGACATTCAGCCCAGACTGAAGAGCCTGTTCAAGCAAAAGTATTCAGCAGAAAGAATCATGAGCA ACTGGAAAAAATAATAAAATGTAATAGGTCTACAGAAATATCTTCAGAAACTGGGAGTGATTTTTCCATGTTTGAAGCTTTGCGAGATAC TATTTATTCTGAAGTAGCTACATTAATTTCTCAAAATGAATCTCGTCCACATTTTCTTATTGAACTCTTCCATGAGCTGCAGCTACTAAA CACAGACTACTTGAGACAGAGGGCTTTATATGCATTGCAGGACATAGTATCCAGACATATTTCTGAGAGCCATGAAAAAGGAGAAAATGT AAAGTCAGTAAACTCTGGTACTTGGATAGCATCAAACTCAGAACTTACTCCTAGTGAGAGCCTTGCTACTACTGATGATGAAACTTTTGA GAAGAACTTTGAAAGAGAAACCCATAAAATAAGTGAGCAAAATGATGCTGATAATGCTAGTGTCCTGTCTGTATCATCAAATTTTGAGCC TTTTGCAACAGATGATCTAGGTAACACCGTGATTCACTTAGATCAAGCATTAGCCAGAATGAGAGAATATGAGCGTATGAAGACTGAGGC TGAAAGTAACTCAAATATGAGATGCACCTGCAGGATTATTGAGGATGGAGATGGTGCTGGTGCAGGTACTACAGTTAATAATTTAGAAGA AACTCCCGTTATTGAAAATCGTAGTTCACAACAACCTGTAAGTGAAGTTTCTACCATCCCATGTCCTAGAATTGATACTCAGCAGCTGGA CCGGCAAATTAAAGCAATTATGAAAGAAGTCATTCCTTTTTTGAAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGG AAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGT GAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGT CATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCG CGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCAC CATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGC CAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAA GAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTT TGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGG CCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGT GTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCT GATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGAT TGAAAACAAACTCTATGGTAGAATTTCCCATGCATTTACTAGATTCTAGCACCGCTGTCCCCTTTGCACTATCCTTCCTCTCTGTGATGC TTTTTAAAAATGTTTCTGGTCTGAACAAAACCAAAGTCTGCTCTGAACCTTTTTATTTGTAAATGTCTGACTTTGCATCCAGTTTACATT TAGGCATTATTGCAACTATGTTTTTCTAAAAGGATGTGAAAATAAGTGTAATTACCACATTGCCCAGCAACTTAGGATGGTAGAGGAAAA AACAGATCAGGGCGGAACTCTCAGGGGAGACCAAGAACAGGTTGAATAAGGCGCTTCTGGGGTGGGAATCAAGTCATAGTACTTCTACTT TAACTAAGTGGATAAATATACAAATCTGGGGAGGTATTCAGTTGAGAAAGGAGCCACCAGCACCACTCAGCCTGCACTGGGAGCACAGCC AGGTTCCCCCAGACCCCTCCTGGGCAGGCAGGTGCCTCTCAGAGGCCACCCGGCACTGGCGAGCAGCCACTGGCCAAGCCTCAGCCCCAG TCCCAGCCACATGTCCTCCATCAGGGGTAGCGAGGTTGCAGGAGCTGGCTGGCCCTGGGAGGACGCACCCCCACTGCTGTTTTCACATCC TTTCCCTTACCCACCTTCAGGACGGTTGTCACTTATGAAGTCAGTGCTAAAGCTGGAGCAGTTGCTTTTTGAAAGAACATGGTCTGTGGT >In-frame_PCM1_ENST00000519253_chr8_17851129_+_RET_ENST00000355710_chr10_43612030_+_8345nt GCTGCGTAGCTGAGGTCGAAAAGGCGGCCACTGGGGCCGAGGCAGCCAGGAAACGTGTGGGCCTCTCTGCTGCGGTCTCCGAGGGCCGAC CGCTGCCGGCGGCGGGTCGTGGGGGCTGACTGTCGCTCTGCCTTTGACAGGAGAGGCTGCTTCTTGTAGAGGAAACAGCTTTGAAGTGTG GAGCGGGAAAGGAGCAGTTTCTGAGCTGCAAAAACTAGTTTCTAAACAGAGAGTTAATTGTTAAATCCAGTATGGCCACAGGAGGAGGTC CCTTTGAAGATGGCATGAATGATCAGGATTTACCAAACTGGAGTAATGAGAATGTTGATGACAGGCTCAACAATATGGATTGGGGTGCCC AACAGAAGAAAGCAAATAGATCATCAGAAAAGAATAAGAAAAAGTTTGGTGTAGAAAGTGATAAAAGAGTAACCAATGATATTTCTCCGG AGTCGTCACCAGGAGTTGGAAGGCGAAGAACAAAGACTCCACATACGTTCCCACACAGTAGATACATGAGTCAGATGTCTGTCCCAGAGC AGGCAGAATTAGAGAAACTGAAACAGCGGATAAACTTCAGTGATTTAGATCAGAGAAGCATTGGAAGTGATTCCCAAGGTAGAGCAACAG CTGCTAACAACAAACGTCAGCTTAGTGAAAACCGAAAGCCCTTCAACTTTTTGCCTATGCAGATTAATACTAACAAGAGCAAAGATGCAT CTACAAACCCCCCAAACAGAGAAACGATTGGATCAGCACAGTGTAAAGAGTTGTTTGCTTCTGCTTTAAGTAATGACCTCTTGCAAAACT GTCAGGTGTCTGAAGAAGATGGGAGGGGAGAACCTGCAATGGAGAGCAGCCAGATTGTAAGCAGGCTTGTTCAAATTCGCGATTATATTA CTAAAGCTAGTTCCATGCGGGAAGATCTTGTAGAGAAAAATGAGAGATCTGCTAATGTTGAGCGCCTTACTCATCTAATAGATCACCTTA AAGAACAAGAGAAGTCATATATGAAATTTCTTAAAAAAATCCTTGCCAGAGATCCTCAGCAGGAGCCTATGGAAGAGATAGAAAATTTGA AGAAACAACATGATTTATTAAAAAGAATGTTACAACAGCAGGAGCAACTAAGAGCTCTACAGGGACGGCAGGCTGCACTTCTAGCTCTGC AACATAAAGCAGAGCAAGCTATTGCAGTGATGGATGATTCTGTTGTTGCAGAAACTGCAGGTAGCTTATCTGGCGTCAGTATCACATCTG AACTAAATGAAGAATTGAATGACTTAATTCAGCGTTTTCATAATCAGCTTCGTGATTCTCAGCCTCCAGCTGTTCCAGACAATAGAAGAC AGGCAGAAAGTCTTTCATTAACTAGGGAGGTTTCCCAGAGCAGGAAACCATCAGCTTCAGAACGTTTACCTGATGAGAAAGTCGAACTTT TTAGCAAAATGAGAGTGCTACAGGAAAAGAAACAAAAAATGGACAAATTGCTTGGAGAACTTCATACACTTCGAGATCAGCATCTTAACA ATTCATCATCCTCTCCACAAAGGAGTGTCGATCAGAGAAGTACTTCAGCTCCCTCTGCTTCTGTAGGCTTGGCACCGGTTGTCAATGGAG AATCCAATAGCCTCACATCATCTGTTCCTTATCCTACTGCTTCTCTAGTATCTCAGAATGAGAGTGAAAACGAAGGCCACCTCAATCCAT CTGAAAAACTCCAGAAGTTAAATGAAGTTCGAAAGAGATTGAATGAGCTAAGAGAATTAGTTCATTATTATGAACAAACGTCAGACATGA TGACAGATGCTGTGAATGAAAACAGGAAAGATGAAGAAACTGAAGAGTCAGAATATGATTCTGAGCATGAAAATTCCGAGCCTGTTACTA ACATTCGAAATCCACAAGTAGCTTCCACTTGGAATGAAGTAAATAGTCATAGTAATGCACAGTGTGTTTCTAATAATAGAGATGGGCGAA CAGTTAATTCTAATTGTGAAATTAACAACAGATCTGCTGCCAACATAAGGGCTCTAAACATGCCTCCTTCTTTAGATTGTCGATATAATA GAGAAGGGGAACAGGAGATTCATGTTGCACAAGGTGAAGATGATGAGGAGGAGGAGGAAGAAGCAGAAGAGGAGGGAGTCAGTGGAGCTT CATTATCTAGTCACAGGAGCAGTCTGGTTGATGAGCATCCAGAAGATGCTGAATTTGAACAGAAGATCAACCGACTTATGGCTGCAAAAC AGAAACTTAGACAGTTACAAGATCTTGTTGCTATGGTACAGGATGATGATGCAGCTCAAGGAGTTATCTCTGCCAGTGCATCAAATTTGG ATGATTTCTACCCAGCAGAAGAAGACACCAAGCAAAATTCAAATAACACTAGAGGAAATGCCAATAAAACACAGAAAGATACTGGAGTAA ATGAAAAGGCAAGAGAGAAATTTTATGAGGCTAAACTACAGCAGCAACAGAGAGAGCTAAAACAATTGCAGGAAGAAAGAAAGAAACTGA TTGACATTCAGGAGAAAATTCAAGCATTGCAAACGGCATGCCCTGACTTACAGCTGTCAGCTGCTAGTGTGGGTAACTGTCCCACCAAAA AATATATGCCAGCTGTTACTTCAACCCCAACTGTTAATCAACACGAGACCAGTACAAGCAAATCTGTTTTTGAGCCTGAAGATTCTTCAA TAGTAGATAATGAGTTGTGGTCAGAAATGAGAAGACATGAAATGTTGAGGGAGGAGCTGCGACAGAGAAGAAAGCAGCTTGAAGCTCTGA TGGCTGAACATCAGAGGAGGCAAGGTCTAGCTGAAACTGCATCTCCAGTGGCTGTGTCATTGAGAAGTGATGGATCTGAGAACCTATGTA CTCCTCAGCAAAGTAGAACAGAAAAAACGATGGCAACTTGGGGAGGGTCTACCCAGTGTGCACTAGATGAAGAAGGAGATGAAGACGGTT ACCTTTCTGAAGGAATTGTTCGGACAGATGAAGAGGAGGAAGAAGAGCAAGATGCCAGTTCCAATGATAACTTTTCTGTGTGTCCTTCTA ACAGTGTGAATCATAACTCCTACAATGGAAAGGAAACTAAAAATAGGTGGAAGAACAATTGCCCTTTTTCGGCAGATGAAAATTATCGTC CTTTAGCCAAGACAAGGCAACAGAATATCAGCATGCAACGGCAAGAAAACCTTCGTTGGGTGTCAGAGCTCTCTTACGTAGAAGAGAAAG AACAATGGCAAGAACAAATCAATCAGCTAAAGAAACAGCTTGATTTTAGTGTCAGTATTTGTCAGACTTTGATGCAAGACCAGCAGACTC TATCTTGTCTGCTACAAACTCTTCTCACGGGTCCTTACAGTGTTATGCCCAGCAATGTTGCATCTCCTCAAGTACACTTCATAATGCACC AGTTGAACCAGTGCTATACTCAGCTAACATGGCAACAGAATAATGTTCAGAGGTTGAAACAAATGCTAAATGAACTTATGCGCCAGCAAA ATCAGCATCCAGAAAAACCTGGAGGCAAGGAAAGAGGCAGTAGTGCATCGCACCCTCCTTCTCCCAGTTTATTTTGTCCTTTCAGCTTTC CAACACAGCCTGTAAATCTCTTCAATATACCTGGATTTACTAACTTTTCATCATTTGCACCAGGTATGAATTTCAGCCCTTTATTTCCTT CTAATTTTGGAGATTTTTCTCAGAATATCTCTACACCCAGTGAACAGCAGCAACCCTTAGCCCAGAATTCTTCAGGAAAAACAGAATATA TGGCTTTTCCAAAACCTTTTGAAAGCAGTTCCTCTATTGGAGCAGAGAAACCAAGGAATAAAAAACTGCCTGAAGAGGAGGTGGAAAGCA GTAGGACACCATGGTTATATGAACAAGAAGGTGAAGTAGAGAAACCATTTATCAAGACTGGATTTTCAGTGTCTGTAGAAAAATCTACAA GTAGTAACCGCAAAAATCAATTAGATACAAACGGAAGAAGACGCCAGTTTGATGAAGAATCACTGGAAAGCTTTAGCAGTATGCCTGATC CAGTAGATCCAACAACAGTGACTAAAACATTCAAGACAAGAAAAGCGTCTGCACAGGCCAGCCTGGCATCTAAAGATAAAACTCCCAAGT CAAAAAGTAAGAAGAGGAATTCTACTCAGCTGAAAAGCAGAGTTAAAAACATCAGGTATGAAAGTGCCAGTATGTCTAGCACATGTGAAC CTTGCAAAAGTAGGAACAGACATTCAGCCCAGACTGAAGAGCCTGTTCAAGCAAAAGTATTCAGCAGAAAGAATCATGAGCAACTGGAAA AAATAATAAAATGTAATAGGTCTACAGAAATATCTTCAGAAACTGGGAGTGATTTTTCCATGTTTGAAGCTTTGCGAGATACTATTTATT CTGAAGTAGCTACATTAATTTCTCAAAATGAATCTCGTCCACATTTTCTTATTGAACTCTTCCATGAGCTGCAGCTACTAAACACAGACT ACTTGAGACAGAGGGCTTTATATGCATTGCAGGACATAGTATCCAGACATATTTCTGAGAGCCATGAAAAAGGAGAAAATGTAAAGTCAG TAAACTCTGGTACTTGGATAGCATCAAACTCAGAACTTACTCCTAGTGAGAGCCTTGCTACTACTGATGATGAAACTTTTGAGAAGAACT TTGAAAGAGAAACCCATAAAATAAGTGAGCAAAATGATGCTGATAATGCTAGTGTCCTGTCTGTATCATCAAATTTTGAGCCTTTTGCAA CAGATGATCTAGGTAACACCGTGATTCACTTAGATCAAGCATTAGCCAGAATGAGAGAATATGAGCGTATGAAGACTGAGGCTGAAAGTA ACTCAAATATGAGATGCACCTGCAGGATTATTGAGGATGGAGATGGTGCTGGTGCAGAAACTCCCGTTATTGAAAATCGTAGTTCACAAC AACCTGTAAGTGAAGTTTCTACCATCCCATGTCCTAGAATTGATACTCAGCAGCTGGACCGGCAAATTAAAGCAATTATGAAAGAAGTCA TTCCTTTTTTGAAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAG TGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTG AGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATG GCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGG GCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGA TCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGA TGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGA TGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAG GGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCG AGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGA TGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGA CACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGCATGTCAGACCCGA ACTGGCCTGGAGAGAGTCCTGTACCACTCACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATATCCAAATGATAGTGTATATGCTA ACTGGATGCTTTCACCCTCAGCGGCAAAATTAATGGACACGTTTGATAGTTAACATTTCTTTGTGAAAGGTAATGGACTCACAAGGGGAA GAAACATGCTGAGAATGGAAAGTCTACCGGCCCTTTCTTTGTGAACGTCACATTGGCCGAGCCGTGTTCAGTTCCCAGGTGGCAGACTCG TTTTTGGTAGTTTGTTTTAACTTCCAAGGTGGTTTTACTTCTGATAGCCGGTGATTTTCCCTCCTAGCAGACATGCCACACCGGGTAAGA GCTCTGAGTCTTAGTGGTTAAGCATTCCTTTCTCTTCAGTGCCCAGCAGCACCCAGTGTTGGTCTGTGTCCATCAGTGACCACCAACATT CTGTGTTCACATGTGTGGGTCCAACACTTACTACCTGGTGTATGAAATTGGACCTGAACTGTTGGATTTTTCTAGTTGCCGCCAAACAAG GCAAAAAAATTTAAACATGAAGCACACACACAAAAAAGGCAGTAGGAAAAATGCTGGCCCTGATGACCTGTCCTTATTCAGAATGAGAGA CTGCGGGGGGGGCCTGGGGGTAGTGTCAATGCCCCTCCAGGGCTGGAGGGGAAGAGGGGCCCCGAGGATGGGCCTGGGCTCAGCATTCGA GATCTTGAGAATGATTTTTTTTAAATCATGCAACCTTTCCTTAGGAAGACATTTGGTTTTCATCATGATTAAGATGATTCCTAGATTTAG CACAATGGAGAGATTCCATGCCATCTTTACTATGTGGATGGTGGTATCAGGGAAGAGGGCTCACAAGACACATTTGTCCCCCGGGCCCAC CACATCATCCTCACGTGTTCGGTACTGAGCAGCCACTACCCCTGATGAGAACAGTATGAAGAAAGGGGGCTGTTGGAGTCCCAGAATTGC TGACAGCAGAGGCTTTGCTGCTGTGAATCCCACCTGCCACCAGCCTGCAGCACACCCCACAGCCAAGTAGAGGCGAAAGCAGTGGCTCAT CCTACCTGTTAGGAGCAGGTAGGGCTTGTACTCACTTTAATTTGAATCTTATCAACTTACTCATAAAGGGACAGGCTAGCTAGCTGTGTT AGAAGTAGCAATGACAATGACCAAGGACTGCTACACCTCTGATTACAATTCTGATGTGAAAAAGATGGTGTTTGGCTCTTATAGAGCCTG TGTGAAAGGCCCATGGATCAGCTCTTCCTGTGTTTGTAATTTAATGCTGCTACAAGATGTTTCTGTTTCTTAGATTCTGACCATGACTCA TAAGCTTCTTGTCATTCTTCATTGCTTGTTTGTGGTCACAGATGCACAACACTCCTCCAGTCTTGTGGGGGCAGCTTTTGGGAAGTCTCA GCAGCTCTTCTGGCTGTGTTGTCAGCACTGTAACTTCGCAGAAAAGAGTCGGATTACCAAAACACTGCCTGCTCTTCAGACTTAAAGCAC TGATAGGACTTAAAATAGTCTCATTCAAATACTGTATTTTATATAGGCATTTCACAAAAACAGCAAAATTGTGGCATTTTGTGAGGCCAA GGCTTGGATGCGTGTGTAATAGAGCCTTGTGGTGTGTGCGCACACACCCAGAGGGAGAGTTTGAAAAATGCTTATTGGACACGTAACCTG GCTCTAATTTGGGCTGTTTTTCAGATACACTGTGATAAGTTCTTTTACAAATATCTATAGACATGGTAAACTTTTGGTTTTCAGATATGC TTAATGATAGTCTTACTAAATGCAGAAATAAGAATAAACTTTCTCAAATTATTAAAAATGCCTACACAGTAAGTGTGAATTGCTGCAACA GGTTTGTTCTCAGGAGGGTAAGAACTCCAGGTCTAAACAGCTGACCCAGTGATGGGGAATTTATCCTTGACCAATTTATCCTTGACCAAT AACCTAATTGTCTATTCCTGAGTTATAAAAGTCCCCATCCTTATTAGCTCTACTGGAATTTTCATACACGTAAATGCAGAAGTTACTAAG TATTAAGTATTACTGAGTATTAAGTAGTAATCTGTCAGTTATTAAAATTTGTAAAATCTATTTATGAAAGGTCATTAAACCAGATCATGT >In-frame_PCM1_ENST00000519253_chr8_17851129_+_RET_ENST00000340058_chr10_43612030_+_6887nt GCTGCGTAGCTGAGGTCGAAAAGGCGGCCACTGGGGCCGAGGCAGCCAGGAAACGTGTGGGCCTCTCTGCTGCGGTCTCCGAGGGCCGAC CGCTGCCGGCGGCGGGTCGTGGGGGCTGACTGTCGCTCTGCCTTTGACAGGAGAGGCTGCTTCTTGTAGAGGAAACAGCTTTGAAGTGTG GAGCGGGAAAGGAGCAGTTTCTGAGCTGCAAAAACTAGTTTCTAAACAGAGAGTTAATTGTTAAATCCAGTATGGCCACAGGAGGAGGTC CCTTTGAAGATGGCATGAATGATCAGGATTTACCAAACTGGAGTAATGAGAATGTTGATGACAGGCTCAACAATATGGATTGGGGTGCCC AACAGAAGAAAGCAAATAGATCATCAGAAAAGAATAAGAAAAAGTTTGGTGTAGAAAGTGATAAAAGAGTAACCAATGATATTTCTCCGG AGTCGTCACCAGGAGTTGGAAGGCGAAGAACAAAGACTCCACATACGTTCCCACACAGTAGATACATGAGTCAGATGTCTGTCCCAGAGC AGGCAGAATTAGAGAAACTGAAACAGCGGATAAACTTCAGTGATTTAGATCAGAGAAGCATTGGAAGTGATTCCCAAGGTAGAGCAACAG CTGCTAACAACAAACGTCAGCTTAGTGAAAACCGAAAGCCCTTCAACTTTTTGCCTATGCAGATTAATACTAACAAGAGCAAAGATGCAT CTACAAACCCCCCAAACAGAGAAACGATTGGATCAGCACAGTGTAAAGAGTTGTTTGCTTCTGCTTTAAGTAATGACCTCTTGCAAAACT GTCAGGTGTCTGAAGAAGATGGGAGGGGAGAACCTGCAATGGAGAGCAGCCAGATTGTAAGCAGGCTTGTTCAAATTCGCGATTATATTA CTAAAGCTAGTTCCATGCGGGAAGATCTTGTAGAGAAAAATGAGAGATCTGCTAATGTTGAGCGCCTTACTCATCTAATAGATCACCTTA AAGAACAAGAGAAGTCATATATGAAATTTCTTAAAAAAATCCTTGCCAGAGATCCTCAGCAGGAGCCTATGGAAGAGATAGAAAATTTGA AGAAACAACATGATTTATTAAAAAGAATGTTACAACAGCAGGAGCAACTAAGAGCTCTACAGGGACGGCAGGCTGCACTTCTAGCTCTGC AACATAAAGCAGAGCAAGCTATTGCAGTGATGGATGATTCTGTTGTTGCAGAAACTGCAGGTAGCTTATCTGGCGTCAGTATCACATCTG AACTAAATGAAGAATTGAATGACTTAATTCAGCGTTTTCATAATCAGCTTCGTGATTCTCAGCCTCCAGCTGTTCCAGACAATAGAAGAC AGGCAGAAAGTCTTTCATTAACTAGGGAGGTTTCCCAGAGCAGGAAACCATCAGCTTCAGAACGTTTACCTGATGAGAAAGTCGAACTTT TTAGCAAAATGAGAGTGCTACAGGAAAAGAAACAAAAAATGGACAAATTGCTTGGAGAACTTCATACACTTCGAGATCAGCATCTTAACA ATTCATCATCCTCTCCACAAAGGAGTGTCGATCAGAGAAGTACTTCAGCTCCCTCTGCTTCTGTAGGCTTGGCACCGGTTGTCAATGGAG AATCCAATAGCCTCACATCATCTGTTCCTTATCCTACTGCTTCTCTAGTATCTCAGAATGAGAGTGAAAACGAAGGCCACCTCAATCCAT CTGAAAAACTCCAGAAGTTAAATGAAGTTCGAAAGAGATTGAATGAGCTAAGAGAATTAGTTCATTATTATGAACAAACGTCAGACATGA TGACAGATGCTGTGAATGAAAACAGGAAAGATGAAGAAACTGAAGAGTCAGAATATGATTCTGAGCATGAAAATTCCGAGCCTGTTACTA ACATTCGAAATCCACAAGTAGCTTCCACTTGGAATGAAGTAAATAGTCATAGTAATGCACAGTGTGTTTCTAATAATAGAGATGGGCGAA CAGTTAATTCTAATTGTGAAATTAACAACAGATCTGCTGCCAACATAAGGGCTCTAAACATGCCTCCTTCTTTAGATTGTCGATATAATA GAGAAGGGGAACAGGAGATTCATGTTGCACAAGGTGAAGATGATGAGGAGGAGGAGGAAGAAGCAGAAGAGGAGGGAGTCAGTGGAGCTT CATTATCTAGTCACAGGAGCAGTCTGGTTGATGAGCATCCAGAAGATGCTGAATTTGAACAGAAGATCAACCGACTTATGGCTGCAAAAC AGAAACTTAGACAGTTACAAGATCTTGTTGCTATGGTACAGGATGATGATGCAGCTCAAGGAGTTATCTCTGCCAGTGCATCAAATTTGG ATGATTTCTACCCAGCAGAAGAAGACACCAAGCAAAATTCAAATAACACTAGAGGAAATGCCAATAAAACACAGAAAGATACTGGAGTAA ATGAAAAGGCAAGAGAGAAATTTTATGAGGCTAAACTACAGCAGCAACAGAGAGAGCTAAAACAATTGCAGGAAGAAAGAAAGAAACTGA TTGACATTCAGGAGAAAATTCAAGCATTGCAAACGGCATGCCCTGACTTACAGCTGTCAGCTGCTAGTGTGGGTAACTGTCCCACCAAAA AATATATGCCAGCTGTTACTTCAACCCCAACTGTTAATCAACACGAGACCAGTACAAGCAAATCTGTTTTTGAGCCTGAAGATTCTTCAA TAGTAGATAATGAGTTGTGGTCAGAAATGAGAAGACATGAAATGTTGAGGGAGGAGCTGCGACAGAGAAGAAAGCAGCTTGAAGCTCTGA TGGCTGAACATCAGAGGAGGCAAGGTCTAGCTGAAACTGCATCTCCAGTGGCTGTGTCATTGAGAAGTGATGGATCTGAGAACCTATGTA CTCCTCAGCAAAGTAGAACAGAAAAAACGATGGCAACTTGGGGAGGGTCTACCCAGTGTGCACTAGATGAAGAAGGAGATGAAGACGGTT ACCTTTCTGAAGGAATTGTTCGGACAGATGAAGAGGAGGAAGAAGAGCAAGATGCCAGTTCCAATGATAACTTTTCTGTGTGTCCTTCTA ACAGTGTGAATCATAACTCCTACAATGGAAAGGAAACTAAAAATAGGTGGAAGAACAATTGCCCTTTTTCGGCAGATGAAAATTATCGTC CTTTAGCCAAGACAAGGCAACAGAATATCAGCATGCAACGGCAAGAAAACCTTCGTTGGGTGTCAGAGCTCTCTTACGTAGAAGAGAAAG AACAATGGCAAGAACAAATCAATCAGCTAAAGAAACAGCTTGATTTTAGTGTCAGTATTTGTCAGACTTTGATGCAAGACCAGCAGACTC TATCTTGTCTGCTACAAACTCTTCTCACGGGTCCTTACAGTGTTATGCCCAGCAATGTTGCATCTCCTCAAGTACACTTCATAATGCACC AGTTGAACCAGTGCTATACTCAGCTAACATGGCAACAGAATAATGTTCAGAGGTTGAAACAAATGCTAAATGAACTTATGCGCCAGCAAA ATCAGCATCCAGAAAAACCTGGAGGCAAGGAAAGAGGCAGTAGTGCATCGCACCCTCCTTCTCCCAGTTTATTTTGTCCTTTCAGCTTTC CAACACAGCCTGTAAATCTCTTCAATATACCTGGATTTACTAACTTTTCATCATTTGCACCAGGTATGAATTTCAGCCCTTTATTTCCTT CTAATTTTGGAGATTTTTCTCAGAATATCTCTACACCCAGTGAACAGCAGCAACCCTTAGCCCAGAATTCTTCAGGAAAAACAGAATATA TGGCTTTTCCAAAACCTTTTGAAAGCAGTTCCTCTATTGGAGCAGAGAAACCAAGGAATAAAAAACTGCCTGAAGAGGAGGTGGAAAGCA GTAGGACACCATGGTTATATGAACAAGAAGGTGAAGTAGAGAAACCATTTATCAAGACTGGATTTTCAGTGTCTGTAGAAAAATCTACAA GTAGTAACCGCAAAAATCAATTAGATACAAACGGAAGAAGACGCCAGTTTGATGAAGAATCACTGGAAAGCTTTAGCAGTATGCCTGATC CAGTAGATCCAACAACAGTGACTAAAACATTCAAGACAAGAAAAGCGTCTGCACAGGCCAGCCTGGCATCTAAAGATAAAACTCCCAAGT CAAAAAGTAAGAAGAGGAATTCTACTCAGCTGAAAAGCAGAGTTAAAAACATCAGGTATGAAAGTGCCAGTATGTCTAGCACATGTGAAC CTTGCAAAAGTAGGAACAGACATTCAGCCCAGACTGAAGAGCCTGTTCAAGCAAAAGTATTCAGCAGAAAGAATCATGAGCAACTGGAAA AAATAATAAAATGTAATAGGTCTACAGAAATATCTTCAGAAACTGGGAGTGATTTTTCCATGTTTGAAGCTTTGCGAGATACTATTTATT CTGAAGTAGCTACATTAATTTCTCAAAATGAATCTCGTCCACATTTTCTTATTGAACTCTTCCATGAGCTGCAGCTACTAAACACAGACT ACTTGAGACAGAGGGCTTTATATGCATTGCAGGACATAGTATCCAGACATATTTCTGAGAGCCATGAAAAAGGAGAAAATGTAAAGTCAG TAAACTCTGGTACTTGGATAGCATCAAACTCAGAACTTACTCCTAGTGAGAGCCTTGCTACTACTGATGATGAAACTTTTGAGAAGAACT TTGAAAGAGAAACCCATAAAATAAGTGAGCAAAATGATGCTGATAATGCTAGTGTCCTGTCTGTATCATCAAATTTTGAGCCTTTTGCAA CAGATGATCTAGGTAACACCGTGATTCACTTAGATCAAGCATTAGCCAGAATGAGAGAATATGAGCGTATGAAGACTGAGGCTGAAAGTA ACTCAAATATGAGATGCACCTGCAGGATTATTGAGGATGGAGATGGTGCTGGTGCAGAAACTCCCGTTATTGAAAATCGTAGTTCACAAC AACCTGTAAGTGAAGTTTCTACCATCCCATGTCCTAGAATTGATACTCAGCAGCTGGACCGGCAAATTAAAGCAATTATGAAAGAAGTCA TTCCTTTTTTGAAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAG TGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTG AGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATG GCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGG GCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGA TCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGA TGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGA TGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAG GGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCG AGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGA TGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGA CACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGTAGAATTTCCCATG CATTTACTAGATTCTAGCACCGCTGTCCCCTTTGCACTATCCTTCCTCTCTGTGATGCTTTTTAAAAATGTTTCTGGTCTGAACAAAACC AAAGTCTGCTCTGAACCTTTTTATTTGTAAATGTCTGACTTTGCATCCAGTTTACATTTAGGCATTATTGCAACTATGTTTTTCTAAAAG GATGTGAAAATAAGTGTAATTACCACATTGCCCAGCAACTTAGGATGGTAGAGGAAAAAACAGATCAGGGCGGAACTCTCAGGGGAGACC AAGAACAGGTTGAATAAGGCGCTTCTGGGGTGGGAATCAAGTCATAGTACTTCTACTTTAACTAAGTGGATAAATATACAAATCTGGGGA GGTATTCAGTTGAGAAAGGAGCCACCAGCACCACTCAGCCTGCACTGGGAGCACAGCCAGGTTCCCCCAGACCCCTCCTGGGCAGGCAGG TGCCTCTCAGAGGCCACCCGGCACTGGCGAGCAGCCACTGGCCAAGCCTCAGCCCCAGTCCCAGCCACATGTCCTCCATCAGGGGTAGCG AGGTTGCAGGAGCTGGCTGGCCCTGGGAGGACGCACCCCCACTGCTGTTTTCACATCCTTTCCCTTACCCACCTTCAGGACGGTTGTCAC TTATGAAGTCAGTGCTAAAGCTGGAGCAGTTGCTTTTTGAAAGAACATGGTCTGTGGTGCTGTGGTCTTACAATGGACAGTAAATATGGT >In-frame_PCM1_ENST00000524226_chr8_17851129_+_RET_ENST00000355710_chr10_43612030_+_8015nt AGCAGTTTCTGAGCTGCAAAAACTAGTTTCTAAACAGAGAGTTAATTGTTAAATCCAGTATGGCCACAGGAGGAGGTCCCTTTGAAGATG GCATGAATGATCAGGATTTACCAAACTGGAGTAATGAGAATGTTGATGACAGGCTCAACAATATGGATTGGGGTGCCCAACAGAAGAAAG CAAATAGATCATCAGAAAAGAATAAGAAAAAGTTTGGTGTAGAAAGTGATAAAAGAGTAACCAATGATATTTCTCCGGAGTCGTCACCAG GAGTTGGAAGGCGAAGAACAAAGACTCCACATACGTTCCCACACAGTAGATACATGAGTCAGATGTCTGTCCCAGAGCAGGCAGAATTAG AGAAACTGAAACAGCGGATAAACTTCAGTGATTTAGATCAGAGAAGCATTGGAAGTGATTCCCAAGGTAGAGCAACAGCTGCTAACAACA AACGTCAGCTTAGTGAAAACCGAAAGCCCTTCAACTTTTTGCCTATGCAGATTAATACTAACAAGAGCAAAGATGCATCTACAAACCCCC CAAACAGAGAAACGATTGGATCAGCACAGTGTAAAGAGTTGTTTGCTTCTGCTTTAAGTAATGACCTCTTGCAAAACTGTCAGGTGTCTG AAGAAGATGGGAGGGGAGAACCTGCAATGGAGAGCAGCCAGATTGTAAGCAGGCTTGTTCAAATTCGCGATTATATTACTAAAGCTAGTT CCATGCGGGAAGATCTTGTAGAGAAAAATGAGAGATCTGCTAATGTTGAGCGCCTTACTCATCTAATAGATCACCTTAAAGAACAAGAGA AGTCATATATGAAATTTCTTAAAAAAATCCTTGCCAGAGATCCTCAGCAGGAGCCTATGGAAGAGATAGAAAATTTGAAGAAACAACATG ATTTATTAAAAAGAATGTTACAACAGCAGGAGCAACTAAGAGCTCTACAGGGACGGCAGGCTGCACTTCTAGCTCTGCAACATAAAGCAG AGCAAGCTATTGCAGTGATGGATGATTCTGTTGTTGCAGAAACTGCAGGTAGCTTATCTGGCGTCAGTATCACATCTGAACTAAATGAAG AATTGAATGACTTAATTCAGCGTTTTCATAATCAGCTTCGTGATTCTCAGCCTCCAGCTGTTCCAGACAATAGAAGACAGGCAGAAAGTC TTTCATTAACTAGGGAGGTTTCCCAGAGCAGGAAACCATCAGCTTCAGAACGTTTACCTGATGAGAAAGTCGAACTTTTTAGCAAAATGA GAGTGCTACAGGAAAAGAAACAAAAAATGGACAAATTGCTTGGAGAACTTCATACACTTCGAGATCAGCATCTTAACAATTCATCATCCT CTCCACAAAGGAGTGTCGATCAGAGAAGTACTTCAGCTCCCTCTGCTTCTGTAGGCTTGGCACCGGTTGTCAATGGAGAATCCAATAGCC TCACATCATCTGTTCCTTATCCTACTGCTTCTCTAGTATCTCAGAATGAGAGTGAAAACGAAGGCCACCTCAATCCATCTGAAAAACTCC AGAAGTTAAATGAAGTTCGAAAGAGATTGAATGAGCTAAGAGAATTAGTTCATTATTATGAACAAACGTCAGACATGATGACAGATGCTG TGAATGAAAACAGGAAAGATGAAGAAACTGAAGAGTCAGAATATGATTCTGAGCATGAAAATTCCGAGCCTGTTACTAACATTCGAAATC CACAAGTAGCTTCCACTTGGAATGAAGTAAATAGTCATAGTAATGCACAGTGTGTTTCTAATAATAGAGATGGGCGAACAGTTAATTCTA ATTGTGAAATTAACAACAGATCTGCTGCCAACATAAGGGCTCTAAACATGCCTCCTTCTTTAGCAGATTGTCGATATAATAGAGAAGGGG AACAGGAGATTCATGTTGCACAAGGTGAAGATGATGAGGAGGAGGAGGAAGAAGCAGAAGAGGAGGGAGTCAGTGGAGCTTCATTATCTA GTCACAGGAGCAGTCTGGTTGATGAGCATCCAGAAGATGCTGAATTTGAACAGAAGATCAACCGACTTATGGCTGCAAAACAGAAACTTA GACAGTTACAAGATCTTGTTGCTATGGTACAGGATGATGATGCAGCTCAAGGAGTTATCTCTGCCAGTGCATCAAATTTGGATGATTTCT ACCCAGCAGAAGAAGACACCAAGCAAAATTCAAATAACACTAGAGGAAATGCCAATAAAACACAGAAAGATACTGGAGTAAATGAAAAGG CAAGAGAGAAATTTTATGAGGCTAAACTACAGCAGCAACAGAGAGAGCTAAAACAATTGCAGGAAGAAAGAAAGAAACTGATTGACATTC AGGAGAAAATTCAAGCATTGCAAACGGCATGCCCTGACTTACAGCTGTCAGCTGCTAGTGTGGGTAACTGTCCCACCAAAAAATATATGC CAGCTGTTACTTCAACCCCAACTGTTAATCAACACGAGACCAGTACAAGCAAATCTGTTTTTGAGCCTGAAGATTCTTCAATAGTAGATA ATGAGTTGTGGTCAGAAATGAGAAGACATGAAATGTTGAGGGAGGAGCTGCGACAGAGAAGAAAGCAGCTTGAAGCTCTGATGGCTGAAC ATCAGAGGAGGCAAGGTCTAGCTGAAACTGCATCTCCAGTGGCTGTGTCATTGAGAAGTGATGGATCTGAGAACCTATGTACTCCTCAGC AAAGTAGAACAGAAAAAACGATGGCAACTTGGGGAGGGTCTACCCAGTGTGCACTAGATGAAGAAGGAGATGAAGACGGTTACCTTTCTG AAGGAATTGTTCGGACAGATGAAGAGGAGGAAGAAGAGCAAGATGCCAGTTCCAATGATAACTTTTCTGTGTGTCCTTCTAACAGTGTGA ATCATAACTCCTACAATGGAAAGGAAACTAAAAATAGGTGGAAGAACAATTGCCCTTTTTCGGCAGATGAAAATTATCGTCCTTTAGCCA AGACAAGGCAACAGAATATCAGCATGCAACGGCAAGAAAACCTTCGTTGGGTGTCAGAGCTCTCTTACGTAGAAGAGAAAGAACAATGGC AAGAACAAATCAATCAGCTAAAGAAACAGCTTGATTTTAGTGTCAGTATTTGTCAGACTTTGATGCAAGACCAGCAGACTCTATCTTGTC TGCTACAAACTCTTCTCACGGGTCCTTACAGTGTTATGCCCAGCAATGTTGCATCTCCTCAAGTACACTTCATAATGCACCAGTTGAACC AGTGCTATACTCAGCTAACATGGCAACAGAATAATGTTCAGAGGTTGAAACAAATGCTAAATGAACTTATGCGCCAGCAAAATCAGCATC CAGAAAAACCTGGAGGCAAGGAAAGAGGCAGTAGTGCATCGCACCCTCCTTCTCCCAGTTTATTTTGTCCTTTCAGCTTTCCAACACAGC CTGTAAATCTCTTCAATATACCTGGATTTACTAACTTTTCATCATTTGCACCAGGTATGAATTTCAGCCCTTTATTTCCTTCTAATTTTG GAGATTTTTCTCAGAATATCTCTACACCCAGTGAACAGCAGCAACCCTTAGCCCAGAATTCTTCAGGAAAAACAGAATATATGGCTTTTC CAAAACCTTTTGAAAGCAGTTCCTCTATTGGAGCAGAGAAACCAAGGAATAAAAAACTGCCTGAAGAGGAGGTGGAAAGCAGTAGGACAC CATGGTTATATGAACAAGAAGGTGAAGTAGAGAAACCATTTATCAAGACTGGATTTTCAGTGTCTGTAGAAAAATCTACAAGTAGTAACC GCAAAAATCAATTAGATACAAACGGAAGAAGACGCCAGTTTGATGAAGAATCACTGGAAAGCTTTAGCAGTATGCCTGATCCAGTAGATC CAACAACAGTGACTAAAACATTCAAGACAAGAAAAGCGTCTGCACAGGCCAGCCTGGCATCTAAAGATAAAACTCCCAAGTCAAAAAGTA AGAAGAGGAATTCTACTCAGCTGAAAAGCAGAGTTAAAAACATCAAAACTGGGAGTGATTTTTCCATGTTTGAAGCTTTGCGAGATACTA TTTATTCTGAAGTAGCTACATTAATTTCTCAAAATGAATCTCGTCCACATTTTCTTATTGAACTCTTCCATGAGCTGCAGCTACTAAACA CAGACTACTTGAGACAGAGGGCTTTATATGCATTGCAGGACATAGTATCCAGACATATTTCTGAGAGCCATGAAAAAGGAGAAAATGTAA AGTCAGTAAACTCTGGTACTTGGATAGCATCAAACTCAGAACTTACTCCTAGTGAGAGCCTTGCTACTACTGATGATGAAACTTTTGAGA AGAACTTTGAAAGAGAAACCCATAAAATAAGTGAGCAAAATGATGCTGATAATGCTAGTGTCCTGTCTGTATCATCAAATTTTGAGCCTT TTGCAACAGATGATCTAGGTAACACCGTGATTCACTTAGATCAAGCATTAGCCAGAATGAGAGAATATGAGCGTATGAAGACTGAGGCTG AAAGTAACTCAAATATGAGATGCACCTGCAGGATTATTGAGGATGGAGATGGTGCTGGTGCAGGTACTACAGTTAATAATTTAGAAGAAA CTCCCGTTATTGAAAATCGTAGTTCACAACAACCTGTAAGTGAAGTTTCTACCATCCCATGTCCTAGAATTGATACTCAGCAGCTGGACC GGCAAATTAAAGCAATTATGAAAGAAGTCATTCCTTTTTTGAAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAA AAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGA AGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCA TCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCG AGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCA TGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCA GAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGA GGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTG GTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCC ACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGT TTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGA TTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTG AAAACAAACTCTATGGCATGTCAGACCCGAACTGGCCTGGAGAGAGTCCTGTACCACTCACGAGAGCTGATGGCACTAACACTGGGTTTC CAAGATATCCAAATGATAGTGTATATGCTAACTGGATGCTTTCACCCTCAGCGGCAAAATTAATGGACACGTTTGATAGTTAACATTTCT TTGTGAAAGGTAATGGACTCACAAGGGGAAGAAACATGCTGAGAATGGAAAGTCTACCGGCCCTTTCTTTGTGAACGTCACATTGGCCGA GCCGTGTTCAGTTCCCAGGTGGCAGACTCGTTTTTGGTAGTTTGTTTTAACTTCCAAGGTGGTTTTACTTCTGATAGCCGGTGATTTTCC CTCCTAGCAGACATGCCACACCGGGTAAGAGCTCTGAGTCTTAGTGGTTAAGCATTCCTTTCTCTTCAGTGCCCAGCAGCACCCAGTGTT GGTCTGTGTCCATCAGTGACCACCAACATTCTGTGTTCACATGTGTGGGTCCAACACTTACTACCTGGTGTATGAAATTGGACCTGAACT GTTGGATTTTTCTAGTTGCCGCCAAACAAGGCAAAAAAATTTAAACATGAAGCACACACACAAAAAAGGCAGTAGGAAAAATGCTGGCCC TGATGACCTGTCCTTATTCAGAATGAGAGACTGCGGGGGGGGCCTGGGGGTAGTGTCAATGCCCCTCCAGGGCTGGAGGGGAAGAGGGGC CCCGAGGATGGGCCTGGGCTCAGCATTCGAGATCTTGAGAATGATTTTTTTTAAATCATGCAACCTTTCCTTAGGAAGACATTTGGTTTT CATCATGATTAAGATGATTCCTAGATTTAGCACAATGGAGAGATTCCATGCCATCTTTACTATGTGGATGGTGGTATCAGGGAAGAGGGC TCACAAGACACATTTGTCCCCCGGGCCCACCACATCATCCTCACGTGTTCGGTACTGAGCAGCCACTACCCCTGATGAGAACAGTATGAA GAAAGGGGGCTGTTGGAGTCCCAGAATTGCTGACAGCAGAGGCTTTGCTGCTGTGAATCCCACCTGCCACCAGCCTGCAGCACACCCCAC AGCCAAGTAGAGGCGAAAGCAGTGGCTCATCCTACCTGTTAGGAGCAGGTAGGGCTTGTACTCACTTTAATTTGAATCTTATCAACTTAC TCATAAAGGGACAGGCTAGCTAGCTGTGTTAGAAGTAGCAATGACAATGACCAAGGACTGCTACACCTCTGATTACAATTCTGATGTGAA AAAGATGGTGTTTGGCTCTTATAGAGCCTGTGTGAAAGGCCCATGGATCAGCTCTTCCTGTGTTTGTAATTTAATGCTGCTACAAGATGT TTCTGTTTCTTAGATTCTGACCATGACTCATAAGCTTCTTGTCATTCTTCATTGCTTGTTTGTGGTCACAGATGCACAACACTCCTCCAG TCTTGTGGGGGCAGCTTTTGGGAAGTCTCAGCAGCTCTTCTGGCTGTGTTGTCAGCACTGTAACTTCGCAGAAAAGAGTCGGATTACCAA AACACTGCCTGCTCTTCAGACTTAAAGCACTGATAGGACTTAAAATAGTCTCATTCAAATACTGTATTTTATATAGGCATTTCACAAAAA CAGCAAAATTGTGGCATTTTGTGAGGCCAAGGCTTGGATGCGTGTGTAATAGAGCCTTGTGGTGTGTGCGCACACACCCAGAGGGAGAGT TTGAAAAATGCTTATTGGACACGTAACCTGGCTCTAATTTGGGCTGTTTTTCAGATACACTGTGATAAGTTCTTTTACAAATATCTATAG ACATGGTAAACTTTTGGTTTTCAGATATGCTTAATGATAGTCTTACTAAATGCAGAAATAAGAATAAACTTTCTCAAATTATTAAAAATG CCTACACAGTAAGTGTGAATTGCTGCAACAGGTTTGTTCTCAGGAGGGTAAGAACTCCAGGTCTAAACAGCTGACCCAGTGATGGGGAAT TTATCCTTGACCAATTTATCCTTGACCAATAACCTAATTGTCTATTCCTGAGTTATAAAAGTCCCCATCCTTATTAGCTCTACTGGAATT TTCATACACGTAAATGCAGAAGTTACTAAGTATTAAGTATTACTGAGTATTAAGTAGTAATCTGTCAGTTATTAAAATTTGTAAAATCTA TTTATGAAAGGTCATTAAACCAGATCATGTTCCTTTTTTTGTAATCAAGGTGACTAAGAAAATCAGTTGTGTAAATAAAATCATGTATCA >In-frame_PCM1_ENST00000524226_chr8_17851129_+_RET_ENST00000340058_chr10_43612030_+_6557nt AGCAGTTTCTGAGCTGCAAAAACTAGTTTCTAAACAGAGAGTTAATTGTTAAATCCAGTATGGCCACAGGAGGAGGTCCCTTTGAAGATG GCATGAATGATCAGGATTTACCAAACTGGAGTAATGAGAATGTTGATGACAGGCTCAACAATATGGATTGGGGTGCCCAACAGAAGAAAG CAAATAGATCATCAGAAAAGAATAAGAAAAAGTTTGGTGTAGAAAGTGATAAAAGAGTAACCAATGATATTTCTCCGGAGTCGTCACCAG GAGTTGGAAGGCGAAGAACAAAGACTCCACATACGTTCCCACACAGTAGATACATGAGTCAGATGTCTGTCCCAGAGCAGGCAGAATTAG AGAAACTGAAACAGCGGATAAACTTCAGTGATTTAGATCAGAGAAGCATTGGAAGTGATTCCCAAGGTAGAGCAACAGCTGCTAACAACA AACGTCAGCTTAGTGAAAACCGAAAGCCCTTCAACTTTTTGCCTATGCAGATTAATACTAACAAGAGCAAAGATGCATCTACAAACCCCC CAAACAGAGAAACGATTGGATCAGCACAGTGTAAAGAGTTGTTTGCTTCTGCTTTAAGTAATGACCTCTTGCAAAACTGTCAGGTGTCTG AAGAAGATGGGAGGGGAGAACCTGCAATGGAGAGCAGCCAGATTGTAAGCAGGCTTGTTCAAATTCGCGATTATATTACTAAAGCTAGTT CCATGCGGGAAGATCTTGTAGAGAAAAATGAGAGATCTGCTAATGTTGAGCGCCTTACTCATCTAATAGATCACCTTAAAGAACAAGAGA AGTCATATATGAAATTTCTTAAAAAAATCCTTGCCAGAGATCCTCAGCAGGAGCCTATGGAAGAGATAGAAAATTTGAAGAAACAACATG ATTTATTAAAAAGAATGTTACAACAGCAGGAGCAACTAAGAGCTCTACAGGGACGGCAGGCTGCACTTCTAGCTCTGCAACATAAAGCAG AGCAAGCTATTGCAGTGATGGATGATTCTGTTGTTGCAGAAACTGCAGGTAGCTTATCTGGCGTCAGTATCACATCTGAACTAAATGAAG AATTGAATGACTTAATTCAGCGTTTTCATAATCAGCTTCGTGATTCTCAGCCTCCAGCTGTTCCAGACAATAGAAGACAGGCAGAAAGTC TTTCATTAACTAGGGAGGTTTCCCAGAGCAGGAAACCATCAGCTTCAGAACGTTTACCTGATGAGAAAGTCGAACTTTTTAGCAAAATGA GAGTGCTACAGGAAAAGAAACAAAAAATGGACAAATTGCTTGGAGAACTTCATACACTTCGAGATCAGCATCTTAACAATTCATCATCCT CTCCACAAAGGAGTGTCGATCAGAGAAGTACTTCAGCTCCCTCTGCTTCTGTAGGCTTGGCACCGGTTGTCAATGGAGAATCCAATAGCC TCACATCATCTGTTCCTTATCCTACTGCTTCTCTAGTATCTCAGAATGAGAGTGAAAACGAAGGCCACCTCAATCCATCTGAAAAACTCC AGAAGTTAAATGAAGTTCGAAAGAGATTGAATGAGCTAAGAGAATTAGTTCATTATTATGAACAAACGTCAGACATGATGACAGATGCTG TGAATGAAAACAGGAAAGATGAAGAAACTGAAGAGTCAGAATATGATTCTGAGCATGAAAATTCCGAGCCTGTTACTAACATTCGAAATC CACAAGTAGCTTCCACTTGGAATGAAGTAAATAGTCATAGTAATGCACAGTGTGTTTCTAATAATAGAGATGGGCGAACAGTTAATTCTA ATTGTGAAATTAACAACAGATCTGCTGCCAACATAAGGGCTCTAAACATGCCTCCTTCTTTAGCAGATTGTCGATATAATAGAGAAGGGG AACAGGAGATTCATGTTGCACAAGGTGAAGATGATGAGGAGGAGGAGGAAGAAGCAGAAGAGGAGGGAGTCAGTGGAGCTTCATTATCTA GTCACAGGAGCAGTCTGGTTGATGAGCATCCAGAAGATGCTGAATTTGAACAGAAGATCAACCGACTTATGGCTGCAAAACAGAAACTTA GACAGTTACAAGATCTTGTTGCTATGGTACAGGATGATGATGCAGCTCAAGGAGTTATCTCTGCCAGTGCATCAAATTTGGATGATTTCT ACCCAGCAGAAGAAGACACCAAGCAAAATTCAAATAACACTAGAGGAAATGCCAATAAAACACAGAAAGATACTGGAGTAAATGAAAAGG CAAGAGAGAAATTTTATGAGGCTAAACTACAGCAGCAACAGAGAGAGCTAAAACAATTGCAGGAAGAAAGAAAGAAACTGATTGACATTC AGGAGAAAATTCAAGCATTGCAAACGGCATGCCCTGACTTACAGCTGTCAGCTGCTAGTGTGGGTAACTGTCCCACCAAAAAATATATGC CAGCTGTTACTTCAACCCCAACTGTTAATCAACACGAGACCAGTACAAGCAAATCTGTTTTTGAGCCTGAAGATTCTTCAATAGTAGATA ATGAGTTGTGGTCAGAAATGAGAAGACATGAAATGTTGAGGGAGGAGCTGCGACAGAGAAGAAAGCAGCTTGAAGCTCTGATGGCTGAAC ATCAGAGGAGGCAAGGTCTAGCTGAAACTGCATCTCCAGTGGCTGTGTCATTGAGAAGTGATGGATCTGAGAACCTATGTACTCCTCAGC AAAGTAGAACAGAAAAAACGATGGCAACTTGGGGAGGGTCTACCCAGTGTGCACTAGATGAAGAAGGAGATGAAGACGGTTACCTTTCTG AAGGAATTGTTCGGACAGATGAAGAGGAGGAAGAAGAGCAAGATGCCAGTTCCAATGATAACTTTTCTGTGTGTCCTTCTAACAGTGTGA ATCATAACTCCTACAATGGAAAGGAAACTAAAAATAGGTGGAAGAACAATTGCCCTTTTTCGGCAGATGAAAATTATCGTCCTTTAGCCA AGACAAGGCAACAGAATATCAGCATGCAACGGCAAGAAAACCTTCGTTGGGTGTCAGAGCTCTCTTACGTAGAAGAGAAAGAACAATGGC AAGAACAAATCAATCAGCTAAAGAAACAGCTTGATTTTAGTGTCAGTATTTGTCAGACTTTGATGCAAGACCAGCAGACTCTATCTTGTC TGCTACAAACTCTTCTCACGGGTCCTTACAGTGTTATGCCCAGCAATGTTGCATCTCCTCAAGTACACTTCATAATGCACCAGTTGAACC AGTGCTATACTCAGCTAACATGGCAACAGAATAATGTTCAGAGGTTGAAACAAATGCTAAATGAACTTATGCGCCAGCAAAATCAGCATC CAGAAAAACCTGGAGGCAAGGAAAGAGGCAGTAGTGCATCGCACCCTCCTTCTCCCAGTTTATTTTGTCCTTTCAGCTTTCCAACACAGC CTGTAAATCTCTTCAATATACCTGGATTTACTAACTTTTCATCATTTGCACCAGGTATGAATTTCAGCCCTTTATTTCCTTCTAATTTTG GAGATTTTTCTCAGAATATCTCTACACCCAGTGAACAGCAGCAACCCTTAGCCCAGAATTCTTCAGGAAAAACAGAATATATGGCTTTTC CAAAACCTTTTGAAAGCAGTTCCTCTATTGGAGCAGAGAAACCAAGGAATAAAAAACTGCCTGAAGAGGAGGTGGAAAGCAGTAGGACAC CATGGTTATATGAACAAGAAGGTGAAGTAGAGAAACCATTTATCAAGACTGGATTTTCAGTGTCTGTAGAAAAATCTACAAGTAGTAACC GCAAAAATCAATTAGATACAAACGGAAGAAGACGCCAGTTTGATGAAGAATCACTGGAAAGCTTTAGCAGTATGCCTGATCCAGTAGATC CAACAACAGTGACTAAAACATTCAAGACAAGAAAAGCGTCTGCACAGGCCAGCCTGGCATCTAAAGATAAAACTCCCAAGTCAAAAAGTA AGAAGAGGAATTCTACTCAGCTGAAAAGCAGAGTTAAAAACATCAAAACTGGGAGTGATTTTTCCATGTTTGAAGCTTTGCGAGATACTA TTTATTCTGAAGTAGCTACATTAATTTCTCAAAATGAATCTCGTCCACATTTTCTTATTGAACTCTTCCATGAGCTGCAGCTACTAAACA CAGACTACTTGAGACAGAGGGCTTTATATGCATTGCAGGACATAGTATCCAGACATATTTCTGAGAGCCATGAAAAAGGAGAAAATGTAA AGTCAGTAAACTCTGGTACTTGGATAGCATCAAACTCAGAACTTACTCCTAGTGAGAGCCTTGCTACTACTGATGATGAAACTTTTGAGA AGAACTTTGAAAGAGAAACCCATAAAATAAGTGAGCAAAATGATGCTGATAATGCTAGTGTCCTGTCTGTATCATCAAATTTTGAGCCTT TTGCAACAGATGATCTAGGTAACACCGTGATTCACTTAGATCAAGCATTAGCCAGAATGAGAGAATATGAGCGTATGAAGACTGAGGCTG AAAGTAACTCAAATATGAGATGCACCTGCAGGATTATTGAGGATGGAGATGGTGCTGGTGCAGGTACTACAGTTAATAATTTAGAAGAAA CTCCCGTTATTGAAAATCGTAGTTCACAACAACCTGTAAGTGAAGTTTCTACCATCCCATGTCCTAGAATTGATACTCAGCAGCTGGACC GGCAAATTAAAGCAATTATGAAAGAAGTCATTCCTTTTTTGAAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAA AAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGA AGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCA TCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCG AGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCA TGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCA GAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGA GGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTG GTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCC ACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGT TTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGA TTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTG AAAACAAACTCTATGGTAGAATTTCCCATGCATTTACTAGATTCTAGCACCGCTGTCCCCTTTGCACTATCCTTCCTCTCTGTGATGCTT TTTAAAAATGTTTCTGGTCTGAACAAAACCAAAGTCTGCTCTGAACCTTTTTATTTGTAAATGTCTGACTTTGCATCCAGTTTACATTTA GGCATTATTGCAACTATGTTTTTCTAAAAGGATGTGAAAATAAGTGTAATTACCACATTGCCCAGCAACTTAGGATGGTAGAGGAAAAAA CAGATCAGGGCGGAACTCTCAGGGGAGACCAAGAACAGGTTGAATAAGGCGCTTCTGGGGTGGGAATCAAGTCATAGTACTTCTACTTTA ACTAAGTGGATAAATATACAAATCTGGGGAGGTATTCAGTTGAGAAAGGAGCCACCAGCACCACTCAGCCTGCACTGGGAGCACAGCCAG GTTCCCCCAGACCCCTCCTGGGCAGGCAGGTGCCTCTCAGAGGCCACCCGGCACTGGCGAGCAGCCACTGGCCAAGCCTCAGCCCCAGTC CCAGCCACATGTCCTCCATCAGGGGTAGCGAGGTTGCAGGAGCTGGCTGGCCCTGGGAGGACGCACCCCCACTGCTGTTTTCACATCCTT TCCCTTACCCACCTTCAGGACGGTTGTCACTTATGAAGTCAGTGCTAAAGCTGGAGCAGTTGCTTTTTGAAAGAACATGGTCTGTGGTGC >In-frame_PCM1_ENST00000327578_chr8_17851129_+_RET_ENST00000355710_chr10_43612030_+_4337nt GAAAAGCGTCTGCACAGGCCAGCCTGGCATCTAAAGATAAAACTCCCAAGTCAAAAAGTAAGAAGAGGAATTCTACTCAGCTGAAAAGCA GAGTTAAAAACATCAGGTATGAAAGTGCCAGTATGTCTAGCACATGTGAACCTTGCAAAAGTAGGAACAGACATTCAGCCCAGACTGAAG AGCCTGTTCAAGCAAAAGTATTCAGCAGAAAGAATCATGAGCAACTGGAAAAAATAATAAAATGTAATAGGTCTACAGAAATATCTTCAG CACATGCTAGGAGAATACTACAGCAGTCTAACAGAAATGCATGCAATGAAGCGCCAGAAACTGGGAGTGATTTTTCCATGTTTGAAGCTT TGCGAGATACTATTTATTCTGAAGTAGCTACATTAATTTCTCAAAATGAATCTCGTCCACATTTTCTTATTGAACTCTTCCATGAGCTGC AGCTACTAAACACAGACTACTTGAGACAGAGGGCTTTATATGCATTGCAGGACATAGTATCCAGACATATTTCTGAGAGCCATGAAAAAG GAGAAAATGTAAAGTCAGTAAACTCTGGTACTTGGATAGCATCAAACTCAGAACTTACTCCTAGTGAGAGCCTTGCTACTACTGATGATG AAACTTTTGAGAAGAACTTTGAAAGAGAAACCCATAAAATAAGTGAGCAAAATGATGCTGATAATGCTAGTGTCCTGTCTGTATCATCAA ATTTTGAGCCTTTTGCAACAGATGATCTAGGTAACACCGTGATTCACTTAGATCAAGCATTAGCCAGAATGAGAGAATATGAGCGTATGA AGACTGAGGCTGAAAGTAACTCAAATATGAGATGCACCTGCAGGATTATTGAGGATGGAGATGGTGCTGGTGCAGGTACTACAGTTAATA ATTTAGAAGAAACTCCCGTTATTGAAAATCGTAGTTCACAACAACCTGTAAGTGAAGTTTCTACCATCCCATGTCCTAGAATTGATACTC AGCAGCTGGACCGGCAAATTAAAGCAATTATGAAAGAAGTCATTCCTTTTTTGAAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACT TGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCA CGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACC ACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGG GCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGC GGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGG ACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATT CCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATG TATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTC TGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACA AAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCAT CTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTT CCACATGGATTGAAAACAAACTCTATGGCATGTCAGACCCGAACTGGCCTGGAGAGAGTCCTGTACCACTCACGAGAGCTGATGGCACTA ACACTGGGTTTCCAAGATATCCAAATGATAGTGTATATGCTAACTGGATGCTTTCACCCTCAGCGGCAAAATTAATGGACACGTTTGATA GTTAACATTTCTTTGTGAAAGGTAATGGACTCACAAGGGGAAGAAACATGCTGAGAATGGAAAGTCTACCGGCCCTTTCTTTGTGAACGT CACATTGGCCGAGCCGTGTTCAGTTCCCAGGTGGCAGACTCGTTTTTGGTAGTTTGTTTTAACTTCCAAGGTGGTTTTACTTCTGATAGC CGGTGATTTTCCCTCCTAGCAGACATGCCACACCGGGTAAGAGCTCTGAGTCTTAGTGGTTAAGCATTCCTTTCTCTTCAGTGCCCAGCA GCACCCAGTGTTGGTCTGTGTCCATCAGTGACCACCAACATTCTGTGTTCACATGTGTGGGTCCAACACTTACTACCTGGTGTATGAAAT TGGACCTGAACTGTTGGATTTTTCTAGTTGCCGCCAAACAAGGCAAAAAAATTTAAACATGAAGCACACACACAAAAAAGGCAGTAGGAA AAATGCTGGCCCTGATGACCTGTCCTTATTCAGAATGAGAGACTGCGGGGGGGGCCTGGGGGTAGTGTCAATGCCCCTCCAGGGCTGGAG GGGAAGAGGGGCCCCGAGGATGGGCCTGGGCTCAGCATTCGAGATCTTGAGAATGATTTTTTTTAAATCATGCAACCTTTCCTTAGGAAG ACATTTGGTTTTCATCATGATTAAGATGATTCCTAGATTTAGCACAATGGAGAGATTCCATGCCATCTTTACTATGTGGATGGTGGTATC AGGGAAGAGGGCTCACAAGACACATTTGTCCCCCGGGCCCACCACATCATCCTCACGTGTTCGGTACTGAGCAGCCACTACCCCTGATGA GAACAGTATGAAGAAAGGGGGCTGTTGGAGTCCCAGAATTGCTGACAGCAGAGGCTTTGCTGCTGTGAATCCCACCTGCCACCAGCCTGC AGCACACCCCACAGCCAAGTAGAGGCGAAAGCAGTGGCTCATCCTACCTGTTAGGAGCAGGTAGGGCTTGTACTCACTTTAATTTGAATC TTATCAACTTACTCATAAAGGGACAGGCTAGCTAGCTGTGTTAGAAGTAGCAATGACAATGACCAAGGACTGCTACACCTCTGATTACAA TTCTGATGTGAAAAAGATGGTGTTTGGCTCTTATAGAGCCTGTGTGAAAGGCCCATGGATCAGCTCTTCCTGTGTTTGTAATTTAATGCT GCTACAAGATGTTTCTGTTTCTTAGATTCTGACCATGACTCATAAGCTTCTTGTCATTCTTCATTGCTTGTTTGTGGTCACAGATGCACA ACACTCCTCCAGTCTTGTGGGGGCAGCTTTTGGGAAGTCTCAGCAGCTCTTCTGGCTGTGTTGTCAGCACTGTAACTTCGCAGAAAAGAG TCGGATTACCAAAACACTGCCTGCTCTTCAGACTTAAAGCACTGATAGGACTTAAAATAGTCTCATTCAAATACTGTATTTTATATAGGC ATTTCACAAAAACAGCAAAATTGTGGCATTTTGTGAGGCCAAGGCTTGGATGCGTGTGTAATAGAGCCTTGTGGTGTGTGCGCACACACC CAGAGGGAGAGTTTGAAAAATGCTTATTGGACACGTAACCTGGCTCTAATTTGGGCTGTTTTTCAGATACACTGTGATAAGTTCTTTTAC AAATATCTATAGACATGGTAAACTTTTGGTTTTCAGATATGCTTAATGATAGTCTTACTAAATGCAGAAATAAGAATAAACTTTCTCAAA TTATTAAAAATGCCTACACAGTAAGTGTGAATTGCTGCAACAGGTTTGTTCTCAGGAGGGTAAGAACTCCAGGTCTAAACAGCTGACCCA GTGATGGGGAATTTATCCTTGACCAATTTATCCTTGACCAATAACCTAATTGTCTATTCCTGAGTTATAAAAGTCCCCATCCTTATTAGC TCTACTGGAATTTTCATACACGTAAATGCAGAAGTTACTAAGTATTAAGTATTACTGAGTATTAAGTAGTAATCTGTCAGTTATTAAAAT TTGTAAAATCTATTTATGAAAGGTCATTAAACCAGATCATGTTCCTTTTTTTGTAATCAAGGTGACTAAGAAAATCAGTTGTGTAAATAA >In-frame_PCM1_ENST00000327578_chr8_17851129_+_RET_ENST00000340058_chr10_43612030_+_2879nt GAAAAGCGTCTGCACAGGCCAGCCTGGCATCTAAAGATAAAACTCCCAAGTCAAAAAGTAAGAAGAGGAATTCTACTCAGCTGAAAAGCA GAGTTAAAAACATCAGGTATGAAAGTGCCAGTATGTCTAGCACATGTGAACCTTGCAAAAGTAGGAACAGACATTCAGCCCAGACTGAAG AGCCTGTTCAAGCAAAAGTATTCAGCAGAAAGAATCATGAGCAACTGGAAAAAATAATAAAATGTAATAGGTCTACAGAAATATCTTCAG CACATGCTAGGAGAATACTACAGCAGTCTAACAGAAATGCATGCAATGAAGCGCCAGAAACTGGGAGTGATTTTTCCATGTTTGAAGCTT TGCGAGATACTATTTATTCTGAAGTAGCTACATTAATTTCTCAAAATGAATCTCGTCCACATTTTCTTATTGAACTCTTCCATGAGCTGC AGCTACTAAACACAGACTACTTGAGACAGAGGGCTTTATATGCATTGCAGGACATAGTATCCAGACATATTTCTGAGAGCCATGAAAAAG GAGAAAATGTAAAGTCAGTAAACTCTGGTACTTGGATAGCATCAAACTCAGAACTTACTCCTAGTGAGAGCCTTGCTACTACTGATGATG AAACTTTTGAGAAGAACTTTGAAAGAGAAACCCATAAAATAAGTGAGCAAAATGATGCTGATAATGCTAGTGTCCTGTCTGTATCATCAA ATTTTGAGCCTTTTGCAACAGATGATCTAGGTAACACCGTGATTCACTTAGATCAAGCATTAGCCAGAATGAGAGAATATGAGCGTATGA AGACTGAGGCTGAAAGTAACTCAAATATGAGATGCACCTGCAGGATTATTGAGGATGGAGATGGTGCTGGTGCAGGTACTACAGTTAATA ATTTAGAAGAAACTCCCGTTATTGAAAATCGTAGTTCACAACAACCTGTAAGTGAAGTTTCTACCATCCCATGTCCTAGAATTGATACTC AGCAGCTGGACCGGCAAATTAAAGCAATTATGAAAGAAGTCATTCCTTTTTTGAAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACT TGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCA CGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACC ACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGG GCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGC GGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGG ACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATT CCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACGCAAAGTGATG TATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTC TGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACA AAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCAT CTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTT CCACATGGATTGAAAACAAACTCTATGGTAGAATTTCCCATGCATTTACTAGATTCTAGCACCGCTGTCCCCTTTGCACTATCCTTCCTC TCTGTGATGCTTTTTAAAAATGTTTCTGGTCTGAACAAAACCAAAGTCTGCTCTGAACCTTTTTATTTGTAAATGTCTGACTTTGCATCC AGTTTACATTTAGGCATTATTGCAACTATGTTTTTCTAAAAGGATGTGAAAATAAGTGTAATTACCACATTGCCCAGCAACTTAGGATGG TAGAGGAAAAAACAGATCAGGGCGGAACTCTCAGGGGAGACCAAGAACAGGTTGAATAAGGCGCTTCTGGGGTGGGAATCAAGTCATAGT ACTTCTACTTTAACTAAGTGGATAAATATACAAATCTGGGGAGGTATTCAGTTGAGAAAGGAGCCACCAGCACCACTCAGCCTGCACTGG GAGCACAGCCAGGTTCCCCCAGACCCCTCCTGGGCAGGCAGGTGCCTCTCAGAGGCCACCCGGCACTGGCGAGCAGCCACTGGCCAAGCC TCAGCCCCAGTCCCAGCCACATGTCCTCCATCAGGGGTAGCGAGGTTGCAGGAGCTGGCTGGCCCTGGGAGGACGCACCCCCACTGCTGT TTTCACATCCTTTCCCTTACCCACCTTCAGGACGGTTGTCACTTATGAAGTCAGTGCTAAAGCTGGAGCAGTTGCTTTTTGAAAGAACAT |
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FusionGenePPI for PCM1_RET |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PCM1 | BBS4, KRT15, ING5, KIAA0368, KRT19, CCDC53, ABI2, EXOC8, EPS8, CEP72, PCNT, HAP1, EWSR1, HNRNPUL1, CLTC, MIB1, FUS, CEP131, PPIB, SIRT7, NEURL4, PAN2, CASK, E2F4, YWHAQ, LATS2, SAV1, CEP250, HAUS2, OBSL1, CCDC8, CSPP1, CCDC183, SLC25A41, SSFA2, RASSF8, RASSF7, IFT81, NTRK1, BTRC, MED4, HERC2, AHI1, CEP162, RPGRIP1L, CC2D2A, CEP128, LCA5, OFD1, CCDC138, CEP170, PIBF1, SSX2IP, WRAP73, HAUS1, HAUS4, KIAA0753, CCDC77, CCNB2, CEP350, CEP95, CSNK1A1, DSP, KIF20A, LUZP1, MCM10, MCRS1, MPRIP, NDC80, SMARCD2, TPGS1, SUPT5H, SSBP1, KIF7, SKA1, TSPYL1, SREK1IP1, CSNK1D, IFT172, CEP55, IFT20, CCDC14, HMMR, CFAP97, IPO5, KCTD12, SNRPE, SPICE1, ABCD3, ACOT9, ATP5L, CAMSAP1, CC2D1A, CCDC66, CEP120, CKAP2, FGFR1OP, HAUS3, HAUS5, HAUS6, HAUS7, HAUS8, IDH3B, IFT57, IFT74, NCKAP5L, RAE1, STAU1, TP53BP2, TTK, TXLNA, TXLNG, TBC1D31, WDR83, XRN1, ZNF280C, ACTR2, ANKRD26, BAIAP2, BICD1, BICD2, BTF3, C11orf49, KNSTRN, C2CD3, CAMSAP2, CCDC112, CCDC18, CCDC22, CCDC85C, CCDC92, CCNB1, CCP110, CDC123, CEP164, CEP192, CEP57L1, CEP63, CEP85, CEP89, CEP97, CKAP2L, CNOT10, COMMD2, COMMD4, CSNK1E, DAPK3, DIAPH3, ERC1, EXOC4, FOPNL, GNAO1, GPATCH1, IBTK, IQCB1, KIAA1328, KIF14, LRRC49, LRRCC1, MAGED1, MAP7D3, MED29, MIS18A, MIS18BP1, MOB4, MPHOSPH9, MYO9A, NAV1, NEDD1, NME7, NOL11, NUF2, ODF2L, ODF2, PCBP3, PKN2, PLK1, KIZ, PPP1R9B, IFT22, RRM2, SCLT1, SDCCAG3, SECISBP2, SMG5, SMG7, SPATA24, SPATS2, SPC24, SRGAP2, STRN4, TANC1, TCHP, TEX9, TNIP1, TRAF3IP1, TTC12, TTF2, TTLL4, TTLL5, CEP104, CEP290, CEP152, CEP135, CNTRL, FBF1, NINL, NIN, POC5, SASS6, RPGRIP1, STIL, CENPJ, CENPE, PPP2CA, PRKAR2B, DYNLL1, MAPRE1, SLAIN2, CEP170P1, PPP2R3C, YWHAE, YWHAZ, MTMR7, C6orf118, BIN3, CCDC172, LPXN, FAM81B, COG5, ING2, CCDC65, LCA5L, CCDC40, DKK3, NECAB2, ATG14, TSC1, RNF168 | RET | STAT3, DOK6, DOK5, SRC, SHC1, PTPRF, DOK2, DOK4, DOK1, GRB2, CRK, PLCG1, PDLIM7, GRB7, FRS2, NRTN, GFRA1, GRB10, IKBKG, MCRS1, CBL, CBLC, RET, HSP90AA1, NOTCH2NL, NOTCH3, AIP, EGFR, NTRK1, ZBTB48, HNRNPD, SORT1, SYNCRIP, SGTB, BAG6, HIST1H3A, KYNU, TXNL4A, ZCCHC8, ICE2, MAPK3, PTK2, MAPK1, PTPRR, DUSP26 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | PCM1 | chr8:17851129 | chr10:43612030 | ENST00000325083 | + | 29 | 39 | 1913_2024 | 1609 | 2025 | BBS4 |
| Hgene | PCM1 | chr8:17851129 | chr10:43612030 | ENST00000325083 | + | 29 | 39 | 1279_1799 | 1609 | 2025 | HAP1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PCM1_RET |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | RET | P07949 | DB05294 | Vandetanib | Proto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305} | small molecule | approved |
| Tgene | RET | P07949 | DB08896 | Regorafenib | Proto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305} | small molecule | approved |
| Tgene | RET | P07949 | DB00398 | Sorafenib | Proto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305} | small molecule | approved|investigational |
| Tgene | RET | P07949 | DB08875 | Cabozantinib | Proto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305} | small molecule | approved|investigational |
| Tgene | RET | P07949 | DB08901 | Ponatinib | Proto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305} | small molecule | approved|investigational |
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RelatedDiseases for PCM1_RET |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PCM1 | C0036341 | Schizophrenia | 1 | CTD_human |
| Tgene | RET | C3888239 | HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 1 | 15 | UNIPROT |
| Tgene | RET | C0025268 | Multiple Endocrine Neoplasia Type 2a | 14 | CTD_human;ORPHANET;UNIPROT |
| Tgene | RET | C1833921 | Familial medullary thyroid carcinoma | 14 | CTD_human;ORPHANET;UNIPROT |
| Tgene | RET | C0025269 | Multiple Endocrine Neoplasia Type 2b | 8 | CTD_human;ORPHANET;UNIPROT |
| Tgene | RET | C1275808 | Congenital central hypoventilation | 4 | CTD_human;ORPHANET;UNIPROT |
| Tgene | RET | C0009404 | Colorectal Neoplasms | 2 | CTD_human |
| Tgene | RET | C0019569 | Hirschsprung Disease | 2 | CTD_human;HPO;ORPHANET |
| Tgene | RET | C0006413 | Burkitt Lymphoma | 1 | CTD_human |
| Tgene | RET | C0027662 | Multiple Endocrine Neoplasia | 1 | CTD_human |
| Tgene | RET | C0031511 | Pheochromocytoma | 1 | CTD_human;HPO;UNIPROT |
| Tgene | RET | C0038220 | Status Epilepticus | 1 | CTD_human |
| Tgene | RET | C0040136 | Thyroid Neoplasm | 1 | CTD_human |
| Tgene | RET | C0206693 | Medullary carcinoma | 1 | CTD_human |
| Tgene | RET | C0238462 | Medullary carcinoma of thyroid | 1 | CTD_human;HPO |
| Tgene | RET | C0740340 | Amyloidosis, Familial | 1 | CTD_human |
| Tgene | RET | C1609433 | Congenital absence of kidneys syndrome | 1 | CTD_human;ORPHANET |
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