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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26251

FusionGeneSummary for PCM1_PCM1

check button Fusion gene summary
Fusion gene informationFusion gene name: PCM1_PCM1
Fusion gene ID: 26251
HgeneTgene
Gene symbol

PCM1

PCM1

Gene ID

5108

5108

Gene namepericentriolar material 1pericentriolar material 1
SynonymsPTC4|RET/PCM-1PTC4|RET/PCM-1
Cytomap

8p22

8p22

Type of geneprotein-codingprotein-coding
Descriptionpericentriolar material 1 proteinPCM-1hPCM-1pericentriolar material 1, PCM1pericentriolar material 1 proteinPCM-1hPCM-1pericentriolar material 1, PCM1
Modification date2018052320180523
UniProtAcc

Q15154

Q15154

Ensembl transtripts involved in fusion geneENST00000325083, ENST00000519253, 
ENST00000524226, ENST00000518537, 
ENST00000518936, ENST00000327578, 
ENST00000325083, ENST00000519253, 
ENST00000524226, ENST00000518537, 
ENST00000518936, ENST00000327578, 
Fusion gene scores* DoF score8 X 7 X 5=2805 X 5 X 3=75
# samples 85
** MAII scorelog2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PCM1 [Title/Abstract] AND PCM1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CD240310PCM1chr8

17885252

+PCM1chr8

17883089

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000325083ENST00000325083PCM1chr8

17885252

+PCM1chr8

17883089

-
3UTR-3CDSENST00000325083ENST00000519253PCM1chr8

17885252

+PCM1chr8

17883089

-
3UTR-3CDSENST00000325083ENST00000524226PCM1chr8

17885252

+PCM1chr8

17883089

-
3UTR-intronENST00000325083ENST00000518537PCM1chr8

17885252

+PCM1chr8

17883089

-
3UTR-intronENST00000325083ENST00000518936PCM1chr8

17885252

+PCM1chr8

17883089

-
3UTR-intronENST00000325083ENST00000327578PCM1chr8

17885252

+PCM1chr8

17883089

-
3UTR-3CDSENST00000519253ENST00000325083PCM1chr8

17885252

+PCM1chr8

17883089

-
3UTR-3CDSENST00000519253ENST00000519253PCM1chr8

17885252

+PCM1chr8

17883089

-
3UTR-3CDSENST00000519253ENST00000524226PCM1chr8

17885252

+PCM1chr8

17883089

-
3UTR-intronENST00000519253ENST00000518537PCM1chr8

17885252

+PCM1chr8

17883089

-
3UTR-intronENST00000519253ENST00000518936PCM1chr8

17885252

+PCM1chr8

17883089

-
3UTR-intronENST00000519253ENST00000327578PCM1chr8

17885252

+PCM1chr8

17883089

-
3UTR-3CDSENST00000524226ENST00000325083PCM1chr8

17885252

+PCM1chr8

17883089

-
3UTR-3CDSENST00000524226ENST00000519253PCM1chr8

17885252

+PCM1chr8

17883089

-
3UTR-3CDSENST00000524226ENST00000524226PCM1chr8

17885252

+PCM1chr8

17883089

-
3UTR-intronENST00000524226ENST00000518537PCM1chr8

17885252

+PCM1chr8

17883089

-
3UTR-intronENST00000524226ENST00000518936PCM1chr8

17885252

+PCM1chr8

17883089

-
3UTR-intronENST00000524226ENST00000327578PCM1chr8

17885252

+PCM1chr8

17883089

-
intron-3CDSENST00000518537ENST00000325083PCM1chr8

17885252

+PCM1chr8

17883089

-
intron-3CDSENST00000518537ENST00000519253PCM1chr8

17885252

+PCM1chr8

17883089

-
intron-3CDSENST00000518537ENST00000524226PCM1chr8

17885252

+PCM1chr8

17883089

-
intron-intronENST00000518537ENST00000518537PCM1chr8

17885252

+PCM1chr8

17883089

-
intron-intronENST00000518537ENST00000518936PCM1chr8

17885252

+PCM1chr8

17883089

-
intron-intronENST00000518537ENST00000327578PCM1chr8

17885252

+PCM1chr8

17883089

-
intron-3CDSENST00000518936ENST00000325083PCM1chr8

17885252

+PCM1chr8

17883089

-
intron-3CDSENST00000518936ENST00000519253PCM1chr8

17885252

+PCM1chr8

17883089

-
intron-3CDSENST00000518936ENST00000524226PCM1chr8

17885252

+PCM1chr8

17883089

-
intron-intronENST00000518936ENST00000518537PCM1chr8

17885252

+PCM1chr8

17883089

-
intron-intronENST00000518936ENST00000518936PCM1chr8

17885252

+PCM1chr8

17883089

-
intron-intronENST00000518936ENST00000327578PCM1chr8

17885252

+PCM1chr8

17883089

-
Frame-shitENST00000327578ENST00000325083PCM1chr8

17885252

+PCM1chr8

17883089

-
Frame-shitENST00000327578ENST00000519253PCM1chr8

17885252

+PCM1chr8

17883089

-
Frame-shitENST00000327578ENST00000524226PCM1chr8

17885252

+PCM1chr8

17883089

-
5CDS-intronENST00000327578ENST00000518537PCM1chr8

17885252

+PCM1chr8

17883089

-
5CDS-intronENST00000327578ENST00000518936PCM1chr8

17885252

+PCM1chr8

17883089

-
5CDS-intronENST00000327578ENST00000327578PCM1chr8

17885252

+PCM1chr8

17883089

-

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FusionProtFeatures for PCM1_PCM1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PCM1

Q15154

PCM1

Q15154


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PCM1_PCM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PCM1_PCM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PCM1_PCM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PCM1_PCM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePCM1C0036341Schizophrenia1CTD_human
TgenePCM1C0036341Schizophrenia1CTD_human