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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26250

FusionGeneSummary for PCM1_NRG1

check button Fusion gene summary
Fusion gene informationFusion gene name: PCM1_NRG1
Fusion gene ID: 26250
HgeneTgene
Gene symbol

PCM1

NRG1

Gene ID

5108

3084

Gene namepericentriolar material 1neuregulin 1
SynonymsPTC4|RET/PCM-1ARIA|GGF|GGF2|HGL|HRG|HRG1|HRGA|MST131|MSTP131|NDF|NRG1-IT2|SMDF
Cytomap

8p22

8p12

Type of geneprotein-codingprotein-coding
Descriptionpericentriolar material 1 proteinPCM-1hPCM-1pericentriolar material 1, PCM1pro-neuregulin-1, membrane-bound isoformacetylcholine receptor-inducing activityglial growth factor 2heregulin, alpha (45kD, ERBB2 p185-activator)neu differentiation factorpro-NRG1sensory and motor neuron derived factor
Modification date2018052320180523
UniProtAcc

Q15154

Q02297

Ensembl transtripts involved in fusion geneENST00000325083, ENST00000519253, 
ENST00000524226, ENST00000518537, 
ENST00000518936, ENST00000327578, 
ENST00000519301, ENST00000520407, 
ENST00000523079, ENST00000338921, 
ENST00000356819, ENST00000287845, 
ENST00000341377, ENST00000287842, 
ENST00000521670, ENST00000405005, 
ENST00000520502, ENST00000539990, 
ENST00000523681, 
Fusion gene scores* DoF score8 X 7 X 5=28016 X 6 X 11=1056
# samples 816
** MAII scorelog2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1056*10)=-2.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PCM1 [Title/Abstract] AND NRG1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNRG1

GO:0003222

ventricular trabecula myocardium morphogenesis

17336907

TgeneNRG1

GO:0038127

ERBB signaling pathway

11389077

TgeneNRG1

GO:0038129

ERBB3 signaling pathway

27353365

TgeneNRG1

GO:0043497

regulation of protein heterodimerization activity

10559227

TgeneNRG1

GO:0045892

negative regulation of transcription, DNA-templated

15073182

TgeneNRG1

GO:0051048

negative regulation of secretion

10559227

TgeneNRG1

GO:0060379

cardiac muscle cell myoblast differentiation

17336907

TgeneNRG1

GO:0060956

endocardial cell differentiation

17336907


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRCTCGA-B8-5553-01APCM1chr8

17782289

+NRG1chr8

32611890

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000325083ENST00000519301PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-intronENST00000325083ENST00000520407PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-intronENST00000325083ENST00000523079PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-intronENST00000325083ENST00000338921PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-intronENST00000325083ENST00000356819PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-intronENST00000325083ENST00000287845PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-3UTRENST00000325083ENST00000341377PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-3UTRENST00000325083ENST00000287842PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-3UTRENST00000325083ENST00000521670PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-3UTRENST00000325083ENST00000405005PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-intronENST00000325083ENST00000520502PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-intronENST00000325083ENST00000539990PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-intronENST00000325083ENST00000523681PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-3CDSENST00000519253ENST00000519301PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-intronENST00000519253ENST00000520407PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-intronENST00000519253ENST00000523079PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-intronENST00000519253ENST00000338921PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-intronENST00000519253ENST00000356819PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-intronENST00000519253ENST00000287845PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-3UTRENST00000519253ENST00000341377PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-3UTRENST00000519253ENST00000287842PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-3UTRENST00000519253ENST00000521670PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-3UTRENST00000519253ENST00000405005PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-intronENST00000519253ENST00000520502PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-intronENST00000519253ENST00000539990PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-intronENST00000519253ENST00000523681PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-3CDSENST00000524226ENST00000519301PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-intronENST00000524226ENST00000520407PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-intronENST00000524226ENST00000523079PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-intronENST00000524226ENST00000338921PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-intronENST00000524226ENST00000356819PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-intronENST00000524226ENST00000287845PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-3UTRENST00000524226ENST00000341377PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-3UTRENST00000524226ENST00000287842PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-3UTRENST00000524226ENST00000521670PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-3UTRENST00000524226ENST00000405005PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-intronENST00000524226ENST00000520502PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-intronENST00000524226ENST00000539990PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-intronENST00000524226ENST00000523681PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-3CDSENST00000518537ENST00000519301PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-intronENST00000518537ENST00000520407PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-intronENST00000518537ENST00000523079PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-intronENST00000518537ENST00000338921PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-intronENST00000518537ENST00000356819PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-intronENST00000518537ENST00000287845PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-3UTRENST00000518537ENST00000341377PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-3UTRENST00000518537ENST00000287842PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-3UTRENST00000518537ENST00000521670PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-3UTRENST00000518537ENST00000405005PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-intronENST00000518537ENST00000520502PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-intronENST00000518537ENST00000539990PCM1chr8

17782289

+NRG1chr8

32611890

+
5UTR-intronENST00000518537ENST00000523681PCM1chr8

17782289

+NRG1chr8

32611890

+
3UTR-3CDSENST00000518936ENST00000519301PCM1chr8

17782289

+NRG1chr8

32611890

+
3UTR-intronENST00000518936ENST00000520407PCM1chr8

17782289

+NRG1chr8

32611890

+
3UTR-intronENST00000518936ENST00000523079PCM1chr8

17782289

+NRG1chr8

32611890

+
3UTR-intronENST00000518936ENST00000338921PCM1chr8

17782289

+NRG1chr8

32611890

+
3UTR-intronENST00000518936ENST00000356819PCM1chr8

17782289

+NRG1chr8

32611890

+
3UTR-intronENST00000518936ENST00000287845PCM1chr8

17782289

+NRG1chr8

32611890

+
3UTR-3UTRENST00000518936ENST00000341377PCM1chr8

17782289

+NRG1chr8

32611890

+
3UTR-3UTRENST00000518936ENST00000287842PCM1chr8

17782289

+NRG1chr8

32611890

+
3UTR-3UTRENST00000518936ENST00000521670PCM1chr8

17782289

+NRG1chr8

32611890

+
3UTR-3UTRENST00000518936ENST00000405005PCM1chr8

17782289

+NRG1chr8

32611890

+
3UTR-intronENST00000518936ENST00000520502PCM1chr8

17782289

+NRG1chr8

32611890

+
3UTR-intronENST00000518936ENST00000539990PCM1chr8

17782289

+NRG1chr8

32611890

+
3UTR-intronENST00000518936ENST00000523681PCM1chr8

17782289

+NRG1chr8

32611890

+
intron-3CDSENST00000327578ENST00000519301PCM1chr8

17782289

+NRG1chr8

32611890

+
intron-intronENST00000327578ENST00000520407PCM1chr8

17782289

+NRG1chr8

32611890

+
intron-intronENST00000327578ENST00000523079PCM1chr8

17782289

+NRG1chr8

32611890

+
intron-intronENST00000327578ENST00000338921PCM1chr8

17782289

+NRG1chr8

32611890

+
intron-intronENST00000327578ENST00000356819PCM1chr8

17782289

+NRG1chr8

32611890

+
intron-intronENST00000327578ENST00000287845PCM1chr8

17782289

+NRG1chr8

32611890

+
intron-3UTRENST00000327578ENST00000341377PCM1chr8

17782289

+NRG1chr8

32611890

+
intron-3UTRENST00000327578ENST00000287842PCM1chr8

17782289

+NRG1chr8

32611890

+
intron-3UTRENST00000327578ENST00000521670PCM1chr8

17782289

+NRG1chr8

32611890

+
intron-3UTRENST00000327578ENST00000405005PCM1chr8

17782289

+NRG1chr8

32611890

+
intron-intronENST00000327578ENST00000520502PCM1chr8

17782289

+NRG1chr8

32611890

+
intron-intronENST00000327578ENST00000539990PCM1chr8

17782289

+NRG1chr8

32611890

+
intron-intronENST00000327578ENST00000523681PCM1chr8

17782289

+NRG1chr8

32611890

+

Top

FusionProtFeatures for PCM1_NRG1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PCM1

Q15154

NRG1

Q02297


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PCM1_NRG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PCM1_NRG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PCM1BBS4, KRT15, ING5, KIAA0368, KRT19, CCDC53, ABI2, EXOC8, EPS8, CEP72, PCNT, HAP1, EWSR1, HNRNPUL1, CLTC, MIB1, FUS, CEP131, PPIB, SIRT7, NEURL4, PAN2, CASK, E2F4, YWHAQ, LATS2, SAV1, CEP250, HAUS2, OBSL1, CCDC8, CSPP1, CCDC183, SLC25A41, SSFA2, RASSF8, RASSF7, IFT81, NTRK1, BTRC, MED4, HERC2, AHI1, CEP162, RPGRIP1L, CC2D2A, CEP128, LCA5, OFD1, CCDC138, CEP170, PIBF1, SSX2IP, WRAP73, HAUS1, HAUS4, KIAA0753, CCDC77, CCNB2, CEP350, CEP95, CSNK1A1, DSP, KIF20A, LUZP1, MCM10, MCRS1, MPRIP, NDC80, SMARCD2, TPGS1, SUPT5H, SSBP1, KIF7, SKA1, TSPYL1, SREK1IP1, CSNK1D, IFT172, CEP55, IFT20, CCDC14, HMMR, CFAP97, IPO5, KCTD12, SNRPE, SPICE1, ABCD3, ACOT9, ATP5L, CAMSAP1, CC2D1A, CCDC66, CEP120, CKAP2, FGFR1OP, HAUS3, HAUS5, HAUS6, HAUS7, HAUS8, IDH3B, IFT57, IFT74, NCKAP5L, RAE1, STAU1, TP53BP2, TTK, TXLNA, TXLNG, TBC1D31, WDR83, XRN1, ZNF280C, ACTR2, ANKRD26, BAIAP2, BICD1, BICD2, BTF3, C11orf49, KNSTRN, C2CD3, CAMSAP2, CCDC112, CCDC18, CCDC22, CCDC85C, CCDC92, CCNB1, CCP110, CDC123, CEP164, CEP192, CEP57L1, CEP63, CEP85, CEP89, CEP97, CKAP2L, CNOT10, COMMD2, COMMD4, CSNK1E, DAPK3, DIAPH3, ERC1, EXOC4, FOPNL, GNAO1, GPATCH1, IBTK, IQCB1, KIAA1328, KIF14, LRRC49, LRRCC1, MAGED1, MAP7D3, MED29, MIS18A, MIS18BP1, MOB4, MPHOSPH9, MYO9A, NAV1, NEDD1, NME7, NOL11, NUF2, ODF2L, ODF2, PCBP3, PKN2, PLK1, KIZ, PPP1R9B, IFT22, RRM2, SCLT1, SDCCAG3, SECISBP2, SMG5, SMG7, SPATA24, SPATS2, SPC24, SRGAP2, STRN4, TANC1, TCHP, TEX9, TNIP1, TRAF3IP1, TTC12, TTF2, TTLL4, TTLL5, CEP104, CEP290, CEP152, CEP135, CNTRL, FBF1, NINL, NIN, POC5, SASS6, RPGRIP1, STIL, CENPJ, CENPE, PPP2CA, PRKAR2B, DYNLL1, MAPRE1, SLAIN2, CEP170P1, PPP2R3C, YWHAE, YWHAZ, MTMR7, C6orf118, BIN3, CCDC172, LPXN, FAM81B, COG5, ING2, CCDC65, LCA5L, CCDC40, DKK3, NECAB2, ATG14, TSC1, RNF168NRG1LIMK1, ERBB3, ERBB2, EGFR, ERBB4, MBOAT7, LSR, PGAP1, KIAA2013, SREBF2, LEMD3, TMTC3, TMTC4, POMGNT2, SLC38A10, ATP7B, SLC35B2, NDUFA3, ZDHHC17, TMEM39B, DNAAF5, B3GNT2, RHOBTB3, CISD2, POMT1, SPTLC2, SLC25A16, RDH11, MGAT1, HMOX1, KIAA1467, EXTL3, SLC25A23, NETO2, LPHN1, CNTNAP3, HLA-DPB1, UQCRQ, GLMN, DEGS1, TMEM63B, DDX11L8, ABCB10, GYLTL1B, B3GALNT2, TMEM181, INTS7, MYO19, GALNT11, C1GALT1C1, SLC22A18, NEK4, ABCA3, TMEM164, MTCH1, OPA3, HS6ST1, SFXN3, TM2D3, DSE, TMEM205, RNF130, PIGU, CDC5L, LGR4, TUBB3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PCM1_NRG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for PCM1_NRG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePCM1C0036341Schizophrenia1CTD_human
TgeneNRG1C0036341Schizophrenia7CTD_human
TgeneNRG1C0005586Bipolar Disorder5PSYGENET
TgeneNRG1C0024809Marijuana Abuse3PSYGENET
TgeneNRG1C0011570Mental Depression2PSYGENET
TgeneNRG1C0011581Depressive disorder2PSYGENET
TgeneNRG1C0006870Cannabis Dependence1PSYGENET
TgeneNRG1C0007621Neoplastic Cell Transformation1CTD_human
TgeneNRG1C0011616Contact Dermatitis1CTD_human
TgeneNRG1C0018801Heart failure1CTD_human
TgeneNRG1C0019569Hirschsprung Disease1CTD_human
TgeneNRG1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneNRG1C0026650Movement Disorders1CTD_human
TgeneNRG1C0027626Neoplasm Invasiveness1CTD_human
TgeneNRG1C0030193Pain1CTD_human
TgeneNRG1C0032460Polycystic Ovary Syndrome1CTD_human
TgeneNRG1C0033937Psychoses, Drug1PSYGENET
TgeneNRG1C0038358Gastric ulcer1CTD_human
TgeneNRG1C0236733Amphetamine-Related Disorders1CTD_human
TgeneNRG1C1458155Mammary Neoplasms1CTD_human
TgeneNRG1C3495559Juvenile arthritis1CTD_human