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Fusion gene ID: 26233 |
FusionGeneSummary for PCID2_GRTP1 |
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Fusion gene information | Fusion gene name: PCID2_GRTP1 | Fusion gene ID: 26233 | Hgene | Tgene | Gene symbol | PCID2 | GRTP1 | Gene ID | 55795 | 79774 |
Gene name | PCI domain containing 2 | growth hormone regulated TBC protein 1 | |
Synonyms | F10 | TBC1D6 | |
Cytomap | 13q34 | 13q34 | |
Type of gene | protein-coding | protein-coding | |
Description | PCI domain-containing protein 2CSN12-like protein | growth hormone-regulated TBC protein 1TBC1 domain family member 6 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q5JVF3 | Q5TC63 | |
Ensembl transtripts involved in fusion gene | ENST00000337344, ENST00000375477, ENST00000375479, ENST00000493650, ENST00000375459, ENST00000246505, ENST00000375457, | ENST00000375431, ENST00000326039, ENST00000375430, ENST00000476439, | |
Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 1 X 1 X 1=1 |
# samples | 4 | 1 | |
** MAII score | log2(4/60*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: PCID2 [Title/Abstract] AND GRTP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUSC | TCGA-56-A4ZK-01A | PCID2 | chr13 | 113862913 | - | GRTP1 | chr13 | 114018225 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000337344 | ENST00000375431 | PCID2 | chr13 | 113862913 | - | GRTP1 | chr13 | 114018225 | - |
5CDS-intron | ENST00000337344 | ENST00000326039 | PCID2 | chr13 | 113862913 | - | GRTP1 | chr13 | 114018225 | - |
5CDS-intron | ENST00000337344 | ENST00000375430 | PCID2 | chr13 | 113862913 | - | GRTP1 | chr13 | 114018225 | - |
5CDS-5UTR | ENST00000337344 | ENST00000476439 | PCID2 | chr13 | 113862913 | - | GRTP1 | chr13 | 114018225 | - |
Frame-shift | ENST00000375477 | ENST00000375431 | PCID2 | chr13 | 113862913 | - | GRTP1 | chr13 | 114018225 | - |
5CDS-intron | ENST00000375477 | ENST00000326039 | PCID2 | chr13 | 113862913 | - | GRTP1 | chr13 | 114018225 | - |
5CDS-intron | ENST00000375477 | ENST00000375430 | PCID2 | chr13 | 113862913 | - | GRTP1 | chr13 | 114018225 | - |
5CDS-5UTR | ENST00000375477 | ENST00000476439 | PCID2 | chr13 | 113862913 | - | GRTP1 | chr13 | 114018225 | - |
Frame-shift | ENST00000375479 | ENST00000375431 | PCID2 | chr13 | 113862913 | - | GRTP1 | chr13 | 114018225 | - |
5CDS-intron | ENST00000375479 | ENST00000326039 | PCID2 | chr13 | 113862913 | - | GRTP1 | chr13 | 114018225 | - |
5CDS-intron | ENST00000375479 | ENST00000375430 | PCID2 | chr13 | 113862913 | - | GRTP1 | chr13 | 114018225 | - |
5CDS-5UTR | ENST00000375479 | ENST00000476439 | PCID2 | chr13 | 113862913 | - | GRTP1 | chr13 | 114018225 | - |
intron-3CDS | ENST00000493650 | ENST00000375431 | PCID2 | chr13 | 113862913 | - | GRTP1 | chr13 | 114018225 | - |
intron-intron | ENST00000493650 | ENST00000326039 | PCID2 | chr13 | 113862913 | - | GRTP1 | chr13 | 114018225 | - |
intron-intron | ENST00000493650 | ENST00000375430 | PCID2 | chr13 | 113862913 | - | GRTP1 | chr13 | 114018225 | - |
intron-5UTR | ENST00000493650 | ENST00000476439 | PCID2 | chr13 | 113862913 | - | GRTP1 | chr13 | 114018225 | - |
intron-3CDS | ENST00000375459 | ENST00000375431 | PCID2 | chr13 | 113862913 | - | GRTP1 | chr13 | 114018225 | - |
intron-intron | ENST00000375459 | ENST00000326039 | PCID2 | chr13 | 113862913 | - | GRTP1 | chr13 | 114018225 | - |
intron-intron | ENST00000375459 | ENST00000375430 | PCID2 | chr13 | 113862913 | - | GRTP1 | chr13 | 114018225 | - |
intron-5UTR | ENST00000375459 | ENST00000476439 | PCID2 | chr13 | 113862913 | - | GRTP1 | chr13 | 114018225 | - |
Frame-shift | ENST00000246505 | ENST00000375431 | PCID2 | chr13 | 113862913 | - | GRTP1 | chr13 | 114018225 | - |
5CDS-intron | ENST00000246505 | ENST00000326039 | PCID2 | chr13 | 113862913 | - | GRTP1 | chr13 | 114018225 | - |
5CDS-intron | ENST00000246505 | ENST00000375430 | PCID2 | chr13 | 113862913 | - | GRTP1 | chr13 | 114018225 | - |
5CDS-5UTR | ENST00000246505 | ENST00000476439 | PCID2 | chr13 | 113862913 | - | GRTP1 | chr13 | 114018225 | - |
intron-3CDS | ENST00000375457 | ENST00000375431 | PCID2 | chr13 | 113862913 | - | GRTP1 | chr13 | 114018225 | - |
intron-intron | ENST00000375457 | ENST00000326039 | PCID2 | chr13 | 113862913 | - | GRTP1 | chr13 | 114018225 | - |
intron-intron | ENST00000375457 | ENST00000375430 | PCID2 | chr13 | 113862913 | - | GRTP1 | chr13 | 114018225 | - |
intron-5UTR | ENST00000375457 | ENST00000476439 | PCID2 | chr13 | 113862913 | - | GRTP1 | chr13 | 114018225 | - |
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FusionProtFeatures for PCID2_GRTP1 |
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Hgene | Tgene |
PCID2 | GRTP1 |
May act as a GTPase-activating protein for Rab familyprotein(s). |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PCID2_GRTP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PCID2_GRTP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PCID2 | SHFM1, NEK6, UBC, CUL3, SMAD2, EID1, TUBGCP3, IKZF3, SHMT2, MOV10, NXF1, CAPZB, DDX3X, IMPDH2, LSM1, ADPRHL2, TTC4, PSMD6, SNX2, SNX6, UBE4B, VPS35, IFI16, KIF11, TMEM63B, ZFC3H1, CETN1, TRIM25 | GRTP1 | NES, PCDHGC3, GJB7, FAM63A, UBB, ATP2A1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PCID2_GRTP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PCID2_GRTP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |