![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 26229 |
FusionGeneSummary for PCGF3_STAG3L3 |
![]() |
Fusion gene information | Fusion gene name: PCGF3_STAG3L3 | Fusion gene ID: 26229 | Hgene | Tgene | Gene symbol | PCGF3 | STAG3L3 | Gene ID | 10336 | 442578 |
Gene name | polycomb group ring finger 3 | stromal antigen 3-like 3 (pseudogene) | |
Synonyms | DONG1|RNF3|RNF3A | STAG3L1|STAG3L2|STAG3L3P | |
Cytomap | 4p16.3 | 7q11.23 | |
Type of gene | protein-coding | pseudo | |
Description | polycomb group RING finger protein 3RING finger protein 3Aring finger protein 3 | STAG3-like protein 3stromal antigen 3 pseudogene | |
Modification date | 20180523 | 20180329 | |
UniProtAcc | Q3KNV8 | ||
Ensembl transtripts involved in fusion gene | ENST00000362003, ENST00000400151, ENST00000482726, ENST00000470161, ENST00000521023, ENST00000505655, | ENST00000428423, | |
Fusion gene scores | * DoF score | 11 X 7 X 7=539 | 1 X 1 X 1=1 |
# samples | 11 | 1 | |
** MAII score | log2(11/539*10)=-2.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: PCGF3 [Title/Abstract] AND STAG3L3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE835063 | PCGF3 | chr4 | 760473 | + | STAG3L3 | chr7 | 72448304 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000362003 | ENST00000428423 | PCGF3 | chr4 | 760473 | + | STAG3L3 | chr7 | 72448304 | - |
intron-intron | ENST00000400151 | ENST00000428423 | PCGF3 | chr4 | 760473 | + | STAG3L3 | chr7 | 72448304 | - |
intron-intron | ENST00000482726 | ENST00000428423 | PCGF3 | chr4 | 760473 | + | STAG3L3 | chr7 | 72448304 | - |
intron-intron | ENST00000470161 | ENST00000428423 | PCGF3 | chr4 | 760473 | + | STAG3L3 | chr7 | 72448304 | - |
3UTR-intron | ENST00000521023 | ENST00000428423 | PCGF3 | chr4 | 760473 | + | STAG3L3 | chr7 | 72448304 | - |
3UTR-intron | ENST00000505655 | ENST00000428423 | PCGF3 | chr4 | 760473 | + | STAG3L3 | chr7 | 72448304 | - |
Top |
FusionProtFeatures for PCGF3_STAG3L3 |
![]() |
Hgene | Tgene |
PCGF3 | STAG3L3 |
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain thetranscriptionally repressive state of many genes, including Hoxgenes, throughout development. PcG PRC1 complex acts via chromatinremodeling and modification of histones; it mediatesmonoubiquitination of histone H2A 'Lys-119', rendering chromatinheritably changed in its expressibility. Within the PRC1-likecomplex, regulates RNF2 ubiquitin ligase activity(PubMed:26151332). Plays a redundant role with PCGF5 as part of aPRC1-like complex that mediates monoubiquitination of histone H2A'Lys-119' on the X chromosome and is required for normal silencingof one copy of the X chromosome in XX females (By similarity).{ECO:0000250|UniProtKB:Q8BTQ0, ECO:0000269|PubMed:26151332}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for PCGF3_STAG3L3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for PCGF3_STAG3L3 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for PCGF3_STAG3L3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for PCGF3_STAG3L3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |