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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26223

FusionGeneSummary for PCGF3_NCOA1

check button Fusion gene summary
Fusion gene informationFusion gene name: PCGF3_NCOA1
Fusion gene ID: 26223
HgeneTgene
Gene symbol

PCGF3

NCOA1

Gene ID

10336

8648

Gene namepolycomb group ring finger 3nuclear receptor coactivator 1
SynonymsDONG1|RNF3|RNF3AF-SRC-1|KAT13A|RIP160|SRC1|bHLHe42|bHLHe74
Cytomap

4p16.3

2p23.3

Type of geneprotein-codingprotein-coding
Descriptionpolycomb group RING finger protein 3RING finger protein 3Aring finger protein 3nuclear receptor coactivator 1Hin-2 proteinclass E basic helix-loop-helix protein 74renal carcinoma antigen NY-REN-52steroid receptor coactivator-1
Modification date2018052320180523
UniProtAcc

Q3KNV8

Q15788

Ensembl transtripts involved in fusion geneENST00000362003, ENST00000400151, 
ENST00000482726, ENST00000470161, 
ENST00000521023, ENST00000505655, 
ENST00000406961, ENST00000469850, 
ENST00000405141, ENST00000407230, 
ENST00000538539, ENST00000288599, 
ENST00000348332, ENST00000395856, 
Fusion gene scores* DoF score11 X 7 X 7=5397 X 7 X 3=147
# samples 118
** MAII scorelog2(11/539*10)=-2.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/147*10)=-0.877744249949002
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PCGF3 [Title/Abstract] AND NCOA1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNCOA1

GO:0000435

positive regulation of transcription from RNA polymerase II promoter by galactose

10207113

TgeneNCOA1

GO:0006351

transcription, DNA-templated

9223431

TgeneNCOA1

GO:0045893

positive regulation of transcription, DNA-templated

11891224|15367689

TgeneNCOA1

GO:0045944

positive regulation of transcription by RNA polymerase II

15919756


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ956364PCGF3chr4

702588

-NCOA1chr2

24930064

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000362003ENST00000406961PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000362003ENST00000469850PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000362003ENST00000405141PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000362003ENST00000407230PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000362003ENST00000538539PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000362003ENST00000288599PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000362003ENST00000348332PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000362003ENST00000395856PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-3CDSENST00000400151ENST00000406961PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000400151ENST00000469850PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000400151ENST00000405141PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000400151ENST00000407230PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000400151ENST00000538539PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000400151ENST00000288599PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000400151ENST00000348332PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000400151ENST00000395856PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-3CDSENST00000482726ENST00000406961PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000482726ENST00000469850PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000482726ENST00000405141PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000482726ENST00000407230PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000482726ENST00000538539PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000482726ENST00000288599PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000482726ENST00000348332PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000482726ENST00000395856PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-3CDSENST00000470161ENST00000406961PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000470161ENST00000469850PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000470161ENST00000405141PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000470161ENST00000407230PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000470161ENST00000538539PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000470161ENST00000288599PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000470161ENST00000348332PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000470161ENST00000395856PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-3CDSENST00000521023ENST00000406961PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000521023ENST00000469850PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000521023ENST00000405141PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000521023ENST00000407230PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000521023ENST00000538539PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000521023ENST00000288599PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000521023ENST00000348332PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000521023ENST00000395856PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-3CDSENST00000505655ENST00000406961PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000505655ENST00000469850PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000505655ENST00000405141PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000505655ENST00000407230PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000505655ENST00000538539PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000505655ENST00000288599PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000505655ENST00000348332PCGF3chr4

702588

-NCOA1chr2

24930064

+
intron-intronENST00000505655ENST00000395856PCGF3chr4

702588

-NCOA1chr2

24930064

+

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FusionProtFeatures for PCGF3_NCOA1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PCGF3

Q3KNV8

NCOA1

Q15788

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain thetranscriptionally repressive state of many genes, including Hoxgenes, throughout development. PcG PRC1 complex acts via chromatinremodeling and modification of histones; it mediatesmonoubiquitination of histone H2A 'Lys-119', rendering chromatinheritably changed in its expressibility. Within the PRC1-likecomplex, regulates RNF2 ubiquitin ligase activity(PubMed:26151332). Plays a redundant role with PCGF5 as part of aPRC1-like complex that mediates monoubiquitination of histone H2A'Lys-119' on the X chromosome and is required for normal silencingof one copy of the X chromosome in XX females (By similarity).{ECO:0000250|UniProtKB:Q8BTQ0, ECO:0000269|PubMed:26151332}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PCGF3_NCOA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PCGF3_NCOA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PCGF3_NCOA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PCGF3_NCOA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNCOA1C0014175Endometriosis1CTD_human
TgeneNCOA1C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneNCOA1C0027627Neoplasm Metastasis1CTD_human
TgeneNCOA1C0033578Prostatic Neoplasms1CTD_human
TgeneNCOA1C1458155Mammary Neoplasms1CTD_human