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Fusion gene ID: 26195 |
FusionGeneSummary for PCDH7_RAP1A |
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Fusion gene information | Fusion gene name: PCDH7_RAP1A | Fusion gene ID: 26195 | Hgene | Tgene | Gene symbol | PCDH7 | RAP1A | Gene ID | 5099 | 5906 |
Gene name | protocadherin 7 | RAP1A, member of RAS oncogene family | |
Synonyms | BH-Pcdh|BHPCDH|PPP1R120 | C21KG|G-22K|KREV-1|KREV1|RAP1|SMGP21 | |
Cytomap | 4p15.1 | 1p13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | protocadherin-7BH-protocadherin (brain-heart)brain-heart protocadherinprotein phosphatase 1, regulatory subunit 120 | ras-related protein Rap-1AGTP-binding protein smg p21ARas-related protein Krev-1 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | O60245 | P62834 | |
Ensembl transtripts involved in fusion gene | ENST00000543491, ENST00000509925, ENST00000361762, | ENST00000356415, ENST00000436150, ENST00000369709, ENST00000545460, ENST00000494982, | |
Fusion gene scores | * DoF score | 4 X 5 X 1=20 | 5 X 6 X 3=90 |
# samples | 5 | 7 | |
** MAII score | log2(5/20*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/90*10)=-0.362570079384708 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PCDH7 [Title/Abstract] AND RAP1A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | RAP1A | GO:0015031 | protein transport | 17916086 |
Tgene | RAP1A | GO:0071320 | cellular response to cAMP | 21840392 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF948052 | PCDH7 | chr4 | 31144315 | - | RAP1A | chr1 | 112237972 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000543491 | ENST00000356415 | PCDH7 | chr4 | 31144315 | - | RAP1A | chr1 | 112237972 | + |
In-frame | ENST00000543491 | ENST00000436150 | PCDH7 | chr4 | 31144315 | - | RAP1A | chr1 | 112237972 | + |
In-frame | ENST00000543491 | ENST00000369709 | PCDH7 | chr4 | 31144315 | - | RAP1A | chr1 | 112237972 | + |
In-frame | ENST00000543491 | ENST00000545460 | PCDH7 | chr4 | 31144315 | - | RAP1A | chr1 | 112237972 | + |
5CDS-3UTR | ENST00000543491 | ENST00000494982 | PCDH7 | chr4 | 31144315 | - | RAP1A | chr1 | 112237972 | + |
intron-3CDS | ENST00000509925 | ENST00000356415 | PCDH7 | chr4 | 31144315 | - | RAP1A | chr1 | 112237972 | + |
intron-3CDS | ENST00000509925 | ENST00000436150 | PCDH7 | chr4 | 31144315 | - | RAP1A | chr1 | 112237972 | + |
intron-3CDS | ENST00000509925 | ENST00000369709 | PCDH7 | chr4 | 31144315 | - | RAP1A | chr1 | 112237972 | + |
intron-3CDS | ENST00000509925 | ENST00000545460 | PCDH7 | chr4 | 31144315 | - | RAP1A | chr1 | 112237972 | + |
intron-3UTR | ENST00000509925 | ENST00000494982 | PCDH7 | chr4 | 31144315 | - | RAP1A | chr1 | 112237972 | + |
intron-3CDS | ENST00000361762 | ENST00000356415 | PCDH7 | chr4 | 31144315 | - | RAP1A | chr1 | 112237972 | + |
intron-3CDS | ENST00000361762 | ENST00000436150 | PCDH7 | chr4 | 31144315 | - | RAP1A | chr1 | 112237972 | + |
intron-3CDS | ENST00000361762 | ENST00000369709 | PCDH7 | chr4 | 31144315 | - | RAP1A | chr1 | 112237972 | + |
intron-3CDS | ENST00000361762 | ENST00000545460 | PCDH7 | chr4 | 31144315 | - | RAP1A | chr1 | 112237972 | + |
intron-3UTR | ENST00000361762 | ENST00000494982 | PCDH7 | chr4 | 31144315 | - | RAP1A | chr1 | 112237972 | + |
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FusionProtFeatures for PCDH7_RAP1A |
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Hgene | Tgene |
PCDH7 | RAP1A |
Induces morphological reversion of a cell linetransformed by a Ras oncogene. Counteracts the mitogenic functionof Ras, at least partly because it can interact with Ras GAPs andRAF in a competitive manner. Together with ITGB1BP1, regulatesKRIT1 localization to microtubules and membranes. Plays a role innerve growth factor (NGF)-induced neurite outgrowth. Plays a rolein the regulation of embryonic blood vessel formation. Involved inthe establishment of basal endothelial barrier function. May beinvolved in the regulation of the vascular endothelial growthfactor receptor KDR expression at endothelial cell-cell junctions.{ECO:0000269|PubMed:17916086, ECO:0000269|PubMed:21840392}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PCDH7_RAP1A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_PCDH7_ENST00000543491_chr4_31144315_-_RAP1A_ENST00000356415_chr1_112237972_+_0aa >In-frame_PCDH7_ENST00000543491_chr4_31144315_-_RAP1A_ENST00000436150_chr1_112237972_+_0aa >In-frame_PCDH7_ENST00000543491_chr4_31144315_-_RAP1A_ENST00000369709_chr1_112237972_+_0aa >In-frame_PCDH7_ENST00000543491_chr4_31144315_-_RAP1A_ENST00000545460_chr1_112237972_+_0aa |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_PCDH7_ENST00000543491_chr4_31144315_-_RAP1A_ENST00000356415_chr1_112237972_+_0nt >In-frame_PCDH7_ENST00000543491_chr4_31144315_-_RAP1A_ENST00000436150_chr1_112237972_+_0nt >In-frame_PCDH7_ENST00000543491_chr4_31144315_-_RAP1A_ENST00000369709_chr1_112237972_+_0nt >In-frame_PCDH7_ENST00000543491_chr4_31144315_-_RAP1A_ENST00000545460_chr1_112237972_+_0nt |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_PCDH7_ENST00000543491_chr4_31144315_-_RAP1A_ENST00000356415_chr1_112237972_+_0nt >In-frame_PCDH7_ENST00000543491_chr4_31144315_-_RAP1A_ENST00000436150_chr1_112237972_+_0nt >In-frame_PCDH7_ENST00000543491_chr4_31144315_-_RAP1A_ENST00000369709_chr1_112237972_+_0nt >In-frame_PCDH7_ENST00000543491_chr4_31144315_-_RAP1A_ENST00000545460_chr1_112237972_+_0nt |
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FusionGenePPI for PCDH7_RAP1A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PCDH7_RAP1A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PCDH7_RAP1A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |