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Fusion gene ID: 26193 |
FusionGeneSummary for PCDH7_MIB1 |
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Fusion gene information | Fusion gene name: PCDH7_MIB1 | Fusion gene ID: 26193 | Hgene | Tgene | Gene symbol | PCDH7 | MIB1 | Gene ID | 5099 | 57534 |
Gene name | protocadherin 7 | mindbomb E3 ubiquitin protein ligase 1 | |
Synonyms | BH-Pcdh|BHPCDH|PPP1R120 | DIP-1|DIP1|LVNC7|MIB|ZZANK2|ZZZ6 | |
Cytomap | 4p15.1 | 18q11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | protocadherin-7BH-protocadherin (brain-heart)brain-heart protocadherinprotein phosphatase 1, regulatory subunit 120 | E3 ubiquitin-protein ligase MIB1DAPK-interacting protein 1RING-type E3 ubiquitin transferase MIB1ubiquitin ligase mind bombzinc finger ZZ type with ankyrin repeat domain protein 2 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O60245 | Q86YT6 | |
Ensembl transtripts involved in fusion gene | ENST00000543491, ENST00000509925, ENST00000361762, | ENST00000578646, ENST00000261537, | |
Fusion gene scores | * DoF score | 4 X 5 X 1=20 | 3 X 4 X 2=24 |
# samples | 5 | 5 | |
** MAII score | log2(5/20*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/24*10)=1.05889368905357 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PCDH7 [Title/Abstract] AND MIB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BX111823 | PCDH7 | chr4 | 30953872 | - | MIB1 | chr18 | 19341819 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000543491 | ENST00000578646 | PCDH7 | chr4 | 30953872 | - | MIB1 | chr18 | 19341819 | - |
intron-intron | ENST00000543491 | ENST00000261537 | PCDH7 | chr4 | 30953872 | - | MIB1 | chr18 | 19341819 | - |
intron-intron | ENST00000509925 | ENST00000578646 | PCDH7 | chr4 | 30953872 | - | MIB1 | chr18 | 19341819 | - |
intron-intron | ENST00000509925 | ENST00000261537 | PCDH7 | chr4 | 30953872 | - | MIB1 | chr18 | 19341819 | - |
intron-intron | ENST00000361762 | ENST00000578646 | PCDH7 | chr4 | 30953872 | - | MIB1 | chr18 | 19341819 | - |
intron-intron | ENST00000361762 | ENST00000261537 | PCDH7 | chr4 | 30953872 | - | MIB1 | chr18 | 19341819 | - |
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FusionProtFeatures for PCDH7_MIB1 |
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Hgene | Tgene |
PCDH7 | MIB1 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PCDH7_MIB1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PCDH7_MIB1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PCDH7_MIB1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PCDH7_MIB1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | MIB1 | C0036572 | Seizures | 1 | CTD_human |
Tgene | MIB1 | C3554496 | LEFT VENTRICULAR NONCOMPACTION 7 | 1 | UNIPROT |