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Fusion gene ID: 2619 |
FusionGeneSummary for ARID1A_THSD7B |
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Fusion gene information | Fusion gene name: ARID1A_THSD7B | Fusion gene ID: 2619 | Hgene | Tgene | Gene symbol | ARID1A | THSD7B | Gene ID | 8289 | 80731 |
Gene name | AT-rich interaction domain 1A | thrombospondin type 1 domain containing 7B | |
Synonyms | B120|BAF250|BAF250a|BM029|C1orf4|CSS2|ELD|MRD14|OSA1|P270|SMARCF1|hELD|hOSA1 | - | |
Cytomap | 1p36.11 | 2q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | AT-rich interactive domain-containing protein 1AARID domain-containing protein 1AAT rich interactive domain 1A (SWI-like)BRG1-associated factor 250aOSA1 nuclear proteinSWI-like proteinSWI/SNF complex protein p270SWI/SNF-related, matrix-associated, | thrombospondin type-1 domain-containing protein 7Bthrombospondin, type I, domain containing 7B | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | O14497 | Q9C0I4 | |
Ensembl transtripts involved in fusion gene | ENST00000324856, ENST00000457599, ENST00000374152, ENST00000540690, | ENST00000409968, ENST00000272643, ENST00000413152, ENST00000543459, ENST00000485379, | |
Fusion gene scores | * DoF score | 21 X 13 X 13=3549 | 4 X 3 X 3=36 |
# samples | 31 | 4 | |
** MAII score | log2(31/3549*10)=-3.51707245378671 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ARID1A [Title/Abstract] AND THSD7B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ARID1A | GO:0006337 | nucleosome disassembly | 8895581 |
Hgene | ARID1A | GO:0006338 | chromatin remodeling | 11726552 |
Hgene | ARID1A | GO:0030520 | intracellular estrogen receptor signaling pathway | 12200431 |
Hgene | ARID1A | GO:0030521 | androgen receptor signaling pathway | 12200431 |
Hgene | ARID1A | GO:0042921 | glucocorticoid receptor signaling pathway | 12200431 |
Hgene | ARID1A | GO:0045893 | positive regulation of transcription, DNA-templated | 12200431 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LIHC | TCGA-FV-A3I0-01A | ARID1A | chr1 | 27059283 | + | THSD7B | chr2 | 137639714 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000324856 | ENST00000409968 | ARID1A | chr1 | 27059283 | + | THSD7B | chr2 | 137639714 | + |
5CDS-intron | ENST00000324856 | ENST00000272643 | ARID1A | chr1 | 27059283 | + | THSD7B | chr2 | 137639714 | + |
5CDS-intron | ENST00000324856 | ENST00000413152 | ARID1A | chr1 | 27059283 | + | THSD7B | chr2 | 137639714 | + |
5CDS-intron | ENST00000324856 | ENST00000543459 | ARID1A | chr1 | 27059283 | + | THSD7B | chr2 | 137639714 | + |
5CDS-intron | ENST00000324856 | ENST00000485379 | ARID1A | chr1 | 27059283 | + | THSD7B | chr2 | 137639714 | + |
5CDS-5UTR | ENST00000457599 | ENST00000409968 | ARID1A | chr1 | 27059283 | + | THSD7B | chr2 | 137639714 | + |
5CDS-intron | ENST00000457599 | ENST00000272643 | ARID1A | chr1 | 27059283 | + | THSD7B | chr2 | 137639714 | + |
5CDS-intron | ENST00000457599 | ENST00000413152 | ARID1A | chr1 | 27059283 | + | THSD7B | chr2 | 137639714 | + |
5CDS-intron | ENST00000457599 | ENST00000543459 | ARID1A | chr1 | 27059283 | + | THSD7B | chr2 | 137639714 | + |
5CDS-intron | ENST00000457599 | ENST00000485379 | ARID1A | chr1 | 27059283 | + | THSD7B | chr2 | 137639714 | + |
5CDS-5UTR | ENST00000374152 | ENST00000409968 | ARID1A | chr1 | 27059283 | + | THSD7B | chr2 | 137639714 | + |
5CDS-intron | ENST00000374152 | ENST00000272643 | ARID1A | chr1 | 27059283 | + | THSD7B | chr2 | 137639714 | + |
5CDS-intron | ENST00000374152 | ENST00000413152 | ARID1A | chr1 | 27059283 | + | THSD7B | chr2 | 137639714 | + |
5CDS-intron | ENST00000374152 | ENST00000543459 | ARID1A | chr1 | 27059283 | + | THSD7B | chr2 | 137639714 | + |
5CDS-intron | ENST00000374152 | ENST00000485379 | ARID1A | chr1 | 27059283 | + | THSD7B | chr2 | 137639714 | + |
intron-5UTR | ENST00000540690 | ENST00000409968 | ARID1A | chr1 | 27059283 | + | THSD7B | chr2 | 137639714 | + |
intron-intron | ENST00000540690 | ENST00000272643 | ARID1A | chr1 | 27059283 | + | THSD7B | chr2 | 137639714 | + |
intron-intron | ENST00000540690 | ENST00000413152 | ARID1A | chr1 | 27059283 | + | THSD7B | chr2 | 137639714 | + |
intron-intron | ENST00000540690 | ENST00000543459 | ARID1A | chr1 | 27059283 | + | THSD7B | chr2 | 137639714 | + |
intron-intron | ENST00000540690 | ENST00000485379 | ARID1A | chr1 | 27059283 | + | THSD7B | chr2 | 137639714 | + |
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FusionProtFeatures for ARID1A_THSD7B |
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Hgene | Tgene |
ARID1A | THSD7B |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ARID1A_THSD7B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ARID1A_THSD7B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ARID1A | KLF1, GATA1, SMARCB1, SMARCA4, SMARCA2, ING1, SMARCE1, PBRM1, SMARCC2, SMARCC1, PGR, BCL7C, HIC1, CUL2, ARID1B, SMAD2, SMAD3, CARM1, ADNP, RARA, SOX2, CHD7, SMARCD1, TP53, ELAVL1, SIRT7, TFAP4, CUL3, SMARCD2, ACTL6A, SMARCD3, PHF10, ECT2, YAP1, ITCH, NEDD4, SHMT2, MOV10, NXF1, EED, DPF3, DPF2, SS18, UNK, BCL7A, BCL7B, ESR1, NCOA1, RARB, RARG, EWSR1, SNW1, CDC5L, CUL1, SKP1, NFATC1, NFATC2, TOP1, CHEK1, VHL, EYA2, NR3C1, AR, ALDH2, TRIM25 | THSD7B | RANBP10 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ARID1A_THSD7B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ARID1A_THSD7B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ARID1A | C0038356 | Stomach Neoplasms | 3 | CTD_human |
Hgene | ARID1A | C2239176 | Liver carcinoma | 3 | CTD_human |
Hgene | ARID1A | C0001418 | Adenocarcinoma | 1 | CTD_human |
Hgene | ARID1A | C0005695 | Bladder Neoplasm | 1 | CTD_human |
Hgene | ARID1A | C0006413 | Burkitt Lymphoma | 1 | CTD_human |
Hgene | ARID1A | C0007138 | Carcinoma, Transitional Cell | 1 | CTD_human |
Hgene | ARID1A | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
Hgene | ARID1A | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
Hgene | ARID1A | C0027819 | Neuroblastoma | 1 | CTD_human |
Hgene | ARID1A | C0036920 | Sezary Syndrome | 1 | CTD_human |
Hgene | ARID1A | C0079772 | T-Cell Lymphoma | 1 | CTD_human |
Hgene | ARID1A | C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | CTD_human |
Hgene | ARID1A | C0206698 | Cholangiocarcinoma | 1 | CTD_human |
Hgene | ARID1A | C0265338 | Coffin-Siris syndrome | 1 | CTD_human;ORPHANET |
Hgene | ARID1A | C0279628 | Adenocarcinoma Of Esophagus | 1 | CTD_human |
Hgene | ARID1A | C0920269 | Microsatellite Instability | 1 | CTD_human |
Hgene | ARID1A | C2931822 | Nasopharyngeal carcinoma | 1 | CTD_human |
Tgene | THSD7B | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |