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Fusion gene ID: 26185 |
FusionGeneSummary for PCDH10_SLC11A2 |
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Fusion gene information | Fusion gene name: PCDH10_SLC11A2 | Fusion gene ID: 26185 | Hgene | Tgene | Gene symbol | PCDH10 | SLC11A2 | Gene ID | 57575 | 4891 |
Gene name | protocadherin 10 | solute carrier family 11 member 2 | |
Synonyms | OL-PCDH|PCDH19 | AHMIO1|DCT1|DMT1|NRAMP2 | |
Cytomap | 4q28.3 | 12q13.12 | |
Type of gene | protein-coding | protein-coding | |
Description | protocadherin-10 | natural resistance-associated macrophage protein 2DMT-1NRAMP 2divalent cation transporter 1solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2solute carrier family 11 (proton-coupled divalent metal ion transporters), me | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9P2E7 | P49281 | |
Ensembl transtripts involved in fusion gene | ENST00000264360, | ENST00000262051, ENST00000547198, ENST00000262052, ENST00000394904, ENST00000547688, ENST00000541174, ENST00000545993, ENST00000546743, ENST00000549193, | |
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 3 X 2 X 3=18 |
# samples | 3 | 3 | |
** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PCDH10 [Title/Abstract] AND SLC11A2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | SLC11A2 | GO:0006825 | copper ion transport | 12734107 |
Tgene | SLC11A2 | GO:0006828 | manganese ion transport | 17293870 |
Tgene | SLC11A2 | GO:0015684 | ferrous iron transport | 12734107|17293870 |
Tgene | SLC11A2 | GO:0015692 | lead ion transport | 12127992 |
Tgene | SLC11A2 | GO:0070574 | cadmium ion transmembrane transport | 12662899|25326704 |
Tgene | SLC11A2 | GO:1903874 | ferrous iron transmembrane transport | 17293870 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA241148 | PCDH10 | chr4 | 134071251 | + | SLC11A2 | chr12 | 51399179 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000264360 | ENST00000262051 | PCDH10 | chr4 | 134071251 | + | SLC11A2 | chr12 | 51399179 | - |
5UTR-3CDS | ENST00000264360 | ENST00000547198 | PCDH10 | chr4 | 134071251 | + | SLC11A2 | chr12 | 51399179 | - |
5UTR-3CDS | ENST00000264360 | ENST00000262052 | PCDH10 | chr4 | 134071251 | + | SLC11A2 | chr12 | 51399179 | - |
5UTR-3CDS | ENST00000264360 | ENST00000394904 | PCDH10 | chr4 | 134071251 | + | SLC11A2 | chr12 | 51399179 | - |
5UTR-3CDS | ENST00000264360 | ENST00000547688 | PCDH10 | chr4 | 134071251 | + | SLC11A2 | chr12 | 51399179 | - |
5UTR-3CDS | ENST00000264360 | ENST00000541174 | PCDH10 | chr4 | 134071251 | + | SLC11A2 | chr12 | 51399179 | - |
5UTR-3CDS | ENST00000264360 | ENST00000545993 | PCDH10 | chr4 | 134071251 | + | SLC11A2 | chr12 | 51399179 | - |
5UTR-5UTR | ENST00000264360 | ENST00000546743 | PCDH10 | chr4 | 134071251 | + | SLC11A2 | chr12 | 51399179 | - |
5UTR-5UTR | ENST00000264360 | ENST00000549193 | PCDH10 | chr4 | 134071251 | + | SLC11A2 | chr12 | 51399179 | - |
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FusionProtFeatures for PCDH10_SLC11A2 |
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Hgene | Tgene |
PCDH10 | SLC11A2 |
Potential calcium-dependent cell-adhesion protein. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PCDH10_SLC11A2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PCDH10_SLC11A2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PCDH10_SLC11A2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PCDH10_SLC11A2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PCDH10 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Hgene | PCDH10 | C0004352 | Autistic Disorder | 1 | CTD_human |
Tgene | SLC11A2 | C3806153 | ANEMIA, HYPOCHROMIC MICROCYTIC, WITH IRON OVERLOAD 1 | 3 | ORPHANET;UNIPROT |
Tgene | SLC11A2 | C0018995 | Hemochromatosis | 1 | CTD_human |
Tgene | SLC11A2 | C0023903 | Liver neoplasms | 1 | CTD_human |
Tgene | SLC11A2 | C0162316 | Iron deficiency anemia | 1 | CTD_human |