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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26185

FusionGeneSummary for PCDH10_SLC11A2

check button Fusion gene summary
Fusion gene informationFusion gene name: PCDH10_SLC11A2
Fusion gene ID: 26185
HgeneTgene
Gene symbol

PCDH10

SLC11A2

Gene ID

57575

4891

Gene nameprotocadherin 10solute carrier family 11 member 2
SynonymsOL-PCDH|PCDH19AHMIO1|DCT1|DMT1|NRAMP2
Cytomap

4q28.3

12q13.12

Type of geneprotein-codingprotein-coding
Descriptionprotocadherin-10natural resistance-associated macrophage protein 2DMT-1NRAMP 2divalent cation transporter 1solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2solute carrier family 11 (proton-coupled divalent metal ion transporters), me
Modification date2018052320180519
UniProtAcc

Q9P2E7

P49281

Ensembl transtripts involved in fusion geneENST00000264360, ENST00000262051, 
ENST00000547198, ENST00000262052, 
ENST00000394904, ENST00000547688, 
ENST00000541174, ENST00000545993, 
ENST00000546743, ENST00000549193, 
Fusion gene scores* DoF score3 X 3 X 1=93 X 2 X 3=18
# samples 33
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PCDH10 [Title/Abstract] AND SLC11A2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSLC11A2

GO:0006825

copper ion transport

12734107

TgeneSLC11A2

GO:0006828

manganese ion transport

17293870

TgeneSLC11A2

GO:0015684

ferrous iron transport

12734107|17293870

TgeneSLC11A2

GO:0015692

lead ion transport

12127992

TgeneSLC11A2

GO:0070574

cadmium ion transmembrane transport

12662899|25326704

TgeneSLC11A2

GO:1903874

ferrous iron transmembrane transport

17293870


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA241148PCDH10chr4

134071251

+SLC11A2chr12

51399179

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000264360ENST00000262051PCDH10chr4

134071251

+SLC11A2chr12

51399179

-
5UTR-3CDSENST00000264360ENST00000547198PCDH10chr4

134071251

+SLC11A2chr12

51399179

-
5UTR-3CDSENST00000264360ENST00000262052PCDH10chr4

134071251

+SLC11A2chr12

51399179

-
5UTR-3CDSENST00000264360ENST00000394904PCDH10chr4

134071251

+SLC11A2chr12

51399179

-
5UTR-3CDSENST00000264360ENST00000547688PCDH10chr4

134071251

+SLC11A2chr12

51399179

-
5UTR-3CDSENST00000264360ENST00000541174PCDH10chr4

134071251

+SLC11A2chr12

51399179

-
5UTR-3CDSENST00000264360ENST00000545993PCDH10chr4

134071251

+SLC11A2chr12

51399179

-
5UTR-5UTRENST00000264360ENST00000546743PCDH10chr4

134071251

+SLC11A2chr12

51399179

-
5UTR-5UTRENST00000264360ENST00000549193PCDH10chr4

134071251

+SLC11A2chr12

51399179

-

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FusionProtFeatures for PCDH10_SLC11A2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PCDH10

Q9P2E7

SLC11A2

P49281

Potential calcium-dependent cell-adhesion protein.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PCDH10_SLC11A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PCDH10_SLC11A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PCDH10_SLC11A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PCDH10_SLC11A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePCDH10C0001973Alcoholic Intoxication, Chronic1PSYGENET
HgenePCDH10C0004352Autistic Disorder1CTD_human
TgeneSLC11A2C3806153ANEMIA, HYPOCHROMIC MICROCYTIC, WITH IRON OVERLOAD 13ORPHANET;UNIPROT
TgeneSLC11A2C0018995Hemochromatosis1CTD_human
TgeneSLC11A2C0023903Liver neoplasms1CTD_human
TgeneSLC11A2C0162316Iron deficiency anemia1CTD_human